Involvement of G protein-coupled receptor kinase 4 and 6 in rapid desensitization of dopamine D1 receptor in rat IEC-6 intestinal epithelial cells

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 287, Issue 4 56-4, 2004, Pages

  Fraga, Sónia ^a   Jose, Pedro A ^b   Soares Da Silva, Patrício ^a,c  

^a Institute of Pharmacology and Therapeutics   (Portugal)

^b GEORGETOWN UNIVERSITY MEDICAL CENTER   (United States)

^c Inst of Pharmacol and Therapeutics   (Portugal)

Author keywords

Adenylyl cyclase; Na+ H+ exchanger

Indexed keywords

2,3,4,5 TETRAHYDRO 7,8 DIHYDROXY 1 PHENYL 1H 3 BENZAZEPINE; 8 BROMO 2,3,4,5 TETRAHYDRO 3 METHYL 5 PHENYL 1H 3 BENZAZEPIN 7 OL; ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); ADENYLATE CYCLASE; BUCLADESINE; DOPAMINE 1 RECEPTOR; FORSKOLIN; G PROTEIN COUPLED RECEPTOR KINASE; G PROTEIN COUPLED RECEPTOR KINASE 4; G PROTEIN COUPLED RECEPTOR KINASE 6; G PROTEIN COUPLED RECEPTOR KINASE ANTIBODY; HEPARIN; LIPOFECTIN; PROTEIN ANTIBODY; SODIUM PROTON EXCHANGE PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; IMMUNOBLOTTING; INTESTINE ABSORPTION; INTESTINE EPITHELIUM CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTON SODIUM EXCHANGE; RAT; RECEPTOR DOWN REGULATION; RECEPTOR INTRINSIC ACTIVITY; SODIUM ABSORPTION;

2,3,4,5-TETRAHYDRO-7,8-DIHYDROXY-1-PHENYL-1H-3-BENZAZEPINE; ADENYLATE CYCLASE; ANIMALS; ANTIBODIES, BLOCKING; BLOTTING, WESTERN; CELL LINE; CYCLIC AMP; CYCLIC AMP-DEPENDENT PROTEIN KINASES; DOPAMINE AGONISTS; ENZYME INHIBITORS; EPITHELIAL CELLS; HEPARIN; INTESTINES; ISOENZYMES; PROTEIN-SERINE-THREONINE KINASES; RATS; RECEPTORS, DOPAMINE D1; SODIUM-HYDROGEN ANTIPORTER;

EID: 4644290582     PISSN: 03636119     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpregu.00208.2004     Document Type: Article

References (36)

1. Baig AH, Swords FM, Szaszak M, King PJ, Hunyady L, and Clark AJ. Agonist activated adrenocorticotropin receptor internalizes via a clathrin-mediated G protein receptor kinase dependent mechanism. Endocr Res 28: 281-289, 2002.
2. 1 receptors in opossum kidney cells. Studies in cells that stably express a rat cAMP phosphodiesterase (rPDE3) cDNA. J Biol Chem 268: 14757-14763, 1993.
3. Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72: 248-254, 1976.
4. Civelli O, Bunzow JR, and Grandy DK. Molecular diversity of the dopamine receptors. Annu Rev Pharmacol Toxicol 33: 281-307, 1993.
5. Dautzenberg FM, Braun S, and Hauger RL. GRK3 mediates desensitization of CRF1 receptors: a potential mechanism regulating stress adaptation. Am J Physiol Regul Integr Comp Physiol 280: R935-R946, 2001.
6. Felder RA, Sanada H, Xu J, Yu PY, Wang Z, Watanabe H, Asico LD, Wang W, Zheng S, Yamaguchi I, Williams SM, Gainer J, Brown NJ, Hazen-Martin D, Wong LJ, Robillard JE, Carey RM, Eisner GM, and Jose PA. G protein-coupled receptor kinase 4 gene variants in human essential hypertension. Proc Natl Acad Sci USA 99: 3872-3877, 2002.
7. Ferguson SS. Evolving concepts in G protein-coupled receptor endocytosis: the role in receptor desensitization and signaling. Pharmacol Rev 53: 1-24, 2001.
8. Freedman NJ and Lefkowitz RJ. Desensitization of G protein-coupled receptors. Recent Prog Harm Res 51: 319-351, 1996.
9. Freedman NJ, Liggett SB, Drachman DE, Pei G, Caron MG, and Lefkowitz RJ. Phosphorylation and desensitization of the human β1-adrenergic receptor. Involvement of G protein-coupled receptor kinases and cAMP-dependent protein kinase. J Biol Chem 270: 17953-17961, 1995.
10. +-ATPase activity. Am J Physiol Renal Physiol 282: F1084-F1096, 2002.
11. + exchanger. Am J Physiol Regul Integr Comp Physiol 281: R10-R18, 2001.
12. Huff RM. Signaling pathways modulated by dopamine receptors. In: The Dopamine Receptors, edited by Neve KA and Neve RL. Totowa, NJ: Humana, 1997, p. 167-192.
13. 1 dopamine receptors with mutations of protein kinase phosphorylation sites: attenuation of the rate of agonist-induced desensitization. Mol Pharmacol 56: 675-683, 1999.
14. Jose PA, Eisner GM, and Felder RA. Renal dopamine receptors in health and hypertension. Pharmacol Ther 80: 149-182, 1998.
15. Krupnick JG and Benovic JL. The role of receptor kinases and arrestins in G protein-coupled receptor regulation. Anna Rev Pharmacol Toxicol 38: 289-319, 1998.
16. 1A dopamine receptor: efficacy in causing desensitization dissociates from both receptor occupancy and functional potency. J Pharmacol Exp Ther 286: 345-353, 1998.
17. +-ATPase to dopamine. J Nutr 130: 877-881, 2000.
18. + ATPase to inhibition by dopamine in spontaneous hypertensive and Wistar-Kyoto rats. Clin Exp Hypertens 22: 455-469, 2000.
19. 1 receptor trafficking by protein kinase A-dependent phosphorylation. Mol Pharmacol 61: 806-816, 2002.
20. Neve KA and Neve RL. Molecular biology of dopamine receptors. In: The Dopamine Receptors, edited by Neve KA and Neve RL. Totowa, NJ: Humana, 1997, p. 27-76.
21. 1 receptor. Eur J Pharmacol 267: 7-19, 1994.
22. + exchanger isoforms. Am J Physiol Cell Physiol 268: C283-C296, 1995.
23. + exchanger isoforms (NHE1 and NHE3) in polarized epithelial cell lines. J Cell Sci 109: 929-939, 1996.
24. Pao CS and Benovic JL. Phosphorylation-independent desensitization of G protein-coupled receptors? Sci STKE 153: PE42, 2002.
25. Pierce KL and Lefkowitz RJ. Classical and new roles of beta-arrestins in the regulation of G-protein-coupled receptors. Nat Rev Neurosci 2: 727-733, 2001.
26. Pierce KL, Premont RT, and Lefkowitz RJ. Seven-transmembrane receptors. Nat Rev Mol Cell Biol 3: 639-650, 2002.
27. Quaroni A, Wands J, Trelstad RL, and Isselbacher KJ. Epithelioid cell cultures from rat small intestine. Characterization by morphologic and immunologic criteria. J Cell Biol 80: 248-265, 1979.
28. Robinson SW and Caron MG. Interactions of dopamine receptors with G proteins. In: The Dopamine Receptors, edited by Neve KA and Neve RL. Totowa, NJ: Humana, 1997, p. 137-165.
29. Shayo C, Fernandez N, Legnazzi BL, Monczor F, Mladovan A, Baldi A, and Davio C. Histamine H2 receptor desensitization: involvement of a select array of G protein-coupled receptor kinases. Mol Pharmacol 60: 1049-1056, 2001.
30. Sibley DR and Monsma FJ Jr. Molecular biology of dopamine receptors. Trends Pharmacol Sci 13: 61-69, 1992.
31. 1A receptor responsiveness by various G protein-coupled receptor kinases. J Biol Chem 271: 3771-3778, 1996.
32. +-ATPase during high-salt diet in young but not in adult rats. Am J Physiol Regul Integr Comp Physiol 275: R1317-R1323, 1998.
33. + ATPase activity and electrolyte transport. Br J Pharmacol 129: 573-581, 2000.
34. 1 dopamine receptors by G protein-coupled receptor kinase 4. Kidney Int 62: 790-798, 2002.
35. Xu J, Watanabe H, Felder RA, and Jose PA. GRK6 in the kidney in human and rat genetic hypertension (Abstract). FASEB J 15: A774, 2001.
36. 1 dopamine receptor: evidence for involvement of both cyclic AMP-dependent and receptor-specific protein kinases. Mol Cell Neurosci 2: 464-472, 1991.