Visceral adiposity, increased adipocyte lipolysis, and metabolic dysfunction in obese postmenopausal women

American Journal of Physiology - Endocrinology and Metabolism

Volumn 270, Issue 1 33-1, 1996, Pages

  Nicklas, Barbara J ^a   Rogus, Ellen M ^b   Colman, Eric G ^b   Goldberg, Andrew P ^b  

^a BALTIMORE VA MEDICAL CENTER   (United States)

^b NONE

Author keywords

body fat distribution; epinephrine; intra abdominal fat

Indexed keywords

ADRENALIN; ADRENERGIC RECEPTOR; BUCLADESINE; GLYCEROL; HIGH DENSITY LIPOPROTEIN; INSULIN; PROPRANOLOL; TRIACYLGLYCEROL; YOHIMBINE;

ADIPOCYTE; ADULT; AGED; ARTICLE; BODY FAT; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN CELL; INSULIN BLOOD LEVEL; LIPOLYSIS; OBESITY; POSTMENOPAUSE; PRIORITY JOURNAL; SUBCUTANEOUS FAT;

EID: 0030046856     PISSN: 01931849     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpendo.1996.270.1.e72     Document Type: Article

References (31)

1. American Heart Association Steering Committee. Dietary guidelines for healthy American adults. Circulation 77: 721-724, 1988.
2. Bjorntorp, P. "Portal" adipose tissue as a generator of risk factors for cardiovascular disease and diabetes. Arteriosclerosis 10: 493-496, 1990.
3. Boobis, L. H., and R. J. Maughan. A simple one-step enzymatic fluorometric method for determination of glycerol in 20 μl of plasma. Clin. Chim. Acta 132: 173-179, 1983.
4. Bruce, R. A., and T. R. Horstein. Exercise stress testing in evaluation of patients with ischemic heart disease. Prog. Cardiovasc. Dis. 11: 371-390, 1969.
5. Busetto, L., M. Digito, P. D. Monta, R. Carraro, and G. Enzi. Omental and epigastric adipose tissue lipolytic activity in human obesity. Effect of abdominal fat distribution and relationship with hyperinsulinemia. Harm. Metab. Res. 25: 365-371, 1993.
6. Ferrannini, E., E. J. Barrett, S. Bevilacqua, and R. A. DeFronzo. Effect of fatty acids on glucose production and utilization in man. J. Clin. Invest. 72: 1737-1747, 1983.
7. Fujioka, S., Y. Matsuzawa, K. Tokunage, and S. Tarui. Contribution of intra-abdominal fat accumulation to the impairment of glucose and lipid metabolism in human obesity. Metab. Clin. Exp. 36: 54-59, 1987.
8. Haarbo, J., C. Hassager, A. Schlemmer, and C. Christiansen. Infuence of smoking, body fat distribution, and alcohol consumption on serum lipids, lipoproteins, and apolipoproteins in early postmenopausal women. Atherosclerosis 84, 239-244, 1990.
9. Harris, J. A., and F. G. Benedict. A Biomedical Study of Basal Metabolism in Man. Washington, DC: Carnegie Inst., 1919. (Publ. 279)
10. Hellmer, J., C. Marcus, T. Sonnenfeld, and P. Arner. Mechanisms for differences in lipolysis between human subcutaneous and omental fat cells. J. Clin. Endocrinol. Metab. 75: 15-20, 1992.
11. Hirsch, J., and E. Gallian. Methods for the determination of adipose cell size in man and animals. J. Lipid Res. 9: 110-119, 1968.
12. Jensen, M. D., M. W. Haymond, R. A. Rizza, P. E. Cryer, and J. M. Miles. Influence of body fat distribution on free fatty acid metabolism in obesity. J. Clin. Invest. 83: 1168-1173, 1989.
13. Jensen, M. D., M. L. Martin, P. E. Cryer, and L. R. Roust. Effects of estrogen on free fatty acid metabolism in humans. Am. J. Physiol. 266 (Endocrinol. Metab. 29): E914-E920, 1994.
14. Katzel, L. I., P. J. Coon, J. Dengel, A. P. Goldberg. Effects of an American Heart Association Step I diet and weight loss on lipoprotein lipid levels in obese men with silent myocardial ischemia and reduced high-density lipoprotein cholesterol. Metab. Clin. Exp. 44: 307-314, 1995.
15. Kissebah, A. H., S. Alfarsi, P. W. Adams, and V. Wynn. Role of insulin resistance in adipose tissue and liver in the pathogenesis of endogenous hypertriglyceridaemia in man. Diabetologia 12: 563-571, 1976.
16. Lapidus, L., C. Bengtsson, B. Larsson, K. Pennert, E. Rybo, and L. Sjostrom. Distribution of adipose tissue and risk of cardiovascular disease and death: a 12 year follow up of participants in the population study of women in Gothenburg, Sweden. Br. Med. J. 289: 1257-1260, 1984.
17. Ley, C. J., B. Lees, and J. C. Stevenson. Sex- and menopause-associated changes in body-fat distribution. Am. J. Clin. Nutr. 55: 950-954, 1992.
18. Lindberg, U., N. Crona, G. Silfverstolpe, P. Bjorntorp, and M. Rebuffe-Scrive. Regional adipose tissue metabolism in postmenopausal women after treatment with exogenous sex steroids. Horm. Metab. Res. 22: 345-351, 1990.
19. Marin, P., and P. Bjorntorp. Endocrine-metabolic pattern and adipose tissue distribution. Horm. Res. Suppl. 3: 81-85, 1993.
20. Marin, P., B. Oden, and P. Bjorntorp. Assimilation and mobilization of triglycerides in subcutaneous abdominal and femoral adipose tissue in vivo in men: effects of androgens. J. Clin. Endocrinol. Metab. 80: 239-243, 1995.
21. Mauriege, P., J. P. Despres, and M. Marcotte. Abdominal fat cell lipolysis, body fat distribution, and metabolic variables in premenopausal women. J. Clin. Endocrinol. Metab. 71: 1028-1035, 1990.
22. Mauriege, P., J. P. Despres, and D. Prudhomm. Regional variation in adipose tissue lipolysis in lean and obese men. J. Lipid Res. 32: 1625-1633, 1991.
23. Rebuffe-Scrive, M. Regional adipose tissue metabolism in men and postmenopausal women. Int. J. Obesity 11: 347-355, 1987.
24. Rebuffe-Scrive, M., B. Andersson, L. Olbe, and P. Bjorntorp. Metabolism of adipose tissue in intraabdominal depots of nonobese men and women. Metab. Clin. Exp. 38: 453-458, 1989.
25. Reynisdottir, S., K. Ellerfeldt, H. Wahrenberg, H. Lithell, and P. Amer. Multiple lipolysis defects in the insulin resistance (metabolic) syndrome. J. Clin. Invest. 93: 2590-2599, 1994.
26. 2-adrenoceptors. Diabetologia 37: 428-435, 1994.
27. Rodbell, M. Metabolism of isolated fat cells. I. Effects of hormones on glucose metabolism and lipolysis. J. Biol. Chem. 239: 375-380, 1964.
28. Roust, L. R., and M. D. Jensen. Postprandial free fatty acid kinetics are abnormal in upper body obesity. Diabetes 42: 1567-1573, 1993.
29. Steinberg, D., M. Vaughan, and S. Margolis. Studies of triglyceride biosynthesis in homogenates of adipose tissue. J. Biol. Chem. 236: 1631-1635, 1961.
30. Svedberg, J., P. Bjorntorp, U. Smith, and P. Lonnroth. Free-fatty acid inhibition of insulin binding, degradation and action in isolated rat hepatocytes. Diabetes 39: 570-575, 1990.
31. Wahrenberg, H., F. Lonnqvist, and P. Arner. Mechanisms underlying regional differences in lipolysis in human adipose tissue. J. Clin. Invest. 84: 458-467, 1989.