Human DNA primase uses Watson-Crick hydrogen bonds to distinguish between correct and incorrect nucleoside triphosphates

Biochemistry

Volumn 43, Issue 38, 2004, Pages 12367-12374

  Moore, Chad L ^a   Zivkovic, Aleksandra ^b   Engels, Joachim W ^b   Kuchta, Robert D ^a  

^a UNIVERSITY OF COLORADO   (United States)

^b GOETHE UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMISTRY; HYDROGEN BONDS; HYDROPHOBICITY; POLYMERIZATION; RNA;

EXOCYCLIC GROUPS; HUMAN PRIMASES;

DNA;

2 CHLOROADENINE; 2 FLUOROADENINE; 3 DEAZAADENINE; 4 (TRIFLUOROMETHYL)BENZIMIDAZOLE; 4 AMINOBENZIMIDAZOLE; 4,6 DIFLUOROBENZIMIDAZOLE; 5 (TRIFLUOROMETHYL)BENZIMIDAZOLE; 6 (TRIFLUOROMETHYL)BENZIMIDAZOLE; 7 (TRIFLUOROMETHYL)BENZIMIDAZOLE; 7BETA DEXTRO GUANINE; BENZIMIDAZOLE DERIVATIVE; DNA BASE; DNA DIRECTED DNA POLYMERASE ALPHA; DNA POLYMERASE; DNA PRIMASE; GUANINE DERIVATIVE; HYPOXANTHINE; NUCLEOSIDE TRIPHOSPHATE; PRIMER RNA; PURINE; PYRIMIDINE; UNCLASSIFIED DRUG;

ARTICLE; BASE MISPAIRING; CONTROLLED STUDY; HUMAN; HYDROGEN BOND; HYDROPHOBICITY; MOLECULAR MODEL; MOLECULAR RECOGNITION; NONHUMAN; POLYMERIZATION; PRIORITY JOURNAL; RNA SYNTHESIS; RNA TRANSLATION;

BASE SEQUENCE; BINDING SITES; CHLORIDES; DNA; DNA PRIMASE; FLUORINE; HUMANS; HYDROGEN BONDING; INHIBITORY CONCENTRATION 50; MOLECULAR SEQUENCE DATA; MOLECULAR STRUCTURE; NUCLEOTIDES; SUBSTRATE SPECIFICITY;

EID: 4644289452     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi0490791     Document Type: Article

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