Eukaryotic DNA primase

Trends in Biochemical Sciences

Volumn 25, Issue 11, 2000, Pages 572-576

  Arezi, Bahram ^a   Kuchta, Robert D ^a  

^a UNIVERSITY OF COLORADO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA DIRECTED DNA POLYMERASE ALPHA; DNA PRIMASE; SINGLE STRANDED DNA;

DNA REPAIR; DNA REPLICATION; ENZYME ACTIVITY; ENZYME CONFORMATION; ENZYME MECHANISM; HUMAN; MOLECULAR DYNAMICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; REACTION ANALYSIS; REVIEW; SEQUENCE HOMOLOGY; TELOMERE;

EUKARYOTA;

EID: 0034326917     PISSN: 09680004     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0004(00)01680-7     Document Type: Review

References (40)

1. Priming of HIV replication by tRNA(Lys3): Role of reverse transcriptase
2. Polymerases and the replisome: Machines within machines
3. The second-largest subunit of the mouse DNA polymerase α-primase complex facilitates both production and nuclear translocation of the catalytic subunit of DNA polymerase α
4. The role of the 70-kDa subunit of human DNA polymerase α in DNA replication
5. Intact DNA polymerase α/primase from mouse cells. Purification and characterization
6. Immunoaffinity-purified DNA polymerase α displays novel properties
7. Expression, purification, and characterization of the two human primase subunits and truncated complexes from Escherichia coli
8. Identification of the nuclear localization signal of mouse DNA primase: Nuclear transport of p46 subunit is facilitated by interaction with p54 subunit
9. Primase activity of human DNA polymerase α-primase. Divalent cations stabilize the enzyme activity of the p48 subunit
10. Interactions of DNA with human DNA primase monitored with photoactivatable cross-linking agents: Implications for the role of the p58 subunit
11. Enzymatic characterization of the individual mammalian primase subunits reveals a biphasic mechanism for initiation of DNA replication
12. DNA polymerase β belongs to an ancient nucleotidyltransferase superfamily
13. Active site mapping of the catalytic mouse primase subunit by alanine scanning mutagenesis
14. Arg304 of human DNA primase is a key contributor to catalysis and NTP binding: Primase and the family X polymerases share significant sequence homology
15. Crystal structures of human DNA polymerase β complexed with DNA: Implications for catalytic mechanism, processivity, and fidelity
16. Identification and characterization of a DNA primase from the hyperthermophilic archaeon Methanococcus jannaschii
17. Structure of the RNA polymerase domain of E. coli primase
18. DNA polymerase-primase from embryos of Drosophila melanogaster
19. The mechanism of calf thymus DNA primase: Slow initiation, rapid polymerization and intelligent termination
20. Kinetic mechanism of DNA polymerase I (Klenow)
21. DNA primase-DNA polymerase α from simian cells: Sequence specificity of initiation sites on simian virus 40 DNA
22. Protein-protein interactions of the primase subunits p58 and p48 with simian virus 20 T antigen are required for efficient primer synthesis in a cell-free system
23. Eucaryotic DNA primase does not prefer to synthesize primers at pyrimidine rich DNA sequences when nucleoside triphosphates are present at concentrations found in whole cells
24. Calf thymus DNA polymerase alpha-primase: 'Communication' and primer: Template movement between the two active sites
25. Misincorporation of nucleotides by calf thymus DNA primase and elongation of primers containing multiple noncognate nucleotides by DNA polymerase α
26. Inhibition of DNA primase and polymerase α by arabinofuranosylnucleoside triphosphates and related compounds
27. Abasic template lesions are strong chain terminators for DNA primase but not for DNA polymerase α during the synthesis of a new DNA strand
28. Interactions of DNA polymerase α holoenzyme with synthetic template-primers containing mismatched bases or propanodeoxyguanosine adducts at various positions in template and primer regions
29. Human CDC45 protein binds to minichromosome maintenance 7 protein and the p70 subunit of DNA polymerase α
30. Uninterrupted MCM2-7 function required for DNA replication fork progression
31. Functional association of poly(ADP-ribose) polymerase with DNA polymerase α-primase complex: A link between DNA strand break detection and DNA replication
32. Poly(ADP-ribose) polymerase inhibits DNA replication by human replicative DNA polymerase α, δ and ε in vitro
33. XRCC1 is specifically associated with poly(ADP-ribose) polymerase and negatively regulates its activity following DNA damage
34. A role for DNA primase in coupling DNA replication to DNA damage response
35. Activation of the DNA replication checkpoint through RNA synthesis by primase
36. Mutational effect of fission yeast pol α on cell cycle events
37. Functional analysis of the amino-terminal 8-kDa domain of DNA polymerase β as revealed by site-directed mutagenesis. DNA binding and 59-deoxyribose phosphate lyase activities
38. Cell cycle-dependent phosphorylation of human DNA polymerase α
39. Telomerase-mediated telomere addition in vivo requires DNA primase and DNA polymerases α and δ