Propofol does not inhibit lidocaine metabolism during epidural anesthesia

Anesthesia and Analgesia

Volumn 99, Issue 4, 2004, Pages 1131-1135

  Nakayama, Shin ^a   Miyabe, Masayuki ^a   Kakiuchi, Yoshihiro ^a   Inomata, Shinichi ^a   Osaka, Yoshiko ^a   Fukuda, Taeko ^a   Kohda, Yukinao ^a   Toyooka, Hidenori ^a  

^a UNIVERSITY OF TSUKUBA   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BUPIVACAINE; DEETHYLLIDOCAINE; FENTANYL; GLYCINE XYLIDIDE; LIDOCAINE; NIZATIDINE; PROPOFOL; SEVOFLURANE; THIAMYLAL; VECURONIUM;

ADULT; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTINUOUS INFUSION; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG METABOLISM; EPIDURAL ANESTHESIA; FEMALE; HEMODYNAMIC MONITORING; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; MAINTENANCE THERAPY; MALE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; ULTRAFILTRATION;

AGED; ANESTHESIA, EPIDURAL; ANESTHETICS, INTRAVENOUS; ANESTHETICS, LOCAL; BIOTRANSFORMATION; BLOOD LOSS, SURGICAL; BLOOD PRESSURE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG INTERACTIONS; FEMALE; HEART RATE; HUMANS; LIDOCAINE; MALE; MIDDLE AGED; PROPOFOL; ULTRAFILTRATION;

EID: 4644247539     PISSN: 00032999     EISSN: None     Source Type: Journal    
DOI: 10.1213/01.ANE.0000131508.39939.86     Document Type: Article

References (16)

1. Hamaoka N, Oda Y, Hase I, et al. Propofol decreases the clearance of midazolam by inhibiting CYP 3A4: an in vivo and in vitro study. Clin Pharmacol Ther 1999;66:110-7.
2. Wang JS, Backman JT, Taavitsainen P, et al. Involvement of CYP 1A2 and 3A4 in lidocaine N-deethylation and 3-hydroxylation in humans. Drug Metab Dispos 2000;28:959-65.
3. Orlando R, Piccoli P, De Martin S, et al. Cytochrome P450 1A2 is a major determinant of lidocaine metabolism in vivo: effects of liver function. Clin Pharmacol Ther 2004;75:80-8.
4. Oda Y, Mizutani K, Hase I, et al. Fentanyl inhibits metabolism of midazolam: competitive inhibition of CYP3A4 in vitro. Br J Anaesth 1999;82:900-3.
5. Leung BP, Miller E, Park GR. The effect of propofol on midazolam metabolism in human liver microsome suspension. Anaesthesia 1997;52:945-8.
6. Inomata S, Nagashima A, Osaka Y, et al. Propofol inhibits lidocaine metabolism in human and rat liver metabolism. J Anesth 2003;17:246-50.
7. Kohda Y, Kakiuchi Y, Miyabe M, et al. Simultaneous determination of lidocaine and its deethyl-metabolites in plasma and its application to drug level monitoring in infants. J Appl Ther Res 1998;2:33-8.
8. Kakiuchi Y, Fukuda T, Miyabe M, et al. Chromatographic determination of free lidocaine and its active metabolites in plasma from patients under epidural anesthesia. Int J Clin Pharmacol Ther 2002;40:493-8.
9. Hermansson J, Glaumann H, Karlen B, von Bahr C. Metabolism of lidocaine in human liver in vitro. Acta Pharmacol Toxicol 1980;47:49-52.
10. Gemayel J, Geloen A, Mion F. Propofol-induced cytochrome P450 inhibition: an in vitro and in vivo study in rats. Life Sci 2001;68:2957-65.
11. Mazoit JX, Samii K. Binding of propofol to blood components: implications for pharmacokinetics and for pharmacodynamics. Br J Clin Pharmacol 1999;47:35-42.
12. Court MH, Duan SX, Hesse LM, et al. Cytochrome P-450 2B6 is responsible for interindividual variability of propofol hydroxylation by human liver microsomes. Anesthesiology 2001;94:110-9.
13. Isohanni MH, Neuvonen PJ, Palkama VJ, Olkkola KT. Effect of erythromycin and itraconazole on the pharmacokinetics of intravenous lignocaine. Eur J Clin Pharmacol 1998;54:561-5.
14. Ping H, Zhen-Fu C, Shao-Qing X, et al. An in vivo rat model for assessment of extrahepatic metabolism. J Pharmacol Toxicol Methods 2001;45:181-5.
15. Bargetzi MJ, Aoyama T, Gonzales FJ, Meyer UA. Lidocaine metabolism in human liver microsomes by cytochrome P450 3A4. Clin Pharmacol Ther 1989;46:521-7.
16. Kharasch ED, Thummel KE. Identification of cytochrome P450 2E1 as the predominant enzyme catalyzing human liver microsomal defluorination of sevoflurane, isoflurane, and methoxyflurane. Anesthesiology 1993;79:795-807.