Propofol inhibits lidocaine metabolism in human and rat liver microsomes

Journal of Anesthesia

Volumn 17, Issue 4, 2003, Pages 246-250

  Inomata, Shinichi ^a   Nagashima, Atsushi ^a   Osaka, Yoshiko ^a   Kazama, Tomiei ^b   Tanaka, Einosuke ^a   Sato, Shigehito ^b   Toyooka, Hidenori ^a  

^a UNIVERSITY OF TSUKUBA   (Japan)

^b HAMAMATSU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Cytochrome P450; Drug interaction; In vitro; Lidocaine; Propofol

Indexed keywords

CYTOCHROME P450 ISOENZYME; DEETHYLLIDOCAINE; LIDOCAINE; PROPOFOL; HYPNOTIC SEDATIVE AGENT; LOCAL ANESTHETIC AGENT;

ANALYSIS OF VARIANCE; ANIMAL CELL; ARTICLE; CONCENTRATION (PARAMETERS); CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG ANTAGONISM; DRUG METABOLISM; ENZYME ASSAY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; LIVER MICROSOME METABOLISM; MALE; NONHUMAN; RAT; STUDENT T TEST; ANIMAL; DOSE RESPONSE; DRUG EFFECT; DRUG INTERACTION; LIVER MICROSOME; METABOLISM; PHYSIOLOGY; SPRAGUE DAWLEY RAT;

ANESTHETICS, LOCAL; ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; HUMANS; HYPNOTICS AND SEDATIVES; LIDOCAINE; MALE; MICROSOMES, LIVER; PROPOFOL; RATS; RATS, SPRAGUE-DAWLEY;

EID: 1542435943     PISSN: 09138668     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00540-003-0193-5     Document Type: Article

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