Propofol decreases the clearance of midazolam by inhibiting CYP3A4: An in vivo and in vitro study

Clinical Pharmacology and Therapeutics

Volumn 66, Issue 2, 1999, Pages 110-117

  Hamaoka, Naoya ^a,b   Oda, Yutaka ^a,b   Hase, Ichiro ^a,b   Mizutani, Koh ^a,b   Nakamoto, Tatsuo ^a,b   Ishizaki, Takashi ^a,b   Asada, Akira ^a,b  

^a OSAKA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b KUMAMOTO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME P450; MIDAZOLAM; PROPOFOL;

ADULT; ANESTHESIA INDUCTION; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; COMPETITIVE INHIBITION; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG CLEARANCE; DRUG DISPOSITION; DRUG METABOLISM; DRUG PROTEIN BINDING; ELECTIVE SURGERY; ENZYME INHIBITION; FEMALE; HUMAN; INTRAVENOUS ANESTHESIA; INTRAVENOUS DRUG ADMINISTRATION; LIVER MICROSOME METABOLISM; MALE; MICHAELIS CONSTANT; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL;

EID: 0032783856     PISSN: 00099236     EISSN: None     Source Type: Journal    
DOI: 10.1053/cp.1999.v66.100038001     Document Type: Article

References (29)

1. 1. Iselin-Chaves IA, Flaishon R, Sebel PS, Howell S, Gan TJ, Sigl J, et al. The effect of the interaction of propofol and alfentanil on recall, loss of consciousness, and the bispectral index. Anesth Analg 1998;87:949-55.
2. 2. Pavlin DJ, Coda B, Shen DD, Tschanz J, Nguyen Q, Schaffer R, et al. Effects of combining propofol and alfentanil on ventilation, analgesia, sedation, and emesis in human volunteers. Anesthesiology 1996;84:23-37.
3. 3. Short TG, Chui PT. Propofol and midazolam act synergistically in combination. Br J Anaesth 1991;67:539-45.
4. 4. Janicki PK, James MFM, Erskine WAR. Propofol inhibits enzymatic degradation of alfentanil and sufentanil by isolated liver microsomes in vitro. Br J Anaesth 1992;68: 311-2.
5. 5. Allonen H, Ziegler G, Klotz U. Midazolam kinetics. Clin Pharmacol Ther 1981;30:653-61.
6. 6. Olkkola KT, Ahonen J, Neuvonen PJ. The effect of the systemic antimycotics, itraconazole and fluconazole, on the pharmacokinetics and pharmacodynamics of intravenous and oral midazolam. Anesth Analg 1996;82:511-6.
7. 7. Ahonen J, Olkkola KT, Salmenperä M, Hynynen M, Neuvonen PJ. Effect of diltiazem on midazolam and alfentanil disposition in patients undergoing coronary artery bypass grafting. Anesthesiology 1996;85:1246-52.
8. 8. Hase I, Oda Y, Tanaka K, Mizutani K, Nakamoto T, Asada A. I.v. fentanyl decreases the clearance of midazolam. Br J Anaesth 1997;79:740-3.
9. 9. Plummer GF. Improved method for the determination of propofol in blood by high-performance liquid chromatography with fluorescence detection. J Chromatogr 1987; 421:171-6.
10. 10. Oda Y, Mizutani K, Hase I, Nakamoto T, Hamaoka N, Asada A. Fentanyl inhibits the metabolism of midazolam: competitive inhibition of CYP3A4 in vitro. Br J Anaesth 1999;82:900-3.
11. 11. Kobayashi K, Yamamoto T, Chiba K, Tani M, Ishizaki T, Kuroiwa Y. The effects of selective serotonin reuptake inhibitors and their metabolites on S-mephenytoin 4′-hydroxylase activity in human liver microsomes. Br J Clin Pharmacol 1995;40:481-5.
12. 12. Reves JG, Glass PSA, Lubarsky DA. Nonbarbiturate intravenous anesthetics. In: Miller RD, editor. Anesthesia. 4th ed. New York: Churchill Livingstone; 1994, p. 247-89.
13. 13. Thummel KE, Shen DD, Podoll TD, Kunze KL, Trager WF, Hartwell PS, et al. Use of midazolam as a human cytochrome P450 3A probe; I: in vitro-in vivo correlations in liver transplant patients. J Pharmacol Exp Ther 1994;271:549-56.
14. 14. Kronbach T, Mathys D, Umeno M, Gonzalez FJ, Meyer UA. Oxidation of midazolam and triazolam by human liver cytochrome P450IIIA4. Mol Pharmacol 1989;36:89-96.
15. 15. Gorski JC, Hall SD, Jones DR, VandenBranden M, Wrighton SA. Regioselective biotransformation of midazolam by members of the human cytochrome P450 3A (CYP3A) subfamily. Biochem Pharmacol 1994;47: 1643-53.
16. 16. Nelson DR, Koymans L, Kamataki T, Stegeman JJ, Feyereisen R, Waxman DJ, et al. P450 superfamily: update on new sequences, gene mapping, accession numbers and nomenclature. Pharmacogenetics 1996;6:1-42.
17. 17. Thummel KE, O'Shea D, Paine MK, Shen DD, Kunze KL, Perkins JD, et al. Oral first-pass elimination of midazolam involves both gastrointestinal and hepatic CYP3A-mediated metabolism. Clin Pharmacol Ther 1996;59:491-502.
18. 18. Teh J, Short TG, Wong J, Tan P. Pharmacokinetic interactions between midazolam and propofol: an infusion study. Br J Anaesth 1994;72:62-5.
19. 19. Vuyk J, Lim T, Engbers FHM, Burm AGL, Vletter AA, Bovill JG. The pharmacodynamic interaction of propofol and alfentanil during lower abdominal surgery in women. Anesthesiology 1995;83:8-22.
20. 20. Kharasch ED, Thummel KE. Identification of cytochrome P450 2E1 as the predominant enzyme catalyzing human liver microsomal defluorination of sevoflurane, isoflurane, and methoxyflurane. Anesthesiology 1993;79:795-807.
21. 21. Graham SG, Tateishi T, Guengerich FP, Wood AJJ, Wood M. Inhalational anesthetics inhibit CYP2E1 activity specifically [abstract]. Anesthesiology 1995;83:A342.
22. 22. Vree TB, Shimoda M, Driessen JJ, Guelen PJM, Janssen TJ, Termond EFS, et al. Decreased plasma albumin concentration results in increased volume of distribution and decreased elimination of midazolam in intensive care patients. Clin Pharmacol Ther 1989;46:537-44.
23. 23. Lange H, Stephan H, Rieke H, Kellermann M, Sonntag H, Bircher J. Hepatic and extrahepatic disposition of propofol in patients undergoing coronary bypass surgery. Br J Anaesth 1990;64:563-70.
24. 24. von Moltke LL, Greenblatt DJ, Schmider J, Wright CE, Harmatz JS, Shader RI. In vitro approaches to predicting drug interactions in vivo. Biochem Pharmacol 1998;55: 113-22.
25. 25. Servin F, Desmonts JM, Haberer JP, Cockshott ID, Plummer GF, Farinotti R. Pharmacokinetics and protein binding of propofol in patients with cirrhosis. Anesthesiology 1988;69:887-91.
26. 26. Leung BP, Miller E, Park GR. The effect of propofol on midazolam metabolism in human liver microsome suspension. Anaesthesia 1997;52:945-8.
27. 27. Aoyama T, Yamano S, Waxman DJ, Lapenson DP, Meyer UA, Fischer V, et al. Cytochrome P-450 hPCN3, a novel cytochrome P-450 IIIA gene product that is differentially expressed in adult human liver. J Biol Chem 1989;264: 10388-95.
28. 28. Guitton J, Buronfosse T, Desage M, Flinois JP, Perdrix JP, Brazier JL, et al. Possible involvement of multiple human cytochrome P450 isoforms in the liver metabolism of propofol. Br J Anaesth 1998;80:788-95.
29. 29. Serlin MJ, Sibeon RG, Mossman S, Breckenridge AM, Williams JRB, Atwood JL, et al. Cimetidine: interaction with oral anticoagulants in man. Lancet 1979;2:317-9.