Molecular homology and the luminal transport of Hg2+ in the renal proximal tubule

Journal of the American Society of Nephrology

Volumn 11, Issue 3, 2000, Pages 394-402

  Cannon, Vernon T ^a   Barfuss, Delon W ^a   Zalups, Rudolfs K ^b  

^a GEORGIA STATE UNIVERSITY   (United States)

^b MERCER UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACIVICIN; CILASTATIN; CYSTEINYLGLYCINE; GAMMA GLUTAMYLTRANSFERASE; GLUTATHIONE; MERCURY;

ANIMAL TISSUE; ARTICLE; ENZYME ACTIVITY; ENZYME INHIBITION; FEMALE; ISOLATED KIDNEY; KIDNEY PERFUSION; KIDNEY PROXIMAL TUBULE; KIDNEY TUBULE ABSORPTION; NONHUMAN; PRIORITY JOURNAL; RABBIT;

EID: 0034090907     PISSN: 10466673     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (33)

1. Zalups RK: Organic union transport and action of γ-glutamyltranspeptidase in kidney linked mechanistically to renal tubular uptake of inorganic mercury. Toxicol Appl Pharmacol 132: 289-298, 1995
2. Zalups RK: Enhanced renal outer medullary uptake of mercury associated with uninephrectomy: Implication of a luminal mechanism. J Toxicol Environ Health 50: 173-194, 1997
3. Zalups RK, Barfuss DW: Small aliphatic dicarboxylic acids inhibit renal uptake of administered mercury. Toxicol Appl Pharmacol 148: 183-193, 1998
4. Zalups RK, Barfuss DW: Participation of mercuric conjugates of cysteine, homocysteine, and N-acetylcysteine in mechanisms involved in the renal tubular uptake of inorganic mercury. J Am Soc Nephrol 9: 551-561, 1998
5. Zalups RK, Minor KH: Luminal and basolateral mechanisms involved in the renal tubular uptake of inorganic mercury. J Toxicol Environ Health 46: 73-100, 1995
6. Zalups RK, Barfuss DW: Pretreatment with p-aminohippurate inhibits the renal uptake and accumulation of injected inorganic mercury in the rat. Toxicology 103: 23-35, 1995
7. Zalups RK, Lash LH: Advances in understanding the renal transport and toxicity of mercury. J Toxicol Environ Health 42: 1-44, 1994
8. Berndt WO, Bagget JM, Blacker A, Houser M: Renal glutathione and mercury uptake by kidney. Fundam Appl Toxicol 5: 832-839, 1985
9. deCeaurriz J, Payan JP, Morel P, Brondeau MT: Role of extracellular glutathione and γ-glutamyltranspeptidase in the disposition and kidney toxicity of inorganic mercury in rats. J Appl Toxicol 14: 201-206, 1994
10. Tanaka T, Naganuma A, Imura N: Role of γ-glutamyltranspeptidase in renal uptake and toxicity of inorganic mercury in mice. Toxicology 60: 187-198, 1990
11. Tanaka-Kagawa T, Naganuma A, Imura N: Tubular secretion and reasorption of mercury compounds in mouse kidney. J Pharmacol Exp Ther 264: 776-782, 1993
12. Zalups RK, Barfuss DW: Renal disposition of mercury in rats after intravenous injection of inorganic mercury and cysteine. J Toxicol Environ Health 44: 401-413, 1995
13. Zalups RK, Barfuss DW: Nephrotoxicity of inorganic mercury co-administered with L-cysteine. Toxicology 109: 15-29, 1996
14. Zalups RK, Lash LH: Binding of mercury in renal brush-border and basolateral membrane-vesicles: Implication of a cysteine conjugate of mercury involved in the luminal uptake of inorganic mercury in the kidney. Biochem Pharmacol 53: 1889-1900, 1997
15. Zalups RK, Lash LH: Depletion of glutathione in the kidney and the renal disposition of administered inorganic mercury. J Toxicol Environ Health 42: 1-44, 1997
16. Diamond GL, Zalups RK: Understanding renal toxicity of heavy metals. Toxicol Pathol 16: 92-103, 1998
17. Rabenstein DL: Metal complexes of glutathione and their biological significance. In: Glutathione: Chemical Biochemical and Medical Aspects, Vol. 3, Coenzymes and Cofactors, edited by Dolphin D, Avramovic O, Poulson R, New York, Wiley, 1989, pp 147-186
18. Parks-LD, Zalups RK, Barfuss DW: Heterogeneity of glutathione synthesis and secretion in the proximal tubule of the rabbit. Am J Physiol 274: F924-F931, 1998
19. Hirota T, Nishikawa Y, Takahagi H, Igarashi T, Kitagawa H: Simultaneous purification and properties of dehydropeptidase-I and aminopeptidase-M from rat kidney. Res Commun Pathol Pharmacol 49: 435-445, 1985
20. Hirota T, Nishikawa Y, Komai T, Igarashi T, Kitagawa H: Role of dehydropeptidase-I in the metabolism of glutathione and its conjugates in the rat kidney. Res Commun Chem Pathol Pharmacol 56: 235-242, 1987
21. Zalups RK, Robinson MK, Barfuss DW: Factors affecting inorganic mercury transport and toxicity in isolated perfused proximal tubule. J Am Soc Nephrol 2: 866-878, 1991
22. Zalups RK, Barfuss DW: The isolated perfused tubule as a technique to study the transport and toxicity of metals along the nephron. In: Toxicology of Metals, edited by Chang LW, Suzuki T, Magos L, Chapter 48, Boca Raton, CRC Press, 1996, pp 765-782
23. Kim CY, Watanabe C, Kasanuma H, Satoh H: Inhibition of γ-glutamyltranspeptidase decreases renal deposition of mercury after mercury vapor exposure. Arch Toxicol 69: 722-724, 1995
24. Zalups RK, Barfuss DW, Lash LH: Disposition of inorganic mercury following biliary obstruction and chemically induced glutathione depletion: Dispositional changes one hour after the intravenous administration of mercuric chloride. Toxicol Appl Pharmacol 154: 135-144, 1999
25. Zalups RK: Method for studying the in vivo accumulation of inorganic mercury in segments of the nephron in the kidneys of rats treated with mercuric chloride. J Pharmacol Methods 26: 89-104, 1991
26. Zalups RK: Autometallographic localization of inorganic mercury in the kidneys of rats: Effect of unilateral nephrectomy and compensatory renal growth. Exp Mol Pathol 54: 10-21, 1991
27. Zalups RK, Barfuss DW: Accumulation of inorganic mercury along the renal proximal tubule of the rabbit. Toxicol Appl Pharmacol 106: 245-253, 1990
28. Naganuma A, Oda-Urano N, Tanaka T, Imura N: Possible role of hepatic glutathione in transport of methyl mercury into mouse kidney. Biochem Pharmacol 37: 291-296, 1988
29. Clarkson TW: Molecular and ionic mimicry of toxic metals. Annu Rev Pharmacol Toxicol 32: 545-571, 1993
30. Aschner M, Eberle NB, Goderie S, Kimelberg HK: Methyl mercury uptake in rat primary astrocyte cultures: The role of the neutral amino acid transport system. Brain Res 521: 221-228, 1990
31. Aschner M, Clarkson TW: Methyl mercury uptake across bovine brain capillary endothelial cells in vitro: The role of amino acids. Pharmacol Toxicol 64: 293-297, 1989
32. Kerper LE, Ballatori N, Clarkson TW: Methylmercury transport across the blood brain barrier by an amino acid carrier. Am J Physiol 262: R761-R765, 1992
33. Schafer JA, Watkins ML: Transport of L-cystine in isolated perfused proximal straight tubules. Pflügers Arch 401: 143-151, 1984