Renal uptake and excretion of homocysteine in rats with acute hyperhomocysteinemia

Kidney International

Volumn 54, Issue 5, 1998, Pages 1601-1607

  House, James D ^a   Brosnan, Margaret E ^a   Brosnan, John T ^a  

^a MEMORIAL UNIVERSITY OF NEWFOUNDLAND   (Canada)

Author keywords

Cardiovascular disease; Glomerular filtration rate; Kidney; Nitrous oxide; Rat model; Renal plasma flow

Indexed keywords

HOMOCYSTEINE; METHIONINE SYNTHASE; NITROUS OXIDE; OXYGEN;

AMINO ACID BLOOD LEVEL; AMINO ACID METABOLISM; AMINO ACID TRANSPORT; AMINO ACID URINE LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; GLOMERULUS FILTRATION; HYPERHOMOCYSTEINEMIA; KIDNEY TUBULE ABSORPTION; MALE; METHYLATION; NONHUMAN; PRIORITY JOURNAL; RAT;

EID: 0031787437     PISSN: 00852538     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1523-1755.1998.00144.x     Document Type: Article

References (43)

1. NYGARD O, NORDEHAUG NE, REFSUM H, UELAND PM, FARSTAD M, VOLLSET SE: Plasma homocysteine levels and mortality in patients with coronary-artery disease. N Engl J Med 337:230-236, 1997
2. GRAHAM IM, DALY LE, REFSUM HM, ROBINSON K, BRATTSTROM, LE, UELAND PM, PALMAREIS RJ, BOERS GHJ, SHEAHAN RG, ISRAELSSON B, UITERWAAL CS, MELEADY R, MCMASTER D, VERHOEF P, WITTEMAN J, RUBBA P, BELLET H, WAUTRECHT JC, DEVALK HW, LUIS ACS, PARROTROULAUD FM, TAN KS, HIGGINS I, GARCON D, MEDRANO MJ, CANDITO M, EVANS AE, ANDRIA G: Plasma homocysteine as a risk factor for vascular-disease - The European Concerted Action Project. JAMA 277:1775-1781, 1997
3. FINKELSTEIN JD, KYLE WE, HARRIS BJ: Methionine metabolism in mammals. Regulation of homocysteine methyltransferases in rat tissue. Arch Biochem Biophys 146:84-92, 1971
4. MUDD SH, FINKELSTEIN JD, IRREVERRE F, LASTER L: Transsulfuration in mammals. Microassays and tissue distributions of three enzymes of the pathway. J Biol Chem 240:4382-4392, 1965
5. MALINOW MR: Homocyst(e)ine and arterial occlusive diseases. J Intern Med 236:603-617, 1994
6. WILKEN DEL, GUPTA VJ: Sulphur containing amino acids in chronic renal failure with particular reference to homocystine and cysteine-homocysteine mixed disulphide. Eur J Clin Invest 9:301-307, 1979
7. HULTBERG B, ANDERSSON A, STERNER G: Plasma homocysteine in renal failure. Clin Nephrol 40:230-234, 1993
8. BOSTOM AG, SHEMIN D, LAPANF KL, MILLER JW, SUTHERLAND P, NADEAU M, SEYOUM E, HARTMAN W, PRIOR R, WILSON PWF, SELHUB J: Hyperhomocysteinemia and traditional cardiovascular disease risk factors in end-stage renal disease patients on dialysis: A case-control study. Atherosclerosis 114:93-103, 1995
9. CHURCHILL. DN: Comparative morbidity among hemodialysis and continuous ambulatory peritoneal dialysis patients. Kidney Int 43(Suppl 40):S16-S22, 1993
10. BOSTOM AG, LATHROP L: Hyperhomocysteinemia in end-stage renal disease: Prevalence, etiology, and potential relationship to arteriosclerotic outcomes. Kidney Int 52:10-20, 1997
11. BOSTOM AG, BROSNAN JT, HALL B, NADEAU MR, SELHUB J: Net uptake of plasma homocysteine by the rat kidney in vivo. Atherosclerosis 116:59-62, 1995
12. HOUSE JD, BROSNAN ME, BROSNAN JT: Characterization of homocysteine metabolism in the rat kidney. Biochem J 328:287-292, 1997
13. FOREMAN JW, WALD H, BLUMBERG G, PEPE LM, SEGAL S: Homocystine uptake in isolated rat renal cortical tubules. Metabolism 31:613-619, 1982
14. DEACON R, PERRY J, LUMB M, CHANARIN I, MINTY B, HALSFY MJ, NUNN JF: Selective inactivation of vitamin B12 in rats by nitrous oxide. Lancet 2:1023-1024, 1978
15. CANADIAN COUNCIL ON ANIMAL CARE: Guide to the Care and Use of Experimental Animals (2 vols). Ottawa, CCAC, 1980-1984
16. REEVES PG, NIELSEN FH, FAHEY GC: AIN-93 purified diets for laboratory rodents: Final report of the American Institute of Nutrition Ad Hoc Writing Committee on the reformulation of the AIN-76A rodent diet. J Nutr 123:1939-1951, 1993
17. HORNE DW, HOLLOWAY RS: Compartmentation of folate metabolism in rat pancreas: Nitrous oxide inactivation of methionine synthase leads to accumulation of 5-methyltetrafolate in cytosol. J Nutr 127:1772-1775, 1997
18. LOWRY M, HALL DE, HALL MS, BROSNAN JT: Renal metabolism of amino acids in vivo: Studies on serine and glycine fluxes. Am J Physiol 252:F304-F309, 1987
19. DUERRE JA, MILLER CH: Preparation of L-homocysteine from L-homocysteine thiolactone. Anal Biochem 17:310-315, 1966
20. VESTER B, RASMUSSEN K: High performans liquid chromatography method for rapid and accurate determination of homocysteine in plasma and serum. Eur J Clin Chem Clin Biochem 29:549-554, 1991
21. MILLER JW, NADEAU MR, SMITH J, SMITH DE, SELHUB J: Folate-deficiency-induced homocysteinemia in rats: Disruption of S-adenosylmethionine's co-ordinate regulation of homocysteine metabolism. Biochem J 298:415-419, 1994
22. JONES BN, GILLIGAN JP: o-Phthaldialdehyde precolumn derivatization and reversed-phase high-performance liquid chromatography of polypeptide hydrolysates and physiological fluids. J Chromatogr 266:471-482, 1983
23. KOBLIN DD, WATSON JE, DEADY JE. STOKSTAD ELR, EGER EI: Inactivation of methionine synthetase by nitrous oxide in mice. Anesthesiology 54:318-324, 1981
24. GORNALL AG, BARDAWILL CJ, DAVID MM: Determination of serum proteins by means of the biuret reaction. J Biol Chem 177:751-766, 1949
25. JACOBS EE, JACOB J, SANADI DR, BRADLEY LB: Uncoupling of oxidative phosphorylation by cadmium ion. J Biol Chem 223:147-156, 1956
26. WOLF AV: Total renal blood flow at any urine flow or extraction fraction. Am J Physiol 133:496-497, 1941
27. SAS INSTITUTE INC: SAS Statistical Analysis Software, version 6.10, Cary, SAS Institute, 1993
28. ZAR JH: Biostatistical Analysis (2nd ed). Englewood Cliffs, Prentice-Hall Inc., 1984
29. BROSNAN JT, HALL B: Renal serine production in vivo: Effects of dietary manipulation of serine status. Can J Physiol Pharmacol 67:1058-1061, 1989
30. WELBOURNE TC, PHROMPHETCHARAT V, GIVENS G, JOSHI S: Regulation of interorganal glutamine flow in metabolic acidosis. Am J Physiol 250:E457-E463, 1986
31. ARNADOTTIR M, HVLTBERG B, NILSSON-EHLE P, THYSELL H: The effect of reduced glomerular filtration rate on plasma total homocysteine concentration. Scand J Clin Lab Invest 56:41-46, 1996
32. MCKEEVER MP, WEIR DG, MOLLOY A, SCOTT JM: Betaine:homocysteine methyltransferase: Organ distribution in man, pig and rat and subcellular distribution in the rat. Clin Sci 81:551-556, 1991
33. BANKS RGS, HENDERSON RJ, PRATT JM: Reactions of gases in solution. Part III. Some reactions of nitrous oxide with transistion-metal complexes. J Chem Soc (A):2886-2889, 1968
34. KONDO H, OSBORNE ML, KOLHOUSK JF, BINDER MJ, PODELL ER, UTLEY CS, ABRAMS RS, ALLEN RH: Nitrous oxide has multiple deleterious effects on cobalamin metabolism and causes decreases in activities of both mammalian cobalamin-dependent enzymes in rats. J Clin Invest 67:1270-1283, 1981
35. CHRISTENSEN B, GUTTORMSEN AB, SCHNEEDE J, RIEDEL B, REESUM H, SVARDAL A, UELAND PM: Preoperative methionine loading enhances restoration of the cobalamin-dependent enzyme methionine synthase after nitrous oxide anesthesia. Anesthesiology 80:1046-1056, 1994
36. ERMENS AAM, REFSUM H, RUPREHT J, SPIJKERS LJM, GUTTORMSEN AB, LINDEMANS J, UELAND PM, ABELS J: Monitoring cobalamin inactivation during nitrous oxide anesthesia by determination of homocysteine and folate in plasma and urine. Cliin Pharmacol Ther 49:385-393, 1991
37. GUTTORMSEN AB, SCHNEEDE J, UELAND PM, REFSUM H: Kinetics of total plasma homocysteine in subjects with hyperhomocysteinemia due to folate or cobalamin deficiency. Am J Clin Nutr 63:194-202, 1996
38. GUTTORMSEN AB, UELAND PM, SVARSTAD E, REFSUM H: Kinetic basis of hyperhomocysteinemia in patients with chronic renal failure. Kidney Int 52:495-502, 1997
39. SMOLIN LA, BENEVENGA NJ: Accumulation of homocyst(e)ine in Vitamin B-6 deficiency: A model for the study of cystathionine β-synthase deficiency. J Nutr 112:1264-1272, 1982
40. REFSUM H, HELLAND S, UELAND PM: Radioenzymic determination of homocysteine in plasma and urine. Clin Chem 31:624-628, 1985
41. KANG S, WONG PWK, CURLEY K: The effect of d-penicillamine on protein-bound homocyst(e)ine in homocystinurics. Pediatr Res 16:370-372, 1982
42. LAUTERBURG BH, NGUYEN T, HARTMANN B, JUNKER E, KUPFER A, CERNY A: Depletion of total cysteine, glutathionine, and homocysteine in plasma by ifosfamide/mesna therapy. Cancer Chemother Pharmacol 35:132-136, 1994
43. HULTBERG B, ANDERSSON A, MASSON P, LARSON M, TUNEK A: Plasma homocysteine and thiol compound fractions after oral administration of N-acetylcysteine. Scand J Clin Lab Invest 54:417-422, 1994