Glucocorticoids induce human glycoprotein hormone α-subunit gene expression in the gonadotrope

Endocrinology

Volumn 149, Issue 7, 2008, Pages 3643-3655

  Sasson, Ravid ^a,b   Luu, Sang H ^a,c   Thackray, Varykina G ^a   Mellon, Pamela L ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b Betastim Corp   (Israel)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN; CRE RECOMBINASE; CYCLIC AMP; DEXAMETHASONE; DNA; ESTROGEN; GESTAGEN; GLUCOCORTICOID; GLUCOCORTICOID RECEPTOR;

ALPHA CHAIN; ANIMAL CELL; ARTICLE; CELL IMMORTALIZATION; CONTROLLED STUDY; DOSE RESPONSE; DRUG INHIBITION; GEL MOBILITY SHIFT ASSAY; GENE EXPRESSION; GENE MUTATION; GENE OVEREXPRESSION; GENETIC TRANSFECTION; GONADOTROPIN SECRETING CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MOLECULAR CLONING; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION;

BASE SEQUENCE; BINDING SITES; CELL LINE; CHROMATIN IMMUNOPRECIPITATION; DEXAMETHASONE; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROPHORETIC MOBILITY SHIFT ASSAY; GENE EXPRESSION; GLUCOCORTICOIDS; GLYCOPROTEIN HORMONES, ALPHA SUBUNIT; GONADOTROPHS; HOMEODOMAIN PROTEINS; HUMANS; LUCIFERASES; MUTAGENESIS, SITE-DIRECTED; NUCLEAR PROTEINS; PROMOTER REGIONS (GENETICS); PROTEIN BINDING; RECEPTORS, GLUCOCORTICOID; RECOMBINANT FUSION PROTEINS; SEQUENCE HOMOLOGY, NUCLEIC ACID; TRANSCRIPTION FACTORS; TRANSFECTION;

EID: 46349095257     PISSN: 00137227     EISSN: 00137227     Source Type: Journal    
DOI: 10.1210/en.2007-1100     Document Type: Article

References (71)

1. Gharib SD, Wierman ME, Shupnik MA, Chin WW 1990 Molecular biology of the pituitary gonadotropins. Endocr Rev 11:177-199
2. Fiddes JC, Goodman HM 1981 The gene encoding the common α-subunit of the four human glycoprotein hormones. J Mol Appl Genet 1:3-18
3. Shupnik MA 1996 Gonadotropin gene modulation by steroids and gonadotropin-releasing hormone. Biol Reprod 54:279-286
4. Keri RA, Andersen B, Kennedy GC, Hamernik DL, Clay CM, Brace AD, Nett TM, Notides AC, Nilson JH 1991 Estradiol inhibits transcription of the human glycoprotein hormone α-subunit gene despite the absence of a high affinity binding site for estrogen receptor. Mol Endocrinol 5:725-733
5. Dalkin AC, Haisenleder DJ, Ortolano GA, Suhr A, Marshall JC 1990 Gonadal regulation of gonadotropin subunit gene expression: evidence for regulation of follicle-stimulating hormone-β messenger ribonucleic acid by nonsteroidal hormones in female rats. Endocrinology 127:798-806
6. Kerrigan JR, Dalkin AC, Haisenleder DJ, Yasin M, Marshall JC 1993 Failure of gonadotropin-releasing hormone (GnRH) pulses to increase luteinizing hormone β-messenger ribonucleic acid in GnRH-deficient female rats. Endocrinology 133:2071-2079
7. Paul SJ, Ortolano GA, Haisenleder DJ, Stewart JM, Shupnik MA, Marshall JC 1990 Gonadotropin subunit messenger RNA concentrations after blockade of gonadotropin-releasing hormone action: testosterone selectively increases follicle-stimulating hormone β-subunit messengerRNAby posttranscriptional mechanisms. Mol Endocrinol 4:1943-1955
8. Clay CM, Keri RA, Finicle AB, Heckert LL, Hamernik DL, Marschke KM, Wilson EM, French FS, Nilson JH 1993 Transcriptional repression of the glycoprotein hormone α-subunit gene by androgen may involve direct binding of androgen receptor to the proximal promoter. J Biol Chem 268:13556-13564
9. Jorgensen JS, Nilson JH 2001 AR suppresses transcription of the α-glycoprotein hormone subunit gene through protein-protein interactions with cJun and activation transcription factor 2. Mol Endocrinol 15:1496-1504
10. Heckert LL, Wilson EM, Nilson JH 1997 Transcriptional repression of the α-subunit gene by androgen receptor occurs independently of DNA binding but requires the DNA-binding and ligand-binding domains of the receptor. Mol Endocrinol 11:1497-1506
11. Ringstrom SJ, McAndrews JM, Rahal JO, Schwartz NB 1991 Cortisol in vivo increases FSHβ mRNA selectively in pituitaries of male rats. Endocrinology 129:2793-2795
12. Kilen SM, Szabo M, Strasser GA, McAndrews JM, Ringstrom SJ, Schwartz NB 1996 Corticosterone selectively increases follicle-stimulating hormone β-subunit messenger ribonucleic acid in primary anterior pituitary cell culture without affecting its half-life. Endocrinology 137:3802-3807
13. McAndrews JM, Ringstrom SJ, Dahl KD, Schwartz NB 1994 Corticosterone in vivo increases pituitary follicle-stimulating hormone (FSH)-β messenger ribonucleic acid content and serum FSH bioactivity selectively in female rats. Endocrinology 134:158-163
14. Gurr JA, Kourides IA 1989 Regulation of the transfected human glycoprotein hormone α-subunit gene by dexamethasone and thyroid hormone. DNA 8:473-480
15. Akerblom IE, Slater EP, Beato M, Baxter JD, Mellon PL 1988 Negative regulation by glucocorticoids through interference with a cAMP responsive enhancer. Science 241:350-353
16. Chatterjee VK, Madison LD, Mayo S, Jameson JL 1991 Repression of the human glycoprotein hormone α-subunit gene by glucocorticoids: evidence for receptor interactions with limiting transcriptional activators. Mol Endocrinol 5:100-110
17. Pernasetti F, Vasilyev VV, Rosenberg SB, Bailey JS, Huang HJ, Miller WL, Mellon PL 2001 Cell-specific transcriptional regulation of FSHβ by activin and GnRH in the LβT2 pituitary gonadotrope cell model. Endocrinology 142:2284-2295
18. Thackray VG, McGillivray SM, Mellon PL 2006 Androgens, progestins and glucocorticoids induce follicle-stimulating hormone β-subunit gene expression at the level of the gonadotrope. Mol Endocrinol 20:2062-2079
19. Horn F, Windle JJ, Barnhart KM, Mellon PL 1992 Tissue-specific gene expression in the pituitary: the glycoprotein hormone α-subunit gene is regulated by a gonadotrope-specific protein. Mol Cell Biol 12:2143-2153
20. Ikonen T, Palvimo JJ, Janne OA 1998 Heterodimerization is mainly responsible for the dominant negative activity of amino-terminally truncated rat androgen receptor forms. FEBS Lett 430:393-396
21. Resnick EM, Schreihofer DA, Periasamy A, Shupnik MA 2000 Truncated estrogen receptor product-1 suppresses estrogen receptor transactivation by dimerization with estrogen receptors α and β. J Biol Chem 275:7158-7166
22. Stauber C, Altschmied J, Akerblom AE, Marron JL, Mellon PL 1992 Mutual cross-interference between glucocorticoid receptor and CREB inhibits transactivation in placental cells. New Biol 4:527-540
23. Slinker BK 1998 The statistics of synergism. J Mol Cell Cardiol 30:723-731
24. Griffin JE, Ojeda SR 2000 Textbook of endocrine physiology. 4th ed. New York: Oxford University Press
25. Heck S, Kullmann M, Gast A, Ponta H, Rahmsdorf HJ, Herrlich P, Cato AC 1994 A distinct modulating domain in glucocorticoid receptor monomers in the repression of activity of the transcription factor AP-1. EMBO J 13:4087-4095
26. Reichardt HM, Kaestner KH, Tuckermann J, Kretz O, Wessely O, Bock R, Gass P, Schmid W, Herrlich P, Angel P, Schutz G 1998 DNA binding of the glucocorticoid receptor is not essential for survival. Cell 93:531-541
27. Rogers SL, Nabozny G, McFarland M, Pantages-Torok L, Archer J, Kalkbrenner F, Zuvela-Jelaska L, Haynes N, Jiang H, Four mutations in the GR dimerization domain result in perinatal lethal mice. Keystone Symposia, Nuclear Receptors: Steroid Sisters, Keystone, CO 2004, p 194 (Abstract 316)
28. Beato M, Arnemann J, Chalepakis G, Slater E, Willmann T 1987 Gene regulation by steroid hormones. J Steroid Biochem 27:9-14
29. Diamond M, Miner J, Yoshinaga S, Yamamoto K 1990 Transcription factor interactions: Selectors of positive or negative regulation from a single DNA element. Science 249:1266-1272
30. Hoeppner MA, Mordacq JC, Linzer DI 1995 Role of the composite glucocorticoid response element in proliferin gene expression. Gene Expr 5:133-141
31. Xie J, Bliss SP, Nett TM, Ebersole BJ, Sealfon SC, Roberson MS 2005 Transcript profiling of immediate early genes reveals a unique role for activating transcription factor 3 in mediating activation of the glycoprotein hormone α-subunit promoter by gonadotropin-releasing hormone. Mol Endocrinol 19: 2624-2638
32. Schoderbek WE, Kim KE, Ridgway EC, Mellon PL, Maurer RA 1992 Analysis of DNA sequences required for pituitary-specific expression of the glycoprotein hormone α-subunit gene. Mol Endocrinol 6:893-903
33. Gonzalez GA, Montminy MR 1989 Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133. Cell 59:675-680
34. Roberson MS, Meermann S, Morasso MI, Mulvaney-Musa JM, Zhang T 2001 A role for the homeobox protein Distal-less 3 in the activation of the glycoprotein hormone α-subunit gene in choriocarcinoma cells. J Biol Chem 276:10016-10024
35. Bailey JS, Rave-Harel N, Coss D, McGillivray SM, Mellon PL 2004 Activin regulation of the follicle-stimulating hormone β-subunit gene involves Smads and the TALE homeodomain proteins Pbx1 and Prep1. Mol Endocrinol 18:1158-1170
36. Coss D, Thackray VG, Deng CX, Mellon PL 2005 Activin regulates luteinizing hormone β-subunit gene expression through smad-binding and homeobox elements. Mol Endocrinol 19:2610-2623
37. Attardi B, Klatt B, Little G 1995 Repression of glycoprotein hormone α-subunit gene expression and secretion by activin in αT3-1 cells. Mol Endocrinol 9:1737-1749
38. ++ and protein kinase C. Biochem J 309:325-329
39. Coss D, Jacobs SB, Bender CE, Mellon PL 2004 A novel AP-1 site is critical for maximal induction of the follicle-stimulating hormone β gene by gonadotropin-releasing hormone. J Biol Chem 279:152-162
40. Turgeon JL, Kimura Y, Waring DW, Mellon PL 1996 Steroid and pulsatile gonadotropin-releasing hormone (GnRH) regulation of luteinizing hormone and GnRH receptor in a novel gonadotrope cell line. Mol Endocrinol 10:439-450
41. McGillivray SM, Thackray VG, Coss D, Mellon PL 2007 Activin and glucocorticoids synergistically activate follicle-stimulating hormone β-subunit gene expression in the immortalized LβT2 gonadotrope cell line. Endocrinology 148:762-773
42. Leal AM, Blount AL, Donaldson CJ, Bilezikjian LM, Vale WW 2003 Regulation of follicle-stimulating hormone secretion by the interactions of activin-A, dexamethasone and testosterone in anterior pituitary cell cultures of male rats. Neuroendocrinology 77:298-304
43. Sakakura M, Takebe K, Nakagawa S 1975 Inhibition of luteinizing hormone secretion induced by synthetic LRH by long-term treatment with glucocorticoids in human subjects. J Clin Endocrinol Metab 40:774-779
44. Breen KM, Karsch FJ 2004 Does cortisol inhibit pulsatile luteinizing hormone secretion at the hypothalamic or pituitary level? Endocrinology 145:692-698
45. Wilbur JF, Utiger RD 1969 The effect of glucocorticoids on thyrotropin secretion. J Clin Invest 48:2096-2103
46. Faglia G, Ferrari C, Beck-Peccoz P, Spada A, Travaglini P, Ambrosi B 1973 Reduced plasma thyrotropin response to thyrotropin releasing hormone after dexamethasone administration in normal subjects. Horm Metab Res 5:289-292
47. Re RN, Kourides IA, Ridgway EC, Weintraub BD, Maloof F 1976 The effect of glucocorticoid administration on human pituitary secretion of thyrotropin and prolactin. J Clin Endocrinol Metab 43:338-346
48. Nicoloff JT, Fisher DA, Appleman Jr MD 1970 The role of glucocorticoids in the regulation of thyroid function in man. J Clin Invest 49:1922-1929
49. Marceau H, Delgado A, MacIntosh-Hardt B, Fortier C 1972 Metabolic clearance and secretion rates of TSH following adrenalectomy and corticosterone administration in the rat. Endocrinology 90:973-980
50. Fang VS, Shian LR 1981 Adrenal influence on pituitary secretion of thyrotropin and prolactin in rats. Endocrinology 108:1545-1551
51. Ross DS, Ellis MF, Milbury P, Ridgway EC 1987 A comparison of changes in plasma thyrotropin β- and α-subunits, and mouse thyrotropic tumor thyrotropin β- and α-subunit mRNA concentrations after in vivo dexamethasone or T3 administration. Metabolism 36:799-803
52. Buckingham JC, Dohler KD, Wilson CA 1978 Activity of the pituitary-adrenocortical system and thyroid gland during the oestrous cycle of the rat. J Endocrinol 78:359-366
53. Nichols DJ, Chevins PF 1981 Plasma corticosterone fluctuations during the oestrous cycle of the house mouse. Experientia 37:319-320
54. Tebar M, Uilenbroek JT, Kramer P, van Schaik RH, Wierikx CD, Ruiz A, de Jong FH, Sanchez-Criado JE 1997 Effects of progesterone on the secondary surge of follicle-stimulating hormone in the rat. Biol Reprod 57:77-84
55. Szabo M, Kilen SM, Saberi S, Ringstrom SJ, Schwartz NB 1998 Antiprogestins suppress basal and activin-stimulated follicle-stimulating hormone secretion in an estrogen-dependent manner. Endocrinology 139:2223-2228
56. Heckert LL, Schultz K, Nilson JH 1995 Different composite regulatory elements direct expression of the human α-subunit gene to pituitary and placenta. J Biol Chem 270:26497-26504
57. Barnhart KM, Mellon PL 1994 The orphan nuclear receptor, steroidogenic factor-1, regulates the glycoprotein hormone α-subunit gene in pituitary gonadotropes. Mol Endocrinol 8:878-885
58. Steger DJ, Hecht JH, Mellon PL 1994 GATA-binding proteins regulate the human gonadotropin α-subunit gene in placenta and pituitary. Mol Cell Biol 14:5592-5602
59. Imai E, Miner JN, Mitchell JA, Yamamoto KR, Granner DK 1993 Glucocorticoid receptor-cAMP response element-binding protein interaction and the response of the phosphoenolpyruvate carboxykinase gene to glucocorticoids. J Biol Chem 268:5353-5356
60. Johannessen M, Moller S, Hansen T, Moens U, Van Ghelue M 2006 The multifunctional roles of the four-and-a-half-LIM only protein FHL2. Cell Mol Life Sci 63:268-284
61. Jorgensen JS, Quirk CC, Nilson JH 2004 Multiple and overlapping combinatorial codes orchestrate hormonal responsiveness and dictate cell-specific expression of the genes encoding luteinizing hormone. Endocr Rev 25:521-542
62. Budworth PR, Quinn PG, Nilson JH 1997 Multiple characteristics of a pentameric regulatory array endow the human α-subunit glycoprotein hormone promoter with trophoblast specificity and maximal activity. Mol Endocrinol 11:1669-1680
63. Heckert LL, Schultz K, Nilson JH 1996 The cAMP response elements of the α-subunit gene bind similar proteins in trophoblasts and gonadotropes but have distinct functional sequence requirements. J Biol Chem 271:31650-31656
64. Wieland S, Döbbeling U, Rusconi S 1991 Interference and synergism of glucocorticoid receptor and octamer factors. EMBO J 10:2513-2521
65. Duan WR, Shin JL, Jameson JL 1999 Estradiol suppresses phosphorylation of cyclic adenosine 3′,5′-monophosphate response element binding protein (CREB) in the pituitary: evidence for indirect action via gonadotropin-releasing hormone. Mol Endocrinol 13:1338-1352
66. Liu JL, Papachristou DN, Patel YC 1994 Glucocorticoids activate somatostatin gene transcription through co-operative interaction with the cyclic AMP signalling pathway. Biochem J 301:863-869
67. Schüle R, Muller M, Kaltschmidt C, Renkawitz R 1988 Many transcription factors interact synergistically with steroid receptors. Science 242:1418
68. Strähle U, Schmid W, Schütz G 1988 Synergistic action of the glucocorticoid receptor with transcription factors. EMBO J 7:3389-3395
69. Hagiwara M, Alberts A, Brindle P, Meinkoth J, Feramisco J, Deng T, Karin M, Shenolikar S, Montminy M 1992 Transcriptional attenuation following cAMP induction requires PP-1-mediated dephosphorylation of CREB. Cell 70:105-113
70. Ethier JF, Findlay JK 2001 Roles of activin and its signal transduction mechanisms in reproductive tissues. Reproduction 121:667-675
71. Fowkes RC, King P, Burrin JM 2002 Regulation of human glycoprotein hormone α-subunit gene transcription in LβT2 gonadotropes by protein kinase C and extracellular signal-regulated kinase 1/2. Biol Reprod 67:725-734