Gonadotropin gene modulation by steroids and gonadotropin-releasing hormone

Biology of Reproduction

Volumn 54, Issue 2, 1996, Pages 279-286

  Shupnik, Margaret A ^a,b  

^a UNIVERSITY OF VIRGINIA   (United States)

^b UNIVERSITY OF VIRGINIA HEALTH SYSTEM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FOLLITROPIN; GONADORELIN; GONADOTROPIN; LUTEINIZING HORMONE; STEROID;

ARTICLE; GENE EXPRESSION REGULATION; GENETIC ANALYSIS; GENETIC TRANSCRIPTION; HORMONAL REGULATION; NONHUMAN; PRIORITY JOURNAL; REPRODUCTION; TRANSCRIPTION REGULATION; TRANSGENIC ANIMAL;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; BASE SEQUENCE; FEMALE; FOLLICLE STIMULATING HORMONE; GENE EXPRESSION REGULATION; GONADAL STEROID HORMONES; GONADOTROPIN-RELEASING HORMONE; HUMANS; LUTEINIZING HORMONE; MOLECULAR SEQUENCE DATA; TRANSCRIPTION, GENETIC;

EID: 0030031208     PISSN: 00063363     EISSN: None     Source Type: Journal    
DOI: 10.1095/biolreprod54.2.279     Document Type: Article

References (60)

1. Gharib SD, Wierman ME, Shupnik MA, Chin WW Molecular biology of the pituitary gonadotropins. Endocr Rev 1990; 11:177-199
2. Midgley AR, Jaffe RB. Regulation of human gonadotropins X. Episodic fluctuation of LH during the menstrual cycle J Clin Endocrinol & Metab 1971; 33 962-969
3. Belchetz PE, Plant TM, Naka Y, Keough EG, Knobil E Hypophysial responses to continuous and intermittent delivery of hypothalamic gonadotropin-releasing hormone Science 1978; 202.631-633
4. Crowley WF Jr, Filicori M, Spratt D, Santoro NF. The physiology of gonadotroprin-releasing hormone (GnRH) secretion in men and women. Recent Prog Horm Res 1985, 41.473
5. Mercer JE, Clements JR, Funder JW, Clarke IJ. Luteinizing hormone-β mRNA levels are regulated primarily by gonadotropin-releasing hormone and not by negative estrogen feedback on the pituitary Neuroendocrinology 1988; 47:563-570
6. Valk TW, Corley KP, Kelch RP, Marshall JC. Hypogonadotropic hypogonadism; hormonal responses to low dose pulsatile administration of gonadotropin-releasing hormone J Clin Endocrinol & Metab 1980; 51 730-738.
7. Levine JE, Ramirez VD, LHRH release during the rat estrous cycle and after ovariectomy, as estimated with push-pull cannulae. Endocrinology 1982, 111 1439-1448.
8. Shupnik MA Effects of gonadotropin-releasing hormone on rat gonadotropin gene transcription in vitro- requirement for pulsatile administration for luteinizing hormone-β gene stimulation. Mol Endocrinol 1990, 4.1444-1450.
9. Carroll RS, Corrigan AZ, Gharib SD, Vale W, Chin WW Inhibin, activin, and follistatin, regulation of follicle-stimulating hormone messenger ribonucleic acid levels Mol Endocrinol 1989, 3:1969
10. Attardi B, Vaughan J, Vale W Regulation of FSHβ messenger ribonucleic acid levels in the rat by endogenous inhibin. Endocrinology 1991, 129 3204-3209
11. Dalkin AC, Knight, CD, Shupnik MA, Haisenleder DJ, Aloi J, Kirk SE, Yasin M, Marshall JC. Ovariectomy and inhibin immunoneutralization acutely increase follicle-stimulating hormone-β messenger ribonucleic acid concentrations; evidence for a nontranscriptional mechanism Endocrinology 1993, 132:1297-1304
12. Windle JJ, Weiner RI, Mellon PL. Cell lines of the pituitary gonadotrope lineage derived by targeted oncogenesis in transgenic mice. Mol Endocrinol 1990, 4:597-603
13. Papavasiliou SS, Zmeili S, Herbon L, Duncan-Weldon J, Marshall JC, Landefeld TD Alpha and LH beta mRNA of male and female rats after castration quantitation using an optimized dot blot hybridization assay. Endocrinology 1986; 119 691-698
14. Hamernik DL, Nett TM Gonadotropin-releasing hormone increases the amount of messenger ribonucleic acid for gonadotropins in ovariectomized ewes after hypothalamic-pituitary disconnection. Endocrinology 1988, 122:959-966
15. Gharib SD, Bowers SM, Need LR, Chin WW Regulation of rat LH subunit mRNAs by gonadal steroid hormones J Clin Invest 1986; 77 582-588.
16. Gharib SD, Wierman ME, Badger TM, Chin WW Sex steroid hormone regulation of follicle-stimulating hormone subunit messenger ribonucleic acid (mRNA) levels in the rat. J Clin Invest 1987: 80:294-301
17. Paul SJ, Ortolano GA, Haisenleder DJ, Stewart JM, Shupnik MA, Marshall JC Gonadotropin subunit messenger RNA concentrations after blockade of gonadotropin-releasing hormone action testosterone selectively increases follicle-stimulating hormone β-subunit messenger RNA by posttranscriptional mechanisms. Mol Endocrinol 1990; 4:1943-1955
18. Wierman ME, Wang C Androgen selectively stimulates follicle-stimulating hormone-beta mRNA levels after gonadotropin-releasing hormone antagonist administration Biol Reprod 1990, 43:563-571
19. Zmeili SM, Papavasiliou SS, Thorner MO, Evans WS, Marshall JC, Landefeld TD Alpha and LH beta subunit mRNAs during the rat estrous cycle Endocrinology 1986, 119.1867-1869.
20. Ortolano GA, Haisenleder DJ, Dalkin AC, Iliff-Sizemore SA, Landefeld TD, Maurer RA, Marshall JC FSH beta subunit mRNA concentrations during the rat estrous cycle Endocrinology 1988, 123.2149-2151
21. Shupnik MA. Measurement of gene transcription and messenger RNA In. Weintraub BD (ed.), Molecular Endocrinology Basic Concepts and Clinical Correlations New York. NY. Raven Press, 1995. 41-58.
22. Pierce JC, Parsons TF Glycoprotein hormones, structure and function Annu Rev Biochem 1981, 50.465-495.
23. McKnight GS, Palmiter RD Transcriptional regulation of the ovalbumin and conalbumin genes by steroid hormones in chick oviduct. J Biol Chem 1979; 254:9050-9058
24. Shupnik MA. Pulsatile neuropeptide delivery and analysis of hormone biosynthesis Methods Neurosci 1995, 19.445-465.
25. Alexander DC, Miller WL Regulation of ovine follicle-stimulating hormone chain mRNA and 17β-estradiol in vivo and in vitro J Biol Chem 1982; 263:2282.
26. Burrin JM, Jameson JL Regulation of transfected glycoprotein hormone α-gene expression in primary pituitary cell cultures. Mol Endocrinol 1989; 3:1643-1651
27. Kim KE, Day KH, Howard P, Salton SRJ, Roberts JL, Maurer RA. DNA sequences required for expression of the LHβ promoter in primary cultures of rat pituitary cells. Mol Cell Endocrinol 1990, 74:101-107.
28. Kay TWH, Jameson JL. Identification of a gonadotropin-releasing hormone-responsive region in the glycoprotein hormone α-subunit promoter. Mol Endocrinol 1992; 6:1767-1773.
29. Schroderbek WE, Roberson MS, Maurer RA. Two different DNA elements mediate gonadotropin releasing hormone effects on expression of the glycoprotein hormone α-subunit gene. J Biol Chem 1993, 268 3903-3910.
30. Shupnik MA, Rosenzweig BA Identification of an estrogen-responsive element in the rat LHβ gene J Biol Chem 1991; 266 17084-17091.
31. Maurer RA, Notides AC Identification of an estrogen-responsive element from the 5′-flanking region of the rat prolactin gene. Mol Cell Biol 1987; 7.4247-4254
32. Curtis SW, Korach KS. Uterine estrogen receptor interaction with estrogen-responsive DNA sequences in vitro: effects of ligand binding on receptor-DNA complexes. Mol Endocrinol 1990, 4 276-286
33. Camper SA, Saunders TL, Kendall SK, Keri RA, Seasholtz AF, Gordon DF, Birkmeier TS, Keegan CE, Karolyi IJ, Roller MI, Burrows HL, Samuelson LC Implementing transgenic and embryonic stem cell technology to study gene expression, cell-cell interactions and gene function. Biol Reprod 1995; 52:246-257.
34. Keri RA, Wolfe MA, Saunders TL, Anderson I, Kendall SK, Wagner T, Yeung J, Gorski J, Nett TM, Camper SA, Nilson JII. The proximal promoter of the bovine luteinizing hormone β-subunit gene confers gonadotrope-specific expression and regulation by gonadotropin-releasing hormone, testosterone, and 17β-estradiol in transgenic mice Mol Endocrinol 1994; 8.1807-1816
35. Fallest PC, Trader GL, Darrow JM, Shupnik MA. Regulation of rat luteinizing hormone β gene expression in transgenic mice bv steroids and a gonadotropin-releasing hormone antagonist Biol Reprod 1995, 53.103-109
36. Shupnik MA, Gharib SD, Chin WW. Estrogen suppresses rat gonadotropin gene transcription in vivo Endocrinology 1987; 122.1842-1846
37. Shupnik MA, Gharib SD, Chin WW Divergent effects of estradiol on gonadotropin gene transcription in pituitary fragments. Mol Endocrinol 1989, 3 474-480.
38. Shupnik MA, Weinmann CM, Notides AC, Chin WW An upstream region of the rat luteinizing hormone β gene binds estrogen receptor and confers estrogen responsiveness J Biol Chem 1989, 264 80-86
39. Shupnik MA, Gordon MS, Chin WW Tissue-specific regulation of rat estrogen receptor mRNAs. Mol Endocrinol 1989, 3:660-665
40. Koike S, Sakai M, Muramatsu M. Molecular cloning and characterization of the rat estrogen receptor cDNA. Nucleic Acids Res 1987, 15 2499-2513
41. Friend KE, Ang LW, Shupnik MA Estrogen regulates the expression of several different estrogen receptor mRNA isoforms in rat pituitary. Proc Natl Acad Sci USA 1995; 92:4367-4371.
42. Fugua SAW, Fitzgerald SD, Allred DC, Elledge RM, Nawaz Z, McDonnell DP, O'Malley BW, Greene GL, McGuire WL. Inhibition of estrogen receptor action by a naturally occurring variant in human breast tumors. Cancer Res 1992, 52 483-486
43. Fugua SAW, Fitzgerald SD, Chamness GC, Tandon AK, McDonnell DP, Nawaz Z, O'Malley BW, McGuire WL Variant human breast tumor estrogen receptor with constitutive transcriptional activity Cancer Res 1991; 51:105-109
44. Wang Y, Mi Ksicek RJ. Identification of a dominant negative form of the human estrogen receptor. Mol Endocrinol 1991, 11 1707-1715
45. Kaiser UB, Jaku Bowial A, Steinberger A, Chin WW Regulation of rat pituitary gonadotropin-releasing hormone receptor mRNA levels in vivo and in vitro Endocrinology 1993; 133:931-934
46. Kamel F, Balz JA, Kubajak CL, Schneider VA Gonadal steroids modulate pulsatile luteinizing hormone secretion by perifused rat anterior pituitary cells Endocrinology 1987, 120.1651-1658
47. Keri RA, Andersen B, Kennedy GC, Hamernik DL, Clay CM, Brace HD, Nett TM, Notides AC, Nilson JD. Estradiol inhibits transcription of the human glycoprotein hormone α-subunit gene despite the absence of a high affinity binding site for the estrogen receptor. Mol Endocrinol 1991; 5 725-733
48. Clay CM, Keri RA, Finicle AB, Hecker LL, Hamernik DL, Marsch KM, Wilson EM, French FS, Nilson JH. Transcriptional repression of the glycoprotein hormone α-subunit gene by androgen may involve direct binding of the androgen receptor to the proximal promoter J Biol Chem 1993; 268:13556-13564.
49. Gallo RV. Pulsatile LH release during the ovulatory LH surge on proestrus in the rat Biol Reprod 1981; 24:100-104
50. Lalloz MRA, Detta A, Clayton RN Gonadotropin-releasing hormone desensitization preferentially inhibits expression of the luteinizing hormone β-subunit gene in vivo. Endocrinology 1988; 122:1689-1695
51. Wierman ME, Rivier J, Wang C. Gonadotropin-releasing hormone (GnRH)-dependent regulation of gonadotropin subunit mRNA levels in the rat Endocrinology 1989; 24:272-278.
52. Haisenleder DJ, Katt JH, Ortolano GH, El-Gewely MR, Duncan JA, Del C, Marshall JC. Influence of gonadotropin-releasing hormone pulse amplitude, frequency and treatment duration on the regulation of luteinizing hormone subunit messenger ribonucleic acids and LH secretion Mol Endocrinol 1988; 2:1302-1310.
53. Haisenleder DJ, Dalkin AC, Ortolano GA, Marshall JC, Shupnik MA. A pulsatile gonadotropin-releasing hormone stimulus is required to increase transcription of the gonadotropin subunit genes: evidence for differential regulation of transcription by pulse frequency in vivo. Endocrinology 1991, 128:509-517.
54. Weiss J, Jameson JL, Burrin JM, Crowley WF Jr Divergent responses of gonadotropin messenger RNAs to continuous pulsatile gonadotropin-release hormone in vitro. Mol Endocrinol 1990; 4:557-564.
55. Hawes BE, Barnes S, Conn PM, Cholera toxin and pertussis toxin provoke differential effects on luteinizing hormone release, inositol phosphate production, and gonadotropin-releasing hormone (GnRH) receptor binding in the gonadotrope: evidence for multiple guanyl nucleotide binding proteins in GnRH action Endocrinology 1993, 132:2124-2130.
56. Tse A, Tse BV, Almers W, Hille B. Rhythmic exocytosis stimulated by GnRH-induced calcium oscillations in rat gonadotropes. Science 1993; 260:82-84.
57. Roberson MS, Schroderbek WE, Tremmi G, Maurer SA Activation of the glycoprotein hormone α-subunit promoter by a LIM-homeodomain transcription factor Mol Cell Biol 1994; 14:2985-2993
58. Hamernik DL, Keri RA, Clay CM, Clay JN, Sherman GB, Sawyer Jr HR, Nett TM, Nilson JH. Gonadotrope- and thyrotrope-specific expression of the human and bovine glycoprotein hormone α-subunit genes is regulated by distinct cis-acting elements. Mol Endocrinol 1992; 6 1745-1755
59. Ingraham HA, Lala DS, Ikeda Y, Luo X, Shen W-H, Nachtigal MW, Abbud R, Nilson JH, Parker KL The nuclear receptor steroidogenic factor-1 acts at multiple levels of the reproductive axis. Genes & Dev 1994, 8:2302-2312
60. Kendall SK, Gordon DF, Birkmeier TS, Petrey D, Sarapura VD, O'Shea KS, Wood WM, Lloyd RV, Ridgway EC, Camper SA. Enhancer-mediated high level expression of mouse pituitary glycoprotein hormone α-subunit transgene in thyrotropes, gonadotropes, and developing pituitary gland. Mol Endocrinol 1994; 8 1420-1427.