-
1
-
-
0034600849
-
The ErbB signaling network: Receptor heterodimerization in development and cancer
-
Olayioye MA, Neve RM, Lane HA, Hynes NE (2000) The ErbB signaling network: receptor heterodimerization in development and cancer. EMBO J 19: 3159-3167.
-
(2000)
EMBO J
, vol.19
, pp. 3159-3167
-
-
Olayioye, M.A.1
Neve, R.M.2
Lane, H.A.3
Hynes, N.E.4
-
3
-
-
17644387160
-
Coexpression of the type I growth factor receptor family members HER-1, HER-2, and HER-3 has a synergistic negative prognostic effect on breast carcinoma survival
-
Wiseman SM, Makretsov N, Nielsen TO, Gilks B, Yorida E, et al. (2005) Coexpression of the type I growth factor receptor family members HER-1, HER-2, and HER-3 has a synergistic negative prognostic effect on breast carcinoma survival. Cancer 103: 1770-1777.
-
(2005)
Cancer
, vol.103
, pp. 1770-1777
-
-
Wiseman, S.M.1
Makretsov, N.2
Nielsen, T.O.3
Gilks, B.4
Yorida, E.5
-
4
-
-
0033372557
-
Combination of EGFR, HER-2/neu, and HER-3 is a stronger predictor for the outcome of oral squamous cell carcinoma than any individual family members
-
Xia W, Lau YK, Zhang HZ, Xiao FY, Johnston DA, et al. (1999) Combination of EGFR, HER-2/neu, and HER-3 is a stronger predictor for the outcome of oral squamous cell carcinoma than any individual family members. Clin Cancer Res 5: 4164-4174.
-
(1999)
Clin Cancer Res
, vol.5
, pp. 4164-4174
-
-
Xia, W.1
Lau, Y.K.2
Zhang, H.Z.3
Xiao, F.Y.4
Johnston, D.A.5
-
5
-
-
0030944455
-
ErhB-2, the preferred heterodimerization partner of all ErbB receptors, is a mediator of lateral signaling
-
Graus-Porta D, Beerli RR, Daly JM, Hynes NE (1997) ErhB-2, the preferred heterodimerization partner of all ErbB receptors, is a mediator of lateral signaling. EMBO J 16: 1647-1655.
-
(1997)
EMBO J
, vol.16
, pp. 1647-1655
-
-
Graus-Porta, D.1
Beerli, R.R.2
Daly, J.M.3
Hynes, N.E.4
-
6
-
-
0042307325
-
The ErbB2/ErbB3 heterodimer functions as an oncogenic unit: ErbB2 requires ErbB3 to drive breast tumor cell proliferation
-
Holbro T, Beerli RR, Maurer F, Koziczak M, Barbas CF 3rd, et al. (2003) The ErbB2/ErbB3 heterodimer functions as an oncogenic unit: ErbB2 requires ErbB3 to drive breast tumor cell proliferation. Proc Natl Acad Sci U S A 100: 8933-8938.
-
(2003)
Proc Natl Acad Sci U S A
, vol.100
, pp. 8933-8938
-
-
Holbro, T.1
Beerli, R.R.2
Maurer, F.3
Koziczak, M.4
Barbas 3rd, C.F.5
-
7
-
-
33746905531
-
-
Schulze WX, Deng L, Maun M (2005) Phosphotyrosine interactome of the ErbB-rcceptor kinase family. Mol Syst Biol 1: 2005.0008.
-
Schulze WX, Deng L, Maun M (2005) Phosphotyrosine interactome of the ErbB-rcceptor kinase family. Mol Syst Biol 1: 2005.0008.
-
-
-
-
8
-
-
0030795612
-
The ErbB signaling network in embryogenesis and oncogenesis: Signal diversification through combinatorial ligand-receptor interactions
-
Alroy I, Yarden Y (1997) The ErbB signaling network in embryogenesis and oncogenesis: signal diversification through combinatorial ligand-receptor interactions. FEBS Lett 410: 83-86.
-
(1997)
FEBS Lett
, vol.410
, pp. 83-86
-
-
Alroy, I.1
Yarden, Y.2
-
9
-
-
0029912203
-
All ErbB receptors other than the epidermal growth factor receptor are endocytosis impaired
-
Baulida J, Kraus MH, Alimandi M, Di Fiore PP, Carpenter G (1996) All ErbB receptors other than the epidermal growth factor receptor are endocytosis impaired. J Biol Chem 271: 5251-5257.
-
(1996)
J Biol Chem
, vol.271
, pp. 5251-5257
-
-
Baulida, J.1
Kraus, M.H.2
Alimandi, M.3
Di Fiore, P.P.4
Carpenter, G.5
-
10
-
-
0029804204
-
The relationship between human epidermal growth-like factor receptor expression and cellular transformation in NIH3T3 cells
-
Cohen BD, Kiener PA, Green JM, Foy L, Fell HP, et al. (1996) The relationship between human epidermal growth-like factor receptor expression and cellular transformation in NIH3T3 cells. J Biol Chem 271: 30897-30903.
-
(1996)
J Biol Chem
, vol.271
, pp. 30897-30903
-
-
Cohen, B.D.1
Kiener, P.A.2
Green, J.M.3
Foy, L.4
Fell, H.P.5
-
11
-
-
33947547741
-
Quantitative transcriptional control of ErbB receptor signaling undergoes graded to biphasic response for cell differentiation
-
Nagashima T, Shimodaira H, Ide K, Nakakuki T, Tani Y, et al. (2007) Quantitative transcriptional control of ErbB receptor signaling undergoes graded to biphasic response for cell differentiation. J Biol Chem 282: 4045-4056.
-
(2007)
J Biol Chem
, vol.282
, pp. 4045-4056
-
-
Nagashima, T.1
Shimodaira, H.2
Ide, K.3
Nakakuki, T.4
Tani, Y.5
-
12
-
-
0035947724
-
Identification of the mechanisms regulating the differential activation of the mapk cascade by epidermal growth factor and nerve growth factor in PC12 cells
-
Kao S, Jaiswal RK, Kolch W, Landreth GE (2001) Identification of the mechanisms regulating the differential activation of the mapk cascade by epidermal growth factor and nerve growth factor in PC12 cells. J Biol Chem 276: 18169-18177.
-
(2001)
J Biol Chem
, vol.276
, pp. 18169-18177
-
-
Kao, S.1
Jaiswal, R.K.2
Kolch, W.3
Landreth, G.E.4
-
13
-
-
0035106689
-
The two PDGF receptors maintain conserved signaling in vivo despite divergent embryological functions
-
Klinghoffer RA, Mueting-Nelsen PF, Faerman A, Shani M, Soriano P (2001) The two PDGF receptors maintain conserved signaling in vivo despite divergent embryological functions. Mol Cell 7: 343-354.
-
(2001)
Mol Cell
, vol.7
, pp. 343-354
-
-
Klinghoffer, R.A.1
Mueting-Nelsen, P.F.2
Faerman, A.3
Shani, M.4
Soriano, P.5
-
14
-
-
0037163050
-
Regulation of Raf-Akt Cross-talk
-
Moelling K, Schad K, Bosse M, Zimmermann S, Schweneker M (2002) Regulation of Raf-Akt Cross-talk. J Biol Chem 277: 31099-31106.
-
(2002)
J Biol Chem
, vol.277
, pp. 31099-31106
-
-
Moelling, K.1
Schad, K.2
Bosse, M.3
Zimmermann, S.4
Schweneker, M.5
-
15
-
-
0035823542
-
Regulation of Raf by Akt controls growth and differentiation in vascular smooth muscle cells
-
Reusch HP, Zimmermann S, Schaefer M, Paul M, Moelling K (2001) Regulation of Raf by Akt controls growth and differentiation in vascular smooth muscle cells. J Biol Chem 276: 33630-33637.
-
(2001)
J Biol Chem
, vol.276
, pp. 33630-33637
-
-
Reusch, H.P.1
Zimmermann, S.2
Schaefer, M.3
Paul, M.4
Moelling, K.5
-
16
-
-
0029939164
-
SOS phosphorylation and disassociation of the Grb2-SOS complex by the ERK and JNK signaling pathways
-
Chen D, Waters SB, Holt KH, Pessin JE (1996) SOS phosphorylation and disassociation of the Grb2-SOS complex by the ERK and JNK signaling pathways. J Biol Chem 271: 6328-3632.
-
(1996)
J Biol Chem
, vol.271
, pp. 6328-3632
-
-
Chen, D.1
Waters, S.B.2
Holt, K.H.3
Pessin, J.E.4
-
17
-
-
0029923192
-
Epidermal growth factor receptor targeting prevents uncoupling of the Grb2-SOS complex
-
Holt KH, Waters SB, Okada S, Yamauchi K, Decker SJ, et al. (1996) Epidermal growth factor receptor targeting prevents uncoupling of the Grb2-SOS complex. J Biol Chem 271: 8300-8306.
-
(1996)
J Biol Chem
, vol.271
, pp. 8300-8306
-
-
Holt, K.H.1
Waters, S.B.2
Okada, S.3
Yamauchi, K.4
Decker, S.J.5
-
18
-
-
33644856401
-
Identification of novel in vivo Raf-1 phosphorylation sites mediating positive feedback Raf-1 regulation by extracellular signal-regulated kinase
-
Balan V, Leicht DT, Zhu J, Balan K, Kaphin A, et al. (2006) Identification of novel in vivo Raf-1 phosphorylation sites mediating positive feedback Raf-1 regulation by extracellular signal-regulated kinase. Mol Biol Cell 17: 1141-1153.
-
(2006)
Mol Biol Cell
, vol.17
, pp. 1141-1153
-
-
Balan, V.1
Leicht, D.T.2
Zhu, J.3
Balan, K.4
Kaphin, A.5
-
19
-
-
0347363834
-
Identification of novel ERK-mediated feedback phosphorylation sites at the C-terminus of B-Raf
-
Brummer T, Naegele H, Reth M, Misawa Y (2003) Identification of novel ERK-mediated feedback phosphorylation sites at the C-terminus of B-Raf. Oncogene 22: 8823-8834.
-
(2003)
Oncogene
, vol.22
, pp. 8823-8834
-
-
Brummer, T.1
Naegele, H.2
Reth, M.3
Misawa, Y.4
-
20
-
-
19944430124
-
Regulation of Raf-1 by direct feedback phosphorylation
-
Dougherty MK, Muller J, Ritt DA, Zhou M, Zhou XZ, et al. (2005) Regulation of Raf-1 by direct feedback phosphorylation. Mol Cell 17: 215-224.
-
(2005)
Mol Cell
, vol.17
, pp. 215-224
-
-
Dougherty, M.K.1
Muller, J.2
Ritt, D.A.3
Zhou, M.4
Zhou, X.Z.5
-
21
-
-
3042699478
-
Transformation potency of ErbB heterodimer signaling is determined by B-Raf kinase
-
Hatakeyama M, Yumoto N, Yu X, Shirouzu M, Yokoyama S, et al. (2004) Transformation potency of ErbB heterodimer signaling is determined by B-Raf kinase. Oncogene 23: 5023-5031.
-
(2004)
Oncogene
, vol.23
, pp. 5023-5031
-
-
Hatakeyama, M.1
Yumoto, N.2
Yu, X.3
Shirouzu, M.4
Yokoyama, S.5
-
22
-
-
29144462587
-
Wild-type and mutant B-RAF activate C-RAF through distinct mechanisms involving heterodimerization
-
Garnett MJ, Rana S, Paterson H, Barford D, Marais R (2005) Wild-type and mutant B-RAF activate C-RAF through distinct mechanisms involving heterodimerization. Mol Cell 20: 963-969.
-
(2005)
Mol Cell
, vol.20
, pp. 963-969
-
-
Garnett, M.J.1
Rana, S.2
Paterson, H.3
Barford, D.4
Marais, R.5
-
24
-
-
0036285634
-
Mathematical models of protein kinase signal transduction
-
Heinrich R, Neel BG, Rapoport TA (2002) Mathematical models of protein kinase signal transduction. Mol Cel 9: 957-70.
-
(2002)
Mol Cel
, vol.9
, pp. 957-970
-
-
Heinrich, R.1
Neel, B.G.2
Rapoport, T.A.3
-
25
-
-
0029790351
-
Ultrasensitivity in the mitogen-activated protein kinase cascade
-
Huang CY, Ferrell JE (1996) Ultrasensitivity in the mitogen-activated protein kinase cascade. Proc Natl Acad Sci U S A 93: 10078-10083.
-
(1996)
Proc Natl Acad Sci U S A
, vol.93
, pp. 10078-10083
-
-
Huang, C.Y.1
Ferrell, J.E.2
-
26
-
-
0033570090
-
Quantification of short term signaling by the epidermal growth factor receptor
-
Kholodenko BN, Demin OV, Moehren G, Hoek JB (1999) Quantification of short term signaling by the epidermal growth factor receptor. J Biol Chem 274: 30169-30181.
-
(1999)
J Biol Chem
, vol.274
, pp. 30169-30181
-
-
Kholodenko, B.N.1
Demin, O.V.2
Moehren, G.3
Hoek, J.B.4
-
27
-
-
14444279192
-
-
Favata MF, Horiuchi KY, Manus EJ, Daulerio AJ, Stradley DA, et al. (1998) Identification of a novel inhibitor of mitogen-activated protein kinase kinase. J Biol Chem 273: 18623-1862332.
-
Favata MF, Horiuchi KY, Manus EJ, Daulerio AJ, Stradley DA, et al. (1998) Identification of a novel inhibitor of mitogen-activated protein kinase kinase. J Biol Chem 273: 18623-1862332.
-
-
-
-
28
-
-
0842288229
-
Signaling switches and bistability arising from multisite phosphorylation in protein kinase cascades
-
Markevich NI, Hoek JB, Kholodenko BN (2004) Signaling switches and bistability arising from multisite phosphorylation in protein kinase cascades. J Cell Biol 164: 353-359.
-
(2004)
J Cell Biol
, vol.164
, pp. 353-359
-
-
Markevich, N.I.1
Hoek, J.B.2
Kholodenko, B.N.3
-
29
-
-
0041344538
-
A computational model on the modulation of mitogen-activated protein kinase (MAPK) and Akt pathways in heregulin-induced ErbB signalling
-
Hatakeyama M, Kimura S, Naka T, Kawasaki T, Yumoto N, et al. (2003) A computational model on the modulation of mitogen-activated protein kinase (MAPK) and Akt pathways in heregulin-induced ErbB signalling. Biochem J 373: 451-463.
-
(2003)
Biochem J
, vol.373
, pp. 451-463
-
-
Hatakeyama, M.1
Kimura, S.2
Naka, T.3
Kawasaki, T.4
Yumoto, N.5
-
30
-
-
0034613112
-
Differential feedback regulation of the MAPK cascade underlies the quantitative differences in EGF and NGF signalling in PC12 cells
-
Brightman FA, Fell DA (2000) Differential feedback regulation of the MAPK cascade underlies the quantitative differences in EGF and NGF signalling in PC12 cells. FEBS Lett 482: 169-174.
-
(2000)
FEBS Lett
, vol.482
, pp. 169-174
-
-
Brightman, F.A.1
Fell, D.A.2
-
31
-
-
0034667593
-
Meaningful relationships: The regulation of the Ras/Raf/ MEK/ERK pathway by protein interactions
-
Kolch W (2000) Meaningful relationships: the regulation of the Ras/Raf/ MEK/ERK pathway by protein interactions. Biochem J 351: 289-305.
-
(2000)
Biochem J
, vol.351
, pp. 289-305
-
-
Kolch, W.1
-
32
-
-
0028464349
-
Regulation of the Ras signalling network
-
Maruta H, Burgess AW (1994) Regulation of the Ras signalling network. Bioessays 16: 489-496.
-
(1994)
Bioessays
, vol.16
, pp. 489-496
-
-
Maruta, H.1
Burgess, A.W.2
-
33
-
-
33646121988
-
Expression of the ErbB4 receptor causes reversal regulation of PP2A in the She signal transduction pathway in human cancer cells
-
Yumoto N, Yu X, Hatakeyama M (2006) Expression of the ErbB4 receptor causes reversal regulation of PP2A in the She signal transduction pathway in human cancer cells. Mol Cell Biochem 285: 165-171.
-
(2006)
Mol Cell Biochem
, vol.285
, pp. 165-171
-
-
Yumoto, N.1
Yu, X.2
Hatakeyama, M.3
-
34
-
-
34248591612
-
Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancer
-
Roberts PJ, Der CJ (2007) Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancer. Oncogene 26: 3291-3310.
-
(2007)
Oncogene
, vol.26
, pp. 3291-3310
-
-
Roberts, P.J.1
CJ, D.2
-
35
-
-
0031041171
-
Differential regulation of Raf-1, A-Raf, and B-Raf by oncogenic ras and tyrosine kinases
-
Marais R, Light Y, Paterson HF, Mason CS, Marshall CJ (1997) Differential regulation of Raf-1, A-Raf, and B-Raf by oncogenic ras and tyrosine kinases. J Biol Chem 272: 4378-4783.
-
(1997)
J Biol Chem
, vol.272
, pp. 4378-4783
-
-
Marais, R.1
Light, Y.2
Paterson, H.F.3
Mason, C.S.4
Marshall, C.J.5
-
36
-
-
33847355217
-
Growth factor-induced MAPK network topology shapes Erk response determining PC-12 cell fate
-
Santos SD, Verveer PJ, Bastiaens PI (2007) Growth factor-induced MAPK network topology shapes Erk response determining PC-12 cell fate. Nat Cell Biol 9: 324-330.
-
(2007)
Nat Cell Biol
, vol.9
, pp. 324-330
-
-
Santos, S.D.1
Verveer, P.J.2
Bastiaens, P.I.3
-
37
-
-
0032499282
-
Rap1 mediates sustained MAP kinase activation induced by nerve growth factor
-
York RD, Yao H, Dillon T, Ellig CL, Eckert SP, et al. (1998) Rap1 mediates sustained MAP kinase activation induced by nerve growth factor. Nature 392: 622-626.
-
(1998)
Nature
, vol.392
, pp. 622-626
-
-
York, R.D.1
Yao, H.2
Dillon, T.3
Ellig, C.L.4
Eckert, S.P.5
-
38
-
-
0026010983
-
-
Campa MJ, Chang KJ, Molina y Vedia L, Reep BR, Lapetina EG (1991) Inhibition of ras-induced germinal vesicle breakdown in Xenopus oocytes by rap-1B. Biochem Biophys Res Common 174: 1-5.
-
Campa MJ, Chang KJ, Molina y Vedia L, Reep BR, Lapetina EG (1991) Inhibition of ras-induced germinal vesicle breakdown in Xenopus oocytes by rap-1B. Biochem Biophys Res Common 174: 1-5.
-
-
-
-
39
-
-
0027170176
-
RapV12 antagonizes Ras-dependent activation of ERK1 and ERK2 by LPA and EGF in Rat-1 fibroblasts
-
Cook SJ, Rubinfeld B, Albert I, McCormick F (1993) RapV12 antagonizes Ras-dependent activation of ERK1 and ERK2 by LPA and EGF in Rat-1 fibroblasts. EMBO J 12: 3475-3485.
-
(1993)
EMBO J
, vol.12
, pp. 3475-3485
-
-
Cook, S.J.1
Rubinfeld, B.2
Albert, I.3
McCormick, F.4
-
40
-
-
0030963439
-
cAMP activates MAP kinase and Elk-1 through a B-Raf- and Rap1-dependent pathway
-
Vossler MR, Yao H, York RD, Pan MG, Rim CS, et al. (1997) cAMP activates MAP kinase and Elk-1 through a B-Raf- and Rap1-dependent pathway. Cell 89: 73-82.
-
(1997)
Cell
, vol.89
, pp. 73-82
-
-
Vossler, M.R.1
Yao, H.2
York, R.D.3
Pan, M.G.4
Rim, C.S.5
-
41
-
-
0032531756
-
Extracellular signal-regulated activation of Rap1 fails to interfere in Ras effector signalling
-
Zwartkruis FJ, Wolthuis Rfvf, Nabben NM, Franke B, Bus JL (1998) Extracellular signal-regulated activation of Rap1 fails to interfere in Ras effector signalling. EMBO J 17: 5905-5912.
-
(1998)
EMBO J
, vol.17
, pp. 5905-5912
-
-
Zwartkruis, F.J.1
Rfvf, W.2
Nabben, N.M.3
Franke, B.4
Bus, J.L.5
-
42
-
-
0036212767
-
Computational modeling of the dynamics of the MAP kinase cascade activated by surface and internalized EGF receptors
-
Schoeberl B, Eichler-Jonsson C, Gilles ED, Muller G (2002) Computational modeling of the dynamics of the MAP kinase cascade activated by surface and internalized EGF receptors. Nat Biotechnol 20: 370-375.
-
(2002)
Nat Biotechnol
, vol.20
, pp. 370-375
-
-
Schoeberl, B.1
Eichler-Jonsson, C.2
Gilles, E.D.3
Muller, G.4
-
43
-
-
33744927122
-
Modeling the effects of HER/ ErbB1-3 coexpression on receptor dimerization and biological response
-
Shankaran H, Wiley HS, Resat H (2006) Modeling the effects of HER/ ErbB1-3 coexpression on receptor dimerization and biological response. Biophys J 90: 3993-4009.
-
(2006)
Biophys J
, vol.90
, pp. 3993-4009
-
-
Shankaran, H.1
Wiley, H.S.2
Resat, H.3
-
44
-
-
0036093854
-
Chimeric receptor analyses of the interactions of the ectodomains of ErbB-1 with epidermal growth factor and of those of ErbB-4 with neuregulin
-
Kim JH, Saito K, Yokoyama S (2002) Chimeric receptor analyses of the interactions of the ectodomains of ErbB-1 with epidermal growth factor and of those of ErbB-4 with neuregulin. Eur J Biochem 269: 2323-2329.
-
(2002)
Eur J Biochem
, vol.269
, pp. 2323-2329
-
-
Kim, J.H.1
Saito, K.2
Yokoyama, S.3
-
45
-
-
0036684674
-
Untying the regulation of the Raf-1 kinase
-
Dhillon AS, Kolch W (2002) Untying the regulation of the Raf-1 kinase. Arch Biochem Biophys 404: 3-9.
-
(2002)
Arch Biochem Biophys
, vol.404
, pp. 3-9
-
-
Dhillon, A.S.1
Kolch, W.2
-
46
-
-
0037040867
-
Dephosphorylation of Ser-259 regulates Raf-1 membrane association
-
Kubicek M, Pacher M, Abraham D, Podar K, Eulitz M, et al. (2002) Dephosphorylation of Ser-259 regulates Raf-1 membrane association. J Biol Chem 277: 7913-7919.
-
(2002)
J Biol Chem
, vol.277
, pp. 7913-7919
-
-
Kubicek, M.1
Pacher, M.2
Abraham, D.3
Podar, K.4
Eulitz, M.5
-
47
-
-
0037200054
-
The specificity of extracellular signal-regulated kinase 2 dephosphorylation by protein phosphatases
-
Zhou B, Wang ZX, Zhao Y, Brautigan DL, Zhang ZY (2002) The specificity of extracellular signal-regulated kinase 2 dephosphorylation by protein phosphatases. J Biol Chem 277: 31818-31825.
-
(2002)
J Biol Chem
, vol.277
, pp. 31818-31825
-
-
Zhou, B.1
Wang, Z.X.2
Zhao, Y.3
Brautigan, D.L.4
Zhang, Z.Y.5
-
48
-
-
0034096201
-
Protein phosphatases and the regulation of mitogen-activated protein kinase signalling
-
Keyse SM (2000) Protein phosphatases and the regulation of mitogen-activated protein kinase signalling. Curr Opin Cell Biol 12: 186-192.
-
(2000)
Curr Opin Cell Biol
, vol.12
, pp. 186-192
-
-
Keyse, S.M.1
-
49
-
-
0242408956
-
High Dimensional Function Optimization using a new Genetic Local Search suitable for Parallel Computers
-
Man, and Cybernetics
-
Kimura S, Konagaya A (2003) High Dimensional Function Optimization using a new Genetic Local Search suitable for Parallel Computers. Proc. of the 2003 Int. Conf. on Systems, Man, and Cybernetics, 335-342.
-
(2003)
Proc. of the 2003 Int. Conf. on Systems
, pp. 335-342
-
-
Kimura, S.1
Konagaya, A.2
|