Mutations of β-arrestin 2 that limit self-association also interfere with interactions with the β2-adrenoceptor and the ERK1/2 MAPKs: Implications for β2-adrenoceptor signalling via the ERK1/2 MAPKs

Biochemical Journal

Volumn 413, Issue 1, 2008, Pages 51-60

  Xu, Tian Rui ^a   Baillie, George S ^a   Bhari, Narinder ^a   Houslay, Thomas M ^a,d   Pitt, Andrew M ^a   Adams, David R ^b   Kolch, Walter ^a,c   Houslay, Miles D ^a   Milligan, Graeme ^a  

^a UNIVERSITY OF GLASGOW   (United Kingdom)

^b HERIOT WATT UNIVERSITY   (United Kingdom)

^c BEATSON INSTITUTE FOR CANCER RESEARCH   (United Kingdom)

^d ASTRAZENECA   (United Kingdom)

Author keywords

arrestin 2; Scaffolding; Self association

Indexed keywords

ACIDS; AMINATION; AMINES; AMINO ACIDS; ENERGY STORAGE; ENERGY TRANSFER; FLOW INTERACTIONS; FLUORESCENCE; ORGANIC ACIDS;

ARRESTIN; CO-IMMUNOPRECIPITATION; FLUORESCENCE RESONANCE ENERGY TRANSFER (FRETS); IMMOBILIZED PEPTIDE; PROTEIN-PROTEIN INTERACTION (PPI); SELF ASSOCIATIONS; SURFACE EXPOSURE;

ASSOCIATION REACTIONS;

ARGININE; BETA 2 ADRENERGIC RECEPTOR; BETA ARRESTIN 2; CYAN FLUORESCENT PROTEIN; EPITOPE; LYSINE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 10; MITOGEN ACTIVATED PROTEIN KINASE 3; MUTANT PROTEIN; YELLOW FLUORESCENT PROTEIN; BETA ARRESTIN; MITOGEN ACTIVATED PROTEIN KINASE; RETINA S ANTIGEN;

AMINO TERMINAL SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; ENZYME PHOSPHORYLATION; FLUORESCENCE RESONANCE ENERGY TRANSFER; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; MUTATION; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN FOLDING; PROTEIN INTERACTION; PROTEIN PROTEIN INTERACTION; SITE DIRECTED MUTAGENESIS; AMINO ACID SEQUENCE; CELL LINE; CHEMICAL STRUCTURE; GENETICS; METABOLISM; PHOSPHORYLATION; PHYSIOLOGY; POINT MUTATION; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN MICROARRAY; SIGNAL TRANSDUCTION;

AMINO ACID SEQUENCE; ARRESTINS; CELL LINE; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FLUORESCENCE RESONANCE ENERGY TRANSFER; HUMANS; MODELS, MOLECULAR; PHOSPHORYLATION; POINT MUTATION; PROTEIN ARRAY ANALYSIS; PROTEIN BINDING; PROTEIN CONFORMATION; RECEPTORS, ADRENERGIC, BETA-2; SIGNAL TRANSDUCTION;

EID: 46249104682     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20080685     Document Type: Article

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