OP-1 injection increases VEGF expression but not angiogenesis in a rabbit model of distraction osteogenesis

Growth Factors

Volumn 26, Issue 3, 2008, Pages 143-151

  Mandu Hrit, Manuela ^a,b   Seifert, Erin ^c   Kotsiopriftis, Maria ^c   Lauzier, Dominique ^a,c   Haque, Tasima ^a   Rohlicek, Charles ^c   Tabrizian, Maryam ^b   Hamdy, Reggie C ^a,c  

^a SHRINERS HOSPITAL FOR CHILDREN   (Canada)

^b MCGILL UNIVERSITY   (Canada)

^c MONTREAL CHILDREN S HOSPITAL   (Canada)

Author keywords

Angiogenesis; Bone blood flow; Distraction osteogenesis; Immunohistochemistry; VEGF

Indexed keywords

CD31 ANTIGEN; PLACEBO; RECOMBINANT OSTEOGENIC PROTEIN 1; VASCULOTROPIN;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE BLOOD FLOW; BONE REGENERATION; CARTILAGE CELL; CONTROLLED STUDY; DISEASE MODEL; DISTRACTION OSTEOGENESIS; DRUG EFFICACY; DRUG MECHANISM; ENDOTHELIUM CELL; EXPERIMENTAL RABBIT; FIBROBLAST; MALE; NONHUMAN; OSSIFICATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; VASCULAR ENDOTHELIUM;

ANIMALS; BONE MORPHOGENETIC PROTEINS; DISEASE MODELS, ANIMAL; FIBROBLASTS; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; NEOVASCULARIZATION, PATHOLOGIC; OSTEOGENESIS; OSTEOGENESIS, DISTRACTION; RABBITS; RECOMBINANT PROTEINS; REGIONAL BLOOD FLOW; SIGNAL TRANSDUCTION; TRANSFORMING GROWTH FACTOR BETA; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

ANIMALIA; ORYCTOLAGUS CUNICULUS;

EID: 46249102615     PISSN: 08977194     EISSN: 10292292     Source Type: Journal    
DOI: 10.1080/08977190802106154     Document Type: Article

References (29)

1. Anetzberger, H., Thein, E., Becker, M., Zwissler, B. and Messmer, K. (2004) Microspheres accurately predict regional bone blood flow. Clin Orthop Relat Res, 424, pp. 253-265.
2. Aronson, J. (1994) Temporal and spatial increases in blood-flow during distraction osteogenesis. Clin Orthop Relat Res, 301, pp. 124-131.
3. Carlevaro, MF, Cermelli, S., Cancedda, R. and Cancedda, FD (2000) Vascular endothelial growth factor (VEGF) in cartilage neovascularisation and chondrocyte differentiation: Auto-paracrine role during endochondral bone formation. J Cell Sci, 113, pp. 59-69.
4. Carvalho, RS, Einhorn, TA, Lehmann, W., Edgar, C., Al Yamani, A, Apazidis, A., Pacicca, D., Clemens, TL and Gerstenfeld, LC (2004) The role of angiogenesis in a murine tibial model of distraction osteogenesis. Bone, 34, pp. 849-861.
5. Choi, IH, Chung, CY, Cho, TJ and Yoo, WJ (2002) Angiogenesis and mineralization during distraction osteogenesis. J Korean Med Sci, 17, pp. 435-447.
6. Deckers, MML, Van Beek, ER, Van Der Pluijm, G., Wetterwald, A., Wee-Pals, L., Cecchini, MG, Papapoulos, SE and Lowik, CWGM (2002) Dissociation of angiogenesis and osteoclastogenesis during endochondral bone formation in neonatal mice. J Bone Miner Res, 17, pp. 998-1007.
7. Deckers, MML, van Bezooijen, RL, van der Horst, G., Hoogendam, J., van der Bent, C., Papapoulos, SE and Lowik, CWGM (2002) Bone morphogenetic proteins stimulate angiogenesis through osteoblast-derived vascular endothelial growth factor A. Endocrinology, 143, pp. 1545-1553.
8. Eckardt, H., Bundgaard, KG, Christensen, KS, Lind, M., Hansen, ES and Hvid, I. (2003) Effects of locally applied vascular endothelial growth factor (VEGF) and VEGF-inhibitor to the rabbit tibia during distraction osteogenesis. J Orthop Res, 21, pp. 335-340.
9. Ferrara, N. (2004) Vascular endothelial growth factor: Basic science and clinical progress. Endocr Rev, 25, pp. 581-611.
10. Ferrara, N., Gerber, HP and LeCouter, J. (2003) The biology of VEGF and its receptors. Nat Med, 9, pp. 669-676.
11. Ford, JL, Robinson, DE and Scammell, BE (2004) Endochondral ossification in fracture callus during long bone repair: The localisation of "cavity-lining cells" within the cartilage. J Orthop Res, 22, pp. 368-375.
12. Glenny, RW, Bernard, S. and Brinkley, M. (1993) Validation of fluorescent-labeled microspheres for measurement of regional organ perfusion. J Appl Phys, 74, pp. 2585-2597.
13. Gong, NL and Chatterjee, S. (2003) Platelet endothelial cell adhesion molecule in cell signaling and thrombosis. Mol Cell Biochem, 253, pp. 151-158.
14. Hamdy, RC, Amako, M., Beckman, L., Kawaguchi, M., Rauch, F., Lauzier, D. and Steffen, T. (2003) Effects of osteogenic protein-1 on distraction osteogenesis in rabbits. Bone, 33, pp. 248-255.
15. Haque, T., Mandu-Hrit, M., Rauch, F., Lauzier, D., Tabrizian, M. and Hamdy, R. (2005) Immunohistochemical localization of BMP signaling smads during long-bone distraction osteogenesis. J Histochem Cytochem, 54, pp. 407-415.
16. Hu, J., Zou, SJ, Li, JH, Chen, Y., Wang, DZ and Gao, ZW (2003) Temporospatial expression of vascular endothelial growth factor and basic fibroblast growth factor during mandibular distraction osteogenesis. J Cranio Maxillofac Surg, 31, pp. 238-243.
17. Ilizarov, GA (1989) The tension stress effect on the genesis and growth of tissues. 2. The influence of the rate and frequency of distraction. Clin Orthop Relat Res, 239, pp. 263-285.
18. Kang, Q., Sun, MH, Cheng, H., Peng, Y., Montag, AG, Deyrup, AT, Jiang, W., Luu, HH, Luo, J., Szatkowski, JP, Vanichakarn, P., Park, JY, Li, Y., Haydon, RC and He, TC (2004) Characterization of the distinct orthotopic bone-forming activity of 14 BMPs using recombinant adenovirus-mediated gene delivery. Gene Ther, 11, pp. 1312-1320.
19. Li, G., Simpson, AHRW, Kenwright, J. and Triffitt, JT (1999) Effect of lengthening rate on angiogenesis during distraction osteogenesis. J Orthop Res, 17, pp. 362-367.
20. Mandu-Hrit, M., Haque, T., Lauzier, D., Kotsiopriftis, M., Rauch, F., Tabrizian, M., Henderson, JE and Hamdy, RC (2006) Early injection of OP-1 during distraction osteogenesis accelerates new bone formation in rabbits. Growth Factors, 24, pp. 172-183.
21. Mayr-Wohlfart, U., Waltenberger, J., Hausser, H., Kessler, S., Gunther, KP, Dehio, C., Puhl, W. and Brenner, RE (2002) Vascular endothelial growth factor stimulates chemotactic migration of primary human osteoblasts. Bone, 30, pp. 472-477.
22. Mizumoto, Y., Moseley, T., Drews, M., Cooper, VN and Reddi, AH (2003) Acceleration of regenerate ossification during distraction osteogenesis with recombinant human bone morphogenetic protein-7. J Bone Joint Surg Am, 85, pp. 124-130.
23. Ohashi, S., Ohnishi, I., Kageyama, T., Imai, K. and Nakamura, K. (2007) Distraction osteogenesis promotes angiogenesis in the surrounding muscles. Clin Orthop Relat Res, 454, pp. 223-229.
24. Pacicca, DM, Patel, N., Lee, C., Salisbury, K., Lehmann, W., Carvalho, R., Gerstenfeld, LC and Einhorn, TA (2003) Expression of angiogenic factors during distraction osteogenesis. Bone, 33, pp. 889-898.
25. Ramoshebi, LN and Ripamonti, U. (2000) Osteogenic protein-1, a bone morphogenetic protein, induces angiogenesis in the chick chorioallantoic membrane and synergizes with basic fibroblast growth factor and transforming growth factor-beta 1. Anat Rec, 259, pp. 97-107.
26. Rauch, F., Lauzier, D., Croteau, S., Travers, R., Glorieux, FH and Hamdy, R. (2000) Temporal and spatial expression of bone morphogenetic protein-2, -4 and-7 during distraction osteogenesis in rabbits. Bone, 26, pp. 611-617.
27. Weiss, S., Zimmermann, G., Baumgart, R., Kasten, P., Bidlingmaier, M. and Henle, P. (2005) Systemic regulation of angiogenesis and matrix degradation in bone regeneration-distraction osteogenesis compared to rigid fracture healing. Bone, 37, pp. 781-790.
28. Yeh, LCC and Lee, JC (1999) Osteogenic protein-1 increases gene expression of vascular endothelial growth factor in primary cultures of fetal rat calvaria cells. Mol Cell Endocrinol, 153, pp. 113-124.
29. Zelzer, E., Mamluk, R., Ferrara, N., Johnson, RS, Schipani, E. and Olsen, BR (2004) VEGFA is necessary for chondrocyte survival during bone development. Development, 131, pp. 2161-2171.