Microspheres accurately predict regional bone blood flow

Clinical Orthopaedics and Related Research

Volumn 424, Issue , 2004, Pages 253-265

  Anetzberges, Hermann ^a,b,e   Thein, E ^b   Becker, M ^b   Zwissles, B ^c,d   Messmer, K ^b  

^a TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^b LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^c UNIVERSITY OF MUNICH   (Germany)

^d GOETHE UNIVERSITY   (Germany)

^e Department of Orthopaedics ^*  (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CAVAFIX; FLUORESCENT MICROSPHERE; MICROSPHERE; RADIOACTIVE MICROSPHERE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERIAL BLOOD; ARTICLE; BLOOD FLOW VELOCITY; BONE BLOOD FLOW; CAPILLARY; CONTROLLED STUDY; CORRELATION COEFFICIENT; DIAGNOSTIC ACCURACY; DRUG ADMINISTRATION ROUTE; DRUG DISTRIBUTION; FEMUR; FLUORESCENCE; HUMERUS; NONHUMAN; PRIORITY JOURNAL; RABBIT; RADIOACTIVITY; RELIABILITY; SENSITIVITY AND SPECIFICITY; TIBIA; VALIDATION PROCESS;

EID: 3042785616     PISSN: 0009921X     EISSN: 15281132     Source Type: Journal    
DOI: None     Document Type: Article

References (73)

1. Aalto K, Slatis P: Blood flow in rabbit osteotomies studied with radioactive microspheres. Acta Orthop Scand 55:637-639, 1984.
2. Anetzberger H, Thein E, Walli AK, Messmer K: Determination of regional bone blood flow by means of fluorescent microspheres using an automated sample processing procedure. Eur Surg Res 35:337-345, 2003.
3. Archie JPJ, Fixler DE, Ullyot DJ, et al. Measurement of cardiac output with and organ trapping of radioactive microspheres. J Appl Physiol 35:148-154, 1973.
4. Austin Jr RE, Hauck WW, Aldea GS, et al: Quantitating error in blood flow measurements with radioactive microspheres. Am J Physiol 257:H280-H288, 1989.
5. Bland JM, Altman DG: Statistical methods for assessing agreement between two methods of clinical measurement. Lancet 1:307-310, 1986.
6. Bloomfield SA, Hogan HA, Delp MD: Decreases in bone blood flow and bone material properties in aging Fischer-344 rats. Clin Orthop 396:248-257, 2002.
7. Brindley GW, Williams EA, Bronk JT, et al: Parathyroid hormone effects on skeletal exchangeable calcium and bone blood flow. Am J Physiol 255:H94-100, 1988.
8. Brookes M: A measurement of the rates of blood flow, circulating red cell volume and velocity in bone marrow and cortex. Acta Anat (Basel) 69:201-209, 1968.
9. Buckberg GD, Luck JC, Payne DB, et al: Some sources of error in measuring regional blood flow with radioactive microspheres. J Appl Physiol 31:598-604, 1971.
10. Bünger C, Bülow J, Hjermind J, Harving S: Hemodynamics of the juvenile dog knee in relation to increased venous outlet resistance. Pflugers Arch 399:129-133, 1983.
11. Bünger C, Hjermind J, Bülow J: Hemodynamics of the juvenile knee in relation to increasing intra-articular pressure: An experimental study in dogs. Acta Orthop Scand 54:80-87, 1983.
12. Consigny PM, Verrier ED, Payne BD, et al: Acute and chronic microspheres loss from canine left ventricular myocardium. Am J Physiol 242:H392-H404, 1982.
13. Cumming JD: A study of blood flow to bone and marrow by a method of venous effluent collection. J Physiol (Lond) 162:13-20, 1962.
14. Davis RF, Jones LC, Hungerford DS: The effect of sympathectomy on blood flow in bone: Regional distribution and effect over time. J Bone Joint Surg 69A:1384-1390, 1987.
15. Davis TR, Holloway I, Pooley J: The effect of anaesthesia on the bone blood flow of the rabbit. J Orthop Res 8:479-484, 1990.
16. Dole WP, Jackson DL, Rosenblatt JI, Thompson WL: Relative error and variability in blood flow measurements with radiolabeled microspheres. Am J Physiol 243:H371-H378, 1982.
17. Drescher W, Schneider T, Becker C, et al: Reperfusion pattern of the immature femoral head after critical ischemia: A microsphere study in pigs. Acta Orthop Scand 70:439-445, 1999.
18. Drescher W, Schneider T, Becker C, et al: Selective reduction of bone blood flow by short-term treatment with high-dose methylprednisolone: An experimental study in pigs. J Bone Joint Surg 83B:274-277, 2001.
19. Ferrell WR, Khoshbaten A, Angerson WJ: Responses of bone and joint blood vessels in cats and rabbits to electrical stimulation of nerves supplying the knee. J Physiol 431:677-687, 1990.
20. Glenny RW, Bernard S, Brinkley M: Validation of fluorescent-labeled microspheres for measurement of regional organ perfusion. J Appl Physiol 74:2585-2597, 1993.
21. Gregg PJ, Walder DN: Regional distribution of circulating microspheres in the femur of the rabbit. J Bone Joint Surg 62B:222-226, 1980.
22. Gross PM, Heistad DD, Marcus ML: Neurohumoral regulation of blood flow to bones and marrow. Am J Physiol 237:H440-H448, 1979.
23. Gross PM, Marcus ML, Heistad DD: Measurement of blood flow to bone and marrow in experimental animals by means of the microsphere technique. J Bone Joint Surg 63A:1028-1031, 1981.
24. Gross TS, Damji AA, Judex S, Bray RC, Zernicke RF: Bone hyperemia precedes disuse-induced intracortical bone resorption, J Appl Physiol 86:230-235, 1999.
25. Gross W, Schosser R, Messmer K: MIC-III: An integrated software package to support experiments using the radioactive microsphere technique. Comput Methods Programs Biomed 33:65-85, 1990.
26. Grundnes O, Reikeras O: Effect of physical activity on muscle and bone blood flow after fracture: Exercise and tenotomy studied in rats. Acta Orthop Scand 62:67-69, 1991.
27. Grundnes O, Reikeras O: Blood flow and mechanical properties of healing bone: Femoral osteotomies studied in rats. Acta Orthop Scand 63:487-491, 1992.
28. Hansen ES, He SZ, Hjortdal VE, Kjolseth D, Soballe K: Distribution of blood flow in normal and arthritic joints: Role of arteriovenous shunting studied in growing dogs. Am J Physiol 262: H38-H46, 1992.
29. Hansen ES, Hjortdal VE, Kjolseth D, et al: Arteriovenous shunting is not associated with venous congestion in bone: Knee tamponade studied with 15-microns and 50-microns microspheres in immature dogs. Acta Orthop Scand 62:268-275, 1991.
30. Hansen ES, Soballe K, Kjolseth D, Henriksen TB, He SZ: Microvascular hemodynamics in experimental arthritis: Disparity between the distribution of microspheres and plasma flow in bone. Microvasc Res 40:206-217, 1990.
31. Jones LC, Niv AI, Davis RF, Hungerford DS: Bone blood flow in the femora of anesthetized and conscious dogs in a chronic preparation, using the radioactive tracer microsphere method. Clin Orthop 170:286-295, 1982.
32. Kane WJ: Fundamental concepts in bone-blood flow studies. J Bone Joint Surg 50A:801-811, 1968.
33. Kane WJ, Grim E: Blood flow to canine hind-limb bone, muscle, and skin: A quantitative method and its validation. J Bone Joint Surg 51A:309-322, 1969.
34. 125I washout. J Appl Physiol 31:38-47, 1971.
35. Kowallik P, Schulz R, Guth BD, et al: Measurement of regional myocardial blood flow with multiple colored microspheres. Circulation 83:974-982, 1991.
36. Lausten GS, Arnoldi CC: Blood perfusion uneven in femoral head osteonecrosis: Doppler flowmetry and intraosseous pressure in 12 cases. Acta Orthop Scand 64:533-536, 1993.
37. Li G, Bronk JT, Kelly PJ: Canine bone blood flow estimated with microspheres. J Orthop Res 7:61-67, 1989.
38. Marshall WG, Boatman GB, Dickerson G, et al: Shunting, release, and distribution of nine and fifteen micron spheres in myocardium. Surgery 79:631-637, 1976.
39. McGrory BJ, Moran CG, Bronk J, Weaver AL, Wood MB: Canine bone blood flow measurements using serial microsphere injections. Clin Orthop 303:264-279, 1994.
40. Neutze JM, Wyler F, Rudolph AM: Use of radioactive microspheres to assess distribution of cardiac output in rabbits. Am J Physiol 215:486-495, 1968.
41. Nolte D, Raab S, Thein E, et al: A new experimental model for repetitive osseous blood supply measurement. Mund Kiefer Gesichtschir 3(Suppl 1):147-150, 1999.
42. Nose Y, Nakamura T, Nakamura M: The microsphere method facilitates statistical assessment of regional blood flow. Basic Res Cardiol 80:417-429, 1985.
43. Notzli HP, Swiontkowski MF, Thaxter ST, Carpenter GK, Wyatt R: Laser Doppler flowmetry for bone blood flow measurements: Helium-neon laser light attenuation and depth of perfusion assessment. J Orthop Res 7:413-424, 1989,
44. Okubo M, Kinoshita T, Yukimura T, Abe Y, Shimazu A: Experimental study of measurement of regional bone blood flow in the adult mongrel dog using radioactive microspheres. Clin Orthop 138:263-270, 1979.
45. Polissar NL, Stanford DC, Glenny RW: The 400 microsphere per piece "rule" does not apply to all blood flow studies. Am J Physiol Heart Circ Physiol 278:H16-H25, 2000.
46. Prinzen FW, Glenny RW: Developments in non-radioactive microsphere techniques for blood flow measurement. Cardiovasc Res 28:1467-1475, 1994.
47. Raab S, Thein E, Harris AG, Messmer K: A new sample-processing unit for the fluorescent microsphere method. Am J Physiol 276:H1801-H1806, 1999.
48. Reichert IL, McCarthy ID, Hughes SP: The acute vascular response to intramedullary reaming: Microsphere estimation of blood flow in the intact ovine tibia. J Bone Joint Surg 77B:490-493, 1995. [see comments]
49. Revell WJ, Brookes M: Bone blood flow in the rat using arteriolar blockade: Comparisons between labelled resin particles and microspheres. J Anat 182:305-312, 1993.
50. Rudolph AM, Heymann MA: The circulation of the fetus in utero: Methods for studying distribution of blood flow, cardiac output and organ blood flow. Circ Res 21:163-184, 1967.
51. Sachs L: Varianzanalytische Methoden. In Sachs L (ed). Angewandte Statistik. Berlin, Springer-Verlag 664-670, 1999.
52. Schimmel C, Frazer D, Glenny RW: Extending fluorescent microsphere methods for regional organ blood flow to 13 simultaneous colors. Am J Physiol Heart Circ Physiol 280:H2496-H2506, 2001.
53. Schimmel C, Frazer D, Huckins SR, Glenny RW: Validation of automated spectrofluroimetry for measurement of regional organ perfusion using fluorescent microspheres. Comput Methods Programs Biomed 62:115-125, 2000.
54. Shim SS, Copp DH, Patterson FP: Bone blood flow in the limb following complete sciatic nerve section. Surg Gynecol Obstet 123:333-335, 1966.
55. Shim SS, Copp DH, Patterson FP: An indirect method of bone blood-flow measurement based on the bone clearance of a circulating bone-seeking radioisotope. J Bone Joint Surg 49A:693-702, 1967.
56. Shymkiw RC, Bray RC, Boyd SK, Kantzas A, Zernicke RF: Physiological and mechanical adaptation of periarticular cancellous bone after joint ligament injury. J Appl Physiol 90:1083-1087, 2001.
57. Swiontkowski MF, Tepic S, Perren SM, et al: Laser Doppler flowmetry for bone blood flow measurement: Correlation with microsphere estimates and evaluation of the effect of intracapsular pressure on femoral head blood flow. J Orthop Res 4:362-371, 1986.
58. Syftestad GT, Boelkins JN: Effect of hemorrhage on blood flow to marrow and osseous tissue in conscious rabbits. Am J Physiol 238:H360-H364, 1980.
59. Tan W, Riggs KW, Thies RL, Rurak DW: Use of an automated fluorescent microsphere method to measure regional blood flow in the fetal lamb. Can J Physiol Pharmacol 75:959-968, 1997.
60. Thein E, Raab S, Harris AG, et al: Comparison of regional blood flow values measured by radioactive and fluorescent microspheres. Eur Surg Res 34:215-223, 2002.
61. Thein E, Raab S, Harris AG, Messmer K: Automation of the use of fluorescent microspheres for the determination of blood flow. Comput Methods Programs Biomed 61:11-21, 2000.
62. Tondevold E, Bulow J: Bone blood flow in conscious dogs at rest and during exercise. Acta Orthop Scand 54:53-57, 1983.
63. Tothill P: Bone blood flow measurement. J Biomed Eng 6:251-256, 1984.
64. Van Oosterhout MF, Prinzen FW, Sakurada S, Glenny RW, Hales JR: Fluorescent microspheres are superior to radioactive microspheres in chronic blood flow measurements. Am J Physiol 275:H110-H115, 1998.
65. von Ritter C, Hinder RA, Womack W, et al: Microsphere estimates of blood flow: Methodological considerations. Am J Physiol 254:G275-G279, 1988.
66. Wagner Jr HN, Rhodes BA, Sasaki Y, Ryan JP: Studies of the circulation with radioactive microspheres. Invest Radiol 4:374-386, 1969.
67. Wallace AL, Draper ER, Strachan RK, McCarthy ID, Hughes SP: The effect of devascularisation upon early bone healing in dynamic external fixation. J Bone Joint Surg 73B:819-825, 1991.
68. Walter B, Bauer R, Gaser E, Zwiener U: Validation of the multiple colored microsphere technique for regional blood flow measurements in newborn piglets. Basic Res Cardiol 92:191-200, 1997.
69. Wang GJ, Dughman SS, Reger SI, Stamp WG: The effect of core decompression on femoral head blood flow in steroid induced avascular necrosis of the femoral head. J Bone Joint Surg 67A:121-124, 1985.
70. Wang GJ, Hubbard SL, Reger SI, Miller ED, Stamp WG: Femoral head blood flow in long-term steroid therapy: Study of rabbit model. South Med J 76:1530-1532, 1983.
71. Whiteside LA, Lesker PA, Simmons DJ: Measurement of regional bone and bone marrow blood flow in the rabbit using the hydrogen washout technique. Clin Orthop 122:340-346, 1977.
72. Winet H: A horizontal intravital microscope-plus-bone chamber system for observing bone microcirculation. Microvasc Res 37:105-114, 1989.
73. Zwissler B, Schosser R, Weiss C, et al: Methodological error and spatial variability of organ blood flow measurements using radiolabeled microspheres. Res Exp Med (Berl) 191:47-63, 1991.