Dissociation of angiogenesis and osteoclastogenesis during endochondral bone formation in neonatal mice

Journal of Bone and Mineral Research

Volumn 17, Issue 6, 2002, Pages 998-1007

  Deckers, Martine M L ^a   Van Beek, Ermond R ^a   Van Der Pluijm, Gabri ^a   Wetterwald, Antoinette ^b   Van Der Wee Pals, Lianne ^a   Cecchini, Marco G ^b   Papapoulos, Socrates E ^a   Löwik, Clemens W G M ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^b UNIVERSITY OF BERN   (Switzerland)

Author keywords

Bisphosphonates; Endothelial cells; Osteoclasts; Osteopetrosis

Indexed keywords

ALKALINE PHOSPHATASE; ACID PHOSPHATASE TARTRATE RESISTANT ISOENZYME; AGGLUTININ; ALIZARIN; BISPHOSPHONIC ACID DERIVATIVE; CD31 ANTIGEN; CLODRONIC ACID; COLLAGEN TYPE 4; INTERCELLULAR ADHESION MOLECULE 1;

ALBERS SCHOENBERG DISEASE; ANGIOGENESIS; ANIMAL; ARTICLE; BONE DEVELOPMENT; CYTOLOGY; ENDOTHELIUM; ENZYMOLOGY; IMMUNOHISTOCHEMISTRY; METABOLISM; MOUSE; MOUSE MUTANT; NEWBORN; OSTEOCLAST; OSTEOLYSIS; PATHOLOGY; TAIL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; BONE METASTASIS; CAPILLARY ENDOTHELIUM; CONTROLLED STUDY; ENCHONDRAL OSSIFICATION; ENDOTHELIUM CELL; IN VIVO STUDY; KNOCKOUT MOUSE; NONHUMAN; ONCOGENE C FOS; OSTEOPOROSIS; TUMOR GROWTH; VERTEBRA;

ALKALINE PHOSPHATASE; ANIMALS; ANIMALS, NEWBORN; BONE DEVELOPMENT; BONE RESORPTION; ENDOTHELIUM; IMMUNOHISTOCHEMISTRY; MICE; MICE, MUTANT STRAINS; NEOVASCULARIZATION, PHYSIOLOGIC; OSTEOCLASTS; OSTEOPETROSIS; TAIL; ANIMAL;

EID: 0036000591     PISSN: 08840431     EISSN: None     Source Type: Journal    
DOI: 10.1359/jbmr.2002.17.6.998     Document Type: Article

References (67)

1. Hormone regulation of chondrocyte differentiation and endochondral bone formation
2. Chondrogenesis just ain't what it used to be
3. Identification of chondromodulin I as a novel endothelial cell growth inhibitor. Purification and its localization in the avascular zone of epiphyseal cartilage
4. TGF-betal is the factor secreted by proliferative chondrocytes to inhibit neo-angiogenesis
5. Troponin I is present in human cartilage and inhibits angiogenesis
6. A novel angiogenic molecule produced at the time of chondrocyte hypertrophy during endochondral bone formation
7. Immunolocalisation of vascular endothelial growth factor (VEGF) in human neonatal growth plate cartilage
8. Transferrin promotes endothelial cell migration and invasion: Implication in cartilage neovascularization
9. Vascularization and endochondral bone development: Changes in plasminogen activator activity
10. MMP-9/gelatinase B is a key regulator of growth plate angiogenesis and apoptosis of hypertrophic chondrocytes
11. Targeted expression of constitutively active receptors for parathyroid hormone and parathyroid hormone-related peptide delays endochondral bone formation and rescues mice that lack parathyroid hormone-related peptide
12. Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts
13. Toward a molecular understanding of skeletal development
14. Cartilage resorption in the tibial epiphyseal plate of growing rats
15. The osteoclast-endothelium interface during bone resorption in the femurs of young rabbits
16. The mechanism of coupling: A role for the vasculature
17. Vascular endothelial growth factor (VEGF) directly enhances osteoclastic bone resorption and survival of mature osteoclasts
18. Matrix metalloproteinase 9 and vascular endothelial growth factor are essential for osteoclast recruitment into developing long bones
19. Effect of angiogenic and antiangiogenic compounds on the outgrowth of capillary structures from fetal mouse explants
20. The alpha v beta 3 integrin "vitronectin receptor"
21. Role of alpha v integrins during angiogenesis
22. Matrix metalloproteinases are obligatory for the migration of preosteoclasts to the developing marrow cavity of primitive long bones
23. Extracellular matrix-driven matrix metalloproteinase production in endothelial cells: Implications for angiogenesis
24. MT1-MMP-deficient mice develop dwarfism, osteopenia, arthritis, and connective tissue disease due to inadequate collagen turnover
25. The murine mutation osteopetrosis is in the coding region of the macrophage colony stimulating factor gene
26. Bone and haematopoietic defects in mice lacking c-fos
27. c-Fos: A key regulator of osteoclast-macrophage lineage determination and bone remodeling
28. Osteopetrosis, a new recessive skeletal mutation on chromosome 12 of the mouse
29. Structure and development of bone
30. Attachment characteristics and involvement of integrins in adhesion of breast cancer cell lines to extracellular bone matrix components
31. Clodronate and liposome-encapsulated clodronate are metabolized to a toxic ATP analog, adenosine 5′-(beta, gamma-dichloromethylene) triphosphate, by mammalian cells in vitro
32. Farnesol and geranylgeraniol prevent activation of caspases by aminobisphosphonates: Biochemical evidence for two distinct pharmacological classes of bisphosphonate drugs
33. Impairment of macrophage colony-stimulating factor production and lack of resident bone marrow macrophages in the osteopetrotic op/op mouse
34. Macrophage colony stimulating factor restores in vivo bone resorption in the op/op osteopetrotic mouse
35. Delayed hematopoietic development in osteopetrotic (op/op) mice
36. A novel in situ hybridization signal amplification method based on the deposition of biotinylated tyramine
37. Recombinant human extracellular matrix protein 1 inhibits alkaline phosphatase activity and mineralization of mouse embryonic metatarsals in vitro
38. Identification of vascular endothelial cells in murine omentum using lectin, dolichos biflorus agglutinin: Possible applications in the study of angiogenesis
39. An allelic difference determines reciprocal patterns of expression of binding sites for dolichos biflorus lectin in inbred strains of mice
40. Two distinct effects of recombinant human tumor necrosis factor-alpha on osteoclast development and subsequent resorption of mineralized matrix
41. Histochemical method for acid phosphatase using hexazonium pararosalin as a coupler
42. Bone biology; part 1: Structure, blood supply, cells, matrix and mineralization
43. Does adult fracture repair recapitulate embryonic skeletal formation?
44. Bone
45. Preclinical safety evaluation of rhuMAbVEGF, an antiangiogenic humanized monoclonal antibody
46. Role of vascular endothelial growth factor in the regulation of angiogenesis
47. VEGF couples hypertrophic cartilage remodeling, ossification and angiogenesis during endochondral bone formation
48. Angiogenesis in myelodysplastic syndromes
49. Reduced morbidity from skeletal metastases in breast cancer patients during long-term bisphosphonate (APD) treatment
50. Reduction in new metastases in breast cancer with adjuvant clodronate treatment
51. Bisphosphonate action. Alendronate localization in rat bone and effects on osteoclast ultrastructure
52. Bisphosphonates: Mechanisms of action
53. 2MDP) on the calcification and resorption of cartilage and bone in the tibial epiphysis and metaphysis of rats
54. Osteoclast recruitment in mice is stimulated by (3-amino-1-hydroxypropylidene)-1, 1-bisphosphonate
55. Effects of (3-amino-1-hydroxypropylidene)-1, 1-bisphosphonate on mouse osteoclasts
56. CSF-1 treatment promotes angiogenesis in the metaphysis of osteopetrotic (toothless, tl) rats
57. Bisphosphonates inhibit breast and prostate carcinoma cell invasion, an early event in the formation of bone metastases
58. Inhibition of matrix metalloproteinase-1 by dichloromethylene bisphosphonate (clodronate)
59. MMP inhibition and downregulation by bisphosphonates
60. A molecular analysis of matrix remodeling and angiogenesis during long bone development
61. Angiogenesis and bone growth
62. Long-term effects of bisphosphonates on the growing skeleton. Studies of young patients with severe osteoporosis
63. Fine structural aspects of vascular invasion of the tibial epiphyseal plate of growing rats
64. Chondroclasts and endothelial cells collaborate in the process of cartilage resorption
65. Matrix metalloproteinases regulate neovascularization by acting as pericellular fibrinolysins
66. Role and localization of urokinase receptor in the formation of new microvascular structures in fibrin matrices
67. Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis