Anticonvulsant effect of BmK IT2, a sodium channel-specific neurotoxin, in rat models of epilepsy

British Journal of Pharmacology

Volumn 154, Issue 5, 2008, Pages 1116-1124

  Zhao, R ^a   Zhang, X Y ^b   Yang, J ^c   Weng, C C ^c   Jiang, L L ^c   Zhang, J W ^c   Shu, X Q ^c   Ji, Y H ^c  

^a UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

^b NATIONAL INSTITUTES OF HEALTH   (United States)

^c SHANGHAI UNIVERSITY   (China)

Author keywords

BmK IT2; Epileptic seizures; Intrahippocampal injection; Sodium channels; Status epilepticus

Indexed keywords

BMK IT2 TOXIN; LITHIUM CHLORIDE; PENTETRAZOLE; PILOCARPINE; PROTEIN C FOS; SCORPION VENOM; VALPROIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTICONVULSANT ACTIVITY; ARTICLE; BRAIN REGION; BUTHUS MARTENSI; CONTROLLED STUDY; DISEASE SEVERITY; DOSE RESPONSE; DRUG MECHANISM; ELECTROENCEPHALOGRAPHY; EPILEPSY; MALE; MICROINJECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SCORPION; SEIZURE;

ACTION POTENTIALS; ANIMALS; ANTICONVULSANTS; BEHAVIOR, ANIMAL; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ADMINISTRATION ROUTES; ELECTROENCEPHALOGRAPHY; HIPPOCAMPUS; LITHIUM CHLORIDE; MALE; PENTYLENETETRAZOLE; PILOCARPINE; PROTO-ONCOGENE PROTEINS C-FOS; RATS; RATS, SPRAGUE-DAWLEY; SCORPION VENOMS; SEIZURES; SODIUM CHANNELS;

EID: 46249094419     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1038/bjp.2008.156     Document Type: Article

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