Preclinical evaluation of CHF3381 as a novel antiepileptic agent

Neuropharmacology

Volumn 40, Issue 7, 2001, Pages 866-878

  Villetti, G ^a   Bregola, G ^b   Bassani, F ^a   Bergamaschi, M ^a   Rondelli, I ^a   Pietra, C ^a   Simonato, M ^b  

^a CHIESI FARMACEUTICI S P A   (Italy)

^b UNIVERSITY OF FERRARA   (Italy)

Author keywords

Anticonvulsant; Antiepileptogenic; CHF3381; Epilepsy; N methyl D aspartate (NMDA); Therapeutic index

Indexed keywords

4 AMINOBUTYRIC ACID; 4 AMINOPYRIDINE; 8 CYCLOPENTYL 1,3 DIPROPYLXANTHINE; ALPHA AMINO 3 HYDROXY 5 METHYL 4 ISOXAZOLEPROPIONIC ACID; ANTICONVULSIVE AGENT; BICUCULLINE; CHF 3381; CYANOPINDOLOL; DIAZEPAM; DIPRENORPHINE; DIZOCILPINE; FLUNITRAZEPAM; GLUTAMIC ACID; GLYCINE DERIVATIVE; KAINIC ACID; KETANSERIN; LAMOTRIGINE; MEPYRAMINE; MUSCIMOL; N (2 INDANYL)GLYCINAMIDE; N METHYL DEXTRO ASPARTIC ACID; NALTRINDOLE; NITRENDIPINE; PENTETRAZOLE; PICROTOXIN; PRAZOSIN; RAUWOLSCINE; SEROTONIN; SPIPERONE; STRYCHNINE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

AMYGDALOID NUCLEUS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTICONVULSANT ACTIVITY; ANTICONVULSANT THERAPY; ARTICLE; CLONIC SEIZURE; CONTROLLED STUDY; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG BRAIN LEVEL; DRUG EFFICACY; DRUG RECEPTOR BINDING; DRUG SCREENING; DRUG STRUCTURE; DRUG TOLERANCE; KINDLING; LOCOMOTION; MALE; MOTOR PERFORMANCE; MOUSE; NONHUMAN; PASSIVE AVOIDANCE; PRIORITY JOURNAL; RAT; SEIZURE THRESHOLD; SPECIES DIFFERENCE; TONIC SEIZURE; TOXICITY TESTING;

ANIMALS; ANTICONVULSANTS; DIZOCILPINE MALEATE; DRUG EVALUATION, PRECLINICAL; EPILEPSY; EXCITATORY AMINO ACID ANTAGONISTS; GLYCINE; INDANS; KINDLING, NEUROLOGIC; MALE; MICE; MOTOR ACTIVITY; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, N-METHYL-D-ASPARTATE; TRIAZINES;

EID: 0034982869     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0028-3908(01)00026-0     Document Type: Article

References (48)

1. A pharmacological study in the kindling model of epilepsy
2. Advances in the medical treatment of epilepsy
3. The glycine/NMDA receptor antagonist, R-(+)-HA-966, blocks activation of the mesolimbic dopaminergic system induced by phencyclidine and dizocilpine (MK-801) in rodents
4. Antiepileptic drugs
5. Effect of NMDA- and strychnine-insensitive glycine site antagonists on NMDA-mediated convulsions and learning
6. Accurate freehand injection into the lateral brain ventricle of the conscious
7. Glutamate antagonists have different effects on spontaneous locomotor activity in rats
8. Excitatory amino acid receptors in epilepsy
9. Preclinical evaluation of PNU-151774E as a novel anticonvulsant
10. Lamotrigine as an add-on drug in typical absence seizures
11. An improved one-trial passive avoidance learning situation
12. Cognitive adverse effects of antiepileptic drugs. Incidence, mechanisms and therapeutic implications
13. A preliminary procedure for the evaluation of central nervous system depressants
14. Amantadine and memantine are NMDA receptor antagonists
15. Subanaestethic effects of the non-competitive NMDA antagonist, ketamine, in humans. Psychomimetic, perceptual, cognitive, and neuroendocrine responses
16. A simplified method of evaluating dose-effects experiments
17. The role of technical, biological and pharmacological factors in the laboratory evaluation of anticonvulsant drugs. III. Pentylentetrazole seizure models
18. Strategies in antiepileptic drug development: Is rational drug design superior to random screening and structural variation?
19. Drug treatment of uncontrolled seizures
20. Drugs effective in the therapy of the epilepsies
21. The kindling model of epilepsy: A critical review
22. Anticonvulsant and antiepileptogenic actions of MK-801 in the kindling and electroshock models
23. Pharmacological studies on lamotrigine, a novel potential antiepileptic drug. 1. Anticonvulsant profile in mice and rats
24. 3H]-glutamate binding sites in rat brain
25. NMDA receptor blockers facilitate and impair learning via different mechanisms
26. Pre-synaptic and post-synaptic effects of xylazine and naphazoline on the bisected rat vas deferens
27. Convulsions induced by centrally administered NMDA in mice: Effects of NMDA antagonists, benzodiazepines, minor tranquilizers and anticonvulsants
28. BW1003C87, phenytoin and carbamazepine elevate seizure threshold in the rat amygdala-kindling model of epilepsy
29. Carbamazepine: Absorption, distribution and secretion
30. Is the oxidation of milacemide by monoamine oxidase a major factor in its anticonvulsant actions?
31. The effect of lamotrigine upon development of cortical kindled seizures in the rat
32. Effects of lamotrigine and conventional antiepileptic drugs on amygdala- and hippocampal-kindled seizures in rats
33. Clinical and behavioural evaluation in long-term care patients with mild to moderate dementia under Memantine treatment
34. Comparison of the potency, kinetics and voltage-dependency of a series of uncompetitive NMDA receptor antagonists in vitro with anticonvulsant and motor impairment activity in vivo
35. Antiepieptic drugs as a cause of worsening seizures
36. The kindled amygdala model of epilepsy: Anticonvulsant action of amino acid antagonists
37. Effect of stimulus intensity on the profile of anticonvulsant activity of phenytoin, ethosuximide and valproate
38. Modification of seizure activity by electrical stimulation. II. Motor seizure
39. Effects of procaine hydrochloride, diazepam, and diphenylhydantoin on seizure development in cortical and subcortical structures in rats
40. Anticonvulsant action of non-competitive antagonists of NMDA receptors (MK-801) in the kindling model of epilepsy
41. Inhibition or enhancement of kindling evolution by antiepileptics
42. Antiepileptogenic effects of conventional anticonvulsants in the kindling model of epilepsy
43. Locomotor effects of amantadine in mouse are not those of a typical glutamate antagonist
44. Phenytoin: Absorption, distribution and secretion
45. Anticonvulsant activity of milacemide
46. Role of the NMDA-type receptors in the development and maintenance of hippocampal kindling in rats
47. General Principles: Experimental selection, quantification, and evaluation of antiepileptic drugs
48. Effects of anticonvulsant drugs on 4-aminopyridine-induced seizures in mice