메뉴 건너뛰기




Volumn 44, Issue 7, 2003, Pages 904-911

TsTx toxin isolated from Tityus serrulatus scorpion venom induces spontaneous recurrent seizures and mossy fiber sprouting

Author keywords

Epilepsy; Hippocampal damage; Mossy fiber sprouting; Scorpion toxin

Indexed keywords

SCORPION VENOM; TITYUS TOXIN;

EID: 0038153857     PISSN: 00139580     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1528-1157.2003.38001.x     Document Type: Article
Times cited : (18)

References (48)
  • 1
    • 0025855135 scopus 로고
    • Discharge effect on pancreatic exocrine secretion produced by toxins purified from Tityus serrulatus scorpion venom
    • Possani LD, Martin BM, Fletcher MD, et al. Discharge effect on pancreatic exocrine secretion produced by toxins purified from Tityus serrulatus scorpion venom. J Biol Chem 1991;266:3178-85.
    • (1991) J Biol Chem , vol.266 , pp. 3178-3185
    • Possani, L.D.1    Martin, B.M.2    Fletcher, M.D.3
  • 2
    • 0025921546 scopus 로고
    • Further characterization of toxins T1IV (TsTX-III) and T2IV from Tityus serrulatus scorpion venom
    • Sampaio SV, Arantes EC, Prado WA, et al. Further characterization of toxins T1IV (TsTX-III) and T2IV from Tityus serrulatus scorpion venom. Toxicon 1991;29:663-72.
    • (1991) Toxicon , vol.29 , pp. 663-672
    • Sampaio, S.V.1    Arantes, E.C.2    Prado, W.A.3
  • 3
    • 0032078166 scopus 로고    scopus 로고
    • Behavioral, electroencephalographic and histopathologic effects of a neuropeptide isolated from Tityus serrulatus venom in rats
    • Carvalho FF, Nencioni ALA, Lebrun I, et al. Behavioral, electroencephalographic and histopathologic effects of a neuropeptide isolated from Tityus serrulatus venom in rats. Pharmacol Biochem Behav 1998;60:7-14.
    • (1998) Pharmacol Biochem Behav , vol.60 , pp. 7-14
    • Carvalho, F.F.1    Nencioni, A.L.A.2    Lebrun, I.3
  • 4
    • 0030293014 scopus 로고    scopus 로고
    • Action of new world scorpion venom and its neurotoxins in secretion
    • Fletcher LF, Fletcher M, Fainter LK, et al. Action of new world scorpion venom and its neurotoxins in secretion. Toxicon 1996;34:1399-411.
    • (1996) Toxicon , vol.34 , pp. 1399-1411
    • Fletcher, L.F.1    Fletcher, M.2    Fainter, L.K.3
  • 6
    • 0027476184 scopus 로고
    • Tityus serrulatus scorpion venom toxins display a complex pattern of antigenic reactivity
    • De Lima ME, Martin-Eauclaire ME, Chavez-Olortegui C, et al. Tityus serrulatus scorpion venom toxins display a complex pattern of antigenic reactivity. Toxicon 1993;31:223-7.
    • (1993) Toxicon , vol.31 , pp. 223-227
    • De Lima, M.E.1    Martin-Eauclaire, M.E.2    Chavez-Olortegui, C.3
  • 7
    • 0028350972 scopus 로고
    • Biochemical, pharmacological and genomic characterisation of Ts IV, an alphatoxin from the venom of the South American scorpion Tityus serrulatus
    • Martin-Eauclaire ME, Ceard B, Ribeiro AM, et al. Biochemical, pharmacological and genomic characterisation of Ts IV, an alphatoxin from the venom of the South American scorpion Tityus serrulatus. FEBS Lett 1994;342:181-4.
    • (1994) FEBS Lett , vol.342 , pp. 181-184
    • Martin-Eauclaire, M.E.1    Ceard, B.2    Ribeiro, A.M.3
  • 9
    • 0020548843 scopus 로고
    • Classification of Na channel receptors specific for various scorpion toxins
    • Wheeler KP, Watt DD, Lazdunski M. Classification of Na channel receptors specific for various scorpion toxins. Pflugers Archiv (Eur J Physiol) 1983;397:164-5.
    • (1983) Pflugers Archiv (Eur J Physiol) , vol.397 , pp. 164-165
    • Wheeler, K.P.1    Watt, D.D.2    Lazdunski, M.3
  • 10
    • 0022555877 scopus 로고
    • Molecular properties of voltage-sensitive sodium channels
    • Caterall WA. Molecular properties of voltage-sensitive sodium channels. Annu Rev Biochem 1986;55:953-85.
    • (1986) Annu Rev Biochem , vol.55 , pp. 953-985
    • Caterall, W.A.1
  • 11
    • 0018972109 scopus 로고
    • The effects of scorpion venom toxin on the release of amino acid neurotransmitters from cerebral cortex in vivo and in vitro
    • Coutinho-Neto J, Abdul-Ghani AS, Norris PJ, et al. The effects of scorpion venom toxin on the release of amino acid neurotransmitters from cerebral cortex in vivo and in vitro. J Neurochem 1980;35:558-65.
    • (1980) J Neurochem , vol.35 , pp. 558-565
    • Coutinho-Neto, J.1    Abdul-Ghani, A.S.2    Norris, P.J.3
  • 12
    • 0029780491 scopus 로고    scopus 로고
    • Isolation of toxin TsTX-VI from Tityus serrulatus scorpion venom: Effects on the release of neurotransmitters from synaptosomes
    • Sampaio SV, Coutinho-Netto J, Arantes EC, et al. Isolation of toxin TsTX-VI from Tityus serrulatus scorpion venom: effects on the release of neurotransmitters from synaptosomes. Biochem Mol Biol Int 1996;39:729-40.
    • (1996) Biochem Mol Biol Int , vol.39 , pp. 729-740
    • Sampaio, S.V.1    Coutinho-Netto, J.2    Arantes, E.C.3
  • 13
    • 0022384360 scopus 로고
    • The effect of Tityustoxin and ruthenium red on the release of acetylcholine from slices of cortex of rat brain
    • Gomez MV, Farrell N. The effect of Tityustoxin and ruthenium red on the release of acetylcholine from slices of cortex of rat brain. Neuropharmacology 1985;24:1103-7.
    • (1985) Neuropharmacology , vol.24 , pp. 1103-1107
    • Gomez, M.V.1    Farrell, N.2
  • 14
    • 0037211981 scopus 로고    scopus 로고
    • A microdialysis study of glutamate concentration in the hippocampus of rats after TsTx toxin injection and blockade of toxin effects by glutamate receptor antagonists
    • Nencioni ALA, Lebrun I, Dorce VAC. A microdialysis study of glutamate concentration in the hippocampus of rats after TsTx toxin injection and blockade of toxin effects by glutamate receptor antagonists. Pharmacol Biochem Behav 2003;74:455-63.
    • (2003) Pharmacol Biochem Behav , vol.74 , pp. 455-463
    • Nencioni, A.L.A.1    Lebrun, I.2    Dorce, V.A.C.3
  • 15
    • 0036291451 scopus 로고    scopus 로고
    • Modulation of sodium current in mammalian cells by an epilepsy-correlated β1-subunit mutation
    • Tammaro P, Conti F, Moran O. Modulation of sodium current in mammalian cells by an epilepsy-correlated β1-subunit mutation. Biochem Biophys Res Commun 2002;291:1095-101.
    • (2002) Biochem Biophys Res Commun , vol.291 , pp. 1095-1101
    • Tammaro, P.1    Conti, F.2    Moran, O.3
  • 16
    • 0011989352 scopus 로고
    • Summary: Neurotransmitters and epilepsy
    • Fisher RS, Coyle T, eds. New York: Wiley-Liss
    • Fisher RS, Coyle T. Summary: neurotransmitters and epilepsy. In: Fisher RS, Coyle T, eds. Neurotransmitters and epilepsy. New York: Wiley-Liss, 1991:247-52.
    • (1991) Neurotransmitters and Epilepsy , pp. 247-252
    • Fisher, R.S.1    Coyle, T.2
  • 18
    • 0032891686 scopus 로고    scopus 로고
    • + channel-blocking scorpion venom peptide toxins tityustoxin-K (alpha) and pandinustoxin-K (alpha)
    • + channel-blocking scorpion venom peptide toxins tityustoxin-K (alpha) and pandinustoxin-K (alpha). Epilepsy Res 1999;34:177-86.
    • (1999) Epilepsy Res , vol.34 , pp. 177-186
    • Juhng, K.N.1    Kokate, T.G.2    Yamaguchi, S.3
  • 19
    • 0018240145 scopus 로고
    • Microinjection of kainic acid into the rat hippocampus
    • Schwarcz R, Zaczek R, Coyle JT. Microinjection of kainic acid into the rat hippocampus. Eur J Pharmacol 1978;50:209-20.
    • (1978) Eur J Pharmacol , vol.50 , pp. 209-220
    • Schwarcz, R.1    Zaczek, R.2    Coyle, J.T.3
  • 20
    • 0018902044 scopus 로고
    • The role of epileptic activity in hippocampal and remote cerebral lesions induced by kainic acid
    • Ben-Ari Y, Tremblay E, Ottersen OP, et al. The role of epileptic activity in hippocampal and remote cerebral lesions induced by kainic acid. Brain Res 1980;191:79-97.
    • (1980) Brain Res , vol.191 , pp. 79-97
    • Ben-Ari, Y.1    Tremblay, E.2    Ottersen, O.P.3
  • 21
    • 0018843064 scopus 로고
    • Injections of kainic acid into the amygdaloid complex of the rat: An electrographic, clinical and histological study in relation to the pathology of epilepsy
    • Ben-Ari Y, Tremblay E, Ottersen OP, et al. Injections of kainic acid into the amygdaloid complex of the rat: an electrographic, clinical and histological study in relation to the pathology of epilepsy. Neuroscience 1980;5:515-28.
    • (1980) Neuroscience , vol.5 , pp. 515-528
    • Ben-Ari, Y.1    Tremblay, E.2    Ottersen, O.P.3
  • 22
    • 0019472821 scopus 로고
    • Electrographic, clinical and pathological alterations following systemic administration of kainic acid, bicuculline of pentetrazole: Metabolic mapping using the deoxyglucose method with special reference to the pathology of epilepsy
    • Ben-Ari Y, Tremblay E, Riche G, et al. Electrographic, clinical and pathological alterations following systemic administration of kainic acid, bicuculline of pentetrazole: metabolic mapping using the deoxyglucose method with special reference to the pathology of epilepsy. Neuroscience 1981;6:1361-91.
    • (1981) Neuroscience , vol.6 , pp. 1361-1391
    • Ben-Ari, Y.1    Tremblay, E.2    Riche, G.3
  • 23
    • 0017654785 scopus 로고
    • Epileptiform syndrome in rats produced by injecting tetanus toxin into the hippocampus
    • Mellanby J, George G, Robinson A, et al. Epileptiform syndrome in rats produced by injecting tetanus toxin into the hippocampus. J Neurol Neurosurg Psychiatry 1977;40:404-14.
    • (1977) J Neurol Neurosurg Psychiatry , vol.40 , pp. 404-414
    • Mellanby, J.1    George, G.2    Robinson, A.3
  • 24
    • 0020545095 scopus 로고
    • Limbic seizures produced by pilocarpine in rat: Behavioral, electroencephalographic and neuropathologic study
    • Turski WA, Cavalheiro EA, Schwarz M, et al. Limbic seizures produced by pilocarpine in rat: behavioral, electroencephalographic and neuropathologic study. Behav Brain Res 1983;9:315-35.
    • (1983) Behav Brain Res , vol.9 , pp. 315-335
    • Turski, W.A.1    Cavalheiro, E.A.2    Schwarz, M.3
  • 26
    • 0025832553 scopus 로고
    • Synaptic reorganization by mossy fibers in human epileptic fascia dentate
    • Babb TL, Kupfer WR, Pretorius JK, et al. Synaptic reorganization by mossy fibers in human epileptic fascia dentate. Neuroscience 1991;42:351-63.
    • (1991) Neuroscience , vol.42 , pp. 351-363
    • Babb, T.L.1    Kupfer, W.R.2    Pretorius, J.K.3
  • 27
    • 0017862965 scopus 로고
    • Experimental epileptogenesis; kindling-induced epilepsy in rats
    • Pinel JP, Rovner LI. Experimental epileptogenesis; kindling-induced epilepsy in rats. Exp Neurol 1978;58:190-202.
    • (1978) Exp Neurol , vol.58 , pp. 190-202
    • Pinel, J.P.1    Rovner, L.I.2
  • 28
    • 0019952583 scopus 로고
    • Long-term effects of intrahippocampal kainic acid injection in rats: A method for inducing spontaneous recurrent seizures
    • Cavalheiro EA, Riche DA, Le Gal La Salle G. Long-term effects of intrahippocampal kainic acid injection in rats: a method for inducing spontaneous recurrent seizures. Electroencephalogr Clin Neurophysiol 1982;53:581-9.
    • (1982) Electroencephalogr Clin Neurophysiol , vol.53 , pp. 581-589
    • Cavalheiro, E.A.1    Riche, D.A.2    Le Gal La Salle, G.3
  • 29
    • 0026340904 scopus 로고
    • Long-term effects of pilocarpine in rats: Structural damage of the brain triggers kindling and spontaneous recurrent seizures
    • Cavalheiro EA, Leite JP, Bortolotto ZA, et al. Long-term effects of pilocarpine in rats: structural damage of the brain triggers kindling and spontaneous recurrent seizures. Epilepsia 1991;32:778-82.
    • (1991) Epilepsia , vol.32 , pp. 778-782
    • Cavalheiro, E.A.1    Leite, J.P.2    Bortolotto, Z.A.3
  • 30
    • 0031747177 scopus 로고    scopus 로고
    • Recurrent spontaneous motor seizures after repeated low-dose systemic treatment with kainate: Assessment of a rat model of temporal lobe epilepsy
    • Hellier JL, Patrylo PR, Buckmaster PS, et al. Recurrent spontaneous motor seizures after repeated low-dose systemic treatment with kainate: assessment of a rat model of temporal lobe epilepsy. Epilepsy Res 1998;31:73-84.
    • (1998) Epilepsy Res , vol.31 , pp. 73-84
    • Hellier, J.L.1    Patrylo, P.R.2    Buckmaster, P.S.3
  • 31
    • 0028146101 scopus 로고
    • Temporal lobe epilepsy: The various MR appearances of histologically proven mesial temporal sclerosis
    • Meiners LC, van Gils A, Jansen GH, et al. Temporal lobe epilepsy: the various MR appearances of histologically proven mesial temporal sclerosis. AJNR Am J Neuroradiol 1994;15:1547-55.
    • (1994) AJNR Am J Neuroradiol , vol.15 , pp. 1547-1555
    • Meiners, L.C.1    Van Gils, A.2    Jansen, G.H.3
  • 32
    • 0029031842 scopus 로고
    • Reactive microglia in hippocampal sclerosis associated with human temporal lobe epilepsy
    • Beach TG, Woodhurst WB, MacDonald DB, et al. Reactive microglia in hippocampal sclerosis associated with human temporal lobe epilepsy. Neurosci Lett 1995;191:27-30.
    • (1995) Neurosci Lett , vol.191 , pp. 27-30
    • Beach, T.G.1    Woodhurst, W.B.2    MacDonald, D.B.3
  • 33
    • 0024444281 scopus 로고
    • Mossy fiber synaptic reorganization in the epileptic human temporal lobe
    • Sutula T, Cascino G, Cavazos J, et al. Mossy fiber synaptic reorganization in the epileptic human temporal lobe. Ann Neurol 1989;26:321-30.
    • (1989) Ann Neurol , vol.26 , pp. 321-330
    • Sutula, T.1    Cascino, G.2    Cavazos, J.3
  • 34
    • 0021917797 scopus 로고
    • Evidence of functional mossy fiber sprouting in hippocampal formation of kainic acid-treated rats
    • Tauck DL, Nadler JV. Evidence of functional mossy fiber sprouting in hippocampal formation of kainic acid-treated rats. J Neurosci 1985;5:1016-22.
    • (1985) J Neurosci , vol.5 , pp. 1016-1022
    • Tauck, D.L.1    Nadler, J.V.2
  • 35
    • 0027143716 scopus 로고
    • Circuit mechanisms of seizures in the pilocarpine model of chronic epilepsy: Cell loss and mossy fiber sprouting
    • Mello LEAM, Cavalheiro EA, Tan AM, et al. Circuit mechanisms of seizures in the pilocarpine model of chronic epilepsy: cell loss and mossy fiber sprouting. Epilepsia 1993;34:985-95.
    • (1993) Epilepsia , vol.34 , pp. 985-995
    • Mello, L.E.A.M.1    Cavalheiro, E.A.2    Tan, A.M.3
  • 36
    • 0025299049 scopus 로고
    • Brief seizure episodes induce long-term potentiation and mossy fiber sprouting in the hippocampus
    • Ben-Ari Y, Represa A. Brief seizure episodes induce long-term potentiation and mossy fiber sprouting in the hippocampus. TINS 1990;13:312-8.
    • (1990) TINS , vol.13 , pp. 312-318
    • Ben-Ari, Y.1    Represa, A.2
  • 37
    • 0038204771 scopus 로고
    • Progressive neuronal loss induced by kindling: A possible mechanism for mossy fiber synaptic reorganization and hippocampal sclerosis
    • Cavazos J, Sutula T. Progressive neuronal loss induced by kindling: a possible mechanism for mossy fiber synaptic reorganization and hippocampal sclerosis. Psychiatr Clin Neurosci 1990;55:549-57.
    • (1990) Psychiatr Clin Neurosci , vol.55 , pp. 549-557
    • Cavazos, J.1    Sutula, T.2
  • 38
    • 0029008152 scopus 로고
    • A role for mossy fiber activation in the loss of CA3 and hilar neurons induced by transduction of the GluR6 kainate receptor subunit
    • Casaccia-Bonnefil P, Stelzer A, Federof HJ, et al. A role for mossy fiber activation in the loss of CA3 and hilar neurons induced by transduction of the GluR6 kainate receptor subunit. Neurosci Lett 1995;191:67-70.
    • (1995) Neurosci Lett , vol.191 , pp. 67-70
    • Casaccia-Bonnefil, P.1    Stelzer, A.2    Federof, H.J.3
  • 39
    • 0025022424 scopus 로고
    • Altered patterns of dynorphin immunoreactivity suggest mossy fiber reorganization in human hippocampal epilepsy
    • Houser CR, Miyashiro JE, Swartz BE, et al. Altered patterns of dynorphin immunoreactivity suggest mossy fiber reorganization in human hippocampal epilepsy. J Neurosci 1990;10:267-82.
    • (1990) J Neurosci , vol.10 , pp. 267-282
    • Houser, C.R.1    Miyashiro, J.E.2    Swartz, B.E.3
  • 40
    • 0027034178 scopus 로고
    • Granule cell disorganization in the dentate gyrus: Possible alterations of neuronal migration in human temporal lobe epilepsy
    • Houser CR, Swartz BE, Walsh GO, et al. Granule cell disorganization in the dentate gyrus: possible alterations of neuronal migration in human temporal lobe epilepsy. Epilepsy Res Suppl 1992;9:41-8.
    • (1992) Epilepsy Res Suppl , vol.9 , pp. 41-48
    • Houser, C.R.1    Swartz, B.E.2    Walsh, G.O.3
  • 41
    • 0030907041 scopus 로고    scopus 로고
    • Dentate granule cell neurogenesis is increased by seizures and contributes to aberrant network reorganization in the adult rat hippocampus
    • Parent JM, Yu TW, Leibowitz RT, et al. Dentate granule cell neurogenesis is increased by seizures and contributes to aberrant network reorganization in the adult rat hippocampus. J Neurosci 1997;17:3727-38.
    • (1997) J Neurosci , vol.17 , pp. 3727-3738
    • Parent, J.M.1    Yu, T.W.2    Leibowitz, R.T.3
  • 42
    • 0024560520 scopus 로고
    • Long-term loss of paired pulse inhibition in the kainic acid-lesioned hippocampus of the rat
    • Cornish SM, Wheal HV. Long-term loss of paired pulse inhibition in the kainic acid-lesioned hippocampus of the rat. Neuroscience 1989;28:56-71.
    • (1989) Neuroscience , vol.28 , pp. 56-71
    • Cornish, S.M.1    Wheal, H.V.2
  • 43
    • 0027375017 scopus 로고
    • Effect of glutamate receptor antagonists on N-methyl-d-aspartate and (S)-α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid-induced convulsant effects in mice and rats
    • Bisaga A, Krzascik P, Jankowska E, et al. Effect of glutamate receptor antagonists on N-methyl-d-aspartate and (S)-α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid-induced convulsant effects in mice and rats. Eur. J Pharmacol 1993;242:213-20.
    • (1993) Eur J Pharmacol , vol.242 , pp. 213-220
    • Bisaga, A.1    Krzascik, P.2    Jankowska, E.3
  • 44
    • 0028016077 scopus 로고
    • Glutamate receptors and the induction of excitotoxic neuronal death
    • Bloom F, ed. Amsterdam: Elsevier
    • Choi DW. Glutamate receptors and the induction of excitotoxic neuronal death. In: Bloom F, ed. Progress in brain research. Amsterdam: Elsevier, 1994:47-51.
    • (1994) Progress in Brain Research , pp. 47-51
    • Choi, D.W.1
  • 45
    • 0029052786 scopus 로고
    • The effect of 2-amino-3-phosphonopropionic acid (AP3) in the gerbil model of cerebral ischemia
    • Maginn M, Cladwell M, Kelly JP, et al. The effect of 2-amino-3-phosphonopropionic acid (AP3) in the gerbil model of cerebral ischemia. Eur J Pharmacol 1995;282:259-62.
    • (1995) Eur J Pharmacol , vol.282 , pp. 259-262
    • Maginn, M.1    Cladwell, M.2    Kelly, J.P.3
  • 46
    • 0012004248 scopus 로고
    • NMDA receptors and their ion channels
    • Fisher RS, Coyle JT, ed. New York: Wiley-Liss
    • Lehmann J, Etienne P, Cheney DI, et al. NMDA receptors and their ion channels. In: Fisher RS, Coyle JT, ed. Neurotransmitters and epilepsy. New York: Wiley-Liss, 1991:147-65.
    • (1991) Neurotransmitters and Epilepsy , pp. 147-165
    • Lehmann, J.1    Etienne, P.2    Cheney, D.I.3
  • 47
    • 0029611185 scopus 로고
    • Effects of decahydroisoquinoline-3-carboxylic acid monohydrate: A novel AMPA receptor antagonist, on glutamate-induced Ca2+ responses and neurotoxicity in rat cortical and cerebellar granule neurons
    • Liljequist S, Cebers G, Kalda A. Effects of decahydroisoquinoline-3-carboxylic acid monohydrate: a novel AMPA receptor antagonist, on glutamate-induced Ca2+ responses and neurotoxicity in rat cortical and cerebellar granule neurons. Biochem Pharmacol 1995;50:1761-74.
    • (1995) Biochem Pharmacol , vol.50 , pp. 1761-1774
    • Liljequist, S.1    Cebers, G.2    Kalda, A.3
  • 48
    • 0024449997 scopus 로고
    • Animal models of the epilepsies
    • Fisher RS. Animal models of the epilepsies. Brain Res Rev 1989;14:245-78.
    • (1989) Brain Res Rev , vol.14 , pp. 245-278
    • Fisher, R.S.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.