Redox signaling triggers protection during the reperfusion rather than the ischemic phase of preconditioning

Basic Research in Cardiology

Volumn 103, Issue 4, 2008, Pages 378-384

  Dost, Turhan ^a   Cohen, Michael V ^a   Downey, James M ^a  

^a UNIVERSITY OF SOUTH ALABAMA COLLEGE OF MEDICINE   (United States)

Author keywords

Ischemic preconditioning; MPG; Myocardial infarction; Reactive oxygen species

Indexed keywords

TIOPRONIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; HEART INFARCTION; HEART INFARCTION PREVENTION; HEART INFARCTION SIZE; HEART MUSCLE ISCHEMIA; HEART MUSCLE REPERFUSION; HEART PROTECTION; ISCHEMIC PRECONDITIONING; NONHUMAN; OXIDATION REDUCTION REACTION; REPERFUSION INJURY; SIGNAL TRANSDUCTION; STAINING;

ANIMALS; ISCHEMIC PRECONDITIONING, MYOCARDIAL; MYOCARDIAL INFARCTION; MYOCARDIAL ISCHEMIA; MYOCARDIAL REPERFUSION INJURY; OXIDATION-REDUCTION; RABBITS; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; THIOPRONINE;

EID: 46149108580     PISSN: 03008428     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00395-008-0718-z     Document Type: Article

References (32)

1. Baines CP, Goto M, Downey JM (1997) Oxygen radicals released during ischemic preconditioning contribute to cardioprotection in the rabbit myocardium. J Mol Cell Cardiol 29:207-216
2. Becker LB (2004) New concepts in reactive oxygen species and cardiovascular reperfusion physiology. Cardiovasc Res 61:461-470
3. Becker LB, Vanden Hoek TL, Shao Z-H, Li C-Q, Schumacker PT (1999) Generation of superoxide in cardiomyocytes during ischemia before reperfusion. Am J Physiol 277:H2240-H2246
4. Bolli R, Jeroudi MO, Patel BS, Aruoma OI, Halliwell B, Lai EK, McCay PB (1989) Marked reduction of free radical generation and contractile dysfunction by antioxidant therapy begun at the time of reperfusion: evidence that myocardial "stunning" is a manifestation of reperfusion injury. Circ Res 65:607-622
5. Costa ADT, Garlid KD, West IC, Lincoln TM, Downey JM, Cohen MV, Critz SD (2005) Protein kinase G transmits the cardioprotective signal from cytosol to mitochondria. Circ Res 97:329-336
6. + channel activity. Free Radic Biol Med 40:469-479
7. Halestrap AP (2006) Calcium, mitochondria and reperfusion injury: A pore way to die. Biochem Soc Trans 34:232-237
8. Halestrap AP, Clarke SJ, Javadov SA (2004) Mitochondrial permeability transition pore opening during myocardial reperfusion - a target for cardioprotection. Cardiovasc Res 61:372-385
9. Halestrap AP, Kerr PM, Javadov S, Woodfield K-Y (1998) Elucidating the molecular mechanism of the permeability transition pore and its role in reperfusion injury of the heart. Biochim Biophys Acta 1366:79-94
10. Hausenloy DJ, Wynne AM, Yellon DM (2007) Ischemic preconditioning targets the reperfusion phase. Basic Res Cardiol 102:445-452
11. Hausenloy DJ, Yellon DM, Mani-Babu S, Duchen MR (2004) Preconditioning protects by inhibiting the mitochondrial permeability transition. Am J Physiol 287:H841-H849
12. Juhaszova M, Zorov DB, Kim S-H, Pepe S, Fu Q, Fishbein KW, Ziman BD, Wang S, Ytrehus K, Antos CL, Olson EN, Sollott SJ (2004) Glycogen synthase kinase-3β mediates convergence of protection signaling to inhibit the mitochondrial permeability transition pore. J Clin Invest 113:1535-1549
13. Keston AS, Brandt R (1965) The flurometric analysis of ultramicro quantities of hydrogen peroxide. Anal Biochem 11:1-5
14. 2 radicals in intact hearts with ischemia and reperfusion. Am J Physiol 284:H566-H574
15. Krenz M, Oldenburg O, Wimpee H, Cohen MV, Garlid KD, Critz SD, Downey JM, Benoit JN (2002) Opening of ATP-sensitive potassium channels causes generation of free radicals in vascular smooth muscle cells. Basic Res Cardiol 97:365-373
16. Krieg T, Qin Q, Philipp S, Alexeyev MF, Cohen MV, Downey JM (2004) Acetylcholine and bradykinin trigger preconditioning in the heart through a pathway that includes Akt and NOS. Am J Physiol 287:H2606-H2611
17. Laclau MN, Boudina S, Thambo JB, Tariosse L, Gouverneur G, Bonoron-Adèle S, Saks VA, Garlid KD, Dos Santos P (2001) Cardioprotection by ischemic preconditioning preserves mitochondrial function and functional coupling between adenine nucleotide translocase and creatine kinase. J Mol Cell Cardiol 33:947-956
18. Liu Y, Yang X-M, Iliodromitis EK, Kremastinos DT, Dost T, Cohen MV, Downey JM (2008) Redox signaling at reperfusion is required for protection from ischemic preconditioning but not from a direct PKC activator. Basic Res Cardiol 103:54-59
19. Nadtochiy SM, Burwell LS, Brookes PS (2007) Cardioprotection and mitochondrial S-nitrosation: Effects of S-nitroso-2-mercaptopropionyl glycine (SNO-MPG) in cardiac ischemia-reperfusion injury. J Mol Cell Cardiol 42:812-825
20. National Research Council (1996) Guide for the care and use of laboratory animals. 7th edn. National Academy Press, Washington
21. ATP channel opening. J Mol Cell Cardiol 35:653-660
22. Oldenburg O, Qin Q, Krieg T, Yang X-M, Philipp S, Critz SD, Cohen MV, Downey JM (2004) Bradykinin induces mitochondrial ROS generation via NO, cGMP, PKG, and mitoK ATP channel opening and leads to cardioprotection. Am J Physiol 286:H468-H476
23. ATP channels triggers the preconditioned state by generating free radicals. Circ Res 87:460-466
24. + channel and protein kinase C activation. Basic Res Cardiol 101:180-189
25. Schulz R, Cohen MV, Behrends M, Downey JM, Heusch G (2001) Signal transduction of ischemic preconditioning. Cardiovasc Res 52:181-198
26. Solaini G, Harris DA (2005) Biochemical dysfunction in heart mitochondria exposed to ischaemia and reperfusion. Biochem J 390:377-394
27. Tong H, Chen W, Steenbergen C, Murphy E (2000) Ischemic preconditioning activates phosphatidylinositol-3-kinase upstream of protein kinase C. Circ Res 87:309-315
28. Turrens JF (2003) Mitochondrial formation of reactive oxygen species. J Physiol 552:335-344
29. Yang X-M, Proctor JB, Cui L, Krieg T, Downey JM, Cohen MV (2004) Multiple, brief coronary occlusions during early reperfusion protect rabbit hearts by targeting cell signaling pathways. J Am Coll Cardiol 44:1103-1110
30. Yellon DM, Downey JM (2003) Preconditioning the myocardium: From cellular physiology to clinical cardiology. Physiol Rev 83:1113-1151
31. Ytrehus K, Walsh RS, Richards SC, Downey JM (1995) Hydrogen peroxide as a protective agent during reperfusion: A study in the isolated perfused rabbit heart subjected to regional ischemia. Cardiovasc Res 30:1033-1037
32. Zweier JL, Flaherty JT, Weisfeldt ML (1987) Direct measurement of free radical generation following reperfusion of ischemic myocardium. Proc Natl Acad Sci 84:1404-1407