The diversity of KIR gene in Chinese Northern Han population and the impact of donor KIR and patient HLA genotypes on outcome following HLA-identical sibling allogeneic hematopoietic stem cell transplantation for hematological malignancy in Chinese people

International Journal of Hematology

Volumn 87, Issue 4, 2008, Pages 422-433

  Dou, Li Ping ^a   Zheng, De Hua ^a   Wang, Chang ^a   Liu, Jun Hua ^a   Sun, Jing Fen ^a   Jin, Hai Jie ^a   Gao, Chun Ji ^a   Yu, Li ^a   Da, Wan Ming ^a  

^a CHINESE PLA GENERAL HOSPITAL   (China)

Author keywords

Hematopoietic stem cell transplantation; KIR; KIR haplotypes; Natural killer cells; PCR SSP; Population study

Indexed keywords

HLA A ANTIGEN; HLA ANTIGEN; HLA ANTIGEN CLASS 1; HLA B ANTIGEN; HLA C ANTIGEN; KILLER CELL IMMUNOGLOBULIN LIKE RECEPTOR; LIGAND;

ACUTE GRAFT VERSUS HOST DISEASE; ACUTE GRANULOCYTIC LEUKEMIA; ACUTE LYMPHOBLASTIC LEUKEMIA; ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION; ANTIGEN RECOGNITION; ARTICLE; CELL SUBPOPULATION; CHINESE; CHRONIC MYELOID LEUKEMIA; DISEASE SEVERITY; DNA DETERMINATION; ETHNICITY; FEMALE; GENE FREQUENCY; GENE LOCUS; GENE SEQUENCE; GENETIC VARIABILITY; GENOTYPE; HAPLOTYPE; HEMATOLOGIC MALIGNANCY; HLA MATCHING; HUMAN; HUMAN CELL; IMMUNOGENETICS; INCIDENCE; KIR GENE; MAJOR CLINICAL STUDY; MALE; MULTIPLE MYELOMA; MYELODYSPLASTIC SYNDROME; NONHODGKIN LYMPHOMA; RECEPTOR GENE; RECIPIENT;

ASIAN CONTINENTAL ANCESTRY GROUP; FEMALE; GENOTYPE; HEMATOLOGIC NEOPLASMS; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HLA ANTIGENS; HUMANS; LIGANDS; MALE; MONOMERIC GTP-BINDING PROTEINS; SIBLINGS; TRANSPLANTATION, HOMOLOGOUS;

EID: 46149108577     PISSN: 09255710     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12185-008-0058-7     Document Type: Article

References (43)

1. Tanaka J, Asaka M, Imamura M. Potential role of natural killer cell receptor-expressing cells in immunotherapy for leukemia. Int J Hematol. 2005;81:6-12.
2. Ruggeri L, Capanni M, Urbani E, Perruccio K, Shlomchik WD, Tosti A, et al. Effectiveness of donor natural killer cell alloreactivity in mismatched hematopoietic transplants. Science. 2002;295:2097-100.
3. Farag SS, Fehniger TA, Ruggeri L, Velardi A, Caligiuri MA. Natural killer cell receptors: new biology and insights into the graft-versus-leukemia effect. Blood. 2002;100:1935-47.
4. Valiante NM, Uhrberg M, Shilling HG, Lienert-Weidenbach K, Arnett KL, D'Andrea A, et al. Functionally and structurally distinct NK cell receptor repertoires in the peripheral blood of two human donors. Immunity. 1997;7:739-51.
5. Rajagopalan S, Fu J, Long EO. Cutting edge: induction of Ifn-γ production but not cytotoxicity by the killer cell Ig-like receptor KIR2DL4 (cd158d) in resting NK cells. J Immunol. 2001;167:1877-81.
6. Bottino C, Falco M, Sivori S, Moretta L, Moretta A, Biassoni R. Identification and molecular characterization of natural mutant of the p50.2/KIR2DS2 activating NK receptor that fails to mediate NK cell triggering. Eur J Immunol. 2000;30:3569-74.
7. Borregoa F, Kabata J, Kima DK. Structure and function of major histocompatibility complex (MHC) class I specific receptors expressed on human natural killer (NK) cells. Mol Immunol. 2001;38:637-60.
8. Niokou D, Spyropoulou-Vlachouand M, Stavropoulos-Giokas C, Darlamitsou A. Distribution of killer cell immunoglobulin-like receptors in the Greek population. Hum Immunol. 2003;64:11167-76.
9. Martin AM, Kulski JK, Gaudieri S, Witt CS, Freitas EM, Trowsdale J, Christiansen FT. Comparative genomic analysis, diversity and evolution of two KIR haplotypes A and B. Gene. 2004;335:121-31.
10. Yawata M, Yawata N, McQueen KL, Cheng NW, Guethlein LA, Rajalingam R, et al. Predominance of group A KIRhaplotypes in Japanese associated with diverse NK cell repertoires of KIR expression. Immunogenetics. 2002;54:543-50.
11. Ruggeri L, Capanni M, Mancusi A, Urbani E, Perruccio K, Burchielli E, et al. Alloreactive natural killer cells in mismatched hematopoietic stem cell transplantation. Blood Cell Mol Dis. 2004;33:216-21.
12. Mullighan CG, Petersdorf EW. Genomic polymorphism and allogeneic hematopoietic transplantation outcome. Biol Blood Marrow Transplant. 2006;12:19-27.
13. Schaffer M, Malmberg KJ, Ringde'n O, Ljunggren HG, Remberger M. Increased infection-related mortality in KIR-ligand-mismatched unrelated allogeneic hematopoietic stem-cell transplantation. Transplantation. 2004;78:1081-5.
14. Sun JY, Gaidulis L, Dagis A, Palmer J, Rodriguez R, Miller MM, et al. Killer Ig-like receptor (KIR) compatibility plays a role in the prevalence of acute GVHD in unrelated hematopoietic cell transplants for AML. Bone Marrow Transplant. 2005;56:525-30.
15. Hsu KC, Gooley T, Malkki M. KIR ligands and prediction of relapse after unrelated donor hematopoietic cell transplantation for hematologic malignancy. Biol Blood Marrow Transplant. 2006;12:828-36.
16. Malmberg KJ, Schaffer M, Ringd'en O, Remberger M, Ljunggrena HG. KIR-ligand mismatch in allogeneic hematopoietic stem-cell transplantation. Mol Immunol. 2005;42:531-4.
17. Santis DD, Bishara A, Witt CS, Nagler A, Brautbar C, Slavin S, Christiansen FT. Natural killer cell HLA-C epitopes and killer cell immunoglobulin-like receptors both influence outcome of mismatched unrelated donor bone marrow transplants. Tissue Antigens. 2005;65:519-28.
18. Ahlenstiel G, Martin MP, Gao X, Carrington M, Rehermann B. Distinct KIR/HLA compound genotypes affect the kinetics of human antiviral natural killer cell responses. J Clin Invest. 2008;1:1-10.
19. Leung W, Iyengar R, Turner V, Lang P, Bader P, Conn P, et al. Determinants of antileukemia effects of allogeneic NK cells. J Immunol. 2004;172:644-50.
20. Bignon JD, Gagne K. KIR matching in hematopoietic stem cell transplantation. Curr Opinion Immunol. 2005;17:553-9.
21. Martin MP, Nelson G, Lee JH, Pellett F, Gao X, Wade J, et al. Cutting edge: susceptibility to psoriatic arthritis: influence of activating killer Ig-like receptor genes in the absence of specific HLA-C alleles. J Immunol. 2002;169:2818-22.
22. Martin AM, Freitas EM, Witt CS, Christiansen FT. The genomic organization and evolution of the natural killer immunoglobulin-like receptor (KIR) gene cluster. Immunogenetics. 2000;51:268.
23. Norman PJ, Cook MA, Carey BS, Carrington CV, Verity DH, Hameed K, et al. SNP haplotypes and allele frequencies show evidence for disruptive and balancing selection in the human leukocyte receptor complex. Immunogenetics. 2004;56:225-37.
24. Hsu KC, Liu XR, Selvakumar A, Mickelson E, O'Reilly RJ, Dupont B. Killer Ig-like receptor haplotype analysis by gene content: evidence for genomic diversity with a minimum of six basic framework haplotypes, each with multiple subsets. J Immunol. 2002;169:5118-29.
25. Uhrberg M, Valiante NM, Shum BP, Shilling HG, Lienert-Weidenbach K, Corliss B, et al. Human diversity in killer cell inhibitory receptor genes. Immunity. 1997;7:753-63.
26. Norman PJ, Parham P. Complex interactions: the immunogenetics of human leukocyte antigen and killer cell immunoglobulin-like receptors. Semin Hematol. 2005;42:65-75.
27. Parham P. Immunogenetics of killer-cell immunoglobulin-like receptors. Tissue Antigens. 2003;62:194-200.
28. Whang DH, Park H, Yoon JA, Park MH. Haplotype analysis of killer cell immunoglobulin-like receptor genes in 77 Korean families. Hum Immunol. 2005;66:146-54.
29. Cook MA, Moss PAH, Briggs DC. The distribution of 13 killer-cell immunoglobulin-like receptor loci in UK blood donors from three ethnic groups. Eur J Immunol. 2003;30:213-21.
30. Velickovic DM, Heather ZV. Diversity of killer cell immunoglobulin-like receptor genes in Pacific Islands populations. Immunogenetics. 2006;58:523-32.
31. Gagne K, Brizard G, Gueglio B, Milpied N, Herry P, Bonneville F, et al. Relevance of KIR gene polymorphisms in bone marrow transplantation outcome. Hum Immunol. 2002;63:271-80.
32. Cook MA, Milligan DW, Fegan CD, Darbyshire PJ, Mahendra P, Craddock CF, et al. The impact of donor KIR and patient HLA-C genotypes on outcome following HLA-identical sibling hematopoietic stem cell transplantation for myeloid leukemia. Blood. 2004;103:1521-26.
33. Ruggeri L, Capanni M, Mancusi A, Perruccio K, Burchielli E, Martelli MF, et al. Natural killer cell alloreactivity in haploidentical hematopoietic stem cell transplantation. Int J Hematol. 2005;81:13-7.
34. Giebel S, Locatelli F, Lamparelli T, Velardi A, Davies S, Frumento G, et al. Survival advantage with KIR ligand incompatibility in hematopoietic stem cell transplantation from unrelated donors. Blood. 2003;102:814-9.
35. Bishara A, De Santis D, Witt CC, Brautbar C, Christiansen FT, Or R, et al. The beneficial role of inhibitory KIR genes of HLA class I NK epitopes in haploidentically mismatched stem cell allografts may be masked by residual donor-alloreactive T cells causing GVHD. Tissue Antigens. 2004;63:204-11.
36. Ruggeri L, Capanni M, Casucci M, Volpi I, Tosti A, Perruccio K, et al. Role of natural killer cell alloreactivity in HLA-mismatched hematopoietic stem cell transplantation. Blood. 1999;94:333-9.
37. Beelen DW, Ottinger HD, Ferencik S, Elmaagacli AH, Peceny R, Trenschel R, et al. Genotypic inhibitory killer immunoglobulin-like receptor ligand incompatibility enhances the long-term antileukemic effect of unmodified llogeneic hematopoietic stem cell transplantation in patients with myeloid leukemias. Blood. 2005;105(6):2594-600.
38. Davies SM, Ruggieri L, De For T, Wagner JE, Weisdorf DJ, Miller JS, et al. Evaluation of KIR ligand incompatibility in mismatched unrelated donor hematopoietic transplants. Killer immunoglobulin-like receptor. Blood. 2002;100:3825-7.
39. Ruggeri L, Capanni M, Casucci M, Volpi I, Tosti A, Perruccio K, et al. Role of natural killer cell alloreactivity in HLA-mismatched hematopoietic stem cell transplantation. Blood. 1999;94:333.
40. Gumperz JE, Barber LD, Valiante NM, Percival L, Phillips JH, Lanier LL, et al. Conserved and variable residues within the Bw4 motif of HLA-B make separable contributions to recognition by the NKB1 killer cell-inhibitory receptor. J Immunol. 1997;158:5237-41.
41. Hsu KC, Keever-Taylor CA, Wilton A, Pinto C, Heller G, Arkun K, et al. Improved outcome in HLA-identical sibling hematopoietic stem-cell transplantation for acute myelogenous leukemia predicted by KIR and HLAgenotypes. Blood. 2005;105:4878-84.
42. Verheyden S, Schots R, Duquet W, Demanet C. A defined donor activating natural killer cell receptor genotype protects against leukemic relapse after related HLA-identical hematopoietic stem cell transplantation. Leukemia. 2005;19:1446-1.
43. Giebel S, Nowak I, Wojnar J, Markiewicz M, Dziaczkowska J, Wylezol I, et al. Impact of activating killer immunoglobulin-like receptor genotype on outcome of unrelated donor-hematopoietic cell transplantation. Transplant Proc. 2006;38:287-91.