Increased infection-related mortality in KIR-ligand-mismatched unrelated allogeneic hematopoietic stem-cell transplantation

Transplantation

Volumn 78, Issue 7, 2004, Pages 1081-1085

  Schaffer, Marie ^a   Malmberg, Karl Johan ^a   Ringdén, Olle ^a   Ljunggren, Hans Gustaf ^a   Remberger, Mats ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Killer cell immunoglobulin like receptor; Natural killer cell; Opportunistic infections; Stem cell transplantation; Transplantation related mortality

Indexed keywords

CELL RECEPTOR; KILLER CELL IMMUNOGLOBULIN LIKE RECEPTOR; UNCLASSIFIED DRUG;

ACUTE GRANULOCYTIC LEUKEMIA; ACUTE LYMPHOBLASTIC LEUKEMIA; ADOLESCENT; ADULT; AGED; ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION; ARTICLE; CHILD; CHRONIC MYELOID LEUKEMIA; CONTROLLED STUDY; FEMALE; HISTOINCOMPATIBILITY; HLA MATCHING; HODGKIN DISEASE; HUMAN; INFANT; INFECTION RATE; MAJOR CLINICAL STUDY; MALE; MORTALITY; MULTIPLE MYELOMA; MYELODYSPLASTIC SYNDROME; NATURAL KILLER CELL; NONHODGKIN LYMPHOMA; OPPORTUNISTIC INFECTION; POSTOPERATIVE COMPLICATION; PRIORITY JOURNAL;

ADULT; GRAFT VS HOST DISEASE; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HISTOCOMPATIBILITY TESTING; HUMANS; KILLER CELLS, NATURAL; LIGANDS; MIDDLE AGED; OPPORTUNISTIC INFECTIONS; RECEPTORS, IMMUNOLOGIC; RETROSPECTIVE STUDIES; TRANSPLANTATION, HOMOLOGOUS;

EID: 6344222785     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.TP.0000137103.19717.86     Document Type: Article

References (17)

1. Karre K, Ljunggren HG, Piontek G, et al. Selective rejection of H-2-deficient lymphoma variants suggests alternative immune defense strategy. Nature 1986; 319(6055): 675.
2. Ljunggren HG, Karre K. In search of the 'missing self: MHC molecules and NK cell recognition [see comments]. Immunol Today 1990; 11(7): 237.
3. Parham P, McQueen K. Alloreactive killer cells: hindrance and help for haematopoietic transplants. Nat Rev Immunol 2003; 3(2): 108.
4. Farag S, Fehniger T, Ruggeri L, et al. Natural killer cell receptors: new biology and insights into the graft-versus-leukemia effect. Blood 2002; 100(6): 1935.
5. Ruggeri L, Capanni M, Urbani E, et al. Effectiveness of donor natural killer cell alloreactivity in mismatched hematopoietic transplants. Science 2002; 295(5562): 2097.
6. Giebel S, Locatelli F, Lamparelli T, et al. Survival advantage with KIR ligand incompatibility in hematopoietic stem cell transplantation from unrelated donors. Blood 2003; 102(3): 814.
7. Davies SM, Ruggieri L, DeFor T, et al. Evaluation of KIR ligand incompatibility in mismatched unrelated donor hematopoietic transplants. Killer immunoglobulin-like receptor. Blood 2002; 100(10): 3825.
8. Ringden O, Ruutu T, Remberger M, et al. A randomized trial comparing busulphan with total body irradiation as conditioning in allogeneic marrow transplant recipients with leukemia. A report from the Nordic Bone Marrow Transplantation Group. Blood 1994; 83: 2723.
9. Ringden O, Remberger M, Runde V, et al. Peripheral blood stem cell (PBMC) transplantation from unrelated donors: a comparison with marrow transplantation. Blood 1999; 94(2): 455.
10. Slavin S, Nagler A, Naparstek E. Non myeloablative stem cell transplantation and cell therapy as an alternative to conventional bone marrow transplantation with lethal cytoreduction for the treatment of malignant and nonmalignant hematological disease. Blood 1998; 91: 756.
11. Hentschke P, Barkholt L, Uzunel M, et al. Low-intensity conditioning and hematopoietic stem cell transplantation in patients with renal and colon carcinoma. Bone Marrow Transplant 2003; 31: 253.
12. Remberger M, Svahn B-M, Hentschke P, et al. Effect on cytokine release and graft-versus-host-disease of different anti-T-cell antibodies during conditioning for unrelated haematopoietic stem cell transplantation. Bone Marrow Transplant 1999; 24: 823.
13. Glucksberg H, Storb R, Fefer A, et al. Clinical manifestations of graft-versus-host disease in human recipients of marrow from HLA-matched sibling donors. Transplantation 1974; 18(4): 295.
14. Schaffer M, Aldener-Cannava A, Remberger M, et al. Roles of HLA-B, HLA-C and HLA-DPA1 incompatibilities in the outcome of unrelated stem-cell transplantation. Tissue Antigens 2003; 62(3): 243.
15. Ringden O, Schaffer M, Le Blanc K, et al. Which donor should be chosen for hematopoietic stem cell transplantation among unrelated HLA-A, -B, and -DRB1 genomically identical volunteers? Biol Blood Marrow Transplant 2004; 10(2): 128.
16. Kosaka H, Surh CD, Sprent J. Stimulation of mature unprimed CD8+ T cells by semiprofessional antigen-presenting cells in vivo. J Exp Med 1992; 176(5): 1291.
17. Shlomchik WD, Couzens MS, Tang CB, et al. Prevention of graft versus host disease by inactivation of host antigen-presenting cells. Science 1999; 285(5426): 412.