Myocardial gene expression associated with genetic cardiac hypertrophy in the absence of hypertension

Hypertension Research

Volumn 31, Issue 5, 2008, Pages 941-955

  Dwyer, Jeremy P ^a   Ritchie, Matthew E ^b   Smyth, Gordon K ^b   Harrap, Stephen B ^a   Delbridge, Lea M D ^a   Domenighetti, Andrea A ^c   Nicolantonio, Robert ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

^b WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH   (Australia)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Cardiac hypertrophy; Gene expression; Hypertrophic heart rat; Microarray; Remodeling

Indexed keywords

1 ACYLGLYCEROPHOSPHATE ACYLTRANSFERASE; 1,4 ALPHA GLUCAN BRANCHING ENZYME; ACID PHOSPHATASE; ACYLSPHINGOSINE DEACYLASE; ALDEHYDE REDUCTASE; BETA ACTIN; BRAIN NATRIURETIC PEPTIDE; COMPLEMENTARY DNA; CYTOCHROME C OXIDASE; DIAZEPAM BINDING INHIBITOR; ENDONUCLEASE G; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; MITOGEN ACTIVATED PROTEIN KINASE; NEUTROPHIL GELATINASE ASSOCIATED LIPOCALIN; PROCOLLAGEN; PROTEASOME; PROTEIN BMAL1; PROTEIN DNAJ; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATE SYNTHASE; RAS PROTEIN; RIBOSOME PROTEIN; STEROL CARRIER PROTEIN 2; SUCCINATE DEHYDROGENASE; TESTIS DETERMINING FACTOR; TRANSFORMING GROWTH FACTOR BETA; TROPOMYOSIN; TUMOR NECROSIS FACTOR RECEPTOR; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR;

AGE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BAYES THEOREM; BLOOD PRESSURE MEASUREMENT; BODY WEIGHT; CONTROLLED STUDY; DNA MICROARRAY; DOWN REGULATION; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENETIC ASSOCIATION; HEART LEFT VENTRICLE; HEART MUSCLE; HEART VENTRICLE HYPERTROPHY; HEART WEIGHT; HEREDITY; HYPERTENSION; MALE; NEWBORN; NONHUMAN; NUCLEOTIDE SEQUENCE; PATHOGENESIS; RAT; RAT STRAIN; REAL TIME POLYMERASE CHAIN REACTION; STRAIN DIFFERENCE; SYSTOLIC BLOOD PRESSURE; UNINDEXED SEQUENCE; UPREGULATION;

AGING; ANIMALS; BLOOD PRESSURE; DISEASE MODELS, ANIMAL; GENE EXPRESSION; GENE EXPRESSION PROFILING; HYPERTROPHY, LEFT VENTRICULAR; MALE; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; MYOCARDIUM; NF-KAPPA B; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; RAS PROTEINS; RATS; RATS, INBRED F344; RATS, INBRED SHR; RATS, INBRED STRAINS; RECEPTORS, TUMOR NECROSIS FACTOR; SIGNAL TRANSDUCTION; VENTRICULAR REMODELING;

EID: 46049102390     PISSN: 09169636     EISSN: 13484214     Source Type: Journal    
DOI: 10.1291/hypres.31.941     Document Type: Article

References (61)

1. Kannel WB, Dannenberg AL, Levy D: Population implications of electrocardiographic left ventricular hypertrophy. Am J Cardiol 1987; 60: 851-931.
2. Lauer MS, Anderson KM, Kannel WB, Levy D: The impact of obesity on left ventricular mass and geometry. The Framingham Heart Study. JAMA 1991; 266: 231-236.
3. Palmieri V, de Simone G, Roman MJ, Schwartz JE, Pickering TG, Devereux RB: Ambulatory blood pressure and metabolic abnormalities in hypertensive subjects with inappropriately high left ventricular mass. Hypertension 1999; 34: 1032-1040.
4. Tingleff J, Munch M, Jakobsen TJ, et al: Prevalence of left ventricular hypertrophy in a hypertensive population. Eur Heart J 1996; 17: 143-149.
5. Tanase H, Yamori Y, Hansen CT, Lovenberg W: Heart size in inbred strains of rats. Part 1. Genetic determination of the development of cardiovascular enlargement in rats. Hypertension 1982; 4: 864-872.
6. Harrap SB, Danes VR, Ellis JA, Griffiths CD, Jones EF, Delbridge LM: The hypertrophic heart rat: a new normotensive model of genetic cardiac and cardiomyocyte hypertrophy. Physiol Genomics 2002; 9: 43-48.
7. MacLellan WR, Schneider MD: Genetic dissection of cardiac growth control pathways. Annu Rev Physiol 2000; 62: 289-319.
8. Lee HR, Henderson SA, Reynolds R, Dunnmon P, Yuan D, Chien KR: Alpha 1-adrenergic stimulation of cardiac gene transcription in neonatal rat myocardial cells. Effects on myosin light chain-2 gene expression. J Biol Chem 1988; 263: 7352-7358.
9. Dempsey AA, Dzau VJ, Liew CC: Cardiovascular genomics: estimating the total number of genes expressed in the human cardiovascular system. J Mol Cell Cardiol 2001; 33: 1879-1886.
10. Snijders AM, Meijer GA, Brakenhoff RH, van den Brule AJ, van Diest PJ: Microarray techniques in pathology: tool or toy? Mol Pathol 2000; 53: 289-294.
11. Aronow BJ, Toyokawa T, Canning A, et al: Divergent transcriptional responses to independent genetic causes of cardiac hypertrophy. Physiol Genomics 2001; 6: 19-28.
12. Friddle CJ, Koga T, Rubin EM, Bristow J: Expression profiling reveals distinct sets of genes altered during induction and regression of cardiac hypertrophy. Proc Natl Acad Sci U S A 2000; 97: 6745-6750.
13. Lovenberg W: Animal models for hypertension research. Prog Clin Biol Res 1987; 229: 225-240.
14. Tanaka TS, Jaradat SA, Lim MK, et al: Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Proc Natl Acad Sci U S A 2000; 97: 9127-9132.
15. Buckley MJ: Spot User's Giuide. Sydney, CSIRO Mathematical and Information Sciences, 2000.
16. Yang YH, Buckley MJ, Dudoit S, Speed TP: Comparison of methods for image analysis on cDNA microarray data. J Comput Graph Stat 2002; 11: 108-136.
17. Smyth GK, Speed TP: Normalization for cDNA microarray data. Methods 2003; 31: 265-273.
18. Smyth GK: Linear models and empirical bayes methods for assessing differential expression in microarray experiments. Stat Appl Genet Mol Biol 2004; 3: Article3.
19. Smyth GK, Michaud J, Scott HS: Use of within-array replicate spots for assessing differential expression in microarray experiments. Bioinformatics 2005; 21: 2067-2075.
20. Smyth GK, Yang YH, Speed T: Statistical issues in cDNA microarray data analysis. Methods Mol Biol 2003; 224: 111-136.
21. Kargul GJ, Dudekula DB, Qian Y, et al: Verification and initial annotation of the NIA mouse 15K cDNA clone set. Nat Genet 2001; 28: 17-18.
22. Ashburner M, Ball CA, Blake JA, et al: Gene ontology: tool for the unification of biology. The Gene Ontology Consortium. Nat Genet 2000; 25: 25-29.
23. Diehn M, Sherlock G, Binkley G, et al: SOURCE: a unified genornic resource of functional annotations, ontologies, and gene expression data. Nucleic Acids Res 2003; 31: 219-223.
24. Livak KJ, Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 2001; 25: 402-408.
25. Hefti MA, Harder BA, Eppenberger HM, Schaub MC: Signaling pathways in cardiac myocyte bypertrophy. J Mol Cell Cardiol 1997; 29: 2873-2892.
26. Trentin GA, Yin X, Tahir S, et al: A mouse homologue of the Drosophila tumor suppressor 1(2)tid gene defines a novel Ras GTPase-activating protein (RasGAP)-binding protein. J Biol Chem 2001; 276: 13087-13095.
27. Hayes GM, Carrigan PE, Miller LJ: Serine-arginine protein kinase 1 overexpression is associated with tumorigenic imbalance in mitogen-activated protein kinase pathways in breast, colonic, and pancreatic carcinomas. Cancer Res 2007; 67: 2072-2080.
28. McWhinnie R, Pechkovsky DV, Zhou D, et al: Endothelin-1 induces hypertrophy and inhibits apoptosis in human airway smooth muscle cells. Am J Physiol Lung Cell Mol Physiol 2007; 292: L278-L286.
29. Stockand JD, Meszaros JG: Aldosterone stimulates proliferation of cardiac fibroblasts by activating Ki-RasA and MAPK1/2 signaling. Am J Physiol Heart Circ Physiol 2003; 284: H176-H184.
30. Bhattacharya S, Macdonald ST, Farthing CR: Molecular mechanisms controlling the coupled development of myocardium and coronary vasculature. Clin Sci (Lond) 2006; 111: 35-46.
31. Fang JY, Richardson BC: The MAPK signalling pathways and colorectal cancer. Lancet Oncol 2005; 6: 322-327.
32. Murphy KM, Brune KA, Griffin C, et al: Evaluation of candidate genes MAP2K4, MADH4, ACVR1B, and BRCA2 in familial pancreatic cancer: deleterious BRCA2 mutations in 17%. Cancer Res 2002; 62: 3789-3793.
33. Kapoun AM, Liang F, O'Young G, et al: B-type natriuretic peptide exerts broad functional opposition to transforming growth factor-beta in primary human cardiac fibroblasts: fibrosis, myofibroblast conversion, proliferation, and inflammation. Circ Res 2004; 94: 453-461.
34. Marin-Garcia J, Goldenthal MJ: The mitochondrial organelle and the heart. Rev Esp Cardiol 2002; 55: 1293-1310.
35. Raba S, Robinson BH: Mitochondria, oxygen free radicals, disease and ageing. Trends Biochem Sci 2000; 25: 502-508.
36. Eaton P, Wright N, Hearse DJ, Shattock MJ: Glyceraldehyde phosphate dehydrogenase oxidation during cardiac ischemia and reperfusion. J Mol Cell Cardiol 2002; 34: 1549-1560.
37. Kang YJ, Li Y, Sun X, Sun X: Antiapoptotic effect and inhibition of ischemia/reperfusion-induced myocardial injury in metallothionein-overexpressing transgenic mice. Am J Pathol 2003; 163: 1579-1586.
38. Rothe M, Xiong J, Shu HB, Williamson K, Goddard A, Goeddel DV: I-TRAF is a novel TRAF-interacting protein that regulates TRAF-mediated signal transduction. Proc Natl Acad Sci U S A 1996; 93: 8241-8246.
39. Pype S, Declercq W, Ibrahimi A, et al: TTRAP, a novel protein that associates with CD40, tumor necrosis factor (TNF) receptor-75 and TNF receptor-associated factors (TRAFs), and that inhibits nuclear factor-kappa B activation. J Biol Chem 2000; 275: 18586-18593.
40. Purcell NH, Tang G, Yu C, Mercurio F, DiDonato JA, Lin A: Activation of NF-kappa B is required for hypertrophic growth of primary rat neonatal ventricular cardiomyocytes. Proc Natl Acad Sci U S A 2001; 98: 6668-6673.
41. Norris JL, Baldwin AS Jr: Oncogenic Ras enhances NF-kappaB transcriptional activity through Raf-dependent and Raf-independent mitogen-activated protein kinase signaling pathways. J Biol Chem 1999; 274: 13841-13846.
42. Booz GW, Baker KM: Role of type 1 and type 2 angiotensin receptors in angiotensin II-induced cardiomyocyte hypertrophy. Hypertension 1996; 28: 635-640.
43. Brasier AR, Jamaluddin M, Han Y, Patterson C, Runge MS: Angiotensin II induces gene transcription through cell-type-dependent effects on the nuclear factor-kappaB (NF-kappaB) transcription factor. Mol Cell Biochem 2000; 212: 155-169.
44. Abdel-Mageed AB, Agrawal KC: Activation of nuclear factor kappaB: potential role in metallothionein-mediated mitogenic response. Cancer Res 1998; 58: 2335-2338.
45. Marian AJ, Roberts R: Recent advances in the molecular genetics of hypertrophic cardiomyopathy. Circulation 1995; 92: 1336-1347.
46. Kai H, Muraishi A, Sugiu Y, et al: Expression of proto-oncogenes and gene mutation of sarcomeric proteins in patients with hypertrophic cardiomyopathy. Circ Res 1998; 83: 594-601.
47. Ayer DE, Laherty CD, Lawrence QA, Armstrong AP, Eisenman RN: Mad proteins contain a dominant transcription repression domain. Mol Cell Biol 1996; 16: 5772-5781.
48. Ogawa Y, Nakao K, Mukoyama M, et al: Natriuretic peptides as cardiac hormones in normotensive and spontaneously hypertensive rats. The ventricle is a major site of synthesis and secretion of brain natriuretic peptide. Circ Res 1999; 69: 491-500.
49. Nakagawa O, Ogawa Y, Itoh H, et al: Rapid transcriptional activation and early mRNA turnover of brain natriuretic peptide in cardiocyte hypertrophy. Evidence for brain natriuretic peptide as an "emergency" cardiac hormone against ventricular overload. J Clin Invest 1995; 96: 1280-1287.
50. Benitah JP, Gomez AM, Delgado C, Lorente P, Lederer WJ: A chloride current component induced by hypertrophy in rat ventricular myocytes. Am J Physiol 1997; 272: H2500-H2506.
51. Hiramatsu M, Furukawa T, Sawanobori T, Hiraoka M: Ion channel remodeling in cardiac hypertrophy is prevented by blood pressure reduction without affecting heart weight increase in rats with abdominal aortic banding. J Cardiovasc Pharmacol 2002; 39: 866-874.
52. Gupta S, Young D, Sen S: Inhibition of NF-kappaB induces regression of cardiac hypertrophy, independent of blood pressure control, in spontaneously hypertensive rats. Am J Physiol Heart Circ Physiol 2005; 289: H20-H29.
53. Jing L, Zhang JZ, Zhao L, Wang YL, Guo FY: High-expression of transforming growth factor beta1 and phosphorylation of extracellular signal-regulated protein kinase in vascular smooth muscle cells from aorta and renal arterioles of spontaneous hypertension rats. Clin Exp Hypertens 2007; 29: 107-117.
54. Satoh C, Fukuda N, Hu WY, Nakayama M, Kishioka H, Kanmatsuse K: Role of endogenous angiotensin II in the increased expression of growth factors in vascular smooth muscle cells from spontaneously hypertensive rats. J Cardiovasc Pharmacol 2001; 37: 108-118.
55. Haugen E, Chen J, Wikstrom J, Gronros J, Gan LM, Fu LX: Parallel gene expressions of IL-6 and BNP during cardiac hypertrophy complicated with diastolic dysfunction in spontaneously hypertensive rats. Int J Cardiol 2007; 115: 24-28.
56. Kuroski de Bold ML: Atrial natriuretic factor and brain natriurefic peptide gene expression in the spontaneous hypertensive rat during postnatal development. Am J Hypertens 1998; 11: 1006-1018.
57. Ye P, West MJ: Cosegregation analysis of natriuretic peptide genes and blood pressure in the spontaneously hypertensive rat. Clin Exp Pharmacol Physiol 2003; 30: 930-936.
58. Kwon S, Fang LH, Kim B, Ha TS, Lee SJ, Alin HY: p38 Mitogen-activated protein kinase regulates vasoconstriction in spontaneously hypertensive rats. J Pharmacol Sci 2004; 95: 267-272.
59. Scherer CR, Linz W, Busch AE, Steinmeyer K: Gene expression profiles of CLC chloride channels in animal models with different cardiovascular diseases. Cell Physiol Biochem 2001; 11: 321-330.
60. Boutros PC, Okey AB; Assessment of Rat-Mouse Sequence Homology in the NIA 15K Clone Library: Implications for Gene Expression Studies in Species Widely-Used in Toxicology, Society of Toxicology of Canada 35th Annual Symposium (STC). Montreal, 2002.
61. Sehl PD, Tai JT, Hillan KJ, et al: Application of cDNA microarrays in determining molecular phenotype in cardiac growth, development, and response to injury. Circulation 2000; 101: 1990-1999.