Pharmacokinetics of enrofloxacin and flunixin meglumine and interactions between both drugs after intravenous co-administration in healthy and endotoxaemic rabbits

Veterinary Journal

Volumn 177, Issue 3, 2008, Pages 418-424

  Elmas, Muammer ^a   Yazar, Enver ^a   Uney, Kamil ^a  

^a Karabacak), Ayşe   (Turkey)

Author keywords

Endotoxaemia; Enrofloxacin; Flunixin meglumine; Pharmacokinetics; Rabbits

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; CREATININE; ENROFLOXACIN; ESCHERICHIA COLI LIPOPOLYSACCHARIDE; FLUNIXIN MEGLUMINE; FLUVIL; TRIACYLGLYCEROL; UREA;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; AREA UNDER THE CURVE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BLOOD CHEMISTRY; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DRUG BLOOD LEVEL; DRUG EFFICACY; DRUG HALF LIFE; ENDOTOXEMIA; MALE; MEAN RESIDENCE TIME; NONHUMAN; PLASMA CONCENTRATION-TIME CURVE; RABBIT; SINGLE DRUG DOSE; STATISTICAL SIGNIFICANCE; TRIACYLGLYCEROL BLOOD LEVEL; UREA BLOOD LEVEL;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; AREA UNDER CURVE; BLOOD CHEMICAL ANALYSIS; CLONIXIN; CROSS-OVER STUDIES; DRUG INTERACTIONS; ENDOTOXEMIA; FLUOROQUINOLONES; HALF-LIFE; INJECTIONS, INTRAVENOUS; LIPOPOLYSACCHARIDES; MALE; RABBITS; RANDOM ALLOCATION;

ESCHERICHIA COLI; ORYCTOLAGUS CUNICULUS;

EID: 46049087185     PISSN: 10900233     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tvjl.2007.05.021     Document Type: Article

References (53)

1. Anadon A., Martinez-Larranaga M.R., Diaz M.J., Bringas P., Martinez M.A., and Fernandez-Cruz M.L. Pharmacokinetics and residues of enrofloxacin in chickens. American Journal of Veterinary Research 56 (1995) 501-505
2. Anderson K.L., Smith A.R., Shanks R.D., Davis L.E., and Gustafsson B.K. Efficacy of flunixin meglumine for the treatment of endotoxin-induced bovine mastitis. American Journal of Veterinary Research 47 (1986) 1366-1372
3. Baert K., and De Backer P. Disposition of sodium salicylate, flunixin and meloxicam after intravenous administration in broiler chickens. Journal of Veterinary Pharmacology and Therapeutics 25 (2002) 449-453
4. Bregante M.A., Saez P., Aramayona J.J., Fraile L., Garcia M.A., and Solans C. Comparative pharmacokinetics of enrofloxacin in mice, rats, rabbits, sheep, and cows. American Journal of Veterinary Research 60 (1999) 1111-1116
5. Broome R.C., Brooks D.L., Babish J.G., Copeland D.D., and Conzelman G.M. Pharmacokinetics properties of enrofloxacin in rabbits. American Journal of Veterinary Research 52 (1991) 1835-1841
6. Cabanes A., Arboix M., Garcia-Anton J.M., and Reig F. Pharmacokinetics of enrofloxacin after intravenous and intramuscular injection in rabbits. American Journal of Veterinary Research 53 (1992) 2090-2093
7. Cheng Z., McKellar Q.A., and Nolan A.M. Pharmacokinetic studies of flunixin meglumine and phenylbutazone in plasma, exudate and transudate in sheep. Journal of Veterinary Pharmacology and Therapeutics 21 (1998) 315-321
8. 2 α secretion during early pregnancy in mares. American Journal of Veterinary Research 52 (1991) 276-281
9. Dalhoff A., and Shalit I. Immunomodulatory effects of quinolones. The Lancet Infectious Diseases 3 (2003) 359-371
10. el-Banna HA. Pharmacokinetic interactions between flunixin and sulphadimidine in horses. Deutsche Tierärztliche Wochenschrift 106 (1999) 400-403
11. Elmas M., Yazar E., Bas A.L., Tras B., Bayezit M., and Yapar K. Comparative pharmacokinetics of enrofloxacin and tissue concentrations of parent drug and ciprofloxacin after intramuscular administrations of free and liposome-encapsulated enrofloxacin in rabbits. Journal of Veterinary Medicine B 49 (2002) 507-512
12. Elmas M., Uney K., Karabacak A., and Yazar E. Pharmacokinetics of flunixin-meglumine following intravenous administration at two different doses in angora rabbits. Bulletin of the Veterinary Institute in Pulawy 49 (2005) 85-89
13. Elmas M., Yazar E., Uney K., and Karabacak A. Pharmacokinetics of flunixin after intravenous administration in healthy and endotoxaemic rabbits. Veterinary Research Communications 30 (2006) 73-81
14. Elmas M., Yazar E., Uney K., and Karabacak A. Influence of Escherichia coli endotoxin-induced endotoxaemia on the pharmacokinetics of enrofloxacin after intravenous administration in rabbits. Journal of Veterinary Medicine A 53 (2006) 410-414
15. Elmas M., Yazar E., Uney K., and Karabacak A. Pharmacokinetics of enrofloxacin following intravenous and intramuscular administration in Angora rabbits. Research in Veterinary Science 82 (2007) 242-245
16. Elsheikh H.A., Taha A.A.W., Khafallah A.I., and Osman I.A.M. Disposition kinetics of enrofloxacin (Baytril 5%) in sheep and goats following intravenous and intramuscular injection using a microbiological assay. Research in Veterinary Science 73 (2002) 125-129
17. Fraile L.J., Martinez C., Aramayona J.J., Abadia A.R., Bregante M.A., and Garcia M.A. Limited capacity of neonatal rabbits to eliminate enrofloxacin and ciprofloxacin. Veterinary Quarterly 19 (1997) 162-167
18. Haghoo S., Hasegawa T., Nadai{dotless} M., Wang L., Nabeshima T., and Kato N. Effect of a bacterial lipopolysaccharide on biliary excretion of a β-lactam antibiotic, cefoperazone, in rats. Antimicrobial Agents and Chemotherapy 39 (1995) 2258-2261
19. Hewet J.A., and Roth R.A. Hepatic and extrahepatic pathobiology of bacterial lipopolysaccharides. Pharmacological Review 45 (1993) 381-411
20. Khan A.A., Slifer T.R., Araujo F.G., Suzuki Y., and Remington J.S. Protection against lipopolysaccharide-induced death by fluoroquinolones. Antimicrobial Agents and Chemotherapy 44 (2000) 3169-3173
21. Knoppert N.W., Nijmeijer S.M., van Duin C.T.M., Korstanje C., van Gogh H., and van Miert A.S.J.P.A.M. Some pharmacokinetics data of aditoprim and trimethoprim in healthy and tick-borne fever infected dwarf goats. Journal of Veterinary Pharmacology and Therapeutics 11 (1988) 135-144
22. Konyalioglu S., Er A., Uney K., Elmas M., and Yazar E. Effects of flunixin meglumine on the antioxidant status in endotoxemia. Acta Veterinaria Beograd. 57 (2007) 241-246
23. Kumar R., and Malik J.K. Influence of endotoxin on the disposition kinetics and dosage regimens of oxytetracycline in calves. Journal of Veterinary Pharmacology and Therapeutics 26 (2003) 159-164
24. Lohuis J.A.C.M., van Werven T., Brand A., van Miert A.S.J.P.A.M., Rohde E., Ludwig B., Heizmann P., and Rehm W.F. Pharmacodynamics and pharmacokinetics of carprofen, a non-steroidal anti-inflammatory drug, in healthy cows and cows with Escherichia coli endotoxin-induced mastitis. Journal of Veterinary Pharmacology and Therapeutics 14 (1991) 219-229
25. Luthman J., Kindahl H., and Jacobsson S.O. The influence of flunixin on the response to Salmonella typhimurium endotoxin in calves. Acta Veterinaria Scandinavica 30 (1989) 295-300
26. Marrier J.F., Beaudry F., Ducharme M.P., Fortin D., Moreatu J.P., Masse R., and Vachon P. A pharmacokinetics study of amoxycillin in febrile beagle dogs following repeated administrations of endotoxin. Journal of Veterinary Pharmacology and Therapeutics 24 (2001) 379-383
27. Mayeux P.R. Pathobiology of lipopolysaccharide. Journal of Toxicology and Environmental Health 51 (1997) 415-435
28. Miyazaki Y., Horii Y., Ikenaga N., Shimoda M., and Kokue E. Possible active transport mechanism in pharmacokinetics of flunixin-meglumine in rabbits. Journal Veterinary Medical Science 63 (2001) 885-888
29. Monshouwer M., and Witkamp R.F. Cytochromes and cytokines: changes in drug disposition in animals during an acute phase response: a mini review. Veterinary Quarterly 22 (2000) 17-20
30. Ogino T., Mizuno Y., Ogata T., and Takahashi Y. Pharmacokinetic interactions of flunixin meglumine and enrofloxacin in dogs. American Journal of Veterinary Research 66 (2005) 1209-1213
31. Post L.O., Cope C.V., Farrell D.E., Baker J.D., and Myers M.J. Influence of porcine Actinobacillus pleuropneumoniae infection and dexamethasone on the pharmacokinetic parameters of enrofloxacin. The Journal of Pharmacology and Experimental Therapeutics 301 (2002) 217-222
32. Post L.O., Farrell C.V., Baker J.D., and Myers M.J. The effect of endotoxin and dexamethasone on enrofloxacin pharmacokinetic parameters in swine. Journal of Pharmacology and Experimental Therapeutics 304 (2003) 889-895
33. Rantala M., Kaartinen L., Valimaki E., Stryrman M., Hiekkaranta M., Niemi A., Saari L., and Pyorala S. Efficacy and pharmacokinetics of enrofloxacin and flunixin meglumine for treatment of cows with experimentally induced Escherichia coli mastitis. Journal of Veterinary Pharmacology and Therapeutics 25 (2002) 251-258
34. Rao G.S., Ramesh S., Ahmad A.H., Tripathi H.C., Sharma L.D., and Malik J.K. Effects of endotoxin-induced fever and probenecid on disposition of enrofloxacin and its metabolite ciprofloxacin after intravascular administration of enrofloxacin in goats. Journal of Veterinary Pharmacology and Therapeutics 23 (2000) 365-372
35. Riesbeck K. Immunomodulating activity of quinolones: review. Journal of Chemotherapy 14 (2002) 3-12
36. Saitoh T., Kokue E., and Shimoda M. The suppressive effects of lipopolysaccharide-induced acute phase response on hepatic cytochrome P450-dependent drug metabolism in rabbits. Journal of Veterinary Pharmacology and Therapeutics 22 (1999) 87-95
37. Saitoh T., Kokue E., and Shimoda M. The impact of acute phase response on the plasma clearance of antipyrine, theophylline, phenytoin and nifedipine in rabbits. Journal of Veterinary Pharmacology and Therapeutics 23 (2000) 153-158
38. Sarwari A.R., and Mackowiak P.A. The pharmacologic consequences of fever. Infectious Disease Clinics of North America 10 (1996) 21-32
39. Scheer M. Studies on antimicrobial activity of Baytril. Veterinary Medical Reviews 2 (1987) 90-99
40. Shumaker R.C. PKCALC: a basic interactive computer program for statistical and pharmacokinetic analysis of data. Drug Metabolism Reviews 17 (1986) 331-348
41. Soma L.R., Behrend E., Rudy J., and Sweeney R.W. Disposition and excretion of flunixin meglumine in horses. American Journal of Veterinary Research 49 (1988) 1894-1898
42. Toutain P.L., Autefage A., Legrand C., and Alvinerie M. Plasma concentrations and therapeutic efficacy of phenylbutazone and flunixin meglumine in the horse: pharmacokinetic/pharmacodynamic modelling. Journal of Veterinary Pharmacology Therapeutics 17 (1994) 459-469
43. Van Miert A.S.J.P.A.M. Fever and associated clinical haematologic and blood biochemical changes in the goat and other animal species. Veterinary Quarterly 7 (1985) 200-216
44. Van Miert A.S.J.P.A.M. Trends in veterinary clinical and fundamental pharmacology: past and future in the Netherlands. Veterinary Quarterly 22 (2000) 3-11
45. Vancutsem P.M., Babish J.G., and Schwark W.S. The fluoroquinolone antimicrobials: structure, antimicrobial activity, pharmacokinetics, clinical use in domestic animals and toxicity. Cornell Veterinarian 80 (1990) 173-186
46. Wagner J.G. Fundamentals of Clinical Pharmacokinetics (1975), Drug Intelligence Pub Inc 1st Ed., Hamilton Press, IL, USA, p. 57-128
47. Walker R.D., Stein G.E., Hauptman J.G., and McDonald K.H. Pharmacokinetic evaluation of enrofloxacin administered orally to healthy dogs. American Journal of Veterinary Research 53 (1992) 2315-2319
48. Waxman S., San Andres M.D., Gonzalez F., De Lucas J.J., San Andres M.I., and Rodriguez C. Influence of Escherichia coli endotoxin-induced fever on the pharmacokinetic behavior of marbofloxacin after intravenous administration in goats. Journal of Veterinary Pharmacology and Therapeutics 26 (2003) 65-69
49. Whittem T., Firth E.C., Hodge H., and Turner K. Pharmacokinetic interactions between repeated dose phenylbutazone and gentamicin in the horse. Journal of Veterinary Pharmacology and Therapeutics 19 (1996) 454-459
50. Yamaoka K., Nakagawa T., and Uno T. Application of Akaike's information criterion (AIC) in the evaluation of linear pharmacokinetic equations. Journal of Pharmacokinetics and Biopharmaceutics 6 (1978) 165-175
51. Yazar E., Col R., Konyalioglu S., Birdane Y.O., Elmas M., and Bas A.L. Effect of vitamin E and prednisolone on biochemical and haematological parameters in endotoxaemic New Zealand white rabbits. Bulletin of the Veterinary Institute in Pulawy 48 (2004) 105-108
52. Yazar, E., Er, A., Uney, K., Altunok V., Elmas, M., in press. Effect of flunixin meglumine on cytokine levels in lipopolysaccharide-induced endotoxemia. Journal of Veterinary Medicine A.
53. Zeng Z., and Fung K. Effects of experimentally induced Escherichia coli infection on the pharmacokinetics of enrofloxacin in pigs. Journal of Veterinary Pharmacology and Therapeutics 20 Suppl. 1 (1997) 21-86