Possible Active Transport Mechanism in Pharmacokinetics of Flunixin-Meglumin in Rabbits

Journal of Veterinary Medical Science

Volumn 63, Issue 8, 2001, Pages 885-888

  Miyazaki, Yoshie ^a   Horii, Yoshihiro ^a,b,c   Ikenaga, Naohiro ^a   Shimoda, Minoru ^a   Kokue, Eiichi ^a  

^a TOKYO UNIVERSITY OF AGRICULTURE AND TECHNOLOGY   (Japan)

^b DAINIPPON SUMITOMO PHARMA CO LTD   (Japan)

^c GIFU UNIVERSITY   (Japan)

Author keywords

Active transport; Flunixin meglumin; OATP 2; Pharmacokinetics; Rabbit

Indexed keywords

ORYCTOLAGUS CUNICULUS;

CLONIXIN; DRUG DERIVATIVE; FLUNIXIN MEGLUMINE; HYPOCHOLESTEROLEMIC AGENT; NONSTEROID ANTIINFLAMMATORY AGENT; PRAVASTATIN;

ACTIVE TRANSPORT; ANIMAL; ANIMAL DISEASE; AREA UNDER THE CURVE; ARTICLE; BLOOD; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MALE; METABOLIC CLEARANCE RATE; METABOLISM; PHYSIOLOGY; RABBIT; TISSUE DISTRIBUTION; URINE;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ANTICHOLESTEREMIC AGENTS; AREA UNDER CURVE; BIOLOGICAL TRANSPORT, ACTIVE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CLONIXIN; MALE; METABOLIC CLEARANCE RATE; PRAVASTATIN; RABBITS; TISSUE DISTRIBUTION;

EID: 0035431580     PISSN: 09167250     EISSN: None     Source Type: Journal    
DOI: 10.1292/jvms.63.885     Document Type: Article

References (18)

1. Anderson, K. L., Neff-Davis, C. A., Davis, L. E. and Bass, V. D. 1990. Pharmacokinetics of flunixin meglumine in lactating cattle after single and multiple intramuscular and intravenous administrations. Am. J. Vet. Res. 51: 1464-1467.
2. Debacker, P., Braeckman, R., Belpaire, F. and Debackere, M. 1980. Bioavailability and pharmacokinetics of phenylbutazone in the cow. J. Vet. Pharmacol. Ther. 3: 29-33.
3. Dumont, M., Jacquemin, E., D7Hont, C., Descout, C., Cresteil, D., Haouzi, D., Descrochers, M., Stieger, B., Hadchouel, M. and Erlinger, S. 1997. Expression of the liver Na+-independent organic anion transporting polypeptide (oatp-1) in rats with bile duct ligation. J. Hepatol. 27: 1051-1056.
4. Hardee, G.E., Smith, J.A. and Harris, S.J. 1985. Pharmacokinetics of flunixin meglumine in the cow. Res. Vet. Sci. 39: 110-112.
5. Hardie, E., Hardee, G. E. and Rawlings, C. A. 1985. Pharmacokinetics of flunixin meglumine in dogs. Am. J. Vet. Res. 46: 235-237.
6. Horsmans, Y., Desager, J.P., van den Berge, V., Abrassart, M. and Harvengt, C. 1993. Effect of simvastatin and pravastatin on 6β-hydroxycortisol excretion, a potential marker of cytochrome P-453 3A. Pharmacol. Res. 28: 243-248.
7. Hsiang, B., Zhu, Y., Wang, Z., Wu, Y., Sasseville, V., Yang, W.P. and Kirchgessner, T.G. 1999. A novel human hepatic organic anion transporting polypeptide (OATP2). Identification of a liver-specific human organic anion transporting polypeptide and identification of rat and human hydroxymethylglutaryl-CoA reductase inhibitor transporters. J. Biol. Chem. 274: 37161-37168.
8. Kusuhara, H., Han, Y. H., Shimoda, M., Kokue, E., Suzuki, H. and Sugiyama, Y. 1998. Reduced folate derivatives are endogenous substrates for cMOAT in rats. Am. J. Physiol. 275: G789-796.
9. Ishigami, M., Tokui, T., Komai, T., Tsukahara, K., Yamazaki, M. and Sugiyama, Y. 1995. Evaluation of the uptake of pravastatin by perfused rat liver and primary cultured rat hepatocytes. Pharm. Res. 12: 1741-1745.
10. Lees, P. and Taylor, P. M. 1991. Pharmacodynamics and pharmacokinetics of flunixin in the cat. Br. Vet. J. 147: 298-305.
11. Masuda, M., Iizuka, Y., Yamazaki, M., Nishigaki, R., Kato, Y., Niinuma, K., Suzuki, H. and Sugiyama, Y. 1997. Methotrexate is excreted into the bile by canalicular multispecific organic anion transporter in rats. Cancer. Res. 57: 3506-3510.
12. Neuvonem, P.J., Kantola, T. and Kivisto, K.T. 1998. Simvastatin but not pravastatin is very susceptible to the interaction with the CYP 3A4 inhibitor itraconazole. Clin. Pharmacol. Ther. 63: 332-341.
13. Scherkl, R. and Frey, H. H. 1987. Pharmacokinetics of ibuprofen in the dogs. J. Vet. Pharmacol. Ther. 10: 261-265.
14. Soma, L. R., Behrend, E., Rudy, J. and Sweeney. R. W. 1988. Disposition and excretion of flunixin meglumine in horses. Am. J. Vet. Res. 49: 1894-1898.
15. Vandenbossche, G. M. R., Bouckaert, S., De Muynck, C., Mommens, G., Van Zeveren, A. and Remon, J. P. 1992. Bioavailability of two ibuprofen oral paste formulations in fed or nonfed ponies. Am. J. Vet. Res. 53: 528-531.
16. Yamaoka, K., Tanigawara, Y., Nakagawa, T. and Uno, T. 1981. A pharmacokinetic analysis program (MULTI) for microcomputer. J. Pharmacobio-Dyn. 4: 879-885.
17. Yamazaki, M., Suzuki, H., Hanano, M., Tokui, T., Komai, T. and Sugiyama, Y. 1993. Na(+)-independent multispecific anion transporter mediates active transport of pravastatin into rat liver. Am. J. Physiol. 264: G36-44.
18. Ziegler, K. and Hummelsiep, S. 1993. Hepatoselective carrier-mediated sodium-independent uptake of pravastatin and pravastatin-lactone. Biochim. Biophys. Acta 1153: 23-33.