Acid - base chemical mechanism of homocitrate synthase from Saccharomyces cerevisiae

Biochemistry

Volumn 45, Issue 39, 2006, Pages 12136-12143

  Qian, Jinghua ^a   West, Ann H ^a   Cook, Paul F ^a  

^a UNIVERSITY OF OKLAHOMA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2-KETOGLUTARATE; ACETYL-COA; ACTIVE SITE; ALKOXIDES; AVERAGE VALUES; BASE CHEMICALS; CHEMICAL MECHANISM; DEUTERIUM ISOTOPE EFFECT; DEUTERIUM KINETIC ISOTOPE EFFECT; GENERAL BASE; GLYOXYLATE; HOMOCITRATE SYNTHASE; KETOGLUTARATE; METALLOENZYMES; OPTIMUM POSITIONING; PH DEPENDENCE; PROTONATED; PROTONATES; PYRIDINE NITROGEN; PYRIDINE-2; RATE LIMITING;

BINDING SITES; CARRIER MOBILITY; CONDENSATION; DEUTERIUM; ENZYMES; HYDROLYSIS; INDUCTIVELY COUPLED PLASMA MASS SPECTROMETRY; KINETICS; PH; PYRIDINE; YEAST; ZINC;

CARBOXYLATION;

2 OXOGLUTARIC ACID; ACETYL COENZYME A; HOMOCITRATE SYNTHASE; HOMOCITRIC ACID; LYASE; SACCHAROMYCES CEREVISIAE PROTEIN; TRICARBOXYLIC ACID;

ARTICLE; CATALYSIS; CHEMISTRY; ENZYME SPECIFICITY; ENZYMOLOGY; KINETICS; METABOLISM; SACCHAROMYCES CEREVISIAE;

ACETYL COENZYME A; CATALYSIS; KETOGLUTARIC ACIDS; KINETICS; OXO-ACID-LYASES; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; SUBSTRATE SPECIFICITY; TRICARBOXYLIC ACIDS;

EID: 33750715147     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi060889h     Document Type: Article

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