Adoptive transfer of islet antigen-autoreactive T cell clones to transgenic NOD.Ead mice induces diabetes indicating a lack of I-E mediated protection against activated effector T cells

Journal of Autoimmunity

Volumn 21, Issue 2, 2003, Pages 139-147

  Roberts, Samantha A ^a   Barbour, Gene ^b   Matarrese, Marissa R ^a   Mason, David L ^a   Leiter, Edward H ^c   Haskins, Kathryn ^b   Hanson, Matthew S ^a  

^a WITTENBERG UNIVERSITY   (United States)

^b UNIVERSITY OF COLORADO DENVER   (United States)

^c JACKSON LABORATORY   (United States)

Author keywords

Diabetes; I E; MHC; NOD; T cell

Indexed keywords

ANTIGEN; AUTOANTIGEN;

ADOPTIVE TRANSFER; ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN PRESENTING CELL; ANTIGEN SPECIFICITY; ARTICLE; AUTOREGULATION; CELL ACTIVITY; CELL CLONE; CONTROLLED STUDY; DATA ANALYSIS; DIABETES MELLITUS; DIABETOGENESIS; EFFECTOR CELL; FEMALE; MALE; MOUSE; MOUSE STRAIN; NEWBORN; NONHUMAN; PANCREAS ISLET CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY MECHANISM; T LYMPHOCYTE;

EID: 0042520859     PISSN: 08968411     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0896-8411(03)00090-8     Document Type: Article

References (37)

1. Nepom G.T. A unified hypothesis for the complex genetics of HLA associations with IDDM. Diabetes. 39:1990;1153-1157.
2. Todd J.A., Acha-Orbea H., Bell J.I., Chao N., Fronek A., Jacob C.O., et al. A molecular basis for MHC class II-associated autoimmunity. Science. 240:1988;1003-1009.
3. Sheehy M.J. HLA and insulin-dependent diabetes. A protective perspective. Diabetes. 41:1992;123-129.
4. Wicker L.S. Major histocompatibility complex-linked control of autoimmunity. J Exp Med. 186:1997;973-975.
5. Kikutani H., Makino S. The murine autoimmune diabetes model: NOD and related strains. Adv Immunol. 51:1992;285-322.
6. Quartey-Papafio R., Lund T., Chandler P., Picard J., Ozegbe P., Day S., et al. Aspartate at position 57 of nonobese diabetic I-Ag7 β-chain diminishes the spontaneous incidence of insulin-dependent diabetes mellitus. J Immunology. 154:1995;5567-5575.
7. Nishimoto H., Kikutani H., Yamamura K.I., Kishimoto T. Prevention of autoimmune insulitis by expression of I-E molecules in NOD mice. Nature. 329:1987;432-434.
8. Slattery R.M., Kjer-Nielsen L., Allison J., Charlton B., Mandel T.E., Miller J.F. Prevention of diabetes in non-obese diabetic I-Ak transgenic mice. Nature. 345:1990;724-726.
9. Uno M., Miyazaki T., Uchira M., Nishimoto H., Kimoto M., Miyazaki J., et al. Complete prevention of diabetes in transgenic NOD mice expressing I-E molecules. Immunol Lett. 31:1992;47-52.
10. Singer S.M., Tisch R., Yang X.D., McDevitt H.O. An Abd transgene prevents diabetes in nonobese diabetic mice by inducing regulatory T cells. Proc Natl Acad Sci U S A. 90:1993;9566-9570.
11. Hanson M., Cetkovic-Cvrlje M., Ramiya V.K., Atkinson M.A., Maclaren N.K., Singh B., et al. Quantitative thresholds of MHC class II I-E expressed on hematopoietically derived antigen-presenting cells in transgenic NOD/Lt mice determine level of diabetes resistance and indicate mechanism of protection. J Immunology. 157:1996;1279-1287.
12. Johnson E.A., Silveira P., Chapman H.D., Leiter E.H., Serreze D.V. Inhibition of autoimmune diabetes in nonobese diabetic mice by transgenic restoration of H2-E MHC class II expression: additive, but unequal, involvement of multiple APC subtypes. J Immunology. 167:2001;2404-2410.
13. Boehme J., Brenden N., Riez C., Pilstroem B. Dominant disease protection in MHC-transgenic NOD mice: more than one mechanism? The Immunologist. 45:1994.
14. Deng H., Apple R., Clare-Salzler M., Trembleau S., Mathis D., Adorini L., et al. Determinant capture as a possible mechanism of protection afforded by major histocompatibility complex class II molecules in autoimmune disease. J Exp Med. 178:1993;1675-1680.
15. Trembleau S., Gregori S., Penna G., Gorny I., Adorini L. IL-12 administration reveals diabetogenic T cells in genetically resistant I-Ea transgenic nonobese diabetic mice: resistance to autoimmune diabetes is associated with binding of Ea-derived peptides to the I-Ag7 molecule. J Immunology. 167:2001;4104-4114.
16. Peterson J.D., Pike B., McDuffie M., Haskins K. Islet-specific T cell clones transfer diabetes to nonobese diabetic (NOD) F1 mice. J Immunology. 153:1994;2800-2806.
17. Hamaguchi K., Gaskins H.R., Leiter E.H. NIT-1, a pancreatic beta-cell line established from a transgenic NOD/Lt mouse. Diabetes. 40:1991;842-849.
18. Haskins K., Portas M., Bergman B., Lafferty K., Bradley B. Pancreatic islet-specific T-cell clones from nonobese diabetic mice. Proc Natl Acad Sci U S A. 86:1989;8000-8004.
19. Bergman B., McManaman J.L., Haskins K. Biochemicalcharacterization of a beta cell membrane fraction antigenic for autoreactive T cell clones. J Autoimmunity. 14:2000;343-351.
20. Leiter E.H. The role of environmental factors in modulating insulin dependent diabetes. de Vries R., Cohen I., van Rood J. Current topics in immunology and microbiology. 1990;39-55 Springer Verlag, Berlin.
21. Koch-Nolte F., Duffy T., Nissen M., Kahl S., Killeen N., Ablamunits V., et al. A new monoclonal antibody detects a developmentally regulated mouse ecto-ADP-ribosyltransferase on T cells: subset distribution, inbred strain variation, and modulation upon T cell activation. J Immunology. 163:(11):1999;6014-6022.
22. Haskins K., McDuffie M. Acceleration of diabetes in young NOD mice with a CD4+ islet-specifc T-cell clone. Science. 249:1990;1433-1436.
23. Peterson J.D., Haskins K. Transfer of diabetes in the NOD-scid mouse by CD4 T-cell clones. Differential requirement for CD8 T-cells. Diabetes. 45:1996;328-336.
24. Peterson J.D., Pike B., Dallas-Pedretti A., Haskins K. Induction of diabetes with islet-specific T-cell clones is age dependent. Immunology. 85:1995;455-460.
25. Lepault F., Gagnerault M.C. Characterization of peripheral regulatory CD4+ T cells that prevent diabetes onset in nonobese diabetic mice. J Immunology. 164:2000;240-247.
26. Phillips J.M., Parish N.M., Drage M., Cooke A. Interactions through the IL-10 receptor regulate autoimmune diabetes. J Immunology. 167:2001;6087-6091.
27. Salomon B., Lenschow D.J., Rhee L., Ashourian N., Singh B., Sharpe A., et al. B7/CD28 costimulation is essential for the homeostasis of the CD4+CD25+ immunoregulatory T cells that control autoimmune diabetes. Immunity. 12:2000;431-440.
28. Shevach E.M. Certified professionals: CD4+CD25+ suppressor T cells. J Exp Med. 193:(11):2001;F41-F45.
29. Parish N.M., Acha-Orbea H., Simpson E., Qin S.X., Lund T., Cooke A. A comparative study of T-cell receptor Vb usage in non-obese diabetic (NOD) and I-E transgenic NOD mice. Immunology. 78:1992;606-610.
30. Brenden N., Spetz A.L., Pilstrom B., Bohme J. Positive selection of Vβ10 in NOD mice protected from diabetes by an Ea transgene. Immunology Letters. 42:1994;209-210.
31. Gregori S., Trembleau S., Penna G., Gallazzi F., Hammer J., Papadopoulos G.K., et al. A peptide binding motif for I-Eg7, the MHC class II molecule that protects E alpha-transgenic nonobese diabetic mice from autoimmune diabetes. J Immunol. 162:1999;6630-6640.
32. Katz J.D., Wang B., Haskins K., Benoist C., Mathis D. Following a diabetogenic T cell from genesis through pathogenesis. Cell. 74:1993;1089-1100.
33. Dobbs C.M., Haskins K. Comparison of a T cell clone and of T cells from a TCR transgenic mouse: TCR transgenic T cells specific for self-antigen are atypical. J Immunology. 166:2001;2495-2504.
34. Bachman M.F., Sebzda E., Kundig T.M., Shahinian A., Speiser D.E., Mak T.W., et al. T cell responses are governed by avidity and co-stimulatory thresholds. Eur J Immunology. 26:1996;2017-2022.
35. Viola A., Lanzavecchia A. T cell activation determined by T cell receptor number and tunable thresholds. Science. 273:1996;104-106.
36. Hemmer B., Stefanova I., Vergelli M., Germain R.N., Martin R. Relationships among TCR ligand potency, thresholds for effector function elicitation, and the quality of early signaling events in human T cells. J Immunology. 160:1998;5807-5814.
37. Kurts C., Sutherland R.M., Davey G., Li M., Lew A.M., Blanas E., et al. CD8 T cell ignorance or tolerance to islet antigens depends on antigen dose. Proc Natl Acad Sci U S A. 96:1999;12703-12707.