메뉴 건너뛰기




Volumn 4, Issue 2, 2008, Pages 84-90

Asthma: Eosinophil disease, mast cell disease, or both?

Author keywords

Asthma; Eosinophil; Mast cell

Indexed keywords

CORTICOSTEROID; INTERLEUKIN 5 ANTIBODY;

EID: 45849140187     PISSN: 17101484     EISSN: None     Source Type: Journal    
DOI: 10.2310/7480.2008.00011     Document Type: Article
Times cited : (38)

References (72)
  • 1
    • 0033011603 scopus 로고    scopus 로고
    • The bronchial epithelium as a key regulator of airway inflammation and remodelling in asthma
    • Holgate ST, Lackie PM, Davies DE, et al. The bronchial epithelium as a key regulator of airway inflammation and remodelling in asthma. Clin Exp Allergy 1999;29 Suppl 2:90-5.
    • (1999) Clin Exp Allergy , vol.29 , Issue.SUPPL. 2 , pp. 90-95
    • Holgate, S.T.1    Lackie, P.M.2    Davies, D.E.3
  • 2
    • 0036341331 scopus 로고    scopus 로고
    • Increased mast cells and neutrophils in submucosal mucous glands and mucus plugging in patients with asthma
    • Carroll NG, Mutavdzic S, James AL. Increased mast cells and neutrophils in submucosal mucous glands and mucus plugging in patients with asthma. Thorax 2002;57:677-82.
    • (2002) Thorax , vol.57 , pp. 677-682
    • Carroll, N.G.1    Mutavdzic, S.2    James, A.L.3
  • 3
    • 0025368080 scopus 로고
    • Hyperreactive site in the airway tree of asthmatic patients revealed by thickening of bronchial muscles. A morphometric study
    • Ebina M, Yaegashi H, Chiba R, et al. Hyperreactive site in the airway tree of asthmatic patients revealed by thickening of bronchial muscles. A morphometric study. Am Rev Respir Dis 1990;141:1327-32.
    • (1990) Am Rev Respir Dis , vol.141 , pp. 1327-1332
    • Ebina, M.1    Yaegashi, H.2    Chiba, R.3
  • 4
    • 0027181166 scopus 로고
    • Cellular hypertrophy and hyperplasia of airway smooth muscles underlying bronchial asthma. A 3-D morphometric study
    • Ebina M, Takahashi T, Chiba T, Motomiya M. Cellular hypertrophy and hyperplasia of airway smooth muscles underlying bronchial asthma. A 3-D morphometric study. Am Rev Respir Dis 1993;148:720-6.
    • (1993) Am Rev Respir Dis , vol.148 , pp. 720-726
    • Ebina, M.1    Takahashi, T.2    Chiba, T.3    Motomiya, M.4
  • 5
    • 18644380441 scopus 로고    scopus 로고
    • The CXCL10/CXCR3 axis mediates human lung mast cell migration to asthmatic airway smooth muscle
    • Brightling CE, Ammit AJ, Kaur D, et al. The CXCL10/CXCR3 axis mediates human lung mast cell migration to asthmatic airway smooth muscle. Am J Respir Crit Care Med 2005;171:1103-8.
    • (2005) Am J Respir Crit Care Med , vol.171 , pp. 1103-1108
    • Brightling, C.E.1    Ammit, A.J.2    Kaur, D.3
  • 6
    • 33646901630 scopus 로고    scopus 로고
    • The role of the mast cell in the pathophysiology of asthma
    • Bradding P, Walls AF, Holgate ST. The role of the mast cell in the pathophysiology of asthma. J Allergy Clin Immunol 2006;117:1277-84.
    • (2006) J Allergy Clin Immunol , vol.117 , pp. 1277-1284
    • Bradding, P.1    Walls, A.F.2    Holgate, S.T.3
  • 7
    • 0026610142 scopus 로고
    • Predominant TH2-like bronchoalveolar T-lymphocyte population in atopic asthma
    • Robinson DS, Hamid Q, Ying S, et al. Predominant TH2-like bronchoalveolar T-lymphocyte population in atopic asthma. N Engl J Med 1992;326:298-304.
    • (1992) N Engl J Med , vol.326 , pp. 298-304
    • Robinson, D.S.1    Hamid, Q.2    Ying, S.3
  • 8
    • 0028432821 scopus 로고
    • Interleukin-4, -5, and -6 and tumor necrosis factor-alpha in normal and asthmatic airways: Evidence for the human mast cell as a source of these cytokines
    • Bradding P, Roberts JA, Britten KM, et al. Interleukin-4, -5, and -6 and tumor necrosis factor-alpha in normal and asthmatic airways: evidence for the human mast cell as a source of these cytokines. Am J Respir Cell Mol Biol 1994;10:471-80.
    • (1994) Am J Respir Cell Mol Biol , vol.10 , pp. 471-480
    • Bradding, P.1    Roberts, J.A.2    Britten, K.M.3
  • 9
    • 0141497509 scopus 로고    scopus 로고
    • How do corticosteroids work in asthma?
    • Barnes PJ, Adcock IM. How do corticosteroids work in asthma? Ann Intern Med 2003;139:359-70.
    • (2003) Ann Intern Med , vol.139 , pp. 359-370
    • Barnes, P.J.1    Adcock, I.M.2
  • 10
    • 84941812172 scopus 로고
    • The pathology of bronchial asthma
    • Huber HL, Koessler KK. The pathology of bronchial asthma. Arch Intern Med 1922;30:689-95.
    • (1922) Arch Intern Med , vol.30 , pp. 689-695
    • Huber, H.L.1    Koessler, K.K.2
  • 11
    • 0024545977 scopus 로고
    • Cellular events in the bronchi in mild asthma and after bronchial provocation
    • Beasley R, Roche WR, Roberts JA, Holgate ST. Cellular events in the bronchi in mild asthma and after bronchial provocation. Am Rev Respir Dis 1989;139:806-17.
    • (1989) Am Rev Respir Dis , vol.139 , pp. 806-817
    • Beasley, R.1    Roche, W.R.2    Roberts, J.A.3    Holgate, S.T.4
  • 12
    • 0001836436 scopus 로고
    • Mast cells and basophils: Their role in initiating and maintaining inflammatory responses
    • Holgate ST, editor, London: Academic Press;
    • Bradding P, Walls AF, Church MK. Mast cells and basophils: their role in initiating and maintaining inflammatory responses. In: Holgate ST, editor. Immunopharmacology of the respiratory system. London: Academic Press; 1995. p. 53-84.
    • (1995) Immunopharmacology of the respiratory system , pp. 53-84
    • Bradding, P.1    Walls, A.F.2    Church, M.K.3
  • 13
    • 0024500320 scopus 로고
    • Toxicity of eosinophil cationic proteins for guinea pig tracheal epithelium in vitro
    • Motojima S, Frigas E, Loegering DA, Gleich GJ. Toxicity of eosinophil cationic proteins for guinea pig tracheal epithelium in vitro. Am Rev Respir Dis 1989;139:801-5.
    • (1989) Am Rev Respir Dis , vol.139 , pp. 801-805
    • Motojima, S.1    Frigas, E.2    Loegering, D.A.3    Gleich, G.J.4
  • 14
    • 0024312920 scopus 로고
    • Injurious effect of the eosinophil peroxide-hydrogen peroxide-halide system and major basic protein on human nasal epithelium in vitro
    • Ayars GH, Altman LC, McManus MM, et al. Injurious effect of the eosinophil peroxide-hydrogen peroxide-halide system and major basic protein on human nasal epithelium in vitro. Am Rev Respir Dis 1989;140:125-31.
    • (1989) Am Rev Respir Dis , vol.140 , pp. 125-131
    • Ayars, G.H.1    Altman, L.C.2    McManus, M.M.3
  • 15
    • 0019869241 scopus 로고
    • Elevated levels of the eosinophil granule major basic protein in the sputum of patients with bronchial asthma
    • Frigas E, Loegering DA, Solley GO, et al. Elevated levels of the eosinophil granule major basic protein in the sputum of patients with bronchial asthma. Mayo Clin Proc 1981;56:345-53.
    • (1981) Mayo Clin Proc , vol.56 , pp. 345-353
    • Frigas, E.1    Loegering, D.A.2    Solley, G.O.3
  • 16
    • 0025721948 scopus 로고
    • Evidence of ongoing mast cell and eosinophil degranulation in symptomatic asthma airway
    • Broide DH, Gleich GJ, Cuomo AJ, et al. Evidence of ongoing mast cell and eosinophil degranulation in symptomatic asthma airway. J Allergy Clin Immunol 1991;88:637-48.
    • (1991) J Allergy Clin Immunol , vol.88 , pp. 637-648
    • Broide, D.H.1    Gleich, G.J.2    Cuomo, A.J.3
  • 17
    • 0020071965 scopus 로고
    • Identification by immunofluorescence of eosinophil granule major basic protein in lung tissues of patients with bronchial asthma
    • Filley WV, Holley KE, Kephart GM, Gleich GJ. Identification by immunofluorescence of eosinophil granule major basic protein in lung tissues of patients with bronchial asthma. Lancet 1982 3;2:11-6.
    • (1982) Lancet , vol.3 , Issue.2 , pp. 11-16
    • Filley, W.V.1    Holley, K.E.2    Kephart, G.M.3    Gleich, G.J.4
  • 18
    • 0029064543 scopus 로고
    • Cytokine immunoreactivity in seasonal rhinitis: Regulation by a topical corticosteroid
    • Bradding P, Feather IH, Wilson S, et al. Cytokine immunoreactivity in seasonal rhinitis: regulation by a topical corticosteroid. Am J Respir Crit Care Med 1995;151:1900-6.
    • (1995) Am J Respir Crit Care Med , vol.151 , pp. 1900-1906
    • Bradding, P.1    Feather, I.H.2    Wilson, S.3
  • 19
    • 0027979447 scopus 로고
    • Interleukin 5 synthesis by eosinophils: Association with granules and immunoglobulin-dependent secretion
    • Dubucquoi S, Desreumaux P, Janin A, et al. Interleukin 5 synthesis by eosinophils: association with granules and immunoglobulin-dependent secretion. J Exp Med 1994;179:703-8.
    • (1994) J Exp Med , vol.179 , pp. 703-708
    • Dubucquoi, S.1    Desreumaux, P.2    Janin, A.3
  • 20
    • 0037100414 scopus 로고    scopus 로고
    • Eosinophils express functional IL-13 in eosinophilic inflammatory diseases
    • Schmid-Grendelmeier P, Altznauer F, Fischer B, et al. Eosinophils express functional IL-13 in eosinophilic inflammatory diseases. J Immunol 2002;169:1021-7.
    • (2002) J Immunol , vol.169 , pp. 1021-1027
    • Schmid-Grendelmeier, P.1    Altznauer, F.2    Fischer, B.3
  • 21
    • 10544256182 scopus 로고    scopus 로고
    • IL-4 and IL-5 mRNA and protein in bronchial biopsies from patients with atopic and nonatopic asthma: Evidence against "intrinsic" asthma being a distinct immunopathologic entity
    • Humbert M, Durham SR, Ying S, et al. IL-4 and IL-5 mRNA and protein in bronchial biopsies from patients with atopic and nonatopic asthma: evidence against "intrinsic" asthma being a distinct immunopathologic entity. Am J Respir Crit Care Med 1996;154:1497-504.
    • (1996) Am J Respir Crit Care Med , vol.154 , pp. 1497-1504
    • Humbert, M.1    Durham, S.R.2    Ying, S.3
  • 22
    • 0029889058 scopus 로고    scopus 로고
    • High-affinity IgE receptor (FcepsilonRI)-bearing cells in bronchial biopsies from atopic and nonatopic asthma
    • Humbert M, Grant JA, Taborda-Barata L, et al. High-affinity IgE receptor (FcepsilonRI)-bearing cells in bronchial biopsies from atopic and nonatopic asthma. Am J Respir Crit Care Med 1996;153:1931-7.
    • (1996) Am J Respir Crit Care Med , vol.153 , pp. 1931-1937
    • Humbert, M.1    Grant, J.A.2    Taborda-Barata, L.3
  • 23
    • 0031110132 scopus 로고    scopus 로고
    • Expression of IL-4 and IL-5 mRNA and protein product by CD4+ and CD8+ T cells, eosinophils, and mast cells in bronchial biopsies obtained from atopic and nonatopic (intrinsic) asthmatics
    • Ying S, Humbert M, Barkans J, et al. Expression of IL-4 and IL-5 mRNA and protein product by CD4+ and CD8+ T cells, eosinophils, and mast cells in bronchial biopsies obtained from atopic and nonatopic (intrinsic) asthmatics. J Immunol 1997;158:3539-44.
    • (1997) J Immunol , vol.158 , pp. 3539-3544
    • Ying, S.1    Humbert, M.2    Barkans, J.3
  • 24
    • 0028896452 scopus 로고
    • Bronchial inflammation in occupational asthma due to Western red cedar
    • Frew AJ, Chan H, Lam S, Chan-Yeung M. Bronchial inflammation in occupational asthma due to Western red cedar. Am J Respir Crit Care Med 1995;151:340-4.
    • (1995) Am J Respir Crit Care Med , vol.151 , pp. 340-344
    • Frew, A.J.1    Chan, H.2    Lam, S.3    Chan-Yeung, M.4
  • 25
    • 0036795111 scopus 로고    scopus 로고
    • Analysis of induced sputum in adults with asthma: Identification of subgroup with isolated sputum neutrophilia and poor response to inhaled corticosteroids
    • Green RH, Brightling CE, Woltmann G, et al. Analysis of induced sputum in adults with asthma: identification of subgroup with isolated sputum neutrophilia and poor response to inhaled corticosteroids. Thorax 2002;57:875-9.
    • (2002) Thorax , vol.57 , pp. 875-879
    • Green, R.H.1    Brightling, C.E.2    Woltmann, G.3
  • 26
    • 0032875377 scopus 로고    scopus 로고
    • Evidence that severe asthma can be divided pathologically into two inflammatory subtypes with distinct physiologic and clinical characteristics
    • Wenzel SE, Schwartz LB, Langmack EL, et al. Evidence that severe asthma can be divided pathologically into two inflammatory subtypes with distinct physiologic and clinical characteristics. Am J Respir Crit Care Med 1999;160:1001-8.
    • (1999) Am J Respir Crit Care Med , vol.160 , pp. 1001-1008
    • Wenzel, S.E.1    Schwartz, L.B.2    Langmack, E.L.3
  • 27
    • 36749095585 scopus 로고    scopus 로고
    • Pathological features and inhaled corticosteroid response of eosinophilic and non-eosinophilic asthma
    • Berry MA, Morgan A, Shaw DE, et al. Pathological features and inhaled corticosteroid response of eosinophilic and non-eosinophilic asthma. Thorax 2007;62:1043-9.
    • (2007) Thorax , vol.62 , pp. 1043-1049
    • Berry, M.A.1    Morgan, A.2    Shaw, D.E.3
  • 28
    • 33746358214 scopus 로고    scopus 로고
    • Cytokines or their antagonists for the treatment of asthma
    • O'Byrne PM. Cytokines or their antagonists for the treatment of asthma. Chest 2006;130:244-50.
    • (2006) Chest , vol.130 , pp. 244-250
    • O'Byrne, P.M.1
  • 29
    • 6644229440 scopus 로고    scopus 로고
    • Effects of an interleukin-5 blocking monoclonal antibody on eosinophils, airway hyperresponsiveness, and the late asthmatic response
    • Leckie MJ, ten Brinke A, Khan J, et al. Effects of an interleukin-5 blocking monoclonal antibody on eosinophils, airway hyperresponsiveness, and the late asthmatic response. Lancet 2000;356:2144-8.
    • (2000) Lancet , vol.356 , pp. 2144-2148
    • Leckie, M.J.1    ten Brinke, A.2    Khan, J.3
  • 30
    • 0038643527 scopus 로고    scopus 로고
    • Effect of SCH55700, a humanized anti-human interleukin-5 antibody, in severe persistent asthma: A pilot study
    • Kips JC, O'Connor BJ, Langley SJ, et al. Effect of SCH55700, a humanized anti-human interleukin-5 antibody, in severe persistent asthma: a pilot study Am J Respir Crit Care Med 2003;167:1655-9.
    • (2003) Am J Respir Crit Care Med , vol.167 , pp. 1655-1659
    • Kips, J.C.1    O'Connor, B.J.2    Langley, S.J.3
  • 31
    • 36749065556 scopus 로고    scopus 로고
    • A study to evaluate safety and efficacy of mepolizumab in patients with moderate persistent asthma
    • Flood-Page P, Swenson C, Faiferman I, et al. A study to evaluate safety and efficacy of mepolizumab in patients with moderate persistent asthma. Am J Respir Crit Care Med 2007;176:1062-71.
    • (2007) Am J Respir Crit Care Med , vol.176 , pp. 1062-1071
    • Flood-Page, P.1    Swenson, C.2    Faiferman, I.3
  • 32
    • 85047693849 scopus 로고    scopus 로고
    • Anti-IL-5 treatment reduces deposition of ECM proteins in the bronchial subepithelial basement membrane of mild atopic asthmatics
    • Flood-Page P, Menzies-Gow A, Phipps S, et al. Anti-IL-5 treatment reduces deposition of ECM proteins in the bronchial subepithelial basement membrane of mild atopic asthmatics. J Clin Invest 2003;112:1029-36.
    • (2003) J Clin Invest , vol.112 , pp. 1029-1036
    • Flood-Page, P.1    Menzies-Gow, A.2    Phipps, S.3
  • 33
    • 0037202790 scopus 로고    scopus 로고
    • Asthma exacerbations and eosinophil counts. A randomised controlled trial
    • Green RH, Brightling CE, McKenna S, et al. Asthma exacerbations and eosinophil counts. A randomised controlled trial. Lancet 2002;360:1715-21.
    • (2002) Lancet , vol.360 , pp. 1715-1721
    • Green, R.H.1    Brightling, C.E.2    McKenna, S.3
  • 34
    • 18744401130 scopus 로고    scopus 로고
    • Activation of human lung mast cells by monomeric immunoglobulin E
    • Cruse G, Kaur D, Yang W, et al. Activation of human lung mast cells by monomeric immunoglobulin E. Eur Respir J 2005;25:858-63.
    • (2005) Eur Respir J , vol.25 , pp. 858-863
    • Cruse, G.1    Kaur, D.2    Yang, W.3
  • 35
    • 0001467745 scopus 로고    scopus 로고
    • Mast cells in asthma
    • Busse WW, Holgate ST, editors, Boston: Blackwell Scientific Publications;
    • Bradding P. Mast cells in asthma. In: Busse WW, Holgate ST, editors. Asthma & rhinitis. Boston: Blackwell Scientific Publications; 2000. p. 319-38.
    • (2000) Asthma & rhinitis , pp. 319-338
    • Bradding, P.1
  • 36
    • 28244479315 scopus 로고    scopus 로고
    • Tumour necrosis factor (TNF{alpha}) as a novel therapeutic target in symptomatic corticosteroid- dependent asthma
    • Howarth PH, Babu KS, Arshad HS, et al. Tumour necrosis factor (TNF{alpha}) as a novel therapeutic target in symptomatic corticosteroid- dependent asthma. Thorax 2005;60:1012-8.
    • (2005) Thorax , vol.60 , pp. 1012-1018
    • Howarth, P.H.1    Babu, K.S.2    Arshad, H.S.3
  • 37
    • 0028983633 scopus 로고
    • Tumor necrosis factor-alpha increases airway responsiveness and sputum neutrophilia in normal human subjects
    • Thomas PS, Yates DH, Barnes PJ. Tumor necrosis factor-alpha increases airway responsiveness and sputum neutrophilia in normal human subjects. Am J Respir Crit Care Med 1995;152:76-80.
    • (1995) Am J Respir Crit Care Med , vol.152 , pp. 76-80
    • Thomas, P.S.1    Yates, D.H.2    Barnes, P.J.3
  • 38
    • 0036727009 scopus 로고    scopus 로고
    • Effects of inhaled tumour necrosis factor alpha in subjects with mild asthma
    • Thomas PS, Heywood G. Effects of inhaled tumour necrosis factor alpha in subjects with mild asthma. Thorax 2002;57:774-8.
    • (2002) Thorax , vol.57 , pp. 774-778
    • Thomas, P.S.1    Heywood, G.2
  • 39
    • 32644490529 scopus 로고    scopus 로고
    • Evidence of a role of TNFa in refractory asthma
    • Berry MA, Hargadon B, Shelley M, et al. Evidence of a role of TNFa in refractory asthma. N Engl J Med 2006;354:697-708.
    • (2006) N Engl J Med , vol.354 , pp. 697-708
    • Berry, M.A.1    Hargadon, B.2    Shelley, M.3
  • 40
    • 0022353841 scopus 로고
    • Bronchoalveolar mast cells in extrinsic asthma: A mechanism for the initiation of antigen specific bronchoconstriction
    • Flint KC, Leung KB, Hudspith BN, et al. Bronchoalveolar mast cells in extrinsic asthma: a mechanism for the initiation of antigen specific bronchoconstriction. Br Med J 1985;291:923-6.
    • (1985) Br Med J , vol.291 , pp. 923-926
    • Flint, K.C.1    Leung, K.B.2    Hudspith, B.N.3
  • 41
    • 1642370953 scopus 로고    scopus 로고
    • Inhibitors of tryptase as mast cell-stabilizing agents in the human airways: Effects of tryptase and other agonists of proteinase-activated receptor 2 on histamine release
    • He S, Aslam A, Gaca MD, et al. Inhibitors of tryptase as mast cell-stabilizing agents in the human airways: effects of tryptase and other agonists of proteinase-activated receptor 2 on histamine release. J Pharmacol Exp Ther 2004;309:119-26.
    • (2004) J Pharmacol Exp Ther , vol.309 , pp. 119-126
    • He, S.1    Aslam, A.2    Gaca, M.D.3
  • 42
    • 0029822999 scopus 로고    scopus 로고
    • Potential allergens stimulate the release of mediators of the allergic response from cells of mast cell lineage in the absence of sensitization with antigen-specific IgE
    • Machado DC, Horton D, Harrop R, et al. Potential allergens stimulate the release of mediators of the allergic response from cells of mast cell lineage in the absence of sensitization with antigen-specific IgE. Eur J Immunol 1996;26:2972-80.
    • (1996) Eur J Immunol , vol.26 , pp. 2972-2980
    • Machado, D.C.1    Horton, D.2    Harrop, R.3
  • 43
    • 0031044778 scopus 로고    scopus 로고
    • The effect of recombinant stem cell factor on human skin and lung mast cells and basophil leukocytes
    • Frenz AM, Gibbs BF, Pearce FL. The effect of recombinant stem cell factor on human skin and lung mast cells and basophil leukocytes. Inflamm Res 1997;46:35-9.
    • (1997) Inflamm Res , vol.46 , pp. 35-39
    • Frenz, A.M.1    Gibbs, B.F.2    Pearce, F.L.3
  • 44
    • 0036839623 scopus 로고    scopus 로고
    • NF-kappa B and TNF-alpha: A positive autocrine loop in human lung mast cells?
    • Coward WR, Okayama Y, Sagara H, et al. NF-kappa B and TNF-alpha: a positive autocrine loop in human lung mast cells? J Immunol 2002;169:5287-93.
    • (2002) J Immunol , vol.169 , pp. 5287-5293
    • Coward, W.R.1    Okayama, Y.2    Sagara, H.3
  • 45
    • 0141816700 scopus 로고    scopus 로고
    • Identification of specific gene expression profiles in human mast cells mediated by Toll-like receptor 4 and FceRI
    • Okumura S, Kashiwakura J, Tomita H, et al. Identification of specific gene expression profiles in human mast cells mediated by Toll-like receptor 4 and FceRI. Blood 2003;102:2547-54.
    • (2003) Blood , vol.102 , pp. 2547-2554
    • Okumura, S.1    Kashiwakura, J.2    Tomita, H.3
  • 46
    • 20444477046 scopus 로고    scopus 로고
    • Surface CD88 functionally distinguishes the MCTC from the MCT type of human lung mast cell
    • Oskeritzian CA, Zhao W, Min HK, et al. Surface CD88 functionally distinguishes the MCTC from the MCT type of human lung mast cell. J Allergy Clin Immunol 2005;115:1162-8.
    • (2005) J Allergy Clin Immunol , vol.115 , pp. 1162-1168
    • Oskeritzian, C.A.1    Zhao, W.2    Min, H.K.3
  • 47
    • 3442875541 scopus 로고    scopus 로고
    • Activation of mast cells by double-stranded RNA: Evidence for activation through Toll-like receptor 3
    • Kulka M, Alexopoulou L, Flavell RA, Metcalfe DD. Activation of mast cells by double-stranded RNA: evidence for activation through Toll-like receptor 3. J Allergy Clin Immunol 2004;114:174-82.
    • (2004) J Allergy Clin Immunol , vol.114 , pp. 174-182
    • Kulka, M.1    Alexopoulou, L.2    Flavell, R.A.3    Metcalfe, D.D.4
  • 48
    • 0037442003 scopus 로고    scopus 로고
    • Cutting edge: Distinct Toll-like receptor 2 activators selectively induce different classes of mediator production from human mast cells
    • McCurdy JD, Olynych TJ, Maher LH, Marshall JS. Cutting edge: distinct Toll-like receptor 2 activators selectively induce different classes of mediator production from human mast cells. J Immunol 2003;170:1625-9.
    • (2003) J Immunol , vol.170 , pp. 1625-1629
    • McCurdy, J.D.1    Olynych, T.J.2    Maher, L.H.3    Marshall, J.S.4
  • 49
  • 50
    • 0021239291 scopus 로고
    • Interaction between hyperosmolar and IgE-mediated histamine release from basophils and mast cells
    • Eggleston PA, Kagey-Sobotka A, Schleimer RP, et al. Interaction between hyperosmolar and IgE-mediated histamine release from basophils and mast cells. Am Rev Respir Dis 1984;130:86-91.
    • (1984) Am Rev Respir Dis , vol.130 , pp. 86-91
    • Eggleston, P.A.1    Kagey-Sobotka, A.2    Schleimer, R.P.3
  • 51
    • 0037198418 scopus 로고    scopus 로고
    • Mast cell infiltration of airway smooth muscle in asthma
    • Brightling CE, Bradding P, Symon FA, et al. Mast cell infiltration of airway smooth muscle in asthma. N Engl J Med 2002;346:1699-705.
    • (2002) N Engl J Med , vol.346 , pp. 1699-1705
    • Brightling, C.E.1    Bradding, P.2    Symon, F.A.3
  • 52
    • 0032816815 scopus 로고    scopus 로고
    • Immunopathology and human mast cell cytokines
    • Bradding P, Holgate ST. Immunopathology and human mast cell cytokines. Crit Rev Oncol Haematol 1999;31:119-33.
    • (1999) Crit Rev Oncol Haematol , vol.31 , pp. 119-133
    • Bradding, P.1    Holgate, S.T.2
  • 53
    • 0033844454 scopus 로고    scopus 로고
    • Adhesion of human lung mast cells to bronchial epithelium: Evidence for a novel carbohydrate-mediated mechanism
    • Sanmugalingam D, Wardlaw AJ, Bradding P. Adhesion of human lung mast cells to bronchial epithelium: evidence for a novel carbohydrate-mediated mechanism. J Leuk Biol 2000;68:38-46.
    • (2000) J Leuk Biol , vol.68 , pp. 38-46
    • Sanmugalingam, D.1    Wardlaw, A.J.2    Bradding, P.3
  • 54
    • 0030032558 scopus 로고    scopus 로고
    • Mast cell tryptase is a mitogen for epithelial cells. Stimulation of IL-8 production and intercellular adhesion molecule-1 expression
    • Cairns JA, Walls AF. Mast cell tryptase is a mitogen for epithelial cells. Stimulation of IL-8 production and intercellular adhesion molecule-1 expression. J Immunol 1996;156:275-83.
    • (1996) J Immunol , vol.156 , pp. 275-283
    • Cairns, J.A.1    Walls, A.F.2
  • 55
    • 33745272225 scopus 로고    scopus 로고
    • Attenuation of human lung mast cell degranulation by bronchial epithelium
    • Yang W, Wardlaw AJ, Bradding P. Attenuation of human lung mast cell degranulation by bronchial epithelium. Allergy 2006;61:569-75.
    • (2006) Allergy , vol.61 , pp. 569-575
    • Yang, W.1    Wardlaw, A.J.2    Bradding, P.3
  • 56
    • 0018128604 scopus 로고
    • Ultrastructure of airways in children with asthma
    • Cutz E, Levison H, Cooper DM. Ultrastructure of airways in children with asthma. Histopathology 1978;2:407-21.
    • (1978) Histopathology , vol.2 , pp. 407-421
    • Cutz, E.1    Levison, H.2    Cooper, D.M.3
  • 57
    • 0032798777 scopus 로고    scopus 로고
    • Eosinophilic bronchitis is an important cause of chronic cough
    • Brightling CE, Ward R, Goh KL, et al. Eosinophilic bronchitis is an important cause of chronic cough. Am J Respir Crit Care Med 1999;160:406-10.
    • (1999) Am J Respir Crit Care Med , vol.160 , pp. 406-410
    • Brightling, C.E.1    Ward, R.2    Goh, K.L.3
  • 58
    • 0037794333 scopus 로고    scopus 로고
    • Comparison of airway immunopathology of eosinophilic bronchitis and asthma
    • Brightling CE, Symon FA, Birring SS, et al. Comparison of airway immunopathology of eosinophilic bronchitis and asthma. Thorax 2003;58:528-32.
    • (2003) Thorax , vol.58 , pp. 528-532
    • Brightling, C.E.1    Symon, F.A.2    Birring, S.S.3
  • 59
    • 0036882155 scopus 로고    scopus 로고
    • TH2 cytokine expression in bronchoalveolar lavage fluid T lymphocytes and bronchial submucosa is a feature of asthma and eosinophilic bronchitis
    • Brightling CE, Symon FA, Birring SS, et al. TH2 cytokine expression in bronchoalveolar lavage fluid T lymphocytes and bronchial submucosa is a feature of asthma and eosinophilic bronchitis. J Allergy Clin Immunol 2002;110:899-905.
    • (2002) J Allergy Clin Immunol , vol.110 , pp. 899-905
    • Brightling, C.E.1    Symon, F.A.2    Birring, S.S.3
  • 60
    • 33846202881 scopus 로고    scopus 로고
    • Inflammation of bronchial smooth muscle in allergic asthma
    • Begueret H, Berger P, Vernejoux JM, et al. Inflammation of bronchial smooth muscle in allergic asthma. Thorax 2007;62:8-15.
    • (2007) Thorax , vol.62 , pp. 8-15
    • Begueret, H.1    Berger, P.2    Vernejoux, J.M.3
  • 61
    • 24744432295 scopus 로고    scopus 로고
    • The extracellular deposition of mast cell products is increased in hypertrophic airways smooth muscles in allergic asthma but not in nonallergic asthma
    • Amin K, Janson C, Boman G, Venge P. The extracellular deposition of mast cell products is increased in hypertrophic airways smooth muscles in allergic asthma but not in nonallergic asthma. Allergy 2005;60:1241-7.
    • (2005) Allergy , vol.60 , pp. 1241-1247
    • Amin, K.1    Janson, C.2    Boman, G.3    Venge, P.4
  • 62
    • 0642364966 scopus 로고    scopus 로고
    • Tryptase-stimulated human airway smooth muscle cells induce cytokine synthesis and mast cell chemotaxis
    • Berger P, Girodet PO, Begueret H, et al. Tryptase-stimulated human airway smooth muscle cells induce cytokine synthesis and mast cell chemotaxis. FASEB J 2003;17:2139-41.
    • (2003) FASEB J , vol.17 , pp. 2139-2141
    • Berger, P.1    Girodet, P.O.2    Begueret, H.3
  • 63
    • 31144477001 scopus 로고    scopus 로고
    • Fraktalkine produced by airway smooth muscle cells contributes to mast cell recruitment in asthma
    • El-Shazly A, Berger P, Girodet PO, et al. Fraktalkine produced by airway smooth muscle cells contributes to mast cell recruitment in asthma. J Immunol 2006;176:1860-8.
    • (2006) J Immunol , vol.176 , pp. 1860-1868
    • El-Shazly, A.1    Berger, P.2    Girodet, P.O.3
  • 64
    • 0036014530 scopus 로고    scopus 로고
    • Distribution and degranulation of airway mast cells in normal and asthmatic subjects
    • Carroll NG, Mutavdzic S, James AL. Distribution and degranulation of airway mast cells in normal and asthmatic subjects. Eur Respir J 2002;19:879-85.
    • (2002) Eur Respir J , vol.19 , pp. 879-885
    • Carroll, N.G.1    Mutavdzic, S.2    James, A.L.3
  • 65
    • 30744445698 scopus 로고    scopus 로고
    • Human lung mast cells adhere to human airway smooth muscle, in part, via tumor suppressor in lung cancer-1
    • Yang W, Kaur D, Okayama Y, et al. Human lung mast cells adhere to human airway smooth muscle, in part, via tumor suppressor in lung cancer-1. J Immunol 2006;176:1238-43.
    • (2006) J Immunol , vol.176 , pp. 1238-1243
    • Yang, W.1    Kaur, D.2    Okayama, Y.3
  • 66
    • 0033001630 scopus 로고    scopus 로고
    • Mast cell tryptase as a mediator of hyperresponsiveness in human isolated bronchi
    • Berger P, Compton SJ, Molimard M, et al. Mast cell tryptase as a mediator of hyperresponsiveness in human isolated bronchi. Clin Exp Allergy 1999;29:804-12.
    • (1999) Clin Exp Allergy , vol.29 , pp. 804-812
    • Berger, P.1    Compton, S.J.2    Molimard, M.3
  • 67
    • 0034867321 scopus 로고    scopus 로고
    • Tryptase and agonists of PAR-2 induce the proliferation of human airway smooth muscle cells
    • Berger P, Perng DW, Thabrew H, et al. Tryptase and agonists of PAR-2 induce the proliferation of human airway smooth muscle cells. J Appl Physiol 2001;91:1372-9.
    • (2001) J Appl Physiol , vol.91 , pp. 1372-1379
    • Berger, P.1    Perng, D.W.2    Thabrew, H.3
  • 68
    • 0036084456 scopus 로고    scopus 로고
    • Tryptase's potent mitogenic effects in human airway smooth muscle cells are via non-proteolytic actions
    • Brown JK, Jones CA, Rooney LA, et al. Tryptase's potent mitogenic effects in human airway smooth muscle cells are via non-proteolytic actions. Am J Physiol Lung Cell Mol Physiol 2002;282:L197-206.
    • (2002) Am J Physiol Lung Cell Mol Physiol , vol.282
    • Brown, J.K.1    Jones, C.A.2    Rooney, L.A.3
  • 69
    • 0036007308 scopus 로고    scopus 로고
    • The Th2 lymphocyte products IL-4 and IL-13 rapidly induce airway hyperresponsiveness through direct effects on resident airway cells
    • Venkayya R, Lam M, Willkom M, et al. The Th2 lymphocyte products IL-4 and IL-13 rapidly induce airway hyperresponsiveness through direct effects on resident airway cells. Am J Respir Cell Mol Biol 2002;26:202-8.
    • (2002) Am J Respir Cell Mol Biol , vol.26 , pp. 202-208
    • Venkayya, R.1    Lam, M.2    Willkom, M.3
  • 70
    • 0346216118 scopus 로고    scopus 로고
    • IL-4 and IL-13 are colocalised to mast cells within airway smooth muscle in asthma
    • Brightling CE, Symon FA, Holgate ST, et al. IL-4 and IL-13 are colocalised to mast cells within airway smooth muscle in asthma. Clin Exp Allergy 2003;33:1711-6.
    • (2003) Clin Exp Allergy , vol.33 , pp. 1711-1716
    • Brightling, C.E.1    Symon, F.A.2    Holgate, S.T.3
  • 71
    • 18244391711 scopus 로고    scopus 로고
    • Differential expression of CCR3 and CXCR3 by human lung and bone marrow-derived mast cells: Implications for tissue mast cell migration
    • Brightling CE, Kaur D, Berger P, et al. Differential expression of CCR3 and CXCR3 by human lung and bone marrow-derived mast cells: implications for tissue mast cell migration. J Leuk Biol 2005;77:759-66.
    • (2005) J Leuk Biol , vol.77 , pp. 759-766
    • Brightling, C.E.1    Kaur, D.2    Berger, P.3
  • 72
    • 33750019000 scopus 로고    scopus 로고
    • Functional KCa3.1 K+ channels are required for human lung mast cell migration
    • Cruse G, Duffy SM, Brightling CE, Bradding P. Functional KCa3.1 K+ channels are required for human lung mast cell migration. Thorax 2006;61:880-5.
    • (2006) Thorax , vol.61 , pp. 880-885
    • Cruse, G.1    Duffy, S.M.2    Brightling, C.E.3    Bradding, P.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.