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Volumn 79, Issue 1, 2008, Pages 187-194

Hypochlorite-modified high-density lipoprotein acts as a sink for myeloperoxidase in vitro

Author keywords

ApoA I; Hypochlorous acid; Inflammation; MPO hydrogen peroxide halide system; Neutrophils

Indexed keywords

HIGH DENSITY LIPOPROTEIN; HYPOCHLORITE; HYPOCHLOROUS ACID; IODINE 125; MYELOPEROXIDASE; TOSYLCHLORAMIDE SODIUM;

EID: 45849125708     PISSN: 00086363     EISSN: 17553245     Source Type: Journal    
DOI: 10.1093/cvr/cvn051     Document Type: Article
Times cited : (47)

References (51)
  • 1
    • 4644310560 scopus 로고    scopus 로고
    • Role of oxidative modifications in atherosclerosis
    • Stocker R, Keaney JF Jr. Role of oxidative modifications in atherosclerosis. Physiol Rev 2004;84:1381-1478.
    • (2004) Physiol Rev , vol.84 , pp. 1381-1478
    • Stocker, R.1    Keaney Jr, J.F.2
  • 2
    • 18244390487 scopus 로고    scopus 로고
    • Myeloperoxidase: Friend and foe
    • Klebanoff SJ. Myeloperoxidase: friend and foe. J Leukoc Biol 2005;77:598-625.
    • (2005) J Leukoc Biol , vol.77 , pp. 598-625
    • Klebanoff, S.J.1
  • 3
    • 0021807129 scopus 로고
    • Comparative reactivities of various biological compounds with myeloperoxidase-hydrogen peroxide-chloride, and similarity of the oxidant to hypochlorite
    • Winterbourn CC. Comparative reactivities of various biological compounds with myeloperoxidase-hydrogen peroxide-chloride, and similarity of the oxidant to hypochlorite. Biochim Biophys Acta 1985;840:204-210.
    • (1985) Biochim Biophys Acta , vol.840 , pp. 204-210
    • Winterbourn, C.C.1
  • 4
    • 0027360402 scopus 로고
    • Hypochlorous acidmediated modification of cholesterol and phospholipid: Analysis of reaction products by gas chromatography-mass spectrometry
    • van den Berg JJ, Winterbourn CC, Kuypers FA. Hypochlorous acidmediated modification of cholesterol and phospholipid: analysis of reaction products by gas chromatography-mass spectrometry. J Lipid Res 1993;34:2005- 2012.
    • (1993) J Lipid Res , vol.34 , pp. 2005-2012
    • van den Berg, J.J.1    Winterbourn, C.C.2    Kuypers, F.A.3
  • 5
    • 0030220396 scopus 로고    scopus 로고
    • Hypochlorous acid interactions with thiols, nucleotides, DNA, and other biological substrates
    • Prütz WA. Hypochlorous acid interactions with thiols, nucleotides, DNA, and other biological substrates. Arch Biochem Biophys 1996;332:110-120.
    • (1996) Arch Biochem Biophys , vol.332 , pp. 110-120
    • Prütz, W.A.1
  • 6
    • 0344410068 scopus 로고    scopus 로고
    • Hypochlorite-induced oxidation of amino acids, peptides and proteins
    • Hawkins CL, Pattison DI, Davies MJ. Hypochlorite-induced oxidation of amino acids, peptides and proteins. Amino Acids 2003;25:259-274.
    • (2003) Amino Acids , vol.25 , pp. 259-274
    • Hawkins, C.L.1    Pattison, D.I.2    Davies, M.J.3
  • 7
    • 33646826643 scopus 로고    scopus 로고
    • Modification of low-density lipoprotein by myeloperoxidase-derived oxidants and reagent hypochlorous acid
    • Malle E, Marsche G, Arnhold J, Davies MR. Modification of low-density lipoprotein by myeloperoxidase-derived oxidants and reagent hypochlorous acid. Biochim Biophys Acta 2006;1761:392-415.
    • (2006) Biochim Biophys Acta , vol.1761 , pp. 392-415
    • Malle, E.1    Marsche, G.2    Arnhold, J.3    Davies, M.R.4
  • 8
    • 30544444120 scopus 로고    scopus 로고
    • Myeloperoxidase-mediated oxidation of high-density lipoproteins: Fingerprints of newly recognized potential proatherogenic lipoproteins
    • Malle E, Marsche G, Panzenboeck U, Sattler W. Myeloperoxidase-mediated oxidation of high-density lipoproteins: fingerprints of newly recognized potential proatherogenic lipoproteins. Arch Biochem Biophys 2006;445:245-255.
    • (2006) Arch Biochem Biophys , vol.445 , pp. 245-255
    • Malle, E.1    Marsche, G.2    Panzenboeck, U.3    Sattler, W.4
  • 9
    • 0028292033 scopus 로고
    • Myeloperoxidase, a catalyst for lipoprotein oxidation, is expressed in human atherosclerotic lesions
    • Daugherty A, Dunn JL, Rateri DL, Heinecke JW. Myeloperoxidase, a catalyst for lipoprotein oxidation, is expressed in human atherosclerotic lesions. J Clin Invest 1994;94:437-444.
    • (1994) J Clin Invest , vol.94 , pp. 437-444
    • Daugherty, A.1    Dunn, J.L.2    Rateri, D.L.3    Heinecke, J.W.4
  • 10
    • 0001059250 scopus 로고    scopus 로고
    • 2/halide system in human atherosclerotic lesions: Colocalization of myeloperoxidase and hypochlorite-modified proteins
    • 2/halide system in human atherosclerotic lesions: colocalization of myeloperoxidase and hypochlorite-modified proteins. Eur J Biochem 2000;267:4495-4503.
    • (2000) Eur J Biochem , vol.267 , pp. 4495-4503
    • Malle, E.1    Waeg, G.2    Schreiber, R.3    Gröne, E.4    Sattler, W.5    Gröne, H.J.6
  • 11
    • 0035108136 scopus 로고    scopus 로고
    • Macrophage myeloperoxidase regulation by granulocyte macrophage colony-stimulating factor in human atherosclerosis and implications in acute coronary syndromes
    • Sugiyama S, Okada Y, Sukhova GK, Virmani R, Heinecke JW, Libby P. Macrophage myeloperoxidase regulation by granulocyte macrophage colony-stimulating factor in human atherosclerosis and implications in acute coronary syndromes. Am J Pathol 2001;158:879-891.
    • (2001) Am J Pathol , vol.158 , pp. 879-891
    • Sugiyama, S.1    Okada, Y.2    Sukhova, G.K.3    Virmani, R.4    Heinecke, J.W.5    Libby, P.6
  • 12
    • 0035861922 scopus 로고    scopus 로고
    • Hypochlorite-modified (lipo)proteins are present in rabbit lesions in response to dietary cholesterol
    • Malle E, Wäg G, Thiery J, Sattler W, Gröne HJ. Hypochlorite-modified (lipo)proteins are present in rabbit lesions in response to dietary cholesterol. Biochem Biophys Res Commun 2001;289:894- 900.
    • (2001) Biochem Biophys Res Commun , vol.289 , pp. 894-900
    • Malle, E.1    Wäg, G.2    Thiery, J.3    Sattler, W.4    Gröne, H.J.5
  • 13
    • 4444292600 scopus 로고    scopus 로고
    • The myeloperoxidase product hypochlorous acid oxidizes HDL in the human artery wall and impairs ABCA1-dependent cholesterol transport
    • Bergt C, Pennathur S, Fu X, Byun J, O'Brien K, McDonald TO et al. The myeloperoxidase product hypochlorous acid oxidizes HDL in the human artery wall and impairs ABCA1-dependent cholesterol transport. Proc Natl Acad Sci USA 2004;101:13032-13037.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 13032-13037
    • Bergt, C.1    Pennathur, S.2    Fu, X.3    Byun, J.4    O'Brien, K.5    McDonald, T.O.6
  • 14
  • 15
    • 25144473410 scopus 로고    scopus 로고
    • Formation of dysfunctional high-density lipoprotein by myeloperoxidase
    • Nicholls SJ, Zheng L, Hazen SL. Formation of dysfunctional high-density lipoprotein by myeloperoxidase. Trends Cardiovasc Med 2005;15:212-219.
    • (2005) Trends Cardiovasc Med , vol.15 , pp. 212-219
    • Nicholls, S.J.1    Zheng, L.2    Hazen, S.L.3
  • 16
    • 0032966768 scopus 로고    scopus 로고
    • Hypochlorite modification of high density lipoprotein: Effects on cholesterol efflux from J774 macrophages
    • Bergt C, Reicher H, Malle E, Sattler W. Hypochlorite modification of high density lipoprotein: effects on cholesterol efflux from J774 macrophages. FEBS Lett 1999;452:295-300.
    • (1999) FEBS Lett , vol.452 , pp. 295-300
    • Bergt, C.1    Reicher, H.2    Malle, E.3    Sattler, W.4
  • 17
    • 12844268120 scopus 로고    scopus 로고
    • Localization of nitration and chlorination sites on apolipoprotein A-I catalyzed by myeloperoxidase in human atheroma and associated oxidative impairment in ABCA1-dependent cholesterol efflux from macrophages
    • Zheng L, Settle M, Brubaker G, Schmitt D, Hazen SL, Smith JD et al. Localization of nitration and chlorination sites on apolipoprotein A-I catalyzed by myeloperoxidase in human atheroma and associated oxidative impairment in ABCA1-dependent cholesterol efflux from macrophages. J Biol Chem 2005;280:38-47.
    • (2005) J Biol Chem , vol.280 , pp. 38-47
    • Zheng, L.1    Settle, M.2    Brubaker, G.3    Schmitt, D.4    Hazen, S.L.5    Smith, J.D.6
  • 18
    • 26644451392 scopus 로고    scopus 로고
    • Tyrosine modification is not required for myeloperoxidase-induced loss of apolipoprotein A-I functional activities
    • Peng DQ, Wu Z, Brubaker G, Zheng L, Settle M, Gross E et al. Tyrosine modification is not required for myeloperoxidase-induced loss of apolipoprotein A-I functional activities. J Biol Chem 2005;280:33775-33784.
    • (2005) J Biol Chem , vol.280 , pp. 33775-33784
    • Peng, D.Q.1    Wu, Z.2    Brubaker, G.3    Zheng, L.4    Settle, M.5    Gross, E.6
  • 19
    • 14044250955 scopus 로고    scopus 로고
    • Tyrosine 192 in apolipoprotein A-I is the major site of nitration and chlorination by myeloperoxidase, but only chlorination markedly impairs ABCA1-dependent cholesterol transport
    • Shao B, Bergt C, Fu X, Green P, Voss JC, Oda MN et al. Tyrosine 192 in apolipoprotein A-I is the major site of nitration and chlorination by myeloperoxidase, but only chlorination markedly impairs ABCA1-dependent cholesterol transport. J Biol Chem 2005;280:5983-5993.
    • (2005) J Biol Chem , vol.280 , pp. 5983-5993
    • Shao, B.1    Bergt, C.2    Fu, X.3    Green, P.4    Voss, J.C.5    Oda, M.N.6
  • 20
    • 0030669763 scopus 로고    scopus 로고
    • Effects of reagent and enzymatically generated hypochlorite on physicochemical and metabolic properties of high density lipoproteins
    • Panzenboeck U, Raitmayer S, Reicher H, Lindner H, Glatter O, Malle E et al. Effects of reagent and enzymatically generated hypochlorite on physicochemical and metabolic properties of high density lipoproteins. J Biol Chem 1997;272:29711-29720.
    • (1997) J Biol Chem , vol.272 , pp. 29711-29720
    • Panzenboeck, U.1    Raitmayer, S.2    Reicher, H.3    Lindner, H.4    Glatter, O.5    Malle, E.6
  • 21
    • 4344577056 scopus 로고    scopus 로고
    • Apolipoprotein A-I is a selective target for myeloperoxidase-catalyzed oxidation and functional impairment in subjects with cardiovascular disease
    • Zheng L, Nukuna B, Brennan ML, Sun M, Goormastic M, Settle M et al. Apolipoprotein A-I is a selective target for myeloperoxidase-catalyzed oxidation and functional impairment in subjects with cardiovascular disease. J Clin Invest 2004;114:529-541.
    • (2004) J Clin Invest , vol.114 , pp. 529-541
    • Zheng, L.1    Nukuna, B.2    Brennan, M.L.3    Sun, M.4    Goormastic, M.5    Settle, M.6
  • 22
    • 0037200014 scopus 로고    scopus 로고
    • Hypochlorite-modified high density lipoprotein, a high affinity ligand to scavenger receptor class B, type I, impairs high density lipoprotein-dependent selective lipid uptake and reverse cholesterol transport
    • Marsche G, Hammer A, Oskolkova O, Kozarsky KF, Sattler W, Malle E. Hypochlorite-modified high density lipoprotein, a high affinity ligand to scavenger receptor class B, type I, impairs high density lipoprotein-dependent selective lipid uptake and reverse cholesterol transport. J Biol Chem 2002;277:32172-32179.
    • (2002) J Biol Chem , vol.277 , pp. 32172-32179
    • Marsche, G.1    Hammer, A.2    Oskolkova, O.3    Kozarsky, K.F.4    Sattler, W.5    Malle, E.6
  • 23
    • 0028326663 scopus 로고
    • Identification of glycoprotein IIb as the lipoprotein(a)-binding protein on platelets. Lipoprotein(a) binding is independent of an arginyl-glycyl-aspartate tripeptide located in apolipoprotein(a)
    • Malle E, Ibovnik A, Steinmetz A, Kostner GM, Sattler W. Identification of glycoprotein IIb as the lipoprotein(a)-binding protein on platelets. Lipoprotein(a) binding is independent of an arginyl-glycyl-aspartate tripeptide located in apolipoprotein(a). Arterioscler Thromb 1994;14:345-352.
    • (1994) Arterioscler Thromb , vol.14 , pp. 345-352
    • Malle, E.1    Ibovnik, A.2    Steinmetz, A.3    Kostner, G.M.4    Sattler, W.5
  • 24
    • 0035318546 scopus 로고    scopus 로고
    • Identification of the human analog of SR-BI and LOX-1 as receptors for hypochlorite-modified high density lipoprotein on human umbilical venous endothelial cells
    • Marsche G, Levak-Frank S, Quehenberger O, Heller R, Sattler W, Malle E. Identification of the human analog of SR-BI and LOX-1 as receptors for hypochlorite-modified high density lipoprotein on human umbilical venous endothelial cells. FASEB J 2001;15:1095-1097.
    • (2001) FASEB J , vol.15 , pp. 1095-1097
    • Marsche, G.1    Levak-Frank, S.2    Quehenberger, O.3    Heller, R.4    Sattler, W.5    Malle, E.6
  • 25
    • 0028899109 scopus 로고
    • Lysine modification of LDL or lipoprotein(a) by 4-hydroxynonenal or malondialdehyde decreases platelet serotonin secretion without affecting platelet aggregability and eicosanoid formation
    • Malle E, Ibovnik A, Leis HJ, Kostner GM, Verhallen PF, Sattler W. Lysine modification of LDL or lipoprotein(a) by 4-hydroxynonenal or malondialdehyde decreases platelet serotonin secretion without affecting platelet aggregability and eicosanoid formation. Arterioscler Thromb Vasc Biol 1995;15:377-384.
    • (1995) Arterioscler Thromb Vasc Biol , vol.15 , pp. 377-384
    • Malle, E.1    Ibovnik, A.2    Leis, H.J.3    Kostner, G.M.4    Verhallen, P.F.5    Sattler, W.6
  • 28
    • 33947632950 scopus 로고    scopus 로고
    • Hypochlorite-modified albumin colocalizes with RAGE in the artery wall and promotes MCP-1 expression via the RAGE-Erk1/2 MAP-kinase pathway
    • Marsche G, Semlitsch M, Hammer A, Frank S, Weigle B, Demling N et al. Hypochlorite-modified albumin colocalizes with RAGE in the artery wall and promotes MCP-1 expression via the RAGE-Erk1/2 MAP-kinase pathway. FASEB J 2007;21:1145-1152.
    • (2007) FASEB J , vol.21 , pp. 1145-1152
    • Marsche, G.1    Semlitsch, M.2    Hammer, A.3    Frank, S.4    Weigle, B.5    Demling, N.6
  • 29
    • 0035957931 scopus 로고    scopus 로고
    • Hypochlorite-modified low density lipoprotein inhibits nitric oxide synthesis in endothelial cells via an intracellular dislocalization of endothelial nitric-oxide synthase
    • Nuszkowski A, Gräbner R, Marsche G, Unbehaun A, Malle E, Heller R. Hypochlorite-modified low density lipoprotein inhibits nitric oxide synthesis in endothelial cells via an intracellular dislocalization of endothelial nitric-oxide synthase. J Biol Chem 2001;276:14212-14221.
    • (2001) J Biol Chem , vol.276 , pp. 14212-14221
    • Nuszkowski, A.1    Gräbner, R.2    Marsche, G.3    Unbehaun, A.4    Malle, E.5    Heller, R.6
  • 31
  • 33
    • 0035667004 scopus 로고    scopus 로고
    • Endothelial transcytosis of myeloperoxidase confers specificity to vascular ECM proteins as targets of tyrosine nitration
    • Baldus S, Eiserich JP, Mani A, Castro L, Figueroa M, Chumley P et al. Endothelial transcytosis of myeloperoxidase confers specificity to vascular ECM proteins as targets of tyrosine nitration. J Clin Invest 2001;108:1759-1770.
    • (2001) J Clin Invest , vol.108 , pp. 1759-1770
    • Baldus, S.1    Eiserich, J.P.2    Mani, A.3    Castro, L.4    Figueroa, M.5    Chumley, P.6
  • 34
    • 0348049466 scopus 로고    scopus 로고
    • Identification of alpha-chloro fatty aldehydes and unsaturated lysophosphatidylcholine molecular species in human atherosclerotic lesions
    • Thukkani AK, McHowat J, Hsu FF, Brennan ML, Hazen SL, Ford DA. Identification of alpha-chloro fatty aldehydes and unsaturated lysophosphatidylcholine molecular species in human atherosclerotic lesions. Circulation 2003;108:3128-3133.
    • (2003) Circulation , vol.108 , pp. 3128-3133
    • Thukkani, A.K.1    McHowat, J.2    Hsu, F.F.3    Brennan, M.L.4    Hazen, S.L.5    Ford, D.A.6
  • 35
    • 0033538671 scopus 로고    scopus 로고
    • Expression of human scavenger receptor class B type I in cultured human monocyte-derived macrophages and atherosclerotic lesions
    • Hirano K, Yamashita S, Nakagawa Y, Ohya T, Matsuura F, Tsukamoto K et al. Expression of human scavenger receptor class B type I in cultured human monocyte-derived macrophages and atherosclerotic lesions. Circ Res 1999;85:108-116.
    • (1999) Circ Res , vol.85 , pp. 108-116
    • Hirano, K.1    Yamashita, S.2    Nakagawa, Y.3    Ohya, T.4    Matsuura, F.5    Tsukamoto, K.6
  • 36
    • 0037290731 scopus 로고    scopus 로고
    • Plasma phospholipid transfer protein-mediated reactions are impaired by hypochlorite modification of high density lipoprotein
    • Pussinen PJ, Metso J, Keva R, Hirschmugl B, Sattler W, Jauhiainen M et al. Plasma phospholipid transfer protein-mediated reactions are impaired by hypochlorite modification of high density lipoprotein. Int J Biochem Cell Biol 2003;35:192-202.
    • (2003) Int J Biochem Cell Biol , vol.35 , pp. 192-202
    • Pussinen, P.J.1    Metso, J.2    Keva, R.3    Hirschmugl, B.4    Sattler, W.5    Jauhiainen, M.6
  • 37
    • 34548501273 scopus 로고    scopus 로고
    • The refined structure of nascent HDL reveals a key functional domain for particle maturation and dysfunction
    • Wu Z, Wagner MA, Zheng L, Parks JS, Shy JM, Smith JD et al. The refined structure of nascent HDL reveals a key functional domain for particle maturation and dysfunction. Nat Struct Mol Biol 2007;14:861-868.
    • (2007) Nat Struct Mol Biol , vol.14 , pp. 861-868
    • Wu, Z.1    Wagner, M.A.2    Zheng, L.3    Parks, J.S.4    Shy, J.M.5    Smith, J.D.6
  • 38
    • 0034161981 scopus 로고    scopus 로고
    • Reagent or myeloperoxidase-generated hypochlorite affects discrete regions in lipid-free and lipid-associated human apolipoprotein A-I
    • Bergt C, Oettl K, Keller W, Andreae F, Leis HJ, Malle E et al. Reagent or myeloperoxidase-generated hypochlorite affects discrete regions in lipid-free and lipid-associated human apolipoprotein A-I. Biochem J 2000;346:345-354.
    • (2000) Biochem J , vol.346 , pp. 345-354
    • Bergt, C.1    Oettl, K.2    Keller, W.3    Andreae, F.4    Leis, H.J.5    Malle, E.6
  • 39
    • 0031693563 scopus 로고    scopus 로고
    • Effects of hypochlorite-modified low density lipoproteins and high density lipoproteins on platelet function
    • Opper C, Schüssler G, Sattler W, Malle E. Effects of hypochlorite-modified low density lipoproteins and high density lipoproteins on platelet function. Platelets 1998;9:339-341.
    • (1998) Platelets , vol.9 , pp. 339-341
    • Opper, C.1    Schüssler, G.2    Sattler, W.3    Malle, E.4
  • 41
    • 0028091628 scopus 로고
    • Hypochlorous acid and chloramines increase endothelial permeability: Possible involvement of cellular zinc
    • Tatsumi T, Fliss H. Hypochlorous acid and chloramines increase endothelial permeability: possible involvement of cellular zinc. Am J Physiol 1994;267:H1597-H1607.
    • (1994) Am J Physiol , vol.267
    • Tatsumi, T.1    Fliss, H.2
  • 42
    • 0029619239 scopus 로고
    • Cytotoxicity towards human endothelial cells, induced by neutrophil myeloperoxidase: Protection by ceftazidime
    • Mathy-Hartert M, Deby-Dupont G, Deby C, Jadoul L, Vandenberghe A, Lamy M. Cytotoxicity towards human endothelial cells, induced by neutrophil myeloperoxidase: protection by ceftazidime. Mediators Inflamm 1995;4:437-443.
    • (1995) Mediators Inflamm , vol.4 , pp. 437-443
    • Mathy-Hartert, M.1    Deby-Dupont, G.2    Deby, C.3    Jadoul, L.4    Vandenberghe, A.5    Lamy, M.6
  • 44
    • 0029894461 scopus 로고    scopus 로고
    • Phagocytosis and intracellular killing of Candida albicans by macrophages exposed to myeloperoxidase
    • Lefkowitz SS, Gelderman MP, Lefkowitz DL, Moguilevsky N, Bollen A. Phagocytosis and intracellular killing of Candida albicans by macrophages exposed to myeloperoxidase. J Infect Dis 1996;173:1202-1207.
    • (1996) J Infect Dis , vol.173 , pp. 1202-1207
    • Lefkowitz, S.S.1    Gelderman, M.P.2    Lefkowitz, D.L.3    Moguilevsky, N.4    Bollen, A.5
  • 47
    • 0034659164 scopus 로고    scopus 로고
    • Myeloperoxidase-generated oxidants and atherosclerosis
    • Podrez EA, Abu-Soud HM, Hazen SL. Myeloperoxidase-generated oxidants and atherosclerosis. Free Radic Biol Med 2000;28:1717-1725.
    • (2000) Free Radic Biol Med , vol.28 , pp. 1717-1725
    • Podrez, E.A.1    Abu-Soud, H.M.2    Hazen, S.L.3
  • 48
    • 0036143434 scopus 로고    scopus 로고
    • Immunohistochemical detection of hypochlorite-modified proteins in glomeruli of human membranous glomerulonephritis
    • Gröne HJ, Gröne EF, Malle E. Immunohistochemical detection of hypochlorite-modified proteins in glomeruli of human membranous glomerulonephritis. Lab Invest 2002;82:5-14.
    • (2002) Lab Invest , vol.82 , pp. 5-14
    • Gröne, H.J.1    Gröne, E.F.2    Malle, E.3
  • 49
    • 0027359174 scopus 로고
    • Potential roles of hypochlorous acid and N-chloroamines in collagen breakdown by phagocytic cells in synovitis
    • Davies JM, Horwitz DA, Davies KJ. Potential roles of hypochlorous acid and N-chloroamines in collagen breakdown by phagocytic cells in synovitis. Free Radic Biol Med 1993;15:637-643.
    • (1993) Free Radic Biol Med , vol.15 , pp. 637-643
    • Davies, J.M.1    Horwitz, D.A.2    Davies, K.J.3


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