Tyrosine 192 in apolipoprotein A-I is the major site of nitration and chlorination by myeloperoxidase, but only chlorination markedly impairs ABCA1-dependent cholesterol transport

Journal of Biological Chemistry

Volumn 280, Issue 7, 2005, Pages 5983-5993

  Shao, Baohai ^a   Bergt, Constanze ^a   Fu, Xiaoyun ^a   Green, Pattie ^a   Voss, John C ^b   Oda, Michael N ^c   Oram, John F ^a   Heinecke, Jay W ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c CHILDREN S HOSPITAL OAKLAND RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BLOOD; CELLS; CHLORINATION; DISEASES; ENZYMES; HYDROPHILICITY; HYDROPHOBICITY; LIPIDS; NITRATION; OXIDATION;

HIGH DENSITY LIPOPROTEINS (HDL); MYELOPEROXIDASE (MPO); PEROXYNITRITE;

PROTEINS;

ABC TRANSPORTER A1; APOLIPOPROTEIN A1; CHLORINE; CHOLESTEROL; HIGH DENSITY LIPOPROTEIN; MYELOPEROXIDASE; NITROGEN; PEROXYNITRITE; SOLVENT; TYROSINE;

ARTICLE; BIOLOGICAL ACTIVITY; CHLORINATION; CHOLESTEROL TRANSPORT; CONTROLLED STUDY; ELECTRON SPIN RESONANCE; HUMAN; NITRATION; OXIDATION; PRIORITY JOURNAL; TANDEM MASS SPECTROMETRY;

AMINO ACID SEQUENCE; ANIMALS; ANTIOXIDANTS; APOLIPOPROTEIN A-I; ATP-BINDING CASSETTE TRANSPORTERS; BIOLOGICAL TRANSPORT; CELL LINE; CHLORINE; CHOLESTEROL; CRICETINAE; ELECTRON SPIN RESONANCE SPECTROSCOPY; HUMANS; HYDROGEN PEROXIDE; HYDROPHOBICITY; NITRATES; NITROGEN; OXIDATION-REDUCTION; PEPTIDES; PEROXIDASE; PEROXYNITROUS ACID; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; TYROSINE;

EID: 14044250955     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M411484200     Document Type: Article

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