Changes in gene expression induced by carbamazepine and phenytoin: Testing the danger hypothesis

Journal of Immunotoxicology

Volumn 5, Issue 2, 2008, Pages 107-113

  Lu, Wei ^a,b   Li, Xujian ^a   Uetrecht, Jack P ^a  

^a UNIVERSITY OF TORONTO   (Canada)

^b PFIZER INC   (United States)

Author keywords

Biomarkers; Carbamazepine; Cell stress; Gene expression; Idiosyncratic drug reactions; Keap1 Nrf2 ARE signaling pathways; Phenytoin

Indexed keywords

3 HYDROXYCARBAMAZEPINE; 4 HYDROXYPHENYTOIN; BIOLOGICAL MARKER; CARBAMAZEPINE; DRUG METABOLITE; FREE RADICAL; GLUTATHIONE TRANSFERASE; HEAT SHOCK PROTEIN; MESSENGER RNA; PEROXIDASE; PHENOXYL FREE RADICAL; PHENYTOIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTICONVULSANT THERAPY; ANTIGEN PRESENTING CELL; ARTICLE; CELL DAMAGE; CELL STRESS; CLINICAL OBSERVATION; CONTROLLED STUDY; DANGER HYPOTHESIS; DNA MICROARRAY; DRUG SENSITIZATION; FEMALE; GENE EXPRESSION REGULATION; GENE INDUCTION; HUMAN; HYPOTHESIS; IDIOSYNCRATIC DRUG REACTION; IMMUNOLOGICAL TOLERANCE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; PREDICTION; PRIORITY JOURNAL; RISK ASSESSMENT;

ANIMALS; ANTICONVULSANTS; ANTIGEN-PRESENTING CELLS; BIOLOGICAL MARKERS; CARBAMAZEPINE; FEMALE; FREE RADICALS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; IMMUNE SYSTEM DISEASES; MICE; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PHENYTOIN; RNA, MESSENGER; SIGNAL TRANSDUCTION;

MUS;

EID: 45849124661     PISSN: 1547691X     EISSN: 1547691X     Source Type: Journal    
DOI: 10.1080/15476910802085723     Document Type: Article

References (20)

1. Abate, C., Patel, L., Rauscher, F. J., 3rd, and Curran, T. 1990. Redox regulation of fos and jun DNA-binding activity in vitro. Science 249:1157-1161.
2. Andrejko, K. M., Chen, J., and Deutschman, C. S. 1998. Intrahepatic STAT-3 activation and acute phase gene expression predict outcome after CLP sepsis in the rat. Am. J. Physiol. 27:G1423-1429.
3. Carpagnano, G. E., Resta, O., Foschino-Barbaro, M. P., Spanevello, A., Stefano, A., Di Gioia, G., Serviddio, G., and Gramiccioni, E. 2004. Exhaled Interleukine-6 and 8-isoprostane in chronic obstructive pulmonary disease: Effect of carbocysteine lysine salt monohydrate (SCMC-Lys). Eur. J. Pharmacol. 505:169-175.
4. Dinkova-Kostova, A. T., Holtzclaw, W. D., and Kensler, T. W. 2005. The role of Keap1 in cellular protective responses. Chem. Res. Toxicol. 18:1779-1791.
5. Hardardottir, I., Grunfeld, C., and Feingold, K. R. 1995. Effects of endotoxin on lipid metabolism. Biochem. Soc. Trans. 23:1013-1018.
6. Hyson, C., and Sadler, M. 1997. Cross sensitivity of skin rashes with antiepileptic drugs. Can. J. Neurol. Sci. 24:245-249.
7. Kwak, M. K., Wakabayashi, N., Itoh, K., Motohashi, H., Yamamoto, M., and Kensler, T. W. 2003. Modulation of gene expression by cancer chemopreventive dithiolethiones through the Keap1-Nrf2 pathway. Identification of novel gene clusters for cell survival. J. Biol. Chem. 278:8135-8145.
8. Leeder, J. S. 1998. Mechanisms of idiosyncratic hypersensitivity reactions to antiepileptic drugs. Epilepsia 39(S7):S8-16.
9. Leone, A. M., Kao, L. M., McMillian, M. K., Nie, A. Y., Parker, J. B., Kelley, M. F., Usuki, E., Parkinson, A., Lord, P. G., and Johnson, M. D. 2007. Evaluation of felbamate and other antiepileptic drug toxicity potential based on hepatic protein covalent binding and gene expression. Chem. Res. Toxicol. 20:600-608.
10. Leung, P. S., and Gershwin, M. E. 1991. The immunobiology of heat shock proteins. J. Invest. Allergol. Clin. Immunol. 1:23-30.
11. Lu, W., and Uetrecht, J. 2008. Peroxidase-mediated bioactivation of hydroxylated metabolites of carbamazepine and phenytoin. Drug Metab. Dispos. (in press).
12. McMillian, M., Nie, A. Y., Parker, J. B., Leone, A., Bryant, S., Kemmerer, M., Herlich, J., Liu, Y., Yieh, L., Bittner, A., Liu, X., Wan, J., and Johnson, M. D. 2004a. A gene expression signature for oxidant stress/reactive metabolites in rat liver. Biochem. Pharmacol. 68:2249-2261.
13. McMillian, M., Nie, A. Y., Parker, J. B., Leone, A., Kemmerer, M., Bryant, S., J. Herlich, J., Yieh, L., Bittner, A., Liu, X., Wan, J., and Johnson, M. D. 2004b. Inverse gene expression patterns for macrophage activating hepatotoxicants and peroxisome proliferators in rat liver. Biochem. Pharmacol. 67:2141-2165.
14. McMillian, M., Nie, A., Parker, J. B., Leone, A., Kemmerer, M., Bryant, S., Herlich, J., Yieh, L., Bittner, A., Liu, X., Wan, J., Johnson, M. D., and Lord, P. 2005. Drug-induced oxidative stress in rat liver from a toxicogenomics perspective. Toxicol. Appl. Pharmacol. 207(S2):171-178.
15. Pahl, H. L., and Baeuerle, P. A. 1994. Oxygen and the control of gene expression. Bioessays 16:497-502.
16. Seguin, B., and Uetrecht, J. 2003. The danger hypothesis applied to idiosyncratic drug reactions. Curr. Opin. Allergy Clin. Immunol. 3:235-242.
17. Shear, N. H., and Spielberg, S. P. 1988. Anticonvulsant hypersensitivity syndrome. In vitro assessment of risk. J. Clin. Invest. 82:1826-1832.
18. Shen, G., Jeong, W. S., Hu, R., and Kong, A. N. 2005. Regulation of Nrf2, NF-κB, and AP-1 signaling pathways by chemopreventive agents. Antioxid. Redox Signal 7:1648-1663.
19. Talalay, P., Dinkova-Kostova, A. T., and Holtzclaw, W. D. 2003. Importance of Phase 2 gene regulation in protection against electrophile and reactive oxygen toxicity and carcinogenesis. Adv. Enzyme Regul. 43:121-134.
20. Thomas, R. S., Rank, D. R., Penn, S. G., Zastrow, G. M., Hayes, K. R., Pande, K., Glover, E., Silander, T., Craven, M. W., Reddy, J. K., Jovanovich, S. B., and Bradfield, C. A. 2001. Identification of toxicologically predictive gene sets using cDNA microarrays. Mol. Pharmacol. 60:1189-1194.