-
1
-
-
30444454824
-
Drug metabolism and pharmacogenetics: The British contribution to fields of international significance
-
Caldwell, J. Drug metabolism and pharmacogenetics: The British contribution to fields of international significance. Brit. J. Pharmacol. 2006, 147, S89-S99.
-
(2006)
Brit. J. Pharmacol
, vol.147
-
-
Caldwell, J.1
-
2
-
-
0020525989
-
Richard Tecwyn Williams: The man, his work, his impact
-
Neuberger, A.; Smith, L. Richard Tecwyn Williams: the man, his work, his impact. Drug Metab. Rev. 1983, 14, 559-607.
-
(1983)
Drug Metab. Rev
, vol.14
, pp. 559-607
-
-
Neuberger, A.1
Smith, L.2
-
3
-
-
0011218338
-
The estimation of basic organic compounds in biological material. I. General principles
-
Brodie, B.B.; Udenfriend, S.; Baer, J.E. The estimation of basic organic compounds in biological material. I. General principles. J. Biol. Chem. 1947, 168, 299-309.
-
(1947)
J. Biol. Chem
, vol.168
, pp. 299-309
-
-
Brodie, B.B.1
Udenfriend, S.2
Baer, J.E.3
-
4
-
-
45849151774
-
The estimation of basic organic compounds in biological material. VI. Estimation by ultraviolet spectrophotometry
-
Josepheson, E.S.; Udenfriend, S.; Brodie, B.B. The estimation of basic organic compounds in biological material. VI. Estimation by ultraviolet spectrophotometry. J. Biol. Chem. 1947, 168, 341-344.
-
(1947)
J. Biol. Chem
, vol.168
, pp. 341-344
-
-
Josepheson, E.S.1
Udenfriend, S.2
Brodie, B.B.3
-
6
-
-
84908558283
-
The metabolic degradation in the mouse of dibenzanthracene labeled in the 9 and 10 positions with carbon 14
-
Heidelberger, C.; Perkins, M.S.; Kirk, M.R. The metabolic degradation in the mouse of dibenzanthracene labeled in the 9 and 10 positions with carbon 14. Cancer Res. 1948, 8, 261-275.
-
(1948)
Cancer Res
, vol.8
, pp. 261-275
-
-
Heidelberger, C.1
Perkins, M.S.2
Kirk, M.R.3
-
7
-
-
8244245521
-
The distribution of radioactivity following the feeding of carbon 14-labeled 2-acetylaminofluorene to rats
-
Morris, H.P.; Weisburger, J.H.; Weisburger, E.K. The distribution of radioactivity following the feeding of carbon 14-labeled 2-acetylaminofluorene to rats. Cancer Res. 1950, 10, 620-624.
-
(1950)
Cancer Res
, vol.10
, pp. 620-624
-
-
Morris, H.P.1
Weisburger, J.H.2
Weisburger, E.K.3
-
9
-
-
33947448199
-
Chemical analysis and isotopic assay of organic compounds
-
Anderson, R.C.; Delabarre, Y.; Bothner-By, A.A. Chemical analysis and isotopic assay of organic compounds. Anal. Chem. 1952, 24, 1298-1303.
-
(1952)
Anal. Chem
, vol.24
, pp. 1298-1303
-
-
Anderson, R.C.1
Delabarre, Y.2
Bothner-By, A.A.3
-
10
-
-
33947454301
-
Microdetermination of carbon and hydrogen in organic compounds
-
Naughton, J.J.; Frodyma, M.M. Microdetermination of carbon and hydrogen in organic compounds. Anal. Chem. 1950, 22, 711-714.
-
(1950)
Anal. Chem
, vol.22
, pp. 711-714
-
-
Naughton, J.J.1
Frodyma, M.M.2
-
11
-
-
45849126933
-
The metabolism of methylcyclohexane
-
Elliott, T.H.; Tao, R.C.C.; Williams, R.T. The metabolism of methylcyclohexane. Biochem. J. 1965, 95, 70-76.
-
(1965)
Biochem. J
, vol.95
, pp. 70-76
-
-
Elliott, T.H.1
Tao, R.C.C.2
Williams, R.T.3
-
12
-
-
45849122555
-
The fate of 2,4,6-tri-(30,50-di-tert.-butyl-4′-hydroxybenzyl)mesitylene (Ionox 330) in the dog and rat
-
Wright, A.S.; Crowne, R.S.; Hathway, D.E. The fate of 2,4,6-tri-(30,50-di-tert.-butyl-4′-hydroxybenzyl)mesitylene (Ionox 330) in the dog and rat. Biochem. J. 1965, 95, 98-103.
-
(1965)
Biochem. J
, vol.95
, pp. 98-103
-
-
Wright, A.S.1
Crowne, R.S.2
Hathway, D.E.3
-
13
-
-
0014002315
-
Recent investigations on cholesterol metabolism: Critical evaluation of radiochromatography and estimation procedures
-
Pascaud, P. Recent investigations on cholesterol metabolism: Critical evaluation of radiochromatography and estimation procedures. Adv. Tracer Methodol. 1966, 3, 181-198.
-
(1966)
Adv. Tracer Methodol
, vol.3
, pp. 181-198
-
-
Pascaud, P.1
-
14
-
-
0014784183
-
-
Hazelton, H.R.; Johnson, P. British J. Pharmacol. The use of gas-liquid chromatography-mass spectrometry in biochemical pharmacology. Biochem. Pharmacol. 1970, 39, 236P-237P.
-
Hazelton, H.R.; Johnson, P. British J. Pharmacol. The use of gas-liquid chromatography-mass spectrometry in biochemical pharmacology. Biochem. Pharmacol. 1970, 39, 236P-237P.
-
-
-
-
15
-
-
0009283254
-
Radiochromatography: The Chromatography and Electrophoresis of Radiolabelled Compounds
-
Elsevier: Amsterdam
-
Roberts, T.A. Radiochromatography: The Chromatography and Electrophoresis of Radiolabelled Compounds. Journal of chromatography library series Vol. 14; Elsevier: Amsterdam, 1978.
-
(1978)
Journal of chromatography library series
, vol.14
-
-
Roberts, T.A.1
-
16
-
-
0025144610
-
Radiochromatography in pharmaceutical and biomedical analysis
-
Veltkamp, A.C. Radiochromatography in pharmaceutical and biomedical analysis. J. Chromatogr. 1990, 531, 101-129.
-
(1990)
J. Chromatogr
, vol.531
, pp. 101-129
-
-
Veltkamp, A.C.1
-
17
-
-
4544295323
-
The use of radiolabeled compounds for ADME studies in discovery and extraploratory development
-
Marathe, P.H.; Shyu, W.C.; Humphreys, W.G. The use of radiolabeled compounds for ADME studies in discovery and extraploratory development. Curr. Pharmaceut. Des. 2004, 10, 2991-3008.
-
(2004)
Curr. Pharmaceut. Des
, vol.10
, pp. 2991-3008
-
-
Marathe, P.H.1
Shyu, W.C.2
Humphreys, W.G.3
-
18
-
-
0022860421
-
-
Nieves, E.; Rosenspire, K.C.; Filc-DeRicco, S.; Gelbard, A.S.; Cooper, Arthur J.L. High-performance liquid chromatographic on-line flow-through radioactivity detector system for analyzing amino acids and metabolites labeled with nitrogen-13. J. Chromatogr. 1986, 83, (2), 325-337.
-
Nieves, E.; Rosenspire, K.C.; Filc-DeRicco, S.; Gelbard, A.S.; Cooper, Arthur J.L. High-performance liquid chromatographic on-line flow-through radioactivity detector system for analyzing amino acids and metabolites labeled with nitrogen-13. J. Chromatogr. 1986, 83, (2), 325-337.
-
-
-
-
19
-
-
33845734598
-
A regulatory perspective on issues and approaches in characterizing human metabolites
-
Davis-Bruno, K.L.; Atrakchi, A. A regulatory perspective on issues and approaches in characterizing human metabolites. Chem. Res. Toxicol. 2006, 19, 1561-1563.
-
(2006)
Chem. Res. Toxicol
, vol.19
, pp. 1561-1563
-
-
Davis-Bruno, K.L.1
Atrakchi, A.2
-
20
-
-
18644385994
-
Contemporary issues in toxicology, drug metabolites in safety testing
-
Baillie, T.A.; Cayen, M.N.; Fouda, H.; Gerson, R.J.; Green, J.D.; Grossmann, S.J.; Klunk, L.J.; LeBlanc, B.; Perkins, D.G.; Shipley, L.A. Contemporary issues in toxicology, drug metabolites in safety testing. Tox. Appl. Pharmacol. 2002, 182, 188-196.
-
(2002)
Tox. Appl. Pharmacol
, vol.182
, pp. 188-196
-
-
Baillie, T.A.1
Cayen, M.N.2
Fouda, H.3
Gerson, R.J.4
Green, J.D.5
Grossmann, S.J.6
Klunk, L.J.7
LeBlanc, B.8
Perkins, D.G.9
Shipley, L.A.10
-
21
-
-
24944563781
-
Seeing through the mist: Abundance versus percentage, commentary on metabolites in safety testing
-
Smith, D.A.; Obach, R.S. Seeing through the mist: Abundance versus percentage, commentary on metabolites in safety testing. Drug Metabol. Dispos. 2005, 33, 1409-1417.
-
(2005)
Drug Metabol. Dispos
, vol.33
, pp. 1409-1417
-
-
Smith, D.A.1
Obach, R.S.2
-
22
-
-
36849139233
-
Scintillation counters for radioactive sample measurement
-
Anger, H.O. Scintillation counters for radioactive sample measurement. Rev. Sci. Instrum. 1951, 22, 912-914.
-
(1951)
Rev. Sci. Instrum
, vol.22
, pp. 912-914
-
-
Anger, H.O.1
-
23
-
-
36949065778
-
Radioassay of aqueous solutions mixed with solid crystalline fluors
-
Steinberg, D. Radioassay of aqueous solutions mixed with solid crystalline fluors. Nature (London) 1959, 183, 1253-1254.
-
(1959)
Nature (London)
, vol.183
, pp. 1253-1254
-
-
Steinberg, D.1
-
24
-
-
1942510184
-
Radioassay of carbon-14 in aqueous solutions by using a liquid scintillation spectrometer
-
Steinberg, D. Radioassay of carbon-14 in aqueous solutions by using a liquid scintillation spectrometer. Nature (London) 1958, 182, 740-741.
-
(1958)
Nature (London)
, vol.182
, pp. 740-741
-
-
Steinberg, D.1
-
26
-
-
4143116643
-
Liquid chromatography-accurate radioisotope counting and microplate scintillation counter technologies in drug metabolism studies
-
Nassar, A.E.F.; Parmentier, Y.; Martinet, M.; Lee, D.Y. Liquid chromatography-accurate radioisotope counting and microplate scintillation counter technologies in drug metabolism studies. J. Chromatogr. Sci. 2004, 42, 348-353.
-
(2004)
J. Chromatogr. Sci
, vol.42
, pp. 348-353
-
-
Nassar, A.E.F.1
Parmentier, Y.2
Martinet, M.3
Lee, D.Y.4
-
27
-
-
23544462582
-
Limits for qualitative detection and quantitative determination: Application to radiochemistry
-
Lurie, L.A. Limits for qualitative detection and quantitative determination: Application to radiochemistry. Anal. Chem. 1968, 40, 586.
-
(1968)
Anal. Chem
, vol.40
, pp. 586
-
-
Lurie, L.A.1
-
28
-
-
33751109698
-
Unterscheidung und Nachweis von Aktivitäten
-
Plesch, R. Unterscheidung und Nachweis von Aktivitäten. Die Atomwirtschaft 1962, 7, 602.
-
(1962)
Die Atomwirtschaft
, vol.7
, pp. 602
-
-
Plesch, R.1
-
29
-
-
33750102850
-
-
Bruin, G.J.; Waldmeier, F; Boernsen, K.O.; Pfaar, U.; Gross, G.; Zollinger, M. A microplate solid scintillation counter as a radioactive detector for high performance liquid chromatrography in drug metabolism: Validation and applications. J. Chromatogr. A 2006, 1133, 184-194.
-
Bruin, G.J.; Waldmeier, F; Boernsen, K.O.; Pfaar, U.; Gross, G.; Zollinger, M. A microplate solid scintillation counter as a radioactive detector for high performance liquid chromatrography in drug metabolism: Validation and applications. J. Chromatogr. A 2006, 1133, 184-194.
-
-
-
-
30
-
-
45849137526
-
Application of filter paper partition chromatography to radioactive tracer studies
-
Fink, R.M.; Dent, C.E.; Fink, K. Application of filter paper partition chromatography to radioactive tracer studies. Nature (London) 1947, 160, 801-803.
-
(1947)
Nature (London)
, vol.160
, pp. 801-803
-
-
Fink, R.M.1
Dent, C.E.2
Fink, K.3
-
31
-
-
33947087114
-
Summary of the state of the art in radiochromatography
-
Prydz, S. Summary of the state of the art in radiochromatography. Anal. Chem. 1973, 45, (14), 2317-2326.
-
(1973)
Anal. Chem
, vol.45
, Issue.14
, pp. 2317-2326
-
-
Prydz, S.1
-
32
-
-
33947490833
-
A Compact radiochemical gas chromatograph
-
James, A.T.; Piper, E.A. A Compact radiochemical gas chromatograph. Anal. Chem. 1963, 35, 515-520.
-
(1963)
Anal. Chem
, vol.35
, pp. 515-520
-
-
James, A.T.1
Piper, E.A.2
-
33
-
-
0028345703
-
Online coupling of packed column supercritical fluid chromatography with multiple wavelength detector and radioactivity flow-through detector
-
Lembke, P.; Engelhardt, H.; Ecker, R. Online coupling of packed column supercritical fluid chromatography with multiple wavelength detector and radioactivity flow-through detector. Chromatographia 1994, 38, (7-8), 491-501.
-
(1994)
Chromatographia
, vol.38
, Issue.7-8
, pp. 491-501
-
-
Lembke, P.1
Engelhardt, H.2
Ecker, R.3
-
34
-
-
0004290503
-
Metabolism and excretion of carbon-14 labeled diethylcarbamazine
-
Bangham, D.R. Metabolism and excretion of carbon-14 labeled diethylcarbamazine. Brit. J. Pharmacol. Chemother. 1955, 10, 397-405.
-
(1955)
Brit. J. Pharmacol. Chemother
, vol.10
, pp. 397-405
-
-
Bangham, D.R.1
-
35
-
-
45849128393
-
A simple helium - ethanol flow counter for monitoring chromatograph-column effluents containing weak beta-emitting isotopes
-
Bangham, D.R. A simple helium - ethanol flow counter for monitoring chromatograph-column effluents containing weak beta-emitting isotopes. Biochem. J. 1956, 62, (4), 552-553.
-
(1956)
Biochem. J
, vol.62
, Issue.4
, pp. 552-553
-
-
Bangham, D.R.1
-
36
-
-
45849132107
-
Continuous determination of carbon-14 and sulfur-35 in aqueous medium by a scintillation device. Application to chromatographic effluents
-
Schram, E.; Lombaert, R. Continuous determination of carbon-14 and sulfur-35 in aqueous medium by a scintillation device. Application to chromatographic effluents. Anal. Chim. Acta 1957, 17, 417-422.
-
(1957)
Anal. Chim. Acta
, vol.17
, pp. 417-422
-
-
Schram, E.1
Lombaert, R.2
-
37
-
-
0003054424
-
Determination of tritium and carbon-14 in aqueous solution with anthracene powder
-
Schram, E.; Lombaert, R. Determination of tritium and carbon-14 in aqueous solution with anthracene powder. Anal. Biochem. 1962, 3, 68-74.
-
(1962)
Anal. Biochem
, vol.3
, pp. 68-74
-
-
Schram, E.1
Lombaert, R.2
-
38
-
-
0345623696
-
Continuous scintillation counting of carbon-14 and tritium in effluent of the automatic amino acid analyzer
-
Piez, K.A. Continuous scintillation counting of carbon-14 and tritium in effluent of the automatic amino acid analyzer. Anal. Biochem. 1962, 4, 444-458.
-
(1962)
Anal. Biochem
, vol.4
, pp. 444-458
-
-
Piez, K.A.1
-
39
-
-
4244071555
-
A continuous flow analyzer for recording of light absorption and radioactivity in the eluates from chromatographic columns
-
Sjoberg, I.; Agren, G. A continuous flow analyzer for recording of light absorption and radioactivity in the eluates from chromatographic columns. Anal. Chem. 1964, 36, (6), 1017-1021.
-
(1964)
Anal. Chem
, vol.36
, Issue.6
, pp. 1017-1021
-
-
Sjoberg, I.1
Agren, G.2
-
40
-
-
0014289167
-
Continuous-flow monitor system for detection of UV absorbance, carbon-14, and tritium effluent of a column chromatogram
-
Hunt, J.A. Continuous-flow monitor system for detection of UV absorbance, carbon-14, and tritium effluent of a column chromatogram. Anal. Biochem. 1968, 23, (2), 289-300.
-
(1968)
Anal. Biochem
, vol.23
, Issue.2
, pp. 289-300
-
-
Hunt, J.A.1
-
41
-
-
45849086211
-
Scintillation counter for continuous monitoring of radioactivity in solutions
-
Clifford, K.H.; Hewett, A.J.W.; Popjak, G.J. Scintillation counter for continuous monitoring of radioactivity in solutions. J. Chromatogr. 1969, 40, (3-4), 377-385.
-
(1969)
J. Chromatogr
, vol.40
, Issue.3-4
, pp. 377-385
-
-
Clifford, K.H.1
Hewett, A.J.W.2
Popjak, G.J.3
-
42
-
-
45849083569
-
Design and evaluation of a microradiometric detector for column liquid chromatography
-
Van Urk-Schoen, A.M.; Huber, J.F.K. Design and evaluation of a microradiometric detector for column liquid chromatography. Anal. Chim. Acta 1970, 52, (3), 519-527.
-
(1970)
Anal. Chim. Acta
, vol.52
, Issue.3
, pp. 519-527
-
-
Van Urk-Schoen, A.M.1
Huber, J.F.K.2
-
43
-
-
2142688933
-
Continuous detection of radioactive effluents in liquid chromatography by heterogeneous or homogeneous scintillation counting
-
Schutte, L. Continuous detection of radioactive effluents in liquid chromatography by heterogeneous or homogeneous scintillation counting. J. Chromatogr. 1972, 72, (2), 303-309.
-
(1972)
J. Chromatogr
, vol.72
, Issue.2
, pp. 303-309
-
-
Schutte, L.1
-
44
-
-
85012812359
-
Application of solid scintillators in high pressure radio column chromatography
-
Sieswerda, G.B.; Polak, H.L. Application of solid scintillators in high pressure radio column chromatography. Liq. Scintill. Count. 1972, 2, 49-59.
-
(1972)
Liq. Scintill. Count
, vol.2
, pp. 49-59
-
-
Sieswerda, G.B.1
Polak, H.L.2
-
45
-
-
45849144825
-
Flow versus batch detection of radioactivity in column liquid chromatography
-
Sieswerda, G.B.; Poppe, H.; Huber, J.F.K. Flow versus batch detection of radioactivity in column liquid chromatography. Anal. Chim. Acta 1975, 78, (2), 343-358.
-
(1975)
Anal. Chim. Acta
, vol.78
, Issue.2
, pp. 343-358
-
-
Sieswerda, G.B.1
Poppe, H.2
Huber, J.F.K.3
-
46
-
-
0017440360
-
Metabolism and pharmacokinetics of piprozoline in rat, dog and man. 2nd communication: Determination of metabolic profiles with the aid of an HPLC-radioactivity detection system following direct injection of urine and bile onto a reversed-phase column (author's transl.)
-
2b, 508-511
-
Hodenberg, A.V.; Klemisch, W.; Vollmer, K.O. Metabolism and pharmacokinetics of piprozoline in rat, dog and man. 2nd communication: Determination of metabolic profiles with the aid of an HPLC-radioactivity detection system following direct injection of urine and bile onto a reversed-phase column (author's transl.). Arzneimittel-Forschung 1977, 27, (2b), 508-511.
-
(1977)
Arzneimittel-Forschung
, vol.27
-
-
Hodenberg, A.V.1
Klemisch, W.2
Vollmer, K.O.3
-
47
-
-
0016431486
-
Novel method of sample transport and its application for continuous detection of radioactivity in the effluent of the high speed amino acid analyzer
-
Bakay, B. Novel method of sample transport and its application for continuous detection of radioactivity in the effluent of the high speed amino acid analyzer. Anal. Biochem. 1975, 63, (1), 87-98.
-
(1975)
Anal. Biochem
, vol.63
, Issue.1
, pp. 87-98
-
-
Bakay, B.1
-
48
-
-
0348249575
-
High-efficiency solid scintillation radioactivity detection for high-performance liquid chromatography
-
Mackey, L.N.; Rodriguez, P.A.; Schroeder, F.B. High-efficiency solid scintillation radioactivity detection for high-performance liquid chromatography. J. Chromatogr. 1981, 208, (1), 1-8.
-
(1981)
J. Chromatogr
, vol.208
, Issue.1
, pp. 1-8
-
-
Mackey, L.N.1
Rodriguez, P.A.2
Schroeder, F.B.3
-
49
-
-
45849093381
-
-
Kessler, M.J. A sensitive radioactivity detector for HPLC. Amer. Lab. 1982, 14, (8), 52, 54, 56, 58-60, 62-63.
-
Kessler, M.J. A sensitive radioactivity detector for HPLC. Amer. Lab. 1982, 14, (8), 52, 54, 56, 58-60, 62-63.
-
-
-
-
50
-
-
0020647708
-
Quantitation of radiolabeled biological molecules separated by high-performance liquid chromatography
-
Kessler, M.J. Quantitation of radiolabeled biological molecules separated by high-performance liquid chromatography. J. Chromatogr. 1983, 255, 209-217.
-
(1983)
J. Chromatogr
, vol.255
, pp. 209-217
-
-
Kessler, M.J.1
-
51
-
-
45849113332
-
2 (Eu) scintillator for high-performance liquid chromatography
-
2 (Eu) scintillator for high-performance liquid chromatography. J. Chromatogr. 1985, 333, (1), 83-92.
-
(1985)
J. Chromatogr
, vol.333
, Issue.1
, pp. 83-92
-
-
Nakamura, Y.1
Koizumi, Y.2
-
52
-
-
0345458441
-
High performance liquid chromatography coupled with radioactivity detection: A powerful tool for determining drug metabolite profiles in biological fluids. Zeitschrift fuer Naturforschung, C
-
Vollmer, K.O.; Klemisch, W.; Von Hodenberg, A. High performance liquid chromatography coupled with radioactivity detection: A powerful tool for determining drug metabolite profiles in biological fluids. Zeitschrift fuer Naturforschung, C: J. Biosci. 1986, 41, (1-2), 115-125.
-
(1986)
J. Biosci
, vol.41
, Issue.1-2
, pp. 115-125
-
-
Vollmer, K.O.1
Klemisch, W.2
Von Hodenberg, A.3
-
53
-
-
0018588737
-
High-pressure liquid chromatography coupled with a radioactivity detector: Investigation into the biotransformations of tritium and carbon-14 labeled compounds
-
Dugger, H.A.; Orwig, B.A. High-pressure liquid chromatography coupled with a radioactivity detector: Investigation into the biotransformations of tritium and carbon-14 labeled compounds. Drug Metab. Rev. 1979, 10, (2), 247-269.
-
(1979)
Drug Metab. Rev
, vol.10
, Issue.2
, pp. 247-269
-
-
Dugger, H.A.1
Orwig, B.A.2
-
54
-
-
0019881119
-
Application of simultaneous UV radioactivity high-performance liquid chromatography to the study of intermediary metabolism. I. Purine nucleotides, nucleosides and bases
-
Webster, H.K.; Whaun, J.M. Application of simultaneous UV radioactivity high-performance liquid chromatography to the study of intermediary metabolism. I. Purine nucleotides, nucleosides and bases. J. Chromatogr. 1981, 209, (2), 283-292.
-
(1981)
J. Chromatogr
, vol.209
, Issue.2
, pp. 283-292
-
-
Webster, H.K.1
Whaun, J.M.2
-
55
-
-
0023586443
-
HPLC analysis of [3H]-arachidonic acid metabolites produced by smooth muscle and endothelial cells in response to leukotriene D4
-
Clark, M.A.; Conway, T.M.; Crooke, S.T. HPLC analysis of [3H]-arachidonic acid metabolites produced by smooth muscle and endothelial cells in response to leukotriene D4. J. Liq. Chromatogr. 1987, 10, (12), 2707-2719.
-
(1987)
J. Liq. Chromatogr
, vol.10
, Issue.12
, pp. 2707-2719
-
-
Clark, M.A.1
Conway, T.M.2
Crooke, S.T.3
-
56
-
-
0037442578
-
On-line liquid chromatographyaccurate radioisotope counting coupled with a radioactivity detector and mass spectrometer for metabolite identification in drug discovery and development
-
Nassar, A.E.F.; Bjorge, S.M.; Lee, D.Y. On-line liquid chromatographyaccurate radioisotope counting coupled with a radioactivity detector and mass spectrometer for metabolite identification in drug discovery and development. Anal. Chem. 2003, 75, (4), 785-790.
-
(2003)
Anal. Chem
, vol.75
, Issue.4
, pp. 785-790
-
-
Nassar, A.E.F.1
Bjorge, S.M.2
Lee, D.Y.3
-
57
-
-
0025313250
-
Direct and reverse flow-through heterogeneous scintillation counting of radiolabeled amino acids using post-column solvent segmentation
-
Veltkamp, A.C.; Das, H.A.; Brinkman, U.A.T. Direct and reverse flow-through heterogeneous scintillation counting of radiolabeled amino acids using post-column solvent segmentation. J. Chromatogr. 1990, 508, (2), 301-308.
-
(1990)
J. Chromatogr
, vol.508
, Issue.2
, pp. 301-308
-
-
Veltkamp, A.C.1
Das, H.A.2
Brinkman, U.A.T.3
-
59
-
-
0023794108
-
14C]-urapidil and its main metabolites in rat plasma, using post-column ion-pair extraction and solvent segmentation techniques
-
14C]-urapidil and its main metabolites in rat plasma, using post-column ion-pair extraction and solvent segmentation techniques. J. Pharmaceut. Biomed. Anal. 1988, 6, (6-8), 609-622.
-
(1988)
J. Pharmaceut. Biomed. Anal
, vol.6
, Issue.6-8
, pp. 609-622
-
-
Veltkamp, A.C.1
Das, H.A.2
Frei, R.W.3
Brinkman, U.A.T.4
-
60
-
-
0024599326
-
Determination of radiolabeled proline and hydroxyproline in collagen hydrolysates by high-performance liquid chromatography with on-line radiometric detection
-
Macek, J.; Lichy, A.; Pesakova, V.; Adam, M. Determination of radiolabeled proline and hydroxyproline in collagen hydrolysates by high-performance liquid chromatography with on-line radiometric detection. J. Chromatogr. 1989, 488, (1), 267-274.
-
(1989)
J. Chromatogr
, vol.488
, Issue.1
, pp. 267-274
-
-
Macek, J.1
Lichy, A.2
Pesakova, V.3
Adam, M.4
-
61
-
-
0020420184
-
Synchronized accumulating radioisotope detector for high-performance liquid chromatography
-
Baba, S.; Horie, M.; Watanabe, K. Synchronized accumulating radioisotope detector for high-performance liquid chromatography. J. Chromatogr. 1982, 244, (1), 57-64.
-
(1982)
J. Chromatogr
, vol.244
, Issue.1
, pp. 57-64
-
-
Baba, S.1
Horie, M.2
Watanabe, K.3
-
62
-
-
45849144103
-
-
www.raytest.com
-
-
-
-
63
-
-
0006243868
-
Incorporation of a RAM cell in a microcolumn for on-column detection of radiolabeled molecules for LC-RAM-ESI-MS
-
Sep
-
Schultz, G.A.; Alexander, J.N., IV. Incorporation of a RAM cell in a microcolumn for on-column detection of radiolabeled molecules for LC-RAM-ESI-MS. J. Microcol. Sep. 1998, 10, (5), 431-437.
-
(1998)
J. Microcol
, vol.10
, Issue.5
, pp. 431-437
-
-
Schultz, G.A.1
Alexander, J.N.I.2
-
64
-
-
0033566025
-
Whole-column radioactivity detection: Simultaneous separation and enhanced detectability
-
Link, J.M.; Synovec, R.E. Whole-column radioactivity detection: Simultaneous separation and enhanced detectability. Anal. Chem. 1999, 71, (14), 2700-2707.
-
(1999)
Anal. Chem
, vol.71
, Issue.14
, pp. 2700-2707
-
-
Link, J.M.1
Synovec, R.E.2
-
65
-
-
0031059632
-
Narrow-bore liquid chromatography-tandem mass spectrometry with simultaneous radioactivity monitoring for partially characterizing the biliary metabolites of an arginine fluoroalkyl ketone analog of D-MePhe-Pro-Arg, a potent thrombin inhibitor
-
Heath, T.G.; Mooney, J.P.; Broersma, R. Narrow-bore liquid chromatography-tandem mass spectrometry with simultaneous radioactivity monitoring for partially characterizing the biliary metabolites of an arginine fluoroalkyl ketone analog of D-MePhe-Pro-Arg, a potent thrombin inhibitor. J. Chromatogr., B: Biomed. Appl. 1997, 688, (2), 281-289.
-
(1997)
J. Chromatogr., B: Biomed. Appl
, vol.688
, Issue.2
, pp. 281-289
-
-
Heath, T.G.1
Mooney, J.P.2
Broersma, R.3
-
66
-
-
0036099429
-
Radiochemical detection for packed capillary liquid chromatography-mass spectrometry
-
Onisko, B.C. Radiochemical detection for packed capillary liquid chromatography-mass spectrometry. J. Amer. Soc. Mass Spectrom. 2002, 13, (1), 82-84.
-
(2002)
J. Amer. Soc. Mass Spectrom
, vol.13
, Issue.1
, pp. 82-84
-
-
Onisko, B.C.1
-
67
-
-
0036027838
-
Comparison of heterogeneous and homogeneous radioactivity flow detectors for simultaneous profiling and LC-MS/MS characterization of metabolites
-
Egnash, L.A.; Ramanathan, R. Comparison of heterogeneous and homogeneous radioactivity flow detectors for simultaneous profiling and LC-MS/MS characterization of metabolites. J. Pharmaceut. Biomed. Anal. 2002, 27, (1-2), 271-284.
-
(2002)
J. Pharmaceut. Biomed. Anal
, vol.27
, Issue.1-2
, pp. 271-284
-
-
Egnash, L.A.1
Ramanathan, R.2
-
68
-
-
45849124283
-
-
www.stopflow.com
-
-
-
-
69
-
-
33947160983
-
Novel approach to performing metabolite identification in drug metabolism
-
Nassar, A.-E.F.; Lee, D.Y. Novel approach to performing metabolite identification in drug metabolism. J. Chromatogr. Sci. 2007, 45, 113-119.
-
(2007)
J. Chromatogr. Sci
, vol.45
, pp. 113-119
-
-
Nassar, A.-E.F.1
Lee, D.Y.2
-
70
-
-
0034663268
-
Use of a microplate scintillation counter as a radioactive detector for miniaturized separtion techniques in drug metabolism
-
Boernsen, K.O.; Floeckher, J.M.; Bruin, G.J.M. Use of a microplate scintillation counter as a radioactive detector for miniaturized separtion techniques in drug metabolism. Anal. Chem. 2000, 72, (16), 3956-3959.
-
(2000)
Anal. Chem
, vol.72
, Issue.16
, pp. 3956-3959
-
-
Boernsen, K.O.1
Floeckher, J.M.2
Bruin, G.J.M.3
-
71
-
-
23444454671
-
Analysis of low level radioactive metabolites in biological fluids using high-performance liquid chromatography with microplate scintillation counting: Method validation and application
-
Zhu, M.; Zhao, W; Vazquez, N; Mitroka, J.G. Analysis of low level radioactive metabolites in biological fluids using high-performance liquid chromatography with microplate scintillation counting: method validation and application. J. Pharm. Biomed. Anal. 2005, 39, 233-245.
-
(2005)
J. Pharm. Biomed. Anal
, vol.39
, pp. 233-245
-
-
Zhu, M.1
Zhao, W.2
Vazquez, N.3
Mitroka, J.G.4
-
72
-
-
33846019976
-
TopCount coupled to ultra-performance liquid chromatography for the profiling of radiolabeld drug metabolites in complex biological samples
-
Dear, G.J.; Patel, N.; Kelly, P.J.; Webber, L.; Yung, M. TopCount coupled to ultra-performance liquid chromatography for the profiling of radiolabeld drug metabolites in complex biological samples. J. Chromatogr. B 2006, 844, 96-103.
-
(2006)
J. Chromatogr. B
, vol.844
, pp. 96-103
-
-
Dear, G.J.1
Patel, N.2
Kelly, P.J.3
Webber, L.4
Yung, M.5
-
73
-
-
0037442597
-
Combination of high-performance liquid chromatography and microplate scintillation counting for crop and animal metabolism studies: A comparison with classical on-line and thin-layer chromatography radioactivity detection
-
Kiffe, M.; Jehle, A.; Ruembeli, R. Combination of high-performance liquid chromatography and microplate scintillation counting for crop and animal metabolism studies: A comparison with classical on-line and thin-layer chromatography radioactivity detection. Anal. Chem. 2003, 75, 723-730.
-
(2003)
Anal. Chem
, vol.75
, pp. 723-730
-
-
Kiffe, M.1
Jehle, A.2
Ruembeli, R.3
-
74
-
-
0842281553
-
The use of 96-well Scintplates to facilitate definitive metabolism studies for drug candidates
-
Nedderman, A.N.R.; Savage, M.E.; White, K.L.; Walker, D.K. The use of 96-well Scintplates to facilitate definitive metabolism studies for drug candidates. J. Pharm. Biomed. Anal. 2004, 34, 607-617.
-
(2004)
J. Pharm. Biomed. Anal
, vol.34
, pp. 607-617
-
-
Nedderman, A.N.R.1
Savage, M.E.2
White, K.L.3
Walker, D.K.4
-
75
-
-
34250696563
-
Cytostar-T plates - A valid alternative for microplate scintillation counting of low radioactivity in combination with high-performance liquid chromatography in drug metabolism studies?
-
Kiffe, M.; Nufer, R.; Trunzer, M.; Graf, D. Cytostar-T plates - A valid alternative for microplate scintillation counting of low radioactivity in combination with high-performance liquid chromatography in drug metabolism studies? J. Chromatogr. A 2007, 1157, (1-2), 65-72.
-
(2007)
J. Chromatogr. A
, vol.1157
, Issue.1-2
, pp. 65-72
-
-
Kiffe, M.1
Nufer, R.2
Trunzer, M.3
Graf, D.4
-
76
-
-
33947234593
-
Two-dimensional liquid chromatography/ mass spectrometry set-up for structural elucidation of metabolites in complex biological matrices
-
Kiffe, M.; Graf, D.; Trunzer, M. Two-dimensional liquid chromatography/ mass spectrometry set-up for structural elucidation of metabolites in complex biological matrices. Rapid Commun. Mass Spectrom. 2007, 21, 961-970.
-
(2007)
Rapid Commun. Mass Spectrom
, vol.21
, pp. 961-970
-
-
Kiffe, M.1
Graf, D.2
Trunzer, M.3
-
77
-
-
0037365932
-
Big physics, small doses: The use of AMS and PET in human microdosing of development drugs
-
Lappin, G.; Garner, R.C. Big physics, small doses: the use of AMS and PET in human microdosing of development drugs. Nature Rev. 2003, 2, 233-240.
-
(2003)
Nature Rev
, vol.2
, pp. 233-240
-
-
Lappin, G.1
Garner, R.C.2
-
78
-
-
0033059135
-
Biomedical applications of accelerator mass spectrometry - isotope measurements at the level of the atom
-
Barker, J.; Garner, R.C. Biomedical applications of accelerator mass spectrometry - isotope measurements at the level of the atom. Rapid Comm. Mass Spectrom. 1999, 13, 285-293.
-
(1999)
Rapid Comm. Mass Spectrom
, vol.13
, pp. 285-293
-
-
Barker, J.1
Garner, R.C.2
-
79
-
-
33748361948
-
The use of accelerator mass spectrometry to obtain early human ADME/PK data. Expert Opin. Drug Metab
-
Lappin, G.; Garner, R.C. The use of accelerator mass spectrometry to obtain early human ADME/PK data. Expert Opin. Drug Metab. Toxicol. 2005, 1, 23-31.
-
(2005)
Toxicol
, vol.1
, pp. 23-31
-
-
Lappin, G.1
Garner, R.C.2
-
80
-
-
0035987901
-
-
14C-labeled (R)-6-[Amino(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl)methyl] -4-(3-chlorophenyl)-1-methyl-2(1H)-quinolinone (R115777), a farnesyl transferase inhibitor. Drug Metab. Disp. 2002, 30, 823-830.
-
14C-labeled (R)-6-[Amino(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl)methyl] -4-(3-chlorophenyl)-1-methyl-2(1H)-quinolinone (R115777), a farnesyl transferase inhibitor. Drug Metab. Disp. 2002, 30, 823-830.
-
-
-
-
81
-
-
0034281129
-
Accelerator mass spectrometry in pharmaceutical research and development - a new ultrasensitive analytical method for isotope measurement
-
Garner, R.C. Accelerator mass spectrometry in pharmaceutical research and development - a new ultrasensitive analytical method for isotope measurement. Curr. Drug Metab. 2000, 1, 205-213.
-
(2000)
Curr. Drug Metab
, vol.1
, pp. 205-213
-
-
Garner, R.C.1
|