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For an application of Hartwig's tandem intra- intermolecular method for the synthesis of C-3 aryloxindoles, see; Trost, B. M.; Frederiksen, M. U. Angew. Chem., Int. Ed. 2005, 44, 308.
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The susceptibility of oxindole enolates to oxidation is known, see, for example, ref 5c
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The susceptibility of oxindole enolates to oxidation is known, see, for example, ref 5c.
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Detailed studies of this process are beyond the scope of this Letter. However, we have established that simply stirring isolated 3-aryl oxindoles in a THF/PhMe mix open to air is not sufficient to produce the oxidized products.
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Detailed studies of this process are beyond the scope of this Letter. However, we have established that simply stirring isolated 3-aryl oxindoles in a THF/PhMe mix open to air is not sufficient to produce the oxidized products.
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