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Volumn 10, Issue 7, 2008, Pages 1413-1415

Palladium-catalyzed α-arylation of oxindoles

Author keywords

[No Author keywords available]

Indexed keywords

INDOLE DERIVATIVE; OXINDOLE; PALLADIUM;

EID: 45849117260     PISSN: 15237060     EISSN: None     Source Type: Journal    
DOI: 10.1021/ol800141t     Document Type: Article
Times cited : (84)

References (39)
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    • Gribkoff, V. K.; Starrett, J. E., Jr.; Dworetzky, S. I.; Hewawasam, P.; Boissard, C. G.; Cook, D. A.; Frantz, S. W.; Heman, K.; Hibbard, J. R.; Huston, K.; Johnson, G.; Krishnan, B. S.; Kinney, G. G.; Lombardo, L. A.; Meanwell, N. A.; Molinoff, P. B.; Myers, R. A.; Moon, S. L.; Ortiz, A.; Pajor, L.; Pieschl, R. L.; Post-Munson, D. J.; Signor, L. J.; Srinivas, N.; Taber, M. T.; Thalody, G.; Trojnacki, J. T.; Wiener, H.; Yeleswaram. K.; Yeola, S. W. Nat. Med. 2001, 7, 471.
    • (a) Gribkoff, V. K.; Starrett, J. E., Jr.; Dworetzky, S. I.; Hewawasam, P.; Boissard, C. G.; Cook, D. A.; Frantz, S. W.; Heman, K.; Hibbard, J. R.; Huston, K.; Johnson, G.; Krishnan, B. S.; Kinney, G. G.; Lombardo, L. A.; Meanwell, N. A.; Molinoff, P. B.; Myers, R. A.; Moon, S. L.; Ortiz, A.; Pajor, L.; Pieschl, R. L.; Post-Munson, D. J.; Signor, L. J.; Srinivas, N.; Taber, M. T.; Thalody, G.; Trojnacki, J. T.; Wiener, H.; Yeleswaram. K.; Yeola, S. W. Nat. Med. 2001, 7, 471.
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    • (b) Hewawasam, P.; Gribkoff, V. K.; Pendri, Y.; Dworetzky, S. I.; Boissard, C. G.; Martinez, E.; Post-Munson, D. J.; Trojnacki, J. T.; Yeleswaram, K.; Pajor, L. M.; Knipe, J.; Gao, Q.; Perrone, R.; Starrett, J. E., Jr. Bioorg. Med. Chem. Lett. 2002, 12, 1023.
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    • During the preparation of this manuscript a report detailing the α-vinylation of an oxindole derivative appeared: Huang, J.; Bunel, E.; Faul, M. M. Org. Lett. 2007, 9, 4343.
    • During the preparation of this manuscript a report detailing the α-vinylation of an oxindole derivative appeared: Huang, J.; Bunel, E.; Faul, M. M. Org. Lett. 2007, 9, 4343.
  • 34
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    • For an application of Hartwig's tandem intra- intermolecular method for the synthesis of C-3 aryloxindoles, see; Trost, B. M.; Frederiksen, M. U. Angew. Chem., Int. Ed. 2005, 44, 308.
    • For an application of Hartwig's tandem intra- intermolecular method for the synthesis of C-3 aryloxindoles, see; Trost, B. M.; Frederiksen, M. U. Angew. Chem., Int. Ed. 2005, 44, 308.
  • 38
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    • The susceptibility of oxindole enolates to oxidation is known, see, for example, ref 5c
    • The susceptibility of oxindole enolates to oxidation is known, see, for example, ref 5c.
  • 39
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    • Detailed studies of this process are beyond the scope of this Letter. However, we have established that simply stirring isolated 3-aryl oxindoles in a THF/PhMe mix open to air is not sufficient to produce the oxidized products.
    • Detailed studies of this process are beyond the scope of this Letter. However, we have established that simply stirring isolated 3-aryl oxindoles in a THF/PhMe mix open to air is not sufficient to produce the oxidized products.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.