Long-Term Effects of Phytoestrogen Daidzein on Penile Cavernosal Structures in Adult Rats

Urology

Volumn 72, Issue 1, 2008, Pages 220-224

  Huang, Yufeng ^a   Pan, Lianjun ^a   Xia, Xinyi ^a   Feng, Yao ^a   Jiang, Chunxia ^a   Cui, Yingxia ^a  

^a MEDICAL SCHOOL OF NANJING UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGEN FIBER; DAIDZEIN;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CORPUS CAVERNOSUM; DRUG MEGADOSE; ELASTIC FIBER; ERECTILE DYSFUNCTION; IMMUNOHISTOCHEMISTRY; LOW DRUG DOSE; MALE; NONHUMAN; PENIS ERECTION; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RAT; SMOOTH MUSCLE FIBER;

ANIMALS; COLLAGEN; DIETHYLSTILBESTROL; ELASTIC TISSUE; ESTROGENS, NON-STEROIDAL; ISOFLAVONES; MALE; MUSCLE, SMOOTH; PENIS; PHYTOESTROGENS; RATS; RATS, SPRAGUE-DAWLEY;

EID: 45849113606     PISSN: 00904295     EISSN: 15279995     Source Type: Journal    
DOI: 10.1016/j.urology.2007.11.064     Document Type: Article

References (26)

1. Kurzer M.S., and Xu X. Dietary phytoestrogens. Annu Rev Nutr 17 (1997) 353-381
2. Branca F., and Lorenzetti S. Health effects of phytoestrogens. Forum Nutr 57 (2005) 100-111
3. Santti R., Makela S., Strauss L., et al. Phytoestrogens: potential endocrine disruptors in males. Toxicol Ind Health 14 (1998) 223-237
4. Traish A.M., Park K., Dhir V., et al. Effects of castration and androgen replacement on erectile function in a rabbit model. Endocrinology 140 (1999) 1861-1868
5. Pan L., Xia X., Feng Y., et al. Exposure to the phytoestrogen daidzein attenuates apomorphine-induced penile erection concomitant with plasma testosterone level reduction in dose and time-related manner in adult rats. Urology 70 (2007) 613-617
6. Wei A.Y., Cheng Y., and Li Y.G. Effect of elastic fiber alterations in the tunica albuginea of the penis on erectile function of diabetic rats. Nan Fang Yi Ke Da Xue Xue Bao 27 (2007) 276-278
7. Toblli J.E., Stella I., Inserra F., et al. Morphological changes in cavernous tissue in spontaneously hypertensive rats. Am J Hypertens 13 (2000) 686-692
8. Christ G.J., and Lue T. Physiology and biochemistry of erections. Endocrine 23 (2004) 93-100
9. Palese M.A., Crone J.K., and Burnett A.L. A castrated mouse model of erectile dysfunction. J Androl 24 (2003) 699-703
10. Nehra A., Azadzoi K.M., Moreland R.B., et al. Cavernosal expandability is an erectile tissue mechanical property which predicts trabecular histology in an animal model of vasculogenic erectile dysfunction. J Urol 159 (1998) 2229m-2236m
11. Laurent C., Hellström S., Engström-Laurent A., et al. Localization and quantity of hyaluronan in urogenital organs of male and female rats. Cell Tissue Res 279 (1995) 241-248
12. Raviv G., Kiss R., Vanegas J.P., et al. Objective measurement of the different collagen types in the corpus cavernosum of potent and impotent men: an immunohistochemical staining with computerized-image analysis. World J Urol 15 (1997) 50-55
13. Traish A.M., and Guay A.T. Are androgens critical for penile erections in humans?. Examining the clinical and preclinical evidence. J Sex Med 3 (2006) 382-404
14. Traish A.M., and Kim N. The physiological role of androgens in penile erection: regulation of corpus cavernosum structure and function. J Sex Med 2 (2005) 759-770
15. Mowa C.N., Jesmin S., and Miyauchi T. The penis: a new target and source of estrogen in male reproduction. Histol Histopathol 21 (2006) 53-67
16. Crescioli C., Maggi M., Vannelli G.B., et al. Expression of functional estrogen receptors in human fetal male external genitalia. J Clin Endocrinol Metab 88 (2003) 1815-1824
17. Gingerich S., and Krukoff T.L. Estrogen modulates endothelial and neuronal nitric oxide synthase expression via an estrogen receptor beta-dependent mechanism in hypothalamic slice cultures. Endocrinology 146 (2005) 2933-2941
18. Yang S., Bae L., and Zhang L. Estrogen increases eNOS and NOx release in human coronary artery endothelium. J Cardiovasc Pharmacol 36 (2000) 242-247
19. Räthel T.R., Leikert J.F., Vollmar A.M., et al. The soy isoflavone genistein induces a late but sustained activation of the endothelial nitric oxide-synthase system in vitro. Br J Pharmacol 144 (2005) 394-399
20. Pan L., Xia X., Feng Y., et al. Exposure of juvenile rats to phytoestrogen daidzein impairs erectile function in a dose-related manner at adulthood. J Androl 29 (2008) 55-62
21. Moreland R.B. Pathophysiology of erectile dysfunction: the contributions of trabecular structure to function and the role of functional antagonism. Int J Impot Res 12 suppl 4 (2000) S39-S46
22. Moreland R.B. Is there a role of hypoxemia in penile fibrosis: a viewpoint presented to the Society for the Study of Impotence. Int J Impot Res 10 (1998) 113-120
23. Berk J.L., Massoomi N., Hatch C., et al. Hypoxia downregulates tropoelastin gene expression in rat lung fibroblasts by pretranslational mechanisms. Am J Physiol 277 (1999) L566-L572
24. Berk J.L., Hatch C.A., Morris S.M., et al. Hypoxia suppresses elastin repair by rat lung fibroblasts. Am J Physiol Lung Cell Mol Physiol 289 (2005) L931-L936
25. Faqi A.S., Johnson W.D., Morrissey R.L., et al. Reproductive toxicity assessment of chronic dietary exposure to soy isoflavones in male rats. Reprod Toxicol 18 (2004) 605-611
26. Stopper H., Schmitt E., and Kobras K. Genotoxicity of phytoestrogens. Mutat Res 574 (2005) 139-155