Acute expression of hepatitis C core protein in adult mouse liver: Mitochondrial stress and apoptosis

Scandinavian Journal of Gastroenterology

Volumn 43, Issue 6, 2008, Pages 747-755

  Chang, Ming Ling ^a,e   Chen, Jeng Chang ^b   Chang, Ming Yu ^a   Yeh, Chau Ting ^a   Lin, Wei Pin ^a   Liang, Chun Kai ^a   Huang, Shiu Feng ^c   Dang, Kim N ^d   Chiu, Cheng Tang ^a   Lin, Deng Yn ^a  

^a CHANG GUNG UNIVERSITY   (Taiwan)

^b CHANG GUNG UNIVERSITY COLLEGE OF MEDICINE   (Taiwan)

^c NATIONAL HEALTH RESEARCH INSTITUTES   (Taiwan)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e CHANG GUNG MEMORIAL HOSPITAL   (Taiwan)

Author keywords

Apoptosis; HCV core; Hepatic steatosis; Mitochondria; Tetracycline off; Transgenic mice

Indexed keywords

CASPASE 3; CORE PROTEIN; HEPATITIS C CORE PROTEIN; THIOREDOXIN; THIOREDOXIN 2; VIRUS PROTEIN;

ACUTE HEPATITIS; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELLULAR DISTRIBUTION; CELLULAR IMMUNITY; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; ENZYME ACTIVITY; FATTY LIVER; HEPATITIS C VIRUS; LIPID VESICLE; LIVER; LIVER CELL; MITOCHONDRIAL RESPIRATION; MORPHOLOGY; MOUSE; NICK END LABELING; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; TRANSGENIC MOUSE;

ANIMALS; APOPTOSIS; CASPASE 3; CASPASE 9; FATTY LIVER; HEPATITIS C ANTIGENS; HEPATOCYTES; IMMUNOHISTOCHEMISTRY; IN SITU NICK-END LABELING; LIVER; MICE; MICE, TRANSGENIC; MITOCHONDRIA, LIVER; ORGANELLES; OXIDATIVE STRESS; THIOREDOXINS; VIRAL CORE PROTEINS;

EID: 45749131483     PISSN: 00365521     EISSN: 15027708     Source Type: Journal    
DOI: 10.1080/00365520701875987     Document Type: Article

References (32)

1. Liang TJ, Heller T. Pathogenesis of hepatitis C-associated hepatocellular carcinoma. Gastroenterology 2004;127: S62-71.
2. Cooper S, Erickson AL, Adams EJ, Kansopon J. Analysis of a successful immune response against hepatitis C virus. Immunity 1999;10:439-49. 2002;169:3447-58.
3. Collier JD, Woodall T, Wight DG, Shore S, Gimson AE, Alexander GJ. Predicting progressive hepatic fibrosis stage on subsequent liver biopsy in chronic hepatitis C virus infection. J Viral Hepat 2005;12:74-80.
4. Ghany MG, Kleiner DE, Alter H, Doo E, Khokar F, Promrat K, et al. Progression of fibrosis in chronic hepatitis C. Gastroenterology 2003;124:97-104.
5. Koike K, Moriya K. Metabolic aspects of hepatitis C viral infection: steatohepatitis resembling but distinct from NASH. J Gastroenterol 2005;40:329-36.
6. Ray RB, Ray R, Collier JD. Hepatitis C virus core protein: intriguing properties and functional relevance. FEMS Microbiol Lett 2001;202:149-56.
7. Tsutsumi T, Suzuki T, Moriya K, Shintani Y, Fujie H, Miyoshi H, et al. Hepatitis C virus core protein activates ERK and p38 MAPK in cooperation with ethanol in transgenic mice. Hepatology 2003;38:820-8.
8. Okuda M, Li K, Beard MR, Showalter LA, Scholle F, Lemon SM, et al. Mitochondrial injury, oxidative stress, and antioxidant gene expression are induced by hepatitis C virus core protein. Gastroenterology 2002;122:366-75.
9. Alonzi T, Agrati C, Costabile B, Cicchini C, Amicone L, Cavallari C, et al. Steatosis and intrahepatic lymphocyte recruitment in hepatitis C virus transgenic mice. J Gen Virol 2004;85:1509-20.
10. Korenaga M, Wang T, Li Y, Showalter LA, Chan T, Sun J, et al. Hepatitis C virus core protein inhibits mitochondrial electron transport and increases ROS production. J Biol Chem 2005;280:37481-8.
11. Lerat H, Honda M, Beard MR, Loesch K, Sun J, Yang Y, et al. Steatosis and liver cancer in transgenic mice expressing the structural and nonstructural proteins of hepatitis C virus. Gastroenterology 2002;122:352-65.
12. Moriya K, Fujie H, Shintani Y, Yotsuyanagi H, Tsutsumi T, Ishibashi K, et al. The core protein of hepatitis C virus induces hepatocellular carcinoma in transgenic mice. Nat Med 1998;4:1065-7.
13. Shintani Y, Fujie H, Miyoshi H, Tsutsumi T, Tsukamoto K, Kimura S, et al. Hepatitis C virus infection and diabetes: direct involvement of the virus in the development of insulin resistance. Gastroenterology 2004;126:840-8.
14. Yap SH, Willems M, Van den Oord J, Habets W, Middeldorp JM, Hellings JA, et al. Detection of hepatitis C virus antigen by immuno-histochemical staining: a histological marker of hepatitis C virus infection. J Hepatol 1994;20: 275-81.
15. Wakita T, Taya C, Katsume A, Kato J, Yonekawa H, Kanegae Y, et al. Efficient conditional transgene expression in hepatitis C virus cDNA transgenic mice mediated by the Cre/loxP system. J Biol Chem 1998;273:9001-6.
16. Kistner A, Gossen M, Zimmermann F, Jerecic J, Ullmer C, Lubbert H, et al. Doxycycline-mediated quantitative and tissue-specific control of gene expression in transgenic mice. Proc Natl Acad Sci USA 1996;93:10933-8.
17. Bukh J, Purcell RH, Miller RH. Sequence analysis of the core gene of 14 hepatitis C virus genotypes. Proc Natl Acad Sci USA 1994;91:8239-43.
18. Wang R, Ferrell LD,Faouzi S, Maher JJ, Bishop JM. Activation of the Met receptor by cell attachment induces and sustains hepatocellular carcinomas in transgenic mice. J Cell Biol 2001;153:1023-34.
19. Desai BN, Myers BR, Schreiber SL. FKBP12-rapamycin-associated protein associates with mitochondria and senses osmotic stress via mitochondrial dysfunction. Proc Natl Acad Sci USA 2002;99:4319-24.
20. Shachaf CM, Kopelman AM, Arvanitis C, Karlsson A, Beer S, Mandl S, et al. MYC inactivation uncovers pluripotent differentiation and tumour dormancy in hepatocellular cancer. Nature 2004;431:1112-7.
21. Suzuki R, Sakamoto S, Tsutsumi T, Rikimaru A, Tanaka K, Shimoike T, et al. Molecular determinants for subcellular localization of hepatitis C virus core protein. J Virol 2005;79: 1271-81.
22. Schwer B, Ren S, Pietschmann T, Kartenbeck J, Kaehlcke K, Bartenschlager R, et al. Targeting of hepatitis C virus core protein to mitochondria through a novel C-terminal localization motif. J Virol 2004;78:7958-68.
23. Powis G, Montfort WR. Properties and biological activities of thioredoxins. Annu Rev Biophys Biomol Struct 2001;30: 421-55.
24. Tanaka T, Hosoi F, Yamaguchi-Iwai Y, Nakamura H, Masutani H, Ueda S, et al. Thioredoxin-2 (TRX-2) is an essential gene regulating mitochondria-dependent apoptosis. Embo J 2002;21:1695-703.
25. Conrad M, Jakupoglu C, Moreno SG, Lippl S, Banjac A, Schneider M, et al. Essential role for mitochondrial thioredoxin reductase in hematopoiesis, heart development, and heart function. Mol Cell Biol 2004;24:9414-23.
26. Nouri-Aria KT, Sallie R, Mizokami M, Portmann BC, Williams R. Intrahepatic expression of hepatitis C virus antigens in chronic liver disease. J Pathol 1995;175:77-83.
27. Rullier A, Trimoulet P, Urbaniak R, Winnock M, Zauli D, Ballardini G, et al. Immunohistochemical detection of HCV in cirrhosis, dysplastic nodules, and hepatocellular carcinomas with parallel tissue quantitative RT-PCR. Mod Pathol 2001;14:496-505.
28. Santolini E, Migliaccio G, La Monica N. Biosynthesis and biochemical properties of the hepatitis C virus core protein. J Virol 1994;68:3631-41.
29. McLauchlan J, Lemberg MK, Hope G, Martoglio B. Intramembrane proteolysis promotes trafficking of hepatitis C virus core protein to lipid droplets. Embo J 2002;21: 3980-8.
30. Yasui K, Wakita T, Tsukiyama-Kohara K, Funahashi SI, Ichikawa M, Kajita T, et al. The native form and maturation process of hepatitis C virus core protein. J Virol 1998;72: 6048-55.
31. Jaeckel E, Cornberg M, Wedemeyer H, Santantonio T, Mayer J, Zankel M, et al. German Acute Hepatitis C Therapy Group. Treatment of acute hepatitis C with interferon alfa-2b. N Engl J Med 2001;345:1452-7.
32. Schaible UE, Winau F, Sieling PA, Fischer K, Collins HL, Hagens K, et al. Apoptosis facilitates antigen presentation to T lymphocytes through MHC-I and CD1 in tuberculosis. Nat Med 2003;9:1039-46.