Identification of regions required for apical membrane localization of human multidrug resistance protein 2

Molecular Pharmacology

Volumn 74, Issue 1, 2008, Pages 9-19

  Bandler, Paul E ^a,b   Westlake, Christopher J ^a,c   Grant, Caroline E ^a   Cole, Susan P C ^a   Deeley, Roger G ^a  

^a QUEEN S UNIVERSITY   (Canada)

^b ROYAL MILITARY COLLEGE OF CANADA   (Canada)

^c GENENTECH INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCURONIDE; GLUTATHIONE; HYBRID PROTEIN; MULTIDRUG RESISTANCE PROTEIN 1; MULTIDRUG RESISTANCE PROTEIN 2;

ANIMAL CELL; APICAL MEMBRANE; ARTICLE; CONTROLLED STUDY; GENE MUTATION; MOLECULAR INTERACTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN LOCALIZATION;

AMINO ACID MOTIFS; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMALS; ARGININE; AZIDES; BACULOVIRIDAE; CELL LINE; CELL MEMBRANE; CELL POLARITY; CYTOPLASM; DOGS; EPITHELIAL CELLS; GLUTAMIC ACID; GLUTATHIONE; GLYCINE; HUMANS; LEUKOTRIENE C4; LLC-PK1 CELLS; LYSINE; MOLECULAR SEQUENCE DATA; P-GLYCOPROTEINS; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; PROTEIN TRANSPORT; SEQUENCE HOMOLOGY, AMINO ACID; SPODOPTERA; SWINE; TRANSFECTION;

EID: 45749127384     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.108.045674     Document Type: Article

References (38)

1. Babenko AP and Bryan J (2003) SUR domains that associate with and gate KATP pores define a novel gatekeeper. J Biol Chem 278:41577-41580.
2. Bakos E, Evers R, Calenda G, Tusnády GE, Szakács G, Váradi A, and Sarkadi B. (2000) Characterization of the amino-terminal regions in the human multidrug resistance protein (MRP1). J Cell Sci 113:4451-4461.
3. Bakos E, Evers R, Szakacs G, Tusnády GE, Welker E, Szabo K, de Haas M, van Deemter L, Borst P, Varadi A, et al. (1998) Functional multidrug resistance protein (MRP1) lacking the NH2-terminal transmembrane domain. J Biol Chem 273:32167-32175.
4. Ciaccio PJ, Shen H, Kruh GD, and Tew KD (1996) Effects of chronic ethacrynic acid exposure on glutathione conjugation and MRP expression in human colon tumor cells. Biochem Biophys Res Commun 222:111-115.
5. Cole SPC, Bhardwaj G, Gerlach JH, Mackie JE, Grant CE, Almquist KC, Stewart AJ, Kurz EU, Duncan AM, and Deeley RG (1992) Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line. Science 258:1650-1654.
6. Cui Y, Konig J, Buchholz JK, Spring H, Leier I, and Keppler D (1999) Drug resistance and ATP-dependent conjugate transport mediated by the apical multidrug resistance protein, MRP2, permanently expressed in human and canine cells. Mol Pharmacol 55:929-937.
7. Deeley RG, Westlake C, and Cole SPC (2006) Transmembrane transport of endo- and xenobiotics by mammalian ATP-binding cassette multidrug resistance proteins. Physiol Rev 86:849-899.
8. Fernández SB, Hollo Z, Kern A, Bakos E, Fischer PA, Borst P, and Evers R (2002) Role of the NH2-terminal transmembrane region of the multidrug resistance protein MRP2 in routing to the apical membrane in MDCKII cells. J Biol Chem 277:31048-31055.
9. Fivaz M and Meyer T (2003) Specific localization and timing in neuronal signal transduction mediated by protein-lipid interactions. Neuron 40:319-330.
10. 4 transport by co-expression of both half-molecules of human multidrug resistance protein in insect Sf21 cells. J Biol Chem 271:27782-27787.
11. 4. J Biol Chem 273:10733-10740.
12. Heo WD, Inoue T, Park WS, Kim ML, Park BO, Wandless TJ, and Meyer T (2006) PI(3,4,5)P3 and PI(4,5)P2 lipids target proteins with polybasic clusters to the plasma membrane. Science 314:1458-1461.
13. 2 terminus. J Biol Chem 272:23623-23630.
14. Hipfner DR, Gao M, Scheffer G, Scheper RJ, Deeley RG, and Cole SPC (1998) Epitope mapping of monoclonal antibodies specific for the 190-kDa multidrug resistance protein (MRP). Br J Cancer 78:1134-1140.
15. Hung Y and Sheng M (2002) PDZ domains: structural modules for protein complex assembly. J Biol Chem 277:5699-5702.
16. 1254 in the multispecific organic anion transporter, multidrug resistance protein 2 (MRP2) (ABCC2), alters substrate specificity and results in loss of methotrexate transport activity. J Biol Chem 276:38108-38114.
17. Ito K, Weigl KE, Deeley RG, and Cole SPC (2003) Mutation of proline residues in the NH(2)-terminal region of the multidrug resistance protein, MRP1 (ABCC1): effects on protein expression, membrane localization, and transport function. Biochim Biophys Acta 1615:103-114.
18. Keppler D, Leier I, and Jedlitschky G (1997) Transport of glutathione conjugates and glucuronides by the multidrug resistance proteins MRP1 and MRP2. Biol Chem 378:787-791.
19. Kikuchi S, Hata M, Fukumoto K, Yamane Y, Matsui T, Tamura A, Yonemura S, Yamagishi H, Keppler D, Tsukita S, et al. (2002) Radixin deficiency causes conjugated hyperbilirubinemia with loss of Mrp2 from bile canalicular membranes. Nat Genet 31:320-325.
20. Konno T, Ebihara T, Hisaeda K, Uchiumi T, Nakamura T, Shirakusa T, Kuwano M, and Wada M (2003) Identification of domains participating in the substrate specificity and subcellular localization of the multidrug resistance proteins MRP1 and MRP2. J Biol Chem 278:22908-22917.
21. Kubitz R, Huth C, Schmitt M, Horbach A, Kullak-Ublick G, and Häussinger D (2001) Protein kinase C-dependent distribution of the multidrug resistance protein 2 from the canalicular to the basolateral membrane in human HepG2 cells. Hepatology 34:340-350.
22. Leslie EM, Deeley RG, and Cole SP (2008) Multidrug resistance proteins: P-glycoprotein, MRP1, MRP12, and BCRP (ABCG2) in tissue defence. Toxicol Appl Pharmacol 204:216-237.
23. Mason DL and Michaelis S (2002) Requirement of the NH2-terminal extension for vacuolar trafficking and transport activity of yeast Ycf1p, an ATP-binding cassette transporter. Mol Biol Cell 13:4443-4455.
24. Nies AT, Konig J, Cui Y, Brom M, Spring H, and Keppler D (2002) Structural requirements for the apical sorting of human multidrug resistance protein 2 (ABCC2). Eur J Biochem 269:1866-1876.
25. Paulusma CC, Kool M, Bosma PJ, Scheffer GL, Borg F, Scheper RJ, Tytgat GN, Borst P, Baas F, and Oude Elferink RP (1997) A mutation in the human canalicular multispecific organic anion transporter gene causes the Dubin-Johnson syndrome. Hepatology 25:1539-1542.
26. Paulusma CC, van Geer MA, Evers R, Heijn M, Ottenhoff R, Borst P, and Oude Elferink RP (1999) Canalicular multispecific organic anion transporter/multidrug resistance protein 2 mediates low-affinity transport of reduced glutathione. Biochem J 338:393-401.
27. 35S]glutathione. J Biol Chem 277:35225-35231.
28. 2- and COOH-proximal halves of the protein. J Biol Chem 276:38636-38644.
29. Qian YM, Song WC, Cui H, Cole SPC, and Deeley RG (2001b) Glutathione stimulates sulfated estrogen transport by multidrug resistance protein 1. J Biol Chem 276: 6404-6411.
30. 1 epithelial cells. J Biol Chem 273:26862-26869.
31. Sundaram M, Cook HW, and Byers DM (2004) The MARCKS family of phospholipid binding proteins: regulation of phospholipase D and other cellular components. Biochem Cell Biol 82:191-200.
32. Tusnády GE, Bakos E, Varadi A, and Sarkadi B (1997) Membrane topology distinguishes a subfamily of the ATP-binding cassette (ABC) transporters. FEBS Lett 402:1-3.
33. Van Aubel RA, Hartog A, Bindels RJ, Van Os CH, and Russel FG (2000) Expression and immunolocalization of multidrug resistance protein 2 in rabbit small intestine. Eur J Pharmacol 400:195-198.
34. 2-terminal membrane spanning domain of multidrug resistance protein 1/ABCC1 in protein processing and trafficking. Mol Biol Cell 16:2483-2492.
35. Westlake CJ, Payen L, Gao M, Cole SPC, and Deeley RG (2004) Identification and characterization of functionally important elements in the multidrug resistance protein 1 COOH-terminal region. J Biol Chem 279:53571-53583.
36. Westlake CJ, Qian YM, Gao M, Vasa M, Cole SPC, and Deeley RG (2003) Identification of the structural and functional boundaries of the multidrug resistance protein 1 cytoplasmic loop 3. Biochemistry 42:14099-14113.
37. Yeung T, Gilbert GE, Shi J, Silvius J, Kapus A, and Grinstein S (2008) Membrane phosphatidylserine regulates surface charge and protein localization. Science 319:210-213.
38. Yonemura S, Hirao M, Doi Y, Takahashi N, Kondo T, Tsukita S, and Tsukita S (1998) Ezrin/radixin/moesin (ERM) proteins bind to a positively charged amino acid cluster in the juxta-membrane cytoplasmic domain of CD44, CD43, and ICAM-2. J Cell Biol 140:885-895.