Probing the pharmacophore of ginkgolides as glycine receptor antagonists

Journal of Medicinal Chemistry

Volumn 50, Issue 7, 2007, Pages 1610-1617

  Jensen, Anders A ^a   Begum, Nasreen ^a   Vogensen, Stine B ^a   Knapp, Kolja M ^a   Gundertofte, Klaus ^b   Dzyuba, Sergei V ^c   Ishii, Hideki ^c   Nakanishi, Koji ^c   Kristiansen, Uffe ^a   Strømgaard, Kristian ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b H LUNDBECK A S   (Denmark)

^c Och Spine at New York Presbyterian Hospitals   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID; GINKGOLIDE; GINKGOLIDE A; GINKGOLIDE B; GINKGOLIDE C; GINKGOLIDE J; GLYCINE; GLYCINE RECEPTOR; GLYCINE RECEPTOR ALPHA1; GLYCINE RECEPTOR ALPHA1BETA; GLYCINE RECEPTOR ALPHA2; GLYCINE RECEPTOR ANTAGONIST; UNCLASSIFIED DRUG;

ARTICLE; CELL STRAIN HEK293; DATA BASE; DRUG RECEPTOR BINDING; DRUG SCREENING; HUMAN; HUMAN CELL; PHARMACOPHORE; RECEPTOR BLOCKING; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

CELL LINE; CRYSTALLOGRAPHY, X-RAY; DATABASES, FACTUAL; GINKGOLIDES; HUMANS; MEMBRANE POTENTIALS; MODELS, MOLECULAR; PATCH-CLAMP TECHNIQUES; RECEPTORS, GLYCINE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 34147163430     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm070003n     Document Type: Article

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