Cinnamyl derivatives: Synthesis and factor Xa (FXa) inhibitory activities

Chemical and Pharmaceutical Bulletin

Volumn 56, Issue 6, 2008, Pages 758-770

  Noguchi, Tetsuji ^a   Tanaka, Naoki ^a   Nishimata, Toyoki ^a   Goto, Riki ^a   Hayakawa, Miho ^a   Sugidachi, Atsuhiro ^a   Ogawa, Taketoshi ^a   Asai, Fumitoshi ^a   Fujimoto, Koichi ^a  

^a DAIICHI SANKYO CO   (Japan)

Author keywords

Anticoagulant; Cinnamyl derivative; Factor Xa (FXa) inhibitory activity

Indexed keywords

3 [3 [4 [1 (ACETIMIDOYL)PIPERIDIN 4 YLOXY]PHENYLAMINO] 1 PROPENYL]BENZAMIDINE; BLOOD CLOTTING FACTOR 10A INHIBITOR; CINNAMIC ACID DERIVATIVE; N [3 [1 (TERT BUTOXYCARBONYL)PIPERIDIN 3 YLOXY]PHENYL] N [[3 (3 CYANOPHENYL) 2 PROPENYL]SULFAMOYL]ACETIC ACID; N [4 [1 (ACETIMIDOYL)PIPERIDIN 4 YLOXY] 3 CARBAMOYLPHENYL] N [3 (3 AMIDINOPHENYL) 2 PROPENYL]SULFAMOYL]ACETIC ACIC; N [4 [1 (ACETIMIDOYL)PIPERIDIN 4 YLOXY] 3 CHLOROPHENYL] N [3 (3 AMIDINOPHENYL) 2 PROPENYL]SULFAMOYL]ACETIC ACID; N [4 [1 (ACETIMIDOYL)PIPERIDIN 4 YLOXY] 3 CHLOROPHENYL] N [[3 (3 AMIDINOPHENYL) 2 PROPENYL]SULFAMOYL]ACETIC ACID; N [4 [1 (ACETIMIDOYL)PIPERIDIN 4 YLOXY]PHENYL] N [3 (3 AMIDINOPHENYL) 2 PROPENYL]ETHANESULFONAMIDE; N [4 [1 (ACETIMIDOYL)PIPERIDIN 4 YLOXY]PHENYL] N [3 (3 AMIDINOPHENYL)PROPYL]ETHANESULFONAMIDE; N [4 [1 (ACETIMIDOYL)PIPERIDIN 4 YLOXY]PHENYL] N [3 (3 FLUOROPHENYL) 2 PROPENYL]ETHANESULFONAMIDE; N [4 [1 (ACETIMIDOYL)PIPERIDIN 4 YLOXY]PHENYL] N [[3 (3 AMIDINOPHENYL) 2 PROPENYL]SULFAMOYL]ACETIC ACID;

ANTICOAGULATION; ARTICLE; CONTROLLED STUDY; DRUG POTENCY; DRUG SAFETY; DRUG SYNTHESIS; HUMAN; IC 50; IN VITRO STUDY; IN VIVO STUDY; MALE; NONHUMAN; STRUCTURE ACTIVITY RELATION;

ANIMALS; BLOOD COAGULATION; CINNAMATES; CRICETINAE; FACTOR XA; HUMANS; INDICATORS AND REAGENTS; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MASS SPECTROMETRY; TRYPSIN INHIBITORS;

EID: 45749086466     PISSN: 00092363     EISSN: 13475223     Source Type: Journal    
DOI: 10.1248/cpb.56.758     Document Type: Article

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