Development of a new and practical route to chiral 3,4-disubstituted cyclopentanones: Asymmetric alkylation and intramolecular cyclopropanation as key C-C bond-forming steps

Journal of Organic Chemistry

Volumn 67, Issue 16, 2002, Pages 5508-5516

  Palucki, Michael ^a   Um, Joann M ^a   Yasuda, Nobuyoshi ^a   Conlon, David A ^a   Tsay, Fuh Rong ^a   Hartner, Frederick W ^a   Hsiao, Yi ^a   Marcune, Benjamin ^a   Karady, Sandor ^a   Hughes, David L ^a   Dormer, Peter G ^a   Reider, Paul J ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

STEREOCENTER;

ALKYLATION; CATALYSIS; CHEMICAL BONDS; COPPER; HYDROLYSIS; MOLYBDENUM; SYNTHESIS (CHEMICAL);

STEREOCHEMISTRY;

3 HYDROXYMETHYL 4 (3 FLUOROPHENYL)CYCLOPENTANONE; CYCLOPENTANONE DERIVATIVE; UNCLASSIFIED DRUG;

ALKYLATION; ARTICLE; CATALYST; CHEMICAL BOND; CHIRALITY; CYCLIZATION; DECARBOXYLATION; DIASTEREOISOMER; DRUG SYNTHESIS; HYDROLYSIS; STEREOCHEMISTRY;

CYCLOPENTANES; CYCLOPROPANES; INDICATORS AND REAGENTS; MOLECULAR CONFORMATION; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0037047534     PISSN: 00223263     EISSN: None     Source Type: Journal    
DOI: 10.1021/jo025890a     Document Type: Article

References (50)