-
2
-
-
0025226084
-
Caenorhabditis elegans ras gene let-60 acts as a switch in the pathway of vulval induction
-
Beitel G.J., Clark S.G., and Horvitz H.R. Caenorhabditis elegans ras gene let-60 acts as a switch in the pathway of vulval induction. Nature 348 (1990) 503-509
-
(1990)
Nature
, vol.348
, pp. 503-509
-
-
Beitel, G.J.1
Clark, S.G.2
Horvitz, H.R.3
-
3
-
-
0029585636
-
The Caenorhabditis elegans gene lin-1 encodes an ETS-domain protein and defines a branch of the vulval induction pathway
-
Beitel G.J., Tuck S., Greenwald I., and Horvitz H.R. The Caenorhabditis elegans gene lin-1 encodes an ETS-domain protein and defines a branch of the vulval induction pathway. Genes Dev. 9 (1995) 3149-3162
-
(1995)
Genes Dev.
, vol.9
, pp. 3149-3162
-
-
Beitel, G.J.1
Tuck, S.2
Greenwald, I.3
Horvitz, H.R.4
-
5
-
-
0016063911
-
The genetics of Caenorhabditis elegans
-
Brenner S. The genetics of Caenorhabditis elegans. Genetics 77 (1974) 71-94
-
(1974)
Genetics
, vol.77
, pp. 71-94
-
-
Brenner, S.1
-
6
-
-
0035898539
-
Positive and negative regulation of Raf kinase activity and function by phosphorylation
-
Chong H., Lee J., and Guan K.L. Positive and negative regulation of Raf kinase activity and function by phosphorylation. EMBO J. 20 (2001) 3716-3727
-
(2001)
EMBO J.
, vol.20
, pp. 3716-3727
-
-
Chong, H.1
Lee, J.2
Guan, K.L.3
-
7
-
-
0033180210
-
Fluoxetine-resistant mutants in C. elegans define a novel family of transmembrane proteins
-
Choy R.K., and Thomas J.H. Fluoxetine-resistant mutants in C. elegans define a novel family of transmembrane proteins. Mol. Cell 4 (1999) 143-152
-
(1999)
Mol. Cell
, vol.4
, pp. 143-152
-
-
Choy, R.K.1
Thomas, J.H.2
-
8
-
-
0026608178
-
C. elegans cell-signalling gene sem-5 encodes a protein with SH2 and SH3 domains
-
Clark S.G., Stern M.J., and Horvitz H.R. C. elegans cell-signalling gene sem-5 encodes a protein with SH2 and SH3 domains. Nature 356 (1992) 340-344
-
(1992)
Nature
, vol.356
, pp. 340-344
-
-
Clark, S.G.1
Stern, M.J.2
Horvitz, H.R.3
-
9
-
-
0034306450
-
Specificity and mechanism of action of some commonly used protein kinase inhibitors
-
Davies S.P., Reddy H., Caivano M., and Cohen P. Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem. J. 351 (2000) 95-105
-
(2000)
Biochem. J.
, vol.351
, pp. 95-105
-
-
Davies, S.P.1
Reddy, H.2
Caivano, M.3
Cohen, P.4
-
10
-
-
0026679892
-
Raf functions downstream of Ras1 in the Sevenless signal transduction pathway
-
Dickson B., Sprenger F., Morrison D., and Hafen E. Raf functions downstream of Ras1 in the Sevenless signal transduction pathway. Nature 360 (1992) 600-603
-
(1992)
Nature
, vol.360
, pp. 600-603
-
-
Dickson, B.1
Sprenger, F.2
Morrison, D.3
Hafen, E.4
-
11
-
-
14444279192
-
Identification of a novel inhibitor of mitogen-activated protein kinase kinase
-
Favata M.F., Horiuchi K.Y., Manos E.J., Daulerio A.J., Stradley D.A., Feeser W.S., Van Dyk D.E., Pitts W.J., Earl R.A., Hobbs F., Copeland R.A., Magolda R.L., et al. Identification of a novel inhibitor of mitogen-activated protein kinase kinase. J. Biol. Chem. 273 (1998) 18623-18632
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 18623-18632
-
-
Favata, M.F.1
Horiuchi, K.Y.2
Manos, E.J.3
Daulerio, A.J.4
Stradley, D.A.5
Feeser, W.S.6
Van Dyk, D.E.7
Pitts, W.J.8
Earl, R.A.9
Hobbs, F.10
Copeland, R.A.11
Magolda, R.L.12
-
12
-
-
0022065262
-
Identification and characterization of 22 genes that affect the vulval cell lineages of the nematode Caenorhabditis elegans
-
Ferguson E.L., and Horvitz H.R. Identification and characterization of 22 genes that affect the vulval cell lineages of the nematode Caenorhabditis elegans. Genetics 110 (1985) 17-72
-
(1985)
Genetics
, vol.110
, pp. 17-72
-
-
Ferguson, E.L.1
Horvitz, H.R.2
-
13
-
-
0037079003
-
Rules for making human tumor cells
-
Hahn W.C., and Weinberg R.A. Rules for making human tumor cells. N. Engl. J. Med. 347 (2002) 1593-1603
-
(2002)
N. Engl. J. Med.
, vol.347
, pp. 1593-1603
-
-
Hahn, W.C.1
Weinberg, R.A.2
-
14
-
-
34548092385
-
Context-dependent roles of mutant B-Raf signaling in melanoma and colorectal carcinoma cell growth
-
Hao H., Muniz-Medina V.M., Mehta H., Thomas N.E., Khazak V., Der C.J., and Shields J.M. Context-dependent roles of mutant B-Raf signaling in melanoma and colorectal carcinoma cell growth. Mol. Cancer Ther. 6 (2007) 2220-2229
-
(2007)
Mol. Cancer Ther.
, vol.6
, pp. 2220-2229
-
-
Hao, H.1
Muniz-Medina, V.M.2
Mehta, H.3
Thomas, N.E.4
Khazak, V.5
Der, C.J.6
Shields, J.M.7
-
15
-
-
0028898579
-
Ras farnesyltransferase inhibitors suppress the phenotype resulting from an activated ras mutation in Caenorhabditis elegans
-
Hara M., and Han M. Ras farnesyltransferase inhibitors suppress the phenotype resulting from an activated ras mutation in Caenorhabditis elegans. Proc. Natl. Acad. Sci. USA 92 (1995) 3333-3337
-
(1995)
Proc. Natl. Acad. Sci. USA
, vol.92
, pp. 3333-3337
-
-
Hara, M.1
Han, M.2
-
16
-
-
0026763373
-
The gene lin-3 encodes an inductive signal for vulval development in C. elegans
-
Hill R.J., and Sternberg P.W. The gene lin-3 encodes an inductive signal for vulval development in C. elegans. Nature 358 (1992) 470-476
-
(1992)
Nature
, vol.358
, pp. 470-476
-
-
Hill, R.J.1
Sternberg, P.W.2
-
17
-
-
0019977293
-
Serotonin and octopamine in the nematode Caenorhabditis elegans
-
Horvitz H.R., Chalfie M., Trent C., Sulston J.E., and Evans P.D. Serotonin and octopamine in the nematode Caenorhabditis elegans. Science 216 (1982) 1012-1014
-
(1982)
Science
, vol.216
, pp. 1012-1014
-
-
Horvitz, H.R.1
Chalfie, M.2
Trent, C.3
Sulston, J.E.4
Evans, P.D.5
-
18
-
-
0028340308
-
The lin-15 locus encodes two negative regulators of Caenorhabditis elegans vulval development
-
Huang L.S., Tzou P., and Sternberg P.W. The lin-15 locus encodes two negative regulators of Caenorhabditis elegans vulval development. Mol. Biol. Cell 5 (1994) 395-411
-
(1994)
Mol. Biol. Cell
, vol.5
, pp. 395-411
-
-
Huang, L.S.1
Tzou, P.2
Sternberg, P.W.3
-
19
-
-
0030026887
-
A point mutation in the extracellular domain activates LET-23, the Caenorhabditis elegans epidermal growth factor receptor homolog
-
Katz W.S., Lesa G.M., Yannoukakos D., Clandinin T.R., Schlessinger J., and Sternberg P.W. A point mutation in the extracellular domain activates LET-23, the Caenorhabditis elegans epidermal growth factor receptor homolog. Mol. Cell. Biol. 16 (1996) 529-537
-
(1996)
Mol. Cell. Biol.
, vol.16
, pp. 529-537
-
-
Katz, W.S.1
Lesa, G.M.2
Yannoukakos, D.3
Clandinin, T.R.4
Schlessinger, J.5
Sternberg, P.W.6
-
20
-
-
0029588204
-
The ksr-1 gene encodes a novel protein kinase involved in Ras-mediated signaling in C. elegans
-
Kornfeld K., Hom D.B., and Horvitz H.R. The ksr-1 gene encodes a novel protein kinase involved in Ras-mediated signaling in C. elegans. Cell 83 (1995) 903-913
-
(1995)
Cell
, vol.83
, pp. 903-913
-
-
Kornfeld, K.1
Hom, D.B.2
Horvitz, H.R.3
-
21
-
-
0031717482
-
Genetic analysis of the Caenorhabditis elegans MAP kinase gene mpk-1
-
Lackner M.R., and Kim S.K. Genetic analysis of the Caenorhabditis elegans MAP kinase gene mpk-1. Genetics 150 (1998) 103-117
-
(1998)
Genetics
, vol.150
, pp. 103-117
-
-
Lackner, M.R.1
Kim, S.K.2
-
22
-
-
20244378061
-
Chemical genetics identifies Rab geranylgeranyl transferase as an apoptotic target of farnesyl transferase inhibitors
-
Lackner M.R., Kindt R.M., Carroll P.M., Brown K., Cancilla M.R., Chen C., de Silva H., Franke Y., Guan B., Heuer T., Hung T., Keegan K., et al. Chemical genetics identifies Rab geranylgeranyl transferase as an apoptotic target of farnesyl transferase inhibitors. Cancer Cell 7 (2005) 325-336
-
(2005)
Cancer Cell
, vol.7
, pp. 325-336
-
-
Lackner, M.R.1
Kindt, R.M.2
Carroll, P.M.3
Brown, K.4
Cancilla, M.R.5
Chen, C.6
de Silva, H.7
Franke, Y.8
Guan, B.9
Heuer, T.10
Hung, T.11
Keegan, K.12
-
23
-
-
0018879884
-
Levamisole-resistant mutants of the nematode Caenorhabditis elegans appear to lack pharmacological acetylcholine receptors
-
Lewis J.A., Wu C.H., Levine J.H., and Berg H. Levamisole-resistant mutants of the nematode Caenorhabditis elegans appear to lack pharmacological acetylcholine receptors. Neuroscience 5 (1980) 967-989
-
(1980)
Neuroscience
, vol.5
, pp. 967-989
-
-
Lewis, J.A.1
Wu, C.H.2
Levine, J.H.3
Berg, H.4
-
24
-
-
0027200882
-
The GABAergic nervous system of Caenorhabditis elegans
-
McIntire S.L., Jorgensen E., Kaplan J., and Horvitz H.R. The GABAergic nervous system of Caenorhabditis elegans. Nature 364 (1993) 337-341
-
(1993)
Nature
, vol.364
, pp. 337-341
-
-
McIntire, S.L.1
Jorgensen, E.2
Kaplan, J.3
Horvitz, H.R.4
-
25
-
-
34248575149
-
Integrating signals from RTKs to ERK/MAPK
-
McKay M.M., and Morrison D.K. Integrating signals from RTKs to ERK/MAPK. Oncogene 26 (2007) 3113-3121
-
(2007)
Oncogene
, vol.26
, pp. 3113-3121
-
-
McKay, M.M.1
Morrison, D.K.2
-
26
-
-
0027196007
-
lin-31, a Caenorhabditis elegans HNF-3/fork head transcription factor homolog, specifies three alternative cell fates in vulval development
-
Miller L.M., Gallegos M.E., Morisseau B.A., and Kim S.K. lin-31, a Caenorhabditis elegans HNF-3/fork head transcription factor homolog, specifies three alternative cell fates in vulval development. Genes Dev. 7 (1993) 933-947
-
(1993)
Genes Dev.
, vol.7
, pp. 933-947
-
-
Miller, L.M.1
Gallegos, M.E.2
Morisseau, B.A.3
Kim, S.K.4
-
27
-
-
34248140184
-
An activating mutation in sos-1 identifies its Dbl domain as a critical inhibitor of the epidermal growth factor receptor pathway during Caenorhabditis elegans vulval development
-
Modzelewska K., Elgort M.G., Huang J., Jongeward G., Lauritzen A., Yoon C.H., Sternberg P.W., and Moghal N. An activating mutation in sos-1 identifies its Dbl domain as a critical inhibitor of the epidermal growth factor receptor pathway during Caenorhabditis elegans vulval development. Mol. Cell Biol. 27 (2007) 3695-3707
-
(2007)
Mol. Cell Biol.
, vol.27
, pp. 3695-3707
-
-
Modzelewska, K.1
Elgort, M.G.2
Huang, J.3
Jongeward, G.4
Lauritzen, A.5
Yoon, C.H.6
Sternberg, P.W.7
Moghal, N.8
-
28
-
-
0037429739
-
The epidermal growth factor system in Caenorhabditis elegans
-
Moghal N., and Sternberg P.W. The epidermal growth factor system in Caenorhabditis elegans. Exp. Cell Res. 284 (2003) 150-159
-
(2003)
Exp. Cell Res.
, vol.284
, pp. 150-159
-
-
Moghal, N.1
Sternberg, P.W.2
-
29
-
-
4644370323
-
Crystallographic analysis of CaaX prenyltransferases complexed with substrates defines rules of protein substrate selectivity
-
Reid T.S., Terry K.L., Casey P.J., and Beese L.S. Crystallographic analysis of CaaX prenyltransferases complexed with substrates defines rules of protein substrate selectivity. J. Mol. Biol. 343 (2004) 417-433
-
(2004)
J. Mol. Biol.
, vol.343
, pp. 417-433
-
-
Reid, T.S.1
Terry, K.L.2
Casey, P.J.3
Beese, L.S.4
-
30
-
-
34248591612
-
Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancer
-
Roberts P.J., and Der C.J. Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancer. Oncogene 26 (2007) 3291-3310
-
(2007)
Oncogene
, vol.26
, pp. 3291-3310
-
-
Roberts, P.J.1
Der, C.J.2
-
31
-
-
23844458596
-
Caenorhabditis elegans CNK-1 promotes Raf activation but is not essential for Ras/Raf signaling
-
Rocheleau C.E., Ronnlund A., Tuck S., and Sundaram M.V. Caenorhabditis elegans CNK-1 promotes Raf activation but is not essential for Ras/Raf signaling. Proc. Natl. Acad. Sci. USA 102 (2005) 11757-11762
-
(2005)
Proc. Natl. Acad. Sci. USA
, vol.102
, pp. 11757-11762
-
-
Rocheleau, C.E.1
Ronnlund, A.2
Tuck, S.3
Sundaram, M.V.4
-
32
-
-
0035886842
-
Preclinical antitumor activity of BMS-214662, a highly apoptotic and novel farnesyltransferase inhibitor
-
Rose W.C., Lee F.Y., Fairchild C.R., Lynch M., Monticello T., Kramer R.A., and Manne V. Preclinical antitumor activity of BMS-214662, a highly apoptotic and novel farnesyltransferase inhibitor. Cancer Res. 61 (2001) 7507-7517
-
(2001)
Cancer Res.
, vol.61
, pp. 7507-7517
-
-
Rose, W.C.1
Lee, F.Y.2
Fairchild, C.R.3
Lynch, M.4
Monticello, T.5
Kramer, R.A.6
Manne, V.7
-
33
-
-
33746015955
-
Lately, it occurs to me what a long, strange trip it's been for the farnesyltransferase inhibitors
-
Rowinsky E.K. Lately, it occurs to me what a long, strange trip it's been for the farnesyltransferase inhibitors. J. Clin. Oncol. 24 (2006) 2981-2984
-
(2006)
J. Clin. Oncol.
, vol.24
, pp. 2981-2984
-
-
Rowinsky, E.K.1
-
34
-
-
52249089842
-
-
The doi/10.1895/wormbook.1.49.1
-
Shaham S. Methods in Cell Biology. (2006), The . http://www.wormbook.org doi/10.1895/wormbook.1.49.1
-
(2006)
Methods in Cell Biology.
-
-
Shaham, S.1
-
35
-
-
33748331308
-
The mighty mouse: Genetically engineered mouse models in cancer drug development
-
Sharpless N.E., and Depinho R.A. The mighty mouse: Genetically engineered mouse models in cancer drug development. Nat. Rev. Drug Discov. 5 (2006) 741-754
-
(2006)
Nat. Rev. Drug Discov.
, vol.5
, pp. 741-754
-
-
Sharpless, N.E.1
Depinho, R.A.2
-
36
-
-
0032504106
-
SUR-8, a conserved Ras-binding protein with leucine-rich repeats, positively regulates Ras-mediated signaling in C. elegans
-
Sieburth D.S., Sun Q., and Han M. SUR-8, a conserved Ras-binding protein with leucine-rich repeats, positively regulates Ras-mediated signaling in C. elegans. Cell 94 (1998) 119-130
-
(1998)
Cell
, vol.94
, pp. 119-130
-
-
Sieburth, D.S.1
Sun, Q.2
Han, M.3
-
37
-
-
38449085292
-
Maintenance of C. elegans
-
Wormbook (Ed) Wormbook, doi/10.1895/wormbook.1.101.1
-
Stiernagle T. Maintenance of C. elegans. In: Wormbook (Ed). The C. elegans Research Community (2006). http://www.wormbook.org Wormbook, doi/10.1895/wormbook.1.101.1
-
(2006)
The C. elegans Research Community
-
-
Stiernagle, T.1
-
39
-
-
0029559183
-
The C. elegans ksr-1 gene encodes a novel Raf-related kinase involved in Ras-mediated signal transduction
-
Sundaram M., and Han M. The C. elegans ksr-1 gene encodes a novel Raf-related kinase involved in Ras-mediated signal transduction. Cell 83 (1995) 889-901
-
(1995)
Cell
, vol.83
, pp. 889-901
-
-
Sundaram, M.1
Han, M.2
-
40
-
-
0032524912
-
MAP kinase signaling specificity mediated by the LIN-1 Ets/LIN-31 WH transcription factor complex during C. elegans vulval induction
-
Tan P.B., Lackner M.R., and Kim S.K. MAP kinase signaling specificity mediated by the LIN-1 Ets/LIN-31 WH transcription factor complex during C. elegans vulval induction. Cell 93 (1998) 569-580
-
(1998)
Cell
, vol.93
, pp. 569-580
-
-
Tan, P.B.1
Lackner, M.R.2
Kim, S.K.3
-
41
-
-
0029584327
-
KSR, a novel protein kinase required for RAS signal transduction
-
Therrien M., Chang H.C., Solomon N.M., Karim F.D., Wassarman D.A., and Rubin G.M. KSR, a novel protein kinase required for RAS signal transduction. Cell 83 (1995) 879-888
-
(1995)
Cell
, vol.83
, pp. 879-888
-
-
Therrien, M.1
Chang, H.C.2
Solomon, N.M.3
Karim, F.D.4
Wassarman, D.A.5
Rubin, G.M.6
-
42
-
-
0028835184
-
Genetic and pharmacological analysis of neurotransmitters controlling egg-laying in C. elegans
-
Weinshenker D., Garriga G., and Thomas J.H. Genetic and pharmacological analysis of neurotransmitters controlling egg-laying in C. elegans. J. Neurosci. 15 (1995) 6975-6985
-
(1995)
J. Neurosci.
, vol.15
, pp. 6975-6985
-
-
Weinshenker, D.1
Garriga, G.2
Thomas, J.H.3
|