Schizophrenia: A genetic disorder of the synapse?

BMJ

Volumn 330, Issue 7484, 2005, Pages 158-159

  Owen, Michael J ^a   O'donovan, Michael C ^a   Harrison, Paul J ^b  

^a CARDIFF UNIVERSITY   (United Kingdom)

^b WARNEFORD HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

DOPAMINE RECEPTOR; DOPAMINE RECEPTOR STIMULATING AGENT; DYSBINDIN 1; GENE PRODUCT; GLUTAMIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; NEU DIFFERENTIATION FACTOR; NEUROLEPTIC AGENT; RGS PROTEIN; RGS4 PROTEIN; UNCLASSIFIED DRUG;

BRAIN REGION; DNA POLYMORPHISM; DOPAMINERGIC TRANSMISSION; EDITORIAL; NERVE CELL DIFFERENTIATION; NERVE DEGENERATION; NEUROPATHOLOGY; NEUROTRANSMISSION; NEUROTRANSMITTER UPTAKE; PATHOGENESIS; PRIORITY JOURNAL; PSYCHOPHARMACOLOGY; PSYCHOSIS; SCHIZOPHRENIA; SYNAPSE;

EXCITATORY AMINO ACIDS; HUMANS; SCHIZOPHRENIA; SYNAPSES;

EID: 12444258700     PISSN: 09598138     EISSN: 14685833     Source Type: Journal    
DOI: 10.1136/bmj.330.7484.158     Document Type: Editorial

References (12)

1. Owen MJ, O'Donovan MC, Gottesman II. Schizophrenia. In: McGuffin P, Owen MJ, Gottesman II. Psychiatric genetics and genomics. New York: Oxford University Press, 2002: 247–66.
2. Seeman P, Chau-Wong M, Tedesco J, Wong K. Brain receptors for antipsychotic drugs and dopamine: direct binding assays. Proc Natl Acad Sci USA 1975; 72: 4376–80.
3. Abi-Dargham A, Rodenhiser J, Printz D, Zea-Ponce Y, Gil R, Kegeles LS, et al. Increased baseline occupancy of D2 receptors by dopamine in schizophrenia. Proc Natl Acad Sci USA 2000; 97: 8104–9.
4. Weinberger DR, Egan MF, Bertolino A, Callicott JH, Mattay VS, Lipska BK, et al. Prefrontal neurons and the genetics of schizophrenia. Biol Psychiatry 2001; 50: 825–44.
5. Laruelle M, Kegeles LS, Abi-Dargham A. Glutamate, dopamine, and schizophrenia: from pathophysiology to treatment. Ann N Y Acad Sci 2003; 1003: 138–58.
6. Weinberger DR. Implications of normal brain development for the pathogenesis of schizophrenia. Arch Gen Psychiatry 1987; 44: 660–9.
7. Murray RM, Lewis SW. Is schizophrenia a neurodevelopmental disorder? BMJ 1987; 295: 681–2.
8. Harrison PJ. The neuropathology of schizophrenia. A critical review of the data and their interpretation. Brain 1999; 122: 593–624.
9. O'Donovan MC, Williams NM, Owen MJ. Recent advances in the genetics of schizophrenia. Hum Mol Genet 2003; 12: R125–R133.
10. Harrison PJ, Weinberger DR. Schizophrenia genes, gene expression, and neuropathology: on the matter of their convergence. Mol Psychiatry 2005; 10: 40–68
11. Harrison PJ, Owen MJ. Genes for schizophrenia? Recent findings and their pathophysiological implications. Lancet 2003; 361: 417–9.
12. Corfas G, Roy K, Buxbaum JD. Neuregulin 1-erbB signaling and the molecular/cellular basis of schizophrenia. Nat Neurosci 2004; 7: 575–80.