A new fermentation strategy for S-adenosylmethionine production in recombinant Pichia pastoris

Biochemical Engineering Journal

Volumn 41, Issue 1, 2008, Pages 74-78

  Zhang, Jianguo ^a   Wang, Xuedong ^a   Su, Erzheng ^a   Fang, Guochen ^a   Ren, Yuhong ^a   Wei, Dongzhi ^a  

^a EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

High cell density fermentation; Methanol consumption rate; Pichia pastoris; S adenosylmethionine

Indexed keywords

ACOUSTIC MICROSCOPES; AMPLITUDE MODULATION; BIOCHEMICAL ENGINEERING; MISSILE BASES; PHOTOACOUSTIC EFFECT; ULTRASONIC TRANSDUCERS;

BIO REACTOR; CELL DENSITIES; CONSUMPTION RATES; DRY CELL WEIGHT (DCW); MAINTENANCE COEFFICIENT; PICHIA PASTORIS (PPPFK); S ADENOSYLMETHIONINE (ADOMET); SACCHAROMYCES CEREVISIAE; SCALE-UP;

METHANOL;

METHANOL; S ADENOSYLMETHIONINE;

ARTICLE; CELL CULTURE; CELL DENSITY; FED BATCH CULTURE; FERMENTATION; GENE EXPRESSION; NONHUMAN; PICHIA PASTORIS; PRIORITY JOURNAL; SACCHAROMYCES CEREVISIAE;

PICHIA PASTORIS; SACCHAROMYCES CEREVISIAE;

EID: 45449105347     PISSN: 1369703X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bej.2008.03.009     Document Type: Article

References (19)

1. Shiozaki S., Shimizu S., and Yamada H. S-Adenosyl-l-methionine production by Saccharomyces sake: optimization of the culture conditions for the production of cells with a high S-adenosyl-l-methionine content. Agric. Bio. Chem. 53 (1989) 3269-3274
2. Shiozaki S., Shimizu S., and Yamada H. Production of S-adenosyl-l-methionine by Saccharomyces sake. J. Biotechnol. 4 (1986) 345-354
3. Gawel L.J., Turner J.R., and Parks L.W. Accumulation of S-adenosylmethionine by microorganisms. J. Biol. Chem. 83 (1962) 497-499
4. He J.Y., Deng J.J., Zheng Y.H., and Gu J. Synergistic effect on the production of S-adenosyl-l-methionine in Pichia pastoris by knocking in of S-adenosyl-l-methionine synthase and knocking out of cystathionine synthase. J. Biotechnol. 126 (2006) 519-527
5. Hu X.Q., Chu J., Zhang S.L., Zhuang Y.P., Wang Y.H., Zhu S., Zhu Z.G., and Yuan Z.Y. A novel feeding strategy during the production phase for enhancing the enzymatic synthesis of S-adenosyl-l-methionine by methylotrophic Pichia pastoris. Enzyme Microb. Technol. 40 (2007) 669-674
6. Macauley-Patrick S., Fazenda M.L., McNeil B., and Harvey L.M. Heterologous protein production using the Pichia pastoris expression system. Yeast 22 (2005) 249-270
7. Murry W., Duff S.J.B., and Lanthier P.H. Induction and stability of alcohol oxidase in the methylorophic yeast Pichia pastoris. Appl. Microbiol. Biotechnol. 32 (1989) 95-100
8. Lee C.Y., Nakano A., Shiomi N., Lee E.K., and Katoh S. Effect of substrate feed rates on heterologous protein expression by Pichia pastoris in DO-stat fed-batch fermentation. Enzyme Microb. Technol. 33 (2003) 358-365
9. Khatri N.K., and Hoffmann F. Impact of methanol concentration on secreted protein production in oxygen-limited cultures of recombinant Pichia pastoris. Biotechnol. Bioeng. 93 (2006) 871-879
10. Trinh L.B., Phue J.N., and Shiloach J. Effect of methanol feeding strategies on production and yield of recombinant mouse endostatin from Pichia pastoris. Biotechnol. Bioeng. 82 (2003) 438-444
11. Curvers S., Brixius P., Klauser T., Thommes J., Weuster B.D., Takors R., and Wandrey C. Human chymotrypsinogen B production with Pichia pastoris by integrated development of fermentation and downstream processing. Part 1. Fermentation. Biotechnol. Prog. 17 (2001) 495-502
12. Zhang W., Smith L.A., Plantz B.A., Schlegel V.L., and Meagher M.M. Design of methanol feed control in Pichia pastoris fermentations based upon a growth model. Biotechnol. Prog. 18 (2002) 1392-1399
13. Guarna M.M., Lesnicki G.J., Tam B.M., Robinson J., Radziminski C.Z., Hasenwinkle D., Boraston A., Jervis E., MacGillivray R.T.A., Turner R.F.B., and Kilburn1 D.G. On-line monitoring and control of methanol concentration in shake-flask cultures of Pichia pastoris. Biotechnol. Bioeng. 56 (1997) 279-286
14. Kupcsulik B., and Sevella B. Effect of methanol concentration on the recombinant Pichia pastoris MUTs fermentation. Periodica Polytechnica Ser. Chem. Eng. 48 (2004) 73-87
15. Zhang W., Bevins F.M.A., Plantz B.A., Smith L.A., and Meagher M.M. Modeling Pichia pastoris growth on methanol and optimizing the production of a recombinant protein, the heavy-chain fragment C of Botulinum neurotoxin, Serotype A. Biotechnol. Bioeng. 70 (2000) 1-8
16. Duff S.J.B., and Murray W.D. Production and application of methylotrophic yeast Pichia pastoris. Biotechnol. Bioeng. 31 (1988) 44-49
17. Sarramegna V., Demange P., Milon A., and Talmont F. Optimizing functional versus total expression of the human μ-opioid receptor in Pichia pastoris. Protein Expr. Purif. 24 (2002) 212-220
18. Bhattacharya S.K., and Dubey K.A. Metabolic burden as reflected by maintenance coefficient of recombinant Escherichia coli overexpressing target gene. Biotechnol. Lett. 17 (1995) 1155-1160
19. Chain E.B., Gualandi G., and Morisi G. Aeration studies χ, Aeration conditions in 3000 litre submerged fermentations with various microorganisms. Biotechnol. Bioeng. 8 (1966) 595-619