Conformationally constrained analogues of diacylglycerol (DAG). 23. Hydrophobic ligand-protein interactions versus ligand-lipid interactions of DAG-lactones with protein kinase C (PK-C)

Journal of Medicinal Chemistry

Volumn 47, Issue 20, 2004, Pages 4858-4864

  Tamamura, Hirokazu ^a,c   Sigano, Dina M ^a   Lewin, Nancy E ^b   Peach, Megan L ^a   Nicklaus, Marc C ^a   Blumberg, Peter M ^b   Marquez, Victor E ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

^c KYOTO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ALKYL GROUP; DIACYLGLYCEROL DERIVATIVE; GLYCEROL; HYDROGEN; LACTONE DERIVATIVE; LIGAND; LIPID; METHYL GROUP; PHORBOL ESTER; PROTEIN; PROTEIN KINASE C;

ARTICLE; BINDING AFFINITY; BINDING SITE; CONFORMATION; ENZYME SUBSTRATE COMPLEX; HYDROGEN BOND; HYDROPHOBICITY; LIPID MEMBRANE; LIPOPHILICITY; MOLECULAR INTERACTION; PHARMACOPHORE; PROTEIN DOMAIN; STEREOCHEMISTRY;

BINDING SITES; DIGLYCERIDES; HYDROGEN BONDING; HYDROPHOBICITY; LACTONES; LIGANDS; LIPID METABOLISM; LIPIDS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; PHORBOL ESTERS; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN KINASE C; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 4544371097     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm049723+     Document Type: Article

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