The white-phase-specific gene WH11 is not required for white-opaque switching in Candida albicans

Molecular Genetics and Genomics

Volumn 272, Issue 1, 2004, Pages 88-97

  Park, Y N ^a   Strauss A ^a   Morschhauser J ^a  

^a UNIVERSITY OF WÜRZBURG   (Germany)

Author keywords

Candida; Gene regulation; GFP; Phase variation; Switching

Indexed keywords

GENE PRODUCT; GREEN FLUORESCENT PROTEIN;

ARTICLE; CANDIDA ALBICANS; CONTROLLED STUDY; FUNGAL GENE; FUNGAL GENETICS; FUNGAL STRAIN; FUNGAL VIRULENCE; FUNGUS MUTANT; GENE ACTIVATION; GENE CONTROL; GENE DELETION; GENE FREQUENCY; GENE INACTIVATION; GENE SWITCHING; GENETIC VARIABILITY; HOST PATHOGEN INTERACTION; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROMOTER REGION; WH11 GENE; WILD TYPE;

CANDIDA ALBICANS; FUNGAL PROTEINS; MICROSCOPY, ELECTRON, SCANNING; MUTATION; PIGMENTATION; SEQUENCE ANALYSIS, DNA;

CANDIDA; CANDIDA ALBICANS;

EID: 4544362446     PISSN: 16174615     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00438-004-1037-1     Document Type: Article

References (25)

1. Balan I, Alarco AM, Raymond M (1997) The Candida albicans CDR3 gene codes for an opaque-phase ABC transporter. J Bacteriol 179:7210-7218
2. Bedell GW, Soll DR (1979) Effects of low concentrations of zinc on the growth and dimorphism of Candida albicans: evidence for zinc-resistant and -sensitive pathways for mycelium formation. Infect Immun 26:348-354
3. Fonzi WA, Irwin MY (1993) Isogenic strain construction and gene mapping in Candida albicans. Genetics 134:717-728
4. Hull CM, Raisner RM, Johnson AD (2000) Evidence for mating of the "asexual" yeast Candida albicans in a mammalian host. Science 289:307-310
5. Köhler GA, White TC, Agabian N (1997) Overexpression of a cloned IMP dehydrogenase gene of Candida albicans confers resistance to the specific inhibitor mycophenolic acid. J Bacteriol 179:2331-2338
6. Kvaal CA, Srikantha T, Soll DR (1997) Misexpression of the white-phase-specific gene WH11 in the opaque phase of Candida albicans affects switching and virulence. Infect Immun 65:4468-4475
7. Lan CY, Newport G, Murillo LA, Jones T, Scherer S, Davis RW, Agabian N (2002) Metabolic specialization associated with phenotypic switching in Candida albicans. Proc Natl Acad Sci USA 99:14907-14912
8. Lockhart SR, Pujol C, Daniels KJ, Miller MG, Johnson AD, Pfaller MA, Soll DR (2002) In Candida albicans, white-opaque switchers are homozygous for mating type. Genetics 162:737-745
9. Magee BB, Magee PT (2000) Induction of mating in Candida albicans by construction of MTLa and MTLα strains. Science 289:310-313
10. Miller MG, Johnson AD (2002) White-opaque switching in Candida albicans is controlled by mating-type locus homeodomain proteins and allows efficient mating. Cell 110:293-302
11. Millon L, Manteaux A, Reboux G, Drobacheff C, Monod M, Barale T, Michel-Briand Y (1994) Fluconazole-resistant recurrent oral candidiasis in human immunodeficiency virus-positive patients: persistence of Candida albicans strains with the same genotype. J Clin Microbiol 32:1115-1118
12. Morrow B, Srikantha T, Soll DR (1992) Transcription of the gene for a pepsinogen, PEP1, is regulated by white-opaque switching in Candida albicans. Mol Cell Biol 12:2997-3005
13. Morrow B, Srikantha T, Anderson J, Soil DR (1993) Coordinate regulation of two opaque-phase-specific genes during white-opaque switching in Candida albicans. Infect Immun 61:1823-1828
14. Morschhäuser J, Michel S, Staib P (1999) Sequential gene disruption in Candida albicans by FLP-mediated site-specific recombination. Mol Microbiol 32:547-556
15. Praekelt UM, Meacock PA (1990) HSP12, a new small heat shock gene of Saccharomyces cerevisiae: analysis of structure, regulation and function. Mol Gen Genet 223:97-106
16. Schröppel K, Srikantha T, Wessels D, DeCock M, Lockhart SR, Soll DR (1996) Cytoplasmic localization of the white phase-specific WH11 gene product of Candida albicans. Microbiology 142:2245-2254
17. Slutsky B, Staebell M, Anderson J, Risen L, Pfaller M, Soll DR (1987) "White-opaque transition": a second high-frequency switching system in Candida albicans. J Bacteriol 169:189-197
18. Soll DR, Morrow B, Srikantha T (1993) High-frequency phenotypic switching in Candida albicans. Trends Genet 9:61-65
19. Sonneborn A, Tebarth B, Ernst JF (1999) Control of white-opaque phenotypic switching in Candida albicans by the Efg1p morphogenetic regulator. Infect Immun 67:4655-4660
20. Srikantha T, Soll DR (1993) A white-specific gene in the white-opaque switching system of Candida albicans. Gene 131:53-60
21. Srikantha T, Tsai LK, Soll DR (1997) The WH11 gene of Candida albicans is regulated in two distinct developmental programs through the same transcription activation sequences. J Bacteriol 179:3837-3844
22. Srikantha T, Tsai LK, Daniels K, Soll DR (2000) EFG1 null mutants of Candida albicans switch but cannot express the complete phenotype of white-phase budding cells. J Bacteriol 182:1580-1591
23. Stone RL, Matarese V, Magee BB, Magee PT, Bernlohr DA (1990) Cloning, sequencing and chromosomal assignment of a gene from Saccharomyces cerevisiae which is negatively regulated by glucose and positively by lipids. Gene 96:171-176
24. Strauß A, Michel S, Morschhäuser J (2001) Analysis of phase-specific gene expression at the single-cell level in the white-opaque switching system of Candida albicans. J Bacteriol 183:3761-3769
25. White TC, Miyasaki SH, Agabian N (1993) Three distinct secreted aspartyl proteinases in Candida albicans. J Bacteriol 175 6126-6133