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Volumn 32, Issue 3, 1999, Pages 547-556

Sequential gene disruption in candida albicans by FLP-mediated site-specific recombination

Author keywords

[No Author keywords available]

Indexed keywords

ABC TRANSPORTER; CARRIER PROTEIN; FUNGAL DNA; MEMBRANE PROTEIN;

EID: 0032903245     PISSN: 0950382X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2958.1999.01393.x     Document Type: Article
Times cited : (131)

References (29)
  • 1
    • 0023392267 scopus 로고
    • A method for gene disruption that allows repeated use of URA3 selection in the construction of multiply disrupted yeast strains
    • Alani, E., Cao, L., and Kleckner, N. (1987) A method for gene disruption that allows repeated use of URA3 selection in the construction of multiply disrupted yeast strains. Genetics 116: 541-545.
    • (1987) Genetics , vol.116 , pp. 541-545
    • Alani, E.1    Cao, L.2    Kleckner, N.3
  • 3
    • 0030716391 scopus 로고    scopus 로고
    • The Candida albicans CDR3 gene codes for an opaque-phase ABC transporter
    • Balan, I., Alarco, A.-M., and Raymond, M. (1997) The Candida albicans CDR3 gene codes for an opaque-phase ABC transporter. J Bacteriol 179: 7210-7218.
    • (1997) J Bacteriol , vol.179 , pp. 7210-7218
    • Balan, I.1    Alarco, A.-M.2    Raymond, M.3
  • 4
    • 0021668558 scopus 로고
    • A positive selection for mutants lacking orotidine-5′-phosphate decarboxylase activity in yeast: 5-fluoro-orotic acid resistance
    • Boeke, J.D., Lacroute, F., and Fink, G.R. (1984) A positive selection for mutants lacking orotidine-5′-phosphate decarboxylase activity in yeast: 5-fluoro-orotic acid resistance. Mol Gen Genet 197: 345-346.
    • (1984) Mol Gen Genet , vol.197 , pp. 345-346
    • Boeke, J.D.1    Lacroute, F.2    Fink, G.R.3
  • 5
    • 0029739282 scopus 로고    scopus 로고
    • A simple assay to determine the functionality of Cre or FLP recombination targets in genomic manipulation constructs
    • Buchholz, F., Angrand, P.-O., and Stewart, A.F. (1996) A simple assay to determine the functionality of Cre or FLP recombination targets in genomic manipulation constructs. Nucleic Acids Res 24: 3118-3119.
    • (1996) Nucleic Acids Res , vol.24 , pp. 3118-3119
    • Buchholz, F.1    Angrand, P.-O.2    Stewart, A.F.3
  • 6
    • 0029065955 scopus 로고
    • Gene disruption in Escherichia coli: TcR and KmR cassettes with the option of Flp-catalyzed excision of the antibiotic-resistance determinant
    • Cherepanov, P.P., and Wackernagel, W. (1995) Gene disruption in Escherichia coli: TcR and KmR cassettes with the option of Flp-catalyzed excision of the antibiotic-resistance determinant. Gene 158: 09-14.
    • (1995) Gene , vol.158 , pp. 9-14
    • Cherepanov, P.P.1    Wackernagel, W.2
  • 7
    • 0028895693 scopus 로고
    • Avirulence of Candida albicans auxotrophic mutants in a rat model of oropharyngeal candidiasis
    • Cole, M.F., Bowen, W.H., Zhao, X., and Cihlar, R.L. (1995) Avirulence of Candida albicans auxotrophic mutants in a rat model of oropharyngeal candidiasis. FEMS Microbiol Lett 126: 177-180.
    • (1995) FEMS Microbiol Lett , vol.126 , pp. 177-180
    • Cole, M.F.1    Bowen, W.H.2    Zhao, X.3    Cihlar, R.L.4
  • 8
    • 0024742561 scopus 로고
    • Use of site-specific recombination to regenerate selectable markers
    • Cregg, J.M., and Madden, K.R. (1989) Use of site-specific recombination to regenerate selectable markers. Mol Gen Genet 219: 320-323.
    • (1989) Mol Gen Genet , vol.219 , pp. 320-323
    • Cregg, J.M.1    Madden, K.R.2
  • 9
    • 0025774660 scopus 로고
    • Analysis of a Candida albicans gene that encodes a novel mechanism for resistance to benomyl and methothrexate
    • Fling, M.E., Kopf, J., Tamarkin, A., Gorman, J.A., Smith, H.A., and Koltin, Y. (1991) Analysis of a Candida albicans gene that encodes a novel mechanism for resistance to benomyl and methothrexate. Mol Gen Genet 227: 318-329.
    • (1991) Mol Gen Genet , vol.227 , pp. 318-329
    • Fling, M.E.1    Kopf, J.2    Tamarkin, A.3    Gorman, J.A.4    Smith, H.A.5    Koltin, Y.6
  • 10
    • 0027192868 scopus 로고
    • Isogenic strain construction and gene mapping in Candida albicans
    • Fonzi, W.A., and Irwin, M.Y. (1993) Isogenic strain construction and gene mapping in Candida albicans. Genetics 134: 717-728.
    • (1993) Genetics , vol.134 , pp. 717-728
    • Fonzi, W.A.1    Irwin, M.Y.2
  • 11
    • 0031759244 scopus 로고    scopus 로고
    • Multiple molecular mechanisms contribute to a stepwise development of fluconazole resistance in clinical Candida albicans strains
    • Franz, R., Kelly, S.L., Lamb, D.C., Kelly, D.E., Ruhnke, M., and Morschhäuser, J. (1998a) Multiple molecular mechanisms contribute to a stepwise development of fluconazole resistance in clinical Candida albicans strains. Antimicrob Agents Chemother 42: 3065-3072.
    • (1998) Antimicrob Agents Chemother , vol.42 , pp. 3065-3072
    • Franz, R.1    Kelly, S.L.2    Lamb, D.C.3    Kelly, D.E.4    Ruhnke, M.5    Morschhäuser, J.6
  • 12
    • 0032487393 scopus 로고    scopus 로고
    • A fourth gene from the Candida albicans CDR family of ABC transporters
    • Franz, R., Michel, S., and Morschhäuser, J. (1998b) A fourth gene from the Candida albicans CDR family of ABC transporters. Gene 220: 91-98.
    • (1998) Gene , vol.220 , pp. 91-98
    • Franz, R.1    Michel, S.2    Morschhäuser, J.3
  • 13
    • 0021742042 scopus 로고
    • Isolation of the Candida albicans gene for orotidine-5′-phosphate decarboxylase by complementation of S. cerevisiae ura3 and E. coli pyrF mutations
    • Gillum, A.M., Tsay, E.Y.H., and Kirsch, D.R. (1984) Isolation of the Candida albicans gene for orotidine-5′-phosphate decarboxylase by complementation of S. cerevisiae ura3 and E. coli pyrF mutations. Mol Gen Genet 198: 179-182.
    • (1984) Mol Gen Genet , vol.198 , pp. 179-182
    • Gillum, A.M.1    Tsay, E.Y.H.2    Kirsch, D.R.3
  • 14
    • 0025949975 scopus 로고
    • Repeated use of GAL1 for gene disruption in Candida albicans
    • Gorman, J.A., Chan, W., and Gorman, J.W. (1991) Repeated use of GAL1 for gene disruption in Candida albicans. Genetics 129: 19-24.
    • (1991) Genetics , vol.129 , pp. 19-24
    • Gorman, J.A.1    Chan, W.2    Gorman, J.W.3
  • 15
    • 0027940569 scopus 로고
    • Expression of seven members of the gene family encoding secretory aspartyl proteinases in Candida albicans
    • Hube, B., Monod, M., Schofield, D.A., Brown, A.J.P., and Gow, N.A.R. (1994) Expression of seven members of the gene family encoding secretory aspartyl proteinases in Candida albicans. Mol Microbiol 14: 87-99.
    • (1994) Mol Microbiol , vol.14 , pp. 87-99
    • Hube, B.1    Monod, M.2    Schofield, D.A.3    Brown, A.J.P.4    Gow, N.A.R.5
  • 16
    • 0027422291 scopus 로고
    • Site-specific recombinases: Tools for genome engineering
    • Kilby, N.J., Snaith, M.R., and Murray, J.A.H. (1993) Site-specific recombinases: tools for genome engineering. Trends Genet 9: 413-420.
    • (1993) Trends Genet , vol.9 , pp. 413-420
    • Kilby, N.J.1    Snaith, M.R.2    Murray, J.A.H.3
  • 17
    • 0025851152 scopus 로고
    • Pathogenicity of Candida albicans auxotrophic mutants in experimental infections
    • Kirsch, D.R., and Whitney, R.R. (1991) Pathogenicity of Candida albicans auxotrophic mutants in experimental infections. Infect Immun 59: 3297-3300.
    • (1991) Infect Immun , vol.59 , pp. 3297-3300
    • Kirsch, D.R.1    Whitney, R.R.2
  • 18
    • 0030938651 scopus 로고    scopus 로고
    • Overexpression of a cloned IMP dehydrogenase gene of Candida albicans confers resistance to the specific inhibitor mycophenolic acid
    • Köhler, G.A., White, T.C., and Agabian, N. (1997) Overexpression of a cloned IMP dehydrogenase gene of Candida albicans confers resistance to the specific inhibitor mycophenolic acid. J Bacteriol 179: 2331-2338.
    • (1997) J Bacteriol , vol.179 , pp. 2331-2338
    • Köhler, G.A.1    White, T.C.2    Agabian, N.3
  • 19
    • 0024658194 scopus 로고
    • Isolation of Hem3 mutants from Candida albicans by sequential gene disruption
    • Kurtz, M.B., and Marrinan, J. (1989) Isolation of Hem3 mutants from Candida albicans by sequential gene disruption. Mol Gen Genet 217: 47-52.
    • (1989) Mol Gen Genet , vol.217 , pp. 47-52
    • Kurtz, M.B.1    Marrinan, J.2
  • 20
    • 0026619531 scopus 로고
    • β-Galactosidase of Kluyveromyces lactis (Lac4p) as reporter of gene expression in Candida albicans and Candida tropicalis
    • Leuker, C.E., Hahn, A.-M., and Ernst, J.F. (1992) β-Galactosidase of Kluyveromyces lactis (Lac4p) as reporter of gene expression in Candida albicans and Candida tropicalis. Mol Gen Genet 235: 235-241.
    • (1992) Mol Gen Genet , vol.235 , pp. 235-241
    • Leuker, C.E.1    Hahn, A.-M.2    Ernst, J.F.3
  • 21
    • 0028324030 scopus 로고
    • Fluconazole-resistant recurrent oral candidiasis in human immuno-deficiency virus-positive patients: Persistence of Candida albicans strains with the same genotype
    • Millon, L., Manteaux, A., Reboux, G., Drobacheff, C., Monod, M., Barale, T., and Michel-Briand, Y. (1994) Fluconazole-resistant recurrent oral candidiasis in human immuno-deficiency virus-positive patients: persistence of Candida albicans strains with the same genotype. J Clin Microbiol 32: 1115-1118.
    • (1994) J Clin Microbiol , vol.32 , pp. 1115-1118
    • Millon, L.1    Manteaux, A.2    Reboux, G.3    Drobacheff, C.4    Monod, M.5    Barale, T.6    Michel-Briand, Y.7
  • 22
    • 0031952147 scopus 로고    scopus 로고
    • Expression of a chromosomally integrated, single-copy GFP gene in Candida albicans, and its use as a reporter of gene regulation
    • Morschhäuser, J., Michel, S., and Hacker, J. (1998) Expression of a chromosomally integrated, single-copy GFP gene in Candida albicans, and its use as a reporter of gene regulation. Mol Gen Genet 257: 412-420.
    • (1998) Mol Gen Genet , vol.257 , pp. 412-420
    • Morschhäuser, J.1    Michel, S.2    Hacker, J.3
  • 25
    • 0031047670 scopus 로고    scopus 로고
    • Cloning of Candida albicans genes conferring resistance to azole antifungal agents: Characterization of CDR2, a new multidrug ABC transporter gene
    • Sanglard, D., Ischer, F., Monod, M., and Bille, J. (1997) Cloning of Candida albicans genes conferring resistance to azole antifungal agents: Characterization of CDR2, a new multidrug ABC transporter gene. Microbiology 143: 405-416.
    • (1997) Microbiology , vol.143 , pp. 405-416
    • Sanglard, D.1    Ischer, F.2    Monod, M.3    Bille, J.4
  • 26
    • 0030721006 scopus 로고    scopus 로고
    • The non-standard genetic code of Candida spp.: An evolving genetic code or a novel mechanism for adaptation?
    • Santos, M.A., Ueda, T., Watanabe, K., and Tuite, M. (1997) The non-standard genetic code of Candida spp.: an evolving genetic code or a novel mechanism for adaptation? Mol Microbiol 26: 423-431.
    • (1997) Mol Microbiol , vol.26 , pp. 423-431
    • Santos, M.A.1    Ueda, T.2    Watanabe, K.3    Tuite, M.4
  • 27
    • 0031918573 scopus 로고    scopus 로고
    • Intrinsic resistance to inhibitors of fatty acid biosynthesis in Pseudomonas aeruginosa is due to efflux: Application of a novel technique for generation of unmarked chromosomal mutations for the study of efflux systems
    • Schweizer, H. (1998) Intrinsic resistance to inhibitors of fatty acid biosynthesis in Pseudomonas aeruginosa is due to efflux: application of a novel technique for generation of unmarked chromosomal mutations for the study of efflux systems. Antimicrob Agents Chemother 42: 394-398.
    • (1998) Antimicrob Agents Chemother , vol.42 , pp. 394-398
    • Schweizer, H.1
  • 28
    • 0028804452 scopus 로고
    • The frequency of integrative transformation at phase-specific genes of Candida albicans correlates with their transcriptional state
    • Srikantha, T., Morrow, B., Schröppel, K., and Soll, D.R. (1995) The frequency of integrative transformation at phase-specific genes of Candida albicans correlates with their transcriptional state. Mol Gen Genet 246: 342-352.
    • (1995) Mol Gen Genet , vol.246 , pp. 342-352
    • Srikantha, T.1    Morrow, B.2    Schröppel, K.3    Soll, D.R.4
  • 29
    • 0032927712 scopus 로고    scopus 로고
    • Host-induced, stage-specific virulence gene activation in Candida albicans during infection
    • in press
    • Staib, P., Kretschmar, M., Nichterlein, T., Köhler, G., Michel, S., Hof, H., et al. (1999) Host-induced, stage-specific virulence gene activation in Candida albicans during infection. Mol Microbiol (in press).
    • (1999) Mol Microbiol
    • Staib, P.1    Kretschmar, M.2    Nichterlein, T.3    Köhler, G.4    Michel, S.5    Hof, H.6


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