Affinity-enrichment of thyrotropin receptor autoantibodies from Graves' patients and normal individuals provides insight into their properties and possible origin from natural antibodies

Journal of Clinical Endocrinology and Metabolism

Volumn 89, Issue 9, 2004, Pages 4734-4745

  Latrofa, Francesco ^a   Chazenbalk, Gregorio D ^a   Pichurin, Pavel ^a   Chen, Chun Rong ^a   McLachlan, Sandra M ^a   Rapoport, Basil ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b CEDARS SINAI MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; IMMUNOGLOBULIN G; IMMUNOGLOBULIN G ANTIBODY; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G2; IMMUNOGLOBULIN G3; IMMUNOGLOBULIN G4; IMMUNOGLOBULIN LAMBDA CHAIN; POLYSACCHARIDE; RECOMBINANT ANTIGEN; RECOMBINANT THYROTROPIN; THYROTROPIN; THYROTROPIN RECEPTOR; THYROTROPIN RECEPTOR ANTIBODY;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ANTIBODY AFFINITY; ANTIBODY BLOOD LEVEL; ANTIGEN BINDING; ANTIGEN PURIFICATION; ARTICLE; CLINICAL ARTICLE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CROSS REACTION; DISEASE ASSOCIATION; GRAVES DISEASE; HORMONE ACTION; HORMONE BINDING; HUMAN; IMMUNOASSAY; MICROORGANISM; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEPLETION;

ANTIBODIES; ANTIBODY AFFINITY; AUTOANTIBODIES; GRAVES DISEASE; HUMANS; IMMUNOGLOBULIN CLASS SWITCHING; IMMUNOGLOBULIN G; RECEPTORS, THYROTROPIN;

ANIMALIA; MAMMALIA;

EID: 4544336634     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.2003-032068     Document Type: Article

References (42)

1. Rapoport B, Chazenbalk GD, Jaume JC, McLachlan SM 1998 The thyrotropin receptor: interaction with thyrotropin and autoantibodies. Endocr Rev 19:673-716
2. Zakarija M, McKenzie JM 1978 Isoelectric focusing of thyroid-stimulating antibody of Graves' disease. Endocrinology 103:1469-1475
3. Knight J, Laing P, Knight A, Adams D, Ling N 1986 Thyroid stimulating autoantibodies usually contain only λ-light chains: evidence for the "forbidden clone" theory. J Clin Endocrinol Metab 62:342-347
4. Zakarija M 1983 Immunochemical characterization of the thyroid-stimulating antibody (TSAb) of Graves' disease: evidence for restricted heterogeneity. J Clin Lab Immunol 10:77-85
5. Williams Jr RC, Marshall NJ, Kilpatrick K, Montano J, Brickell PM, Goodall M, Ealey PA, Shine B, Weetman AP, Craig RK 1988 κ/λ Immunoglobulin distribution in Graves' thyroid-stimulating antibodies. Simultaneous analysis of C λ gene polymorphisms. J Clin Invest 82:1306-1312
6. Weetman AP, Yateman ME, Ealey PA, Black CM, Reimer CB, Williams Jr RC, Shine B, Marshall NJ 1990 Thyroid-stimulating antibody activity between different immunoglobulin G subclasses. J Clin Invest 86:723-727
7. De Forteza R, Smith CU, Amin J, McKenzie JM, Zakarija M 1994 Visualization of the thyrotropin receptor on the cell surface by potent autoantibodies. J Clin Endocrinol Metab 78:1271-1273
8. Jaume JC, Kakinuma A, Chazenbalk GD, Rapoport B, McLachlan SM 1997 TSH receptor autoantibodies in serum are present at much lower concentrations than thyroid peroxidase autoantibodies: analysis by flow cytometry. J Clin Endocrinol Metab 82:500-507
9. Chazenbalk GD, Jaume JC, McLachlan SM, Rapoport B 1997 Engineering the human thyrotropin receptor ectodomain from a non-secreted form to a secreted, highly immunoreactive glycoprotein that neutralizes autoantibodies in Graves' patients' sera. J Biol Chem 272:18959-18965
10. Chazenbalk GD, Pichurin P, Chen CR, Latrofa F, Johnstone AP, McLachlan SM, Rapoport B 2002 Thyroid-stimulating autoantibodies in Graves disease preferentially recognize the free A subunit, not the thyrotropin holoreceptor. J Clin Invest 110:209-217
11. Sanders J, Evans M, Premawardhana LD, Depraetere H, Jeffreys J, Richards T, Furmaniak J, Rees SB 2003 Human monoclonal thyroid stimulating autoantibody. Lancet 362:126-128
12. Zakarija M, McKenzie JM 1978 Adsorption of thyroid-stimulating antibody (TSAb) of Graves' disease by homologous and heterologous thyroid tissue. J Clin Endocrinol Metab 47:906-908
13. Endo K, Amir SM, Ingbar SH 1981 Development and evaluation of a method for the partial purification of immunoglobulins specific for Graves' disease. J Clin Endocrinol Metab 52:1113-1123
14. Morris JC, Gibson JL, Haas EJ, Bergert ER, Dallas JS, Prabhakar BS 1994 Identification of epitopes and affinity purification of thyroid stimulating autoantibodies using synthetic human TSH receptor peprides. Autoimmunity 17: 287-299
15. Nagayama Y, Wadsworth HL, Russo D, Chazenbalk GD, Rapoport B 1991 Binding domains of stimulatory and inhibitory thyrotropin (TSH) receptor autoantibodies determined with chimeric TSH-lutropin/chorionic gonadotropin receptors. J Clin Invest 88:336-340
16. Minich WB, Weymayer JD, Loos U 1998 Expression of a biotinylated human thyrotropin receptor in HeLa cells using recombinant vaccinia virus and its application for the detection of Graves' autoantibodies. Thyroid 8:3-7
17. Lee MH, Park JY, Cho BY, Chae C-B 1999 Expression of the functional extracellular domain of human thyrotropin receptor using a vaccinia virus system: its purification and analysis of autoantibody binding. J Clin Endocrinol Metab 84:1391-1397
18. Osuga Y, Liang S-G, Dallas JS, Wang C, Hsueh AJW 1998 Soluble ectodomain mutant of thyrotropin (TSH) receptor incapable of binding TSH neutralizes the action of thyroid-stimulating antibodies from Graves' patients. Endocrinology 139:671-676
19. Cornelis S, Uttenweiler-Joseph S, Panneels V, Vassart G, Costagliola S 2001 Purification and characterization of a soluble bioactive amino-terminal extracellular domain of the human thyrotropin receptor. Biochemistry 40:9860-9869
20. Chazenbalk GD, Wang Y, Guo J, Hutchison JS, Segal D, Jaume JC, McLachlan SM, Rapoport B 1999 A mouse monoclonal antibody to a thyrotropin receptor ectodomain variant provides insight into the exquisite antigenie conformational requirement, epitopes and in vivo concentration of human autoantibodies. J Clin Endocrinol Metab 84:702-710
21. Chazenbalk G, McLachlan S, Pichurin P, Rapoport B 2001 A "prion-like" shift between two conformational forms of a recombinant thyrotropin receptor A subunit module: purification and stabilization using chemical chaperones of the form reactive with Graves' autoantibodies. J Clin Endocrinol Metab 86: 1287-1293
22. Chen C-R, Tanaka K, Chazenbalk GD, McLachlan SM, Rapoport B 2001 A full biological response to autoantibodies in Graves' disease requires a disulfide-bond loop in the thyrotropin N-terminus homologous to a laminin EGF-like domain. J Biol Chem 276:14767-14772
23. Chazenbalk GD, Kakinuma A, Jaume JC, McLachlan SM, Rapoport B 1996 Evidence for negative cooperativity among human thyrotropin receptors overexpressed in mammalian cells. Endocrinology 137:4586-4591
24. Da Costa CR, Johnstone AP 1998 Production of the thyrotropin receptor extracellular domain as a glycosylphosphatidylinositol-anchored membrane protein and its interaction with thyrotropin and autoantibodies. J Biol Chem 273:11874-11880
25. Schwarz-Lauer L, Chazenbalk G, McLachlan SM, Ochi Y, Nagayama Y, Rapoport B 2002 Evidence for a simplified view of autoantibody interactions with the TSH receptor. Thyroid 12:115-120
26. Na CH, Lee MH, Cho BY, Chae CB 2003 A method for identification of the peptides that bind to a clone of thyroid-stimulating antibodies in the serum of Graves' disease patients. J Clin Endocrinol Metab 88:1570-1576
27. Sanders J, Jeffreys J, Depraetere H, Richards T, Evans M, Kiddie A, Brereton K, Groenen M, Oda Y, Furmaniak J, Rees Smith B 2002 Thyroid stimulating monoclonal antibodies. Thyroid 12:1043-1050
28. Costagliola S, Franssen JD, Bonomi M, Urizar E, Willnich M, Bergmann A, Vassart G 2002 Generation of a mouse monoclonal TSH receptor antibody with stimulating activity. Biochem Biophys Res Commun 299:891-896
29. Ando T, Latif R, Pritsker A, Moran T, Nagayama Y, Davies TF 2002 A monoclonal thyroid-stimulating antibody. J Clin Invest 110:1667-1674
30. Sanders J, Evans M, Premawardhana LD, Depraete H, Jeffreys J, Richards T, Kiddie A, Brereton K, Furmaniak J, Rees Smith B 2003 Thyroid stimulating monoclonal antibodies - of man and mouse. Thyroid 13:734 (Abstract)
31. Rapoport B, Adams RJ 1978 Bioassay of TSH using dog thyroid cells in monolayer culture. Metabolism 27:1732-1742
32. Costagliola S, Many M-C, Stalmans-Falys M, Tonacchera M, Vassart G, Ludgate M 1994 Recombinant thyrotropin receptor and the induction of autoimmune thyroid disease in BALB/c mice: a new animal model. Endocrinology 135:2150-2159
33. Atger M, Misrahi M, Young J, Jolivet A, Orgiazzi J, Schaison G, Milgrom E 1999 Autoantibodies interacting with purified native thyrotropin receptor. Eur J Biochem 265:1022-1031
34. Metcalfe R, Jordan N, Watson P, Gullu S, Wiltshire M, Crisp M, Evans C, Weetman A, Ludgate M 2002 Demonstration of immunoglobulin G, A, and E autoantibodies to the human thyrotropin receptor using flow cytometry. J Clin Endocrinol Metab 87:1754-1761
35. Brown RS, Kertiles LP, Reichlin S 1983 Partial purification and characterization of thyrotropin binding inhibitory immunoglobulins from normal human plasma. J Clin Endocrinol Metab 56:156-163
36. Bresler HS, Burek CL, Hoffman WH, Rose NR 1990 Autoantigenic determinants on human thyroglobulin. II. Determinants recognized by autoantibodies from patients with chronic autoimmune thyroiditis compared to autoantibodies from healthy subjects. Clin Immunol Immunopathol 54:76-86
37. Tomer Y, Davies TF 1993 Infection, thyroid disease, and autoimmunity. Endoer Rev 14:107-120
38. Weiss M, Ingbar SH, Winblad S, Kasper DL 1983 Demonstration of a sarurable binding site for thyrotropin in Yersinia enterocolitica. Science 219:1331-1333
39. Luo G, Fan J-L, Seetharamaiah GS, Desai RK, Dallas JS, Wagle N, Doan R, Niesel DW, Klimpel GR, Prabhakar BS 1993 Immunization of mice with Yersinia enterocolitica leads to the induction of antithyrotropin receptor antibodies. J Immunol 151:922-928
40. Luo G, Seetharamaiah GS, Niesel DW, Zhang H, Peterson JW, Prabhakar BS, Klimpel GR 1994 Purification and characterization of Yersinia enterocolitica envelope proteins which induce antibodies that react with human thyrotropin receptor. J Immunol 152:2555-2561
41. Zhang H, Kaur I, Niesel DW, Seetharamaiah GS, Peterson JW, Prabhakar BS, Klimpel GR 1997 Lipoprotein from Yersinia enterocolitica contains epitopes that cross-react with the human thyrotropin receptor. J Immunol 158:1976-1983
42. Morgenthaler NG, Minich WB, Willnich M, Bogusch T, Hollidt JM, Weglohner W, Lenzner C, Bergmann A 2003 Affinity purification and diagnostic use of TSH receptor autoantibodies from human serum. Mol Cell Endocrinol 212:73-79