Phloridzin improves absorption of genistin in isolated rat small intestine

Clinical Nutrition

Volumn 23, Issue 5, 2004, Pages 989-995

  Andlauer, Wilfried ^a,b   Kolb, Jochen ^b   Fürst, Peter ^b,c  

^a Haute Ecole Valaisanne   (Switzerland)

^b UNIVERSITY OF HOHENHEIM   (Germany)

^c UNIVERSITY OF BONN   (Germany)

Author keywords

Genistin; Intestinal absorption; Intestinal metabolism; Phloridzin; Rats

Indexed keywords

BICARBONATE; BUFFER; FLUOROCARBON; GENISTIN; GLUCOSE TRANSPORTER 1; OXYGEN; PHLORIZIN; SODIUM CHLORIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER PREVENTION; DRUG ABSORPTION; DRUG DESIGN; DRUG METABOLISM; DRUG UPTAKE; INTESTINE PERFUSION; ISOLATED ORGAN; MALE; NONHUMAN; RAT; SMALL INTESTINE ABSORPTION;

ANIMALS; HEALTH FOOD; INTESTINAL ABSORPTION; INTESTINE, SMALL; ISOFLAVONES; MALE; NEOPLASMS; PHLORHIZIN; RATS; RATS, SPRAGUE-DAWLEY;

EID: 4544324025     PISSN: 02615614     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.clnu.2003.11.009     Document Type: Article

References (32)

1. Marshall E. Search for a killer: focus shifts from fat to hormones in special report on breast cancer Science 259 1993 618-621
2. Bernstein L. Yuan J.M. Ross R.K. et al. Serum hormone levels in pre-menopausal Chinese women in Shanghai and white women in Los Angeles: results from two breast cancer case-control studies Cancer Causes Control 1 1990 51-58
3. Key T.J. Wang D.Y. Brown J.B. et al. A prospective study of urinary oestrogen excretion and breast cancer risk Br J Cancer 73 1996 1615-1619
4. Barnes S. Peterson G. Grubbs C. Setchell K. Potential role of dietary isoflavones in the prevention of cancer Adv Exp Med Biol 354 1994 135-147
5. Adlercreutz H. Phytoestrogens: epidemiology and a possible role in cancer protection Environ Health Perspect 103 1995 103-112
6. Barnes S. The chemopreventive properties of soy isoflavonoids in animal models of breast cancer Breast Cancer Res Treat 46 1997 169-179
7. Zhou J.R. Gugger E.T. Tanaka T. Guo Y. Blackburn G.L. Clinton S.K. Soybean phytochemicals inhibit the growth of transplantable human prostate carcinoma and tumor angiogenesis in mice J Nutr 129 1999 1628-1635
8. Messina M.J. Legumes and soybeans: overview of their nutritional profiles and health effects Am J Clin Nutr 70 1999 439S-450S
9. Adlercreutz H. Western diet and western diseases: some hormonal and biochemical mechanism and associations Scand J Clin Lab Invest 50 1990 3-23
10. Adlercreutz H. Mazur W. Phyto-oestrogens and Western diseases Ann Med 29 1997 95-120
11. Lu L.J. Anderson K.E. Grady J.J. Nagamani M. Effects of soya consumption for one month on steroid hormones in premenopausal women: implications for breast cancer risk reduction Cancer Epidemiol Biomarkers Prev 5 1996 63-70
12. Andlauer W. Kolb J. Fürst P. Absorption and metabolism of genistin in the isolated rat small intestine FEBS Lett 465 2000 127-130
13. Hollman P.C. Bijsman M.N. vanGameren Y. Cnossen E.P. DeVries M.H. Katan M.B. The sugar moiety is a major determinant of the absorption of dietary flavonoid glycosides in man Free Radic Res 31 1999 569-573
14. Hartmann F. Vieillard-Baron D. Heinrich R. Isolated perfusion of the small intestine using perfluorotributylamine as artificial oxygen carrier Adv Exp Med Biol 180 1984 711-720
15. Andlauer W. Kolb J. Siebert K. Fürst P. Assessment of resveratrol bioavailability in the perfused small intestine of the rat Drugs Exp Clin Res 26 2000 47-55
16. Plauth M. Raible A. Bauder-Gross D. Vieillard-Baron D. Fürst P. Hartmann F. Effects of dexamethasone on glutamine metabolism in the isolated vascularly perfused rat small intestine Res Exp Med 191 1991 349-357
17. Andlauer W. Kolb J. Stehle P. Fürst P. Absorption and metabolism of genistein in the isolated rat small intestine J Nutr 130 2000 843-846
18. Sfakianos J. Coward L. Kirk M. Barnes S. Intestinal uptake and biliary excretion of the isoflavone genistein in rats J Nutr 127 1997 1260-1268
19. Wang H-.J. Murphy P.A. Isoflavone content in commercial soybean foods J Agric Food Chem 42 1994 1666-1673
20. Mizuma T. Awazu S. Intestinal Na+/glucose cotransporter-mediated transport of glucose conjugate formed from disaccharide conjugate Biochim Biophys Acta 1379 1998 1-6
21. Lostao M.P. Hirayama B.A. Loo D.D. Wright E.M. Phenylglucosides and the Na+/glucose cotransporter (SGLT1): analysis of interactions J Membr Biol 142 1994 161-170
22. Mizuma T. Hagi K. Awazu S. Intestinal transport of beta-thioglycosides by Na+/glucose cotransporter J Pharm Pharmacol 52 2000 303-310
23. Mizuma T. Ohta K. Hayashi M. Awazu S. Intestinal active absorption of sugar-conjugated compounds by glucose transport system: implication of improvement of poorly absorbable drugs Biochem Pharmacol 43 1992 2037-2039
24. Uhing M.R. Kimura R.E. Active transport of 3-O-methyl-glucose by the small intestine in chronically catheterized rats J Clin Invest 95 1995 2799-2805
25. Walle U.K. French K.L. Walgren R.A. Walle T. Transport of genistein-7-glucoside by human intestinal CACO-2 cells: potential role for MRP2 Res Commun Mol Pathol Pharmacol 103 1999 45-56
26. Takanaga H. Ohnishi A. Matsuo H. Sawada Y. Inhibition of vinblastine efflux mediated by P-glycoprotein by grapefruit juice components in caco-2 cells Biol Pharm Bull 21 1998 1062-1066
27. Hooijberg J.H. Broxterman H.J. Heijn M. Fles D.L. Lankelma J. Pinedo H.M. Modulation by (iso)flavonoids of the ATPase activity of the multidrug resistance protein FEBS Lett 413 1997 344-348
28. Mizuma T. Awazu S. Inhibitory effect of phloridzin and phloretin on glucuronidation of p-nitrophenol, acetaminophen and 1-naphthol: kinetic demonstration of the influence of glucuronidation metabolism on intestinal absorption in rats Biochim Biophys Acta 1425 1998 398-404
29. Zhang Y. Song T.T. Cunnick J.E. Murphy P.A. Hendrich S. Daidzein and genistein glucuronides in vitro are weakly estrogenic and activate human natural killer cells at nutritionally relevant concentrations J Nutr 129 1999 399-405
30. DeVries M.H. Hofman A. Koster A.S.J. Noordhoek J. Systematic intestinal metabolism of 1-Naphthol. A study in the isolated vascularly perfused rat small intestine Drug Metabol Dispos 17 1989 573-578
31. Koster A.S.J. Noordhoek J. Glucuronidation in isolated perfused rat intestinal segments after mucosal and serosal administration of 1-naphthol J Pharmacol Exp Ther 226 1983 533-538
32. Walle U.K. Galijatovic A. Walle T. Transport of the flavonoid chrysin and its conjugated metabolites by the human intestinal cell line Caco-2 Biochem Pharmacol 58 1999 431-438