Inhibitory effect of phloridzin and phloretin on glucuronidation of p-nitrophenol, acetaminophen and 1-naphthol: Kinetic demonstration of the influence of glucuronidation metabolism on intestinal absorption in rats

Biochimica et Biophysica Acta - General Subjects

Volumn 1425, Issue 2, 1998, Pages 398-404

  Mizuma, Takashi ^a   Awazu, Shoji ^a  

^a TOKYO UNIVERSITY OF PHARMACY AND LIFE SCIENCES   (Japan)

Author keywords

Intestinal absorption; Intestinal glucuronidation; Metabolic inhibition model; Phloretin; Phloridzin

Indexed keywords

1 NAPHTHOL; 4 NITROPHENOL; PARACETAMOL; PHLORETIN; PHLORIZIN;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG CLEARANCE; DRUG HYDROLYSIS; DRUG METABOLISM; GLUCURONIDATION; INTESTINE ABSORPTION; MALE; METABOLIC CLEARANCE RATE; NONHUMAN; PRIORITY JOURNAL; RAT;

ACETAMINOPHEN; ANIMALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; GLUCURONATES; GLUCURONIDASE; INTESTINAL ABSORPTION; MALE; NAPHTHOLS; NITROPHENOLS; PHLORETIN; PHLORHIZIN; RATS; RATS, WISTAR;

EID: 0031756980     PISSN: 03044165     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-4165(98)00093-2     Document Type: Article

References (10)

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