Insulin UW solution exacerbates hepatic ischemia/reperfusion injury by energy depletion through the IRS-2/SREBP-1c pathway

Liver Transplantation

Volumn 10, Issue 9, 2004, Pages 1173-1182

  Li, Xian Liang ^a   Man, Kwan ^a   Ng, Kevin T ^a   Lee, Terence K ^a   Lo, Chung Mau ^a   Fan, Sheung Tat ^a  

^a UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

[No Author keywords available]

Indexed keywords

ADENINE NUCLEOTIDE DERIVATIVE; ADENOSINE TRIPHOSPHATE; APOLIPOPROTEIN C3; FATTY ACID; FATTY ACID SYNTHASE; GLUCOKINASE; GLYCOGEN; GLYCOGEN SYNTHASE KINASE 3BETA; INSULIN; INSULIN RECEPTOR SUBSTRATE 2; LIPOPROTEIN; MESSENGER RNA; SOMATOMEDIN BINDING PROTEIN 1; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; STEROL REGULATORY ELEMENT BINDING PROTEIN 1C; UNCLASSIFIED DRUG; UNIVERSITY OF WISCONSIN SOLUTION;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOSYNTHESIS; CONTROLLED STUDY; CRYOPRESERVATION; DISEASE EXACERBATION; ENERGY CONSUMPTION; ENERGY METABOLISM; ENZYME ACTIVATION; ENZYME ACTIVITY; FATTY ACID SYNTHESIS; GENE TARGETING; GENETIC REGULATION; GLYCOGEN SYNTHESIS; LIPOPROTEIN METABOLISM; LIVER GRAFT; LIVER ISCHEMIA; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REPERFUSION INJURY; SIGNAL TRANSDUCTION; STATISTICAL SIGNIFICANCE; UPREGULATION;

EID: 4544321682     PISSN: 15276465     EISSN: None     Source Type: Journal    
DOI: 10.1002/lt.20240     Document Type: Article

References (40)

1. Palombo JD, Pomposelli JJ, Hirschberg Y, Blackburn GL, Bistrian BR. Glycolytic support of adenine nucleotides in rat liver flush-preserved with UW or Collins' II. Importance of donor nutritional status. Transplantation 1989;48:901-905.
2. Lanir A, Jenkins RL, Caldwell C, Lee RG, Khettry U, Clouse ME. Hepatic transplantation survival: correlation with adenine nucleotide level in donor liver. Hepatology 1988;8:471-475.
3. Cywes R, Greig PD, Morgan GR, Sanabria JR, Clavien PA, Harvey PR, Strasberg SM. Rapid donor liver nutritional enhancement in a large animal model. Hepatology 1992;16: 1271-1279.
4. Lochhead PA, Coghlan M, Rice SQ, Sutherland C. Inhibition of GSK-3 selectively reduces glucose-6-phosphatase and phosphatase and phosphoenolpyruvate carboxykinase gene expression. Diabetes 2001;50:937-946.
5. Cywes R, Greig PD, Sanabria,JR, Clavien PA, Levy GA, Harvey PR, Strasberg SM. Effect of intraportal glucose infusion on hepatic glycogen content and degradation, and outcome of liver transplantation. Ann Surg 1992;216:235-246.
6. Li XL, Man K, Liu YF, Lee TK, Tsui SH, Lau CK, et al. Insulin in University of Wisconsin solution exacerbates the ischemic injury and decreases the graft survival rate in rat liver transplantation. Transplantation 2003;76:44-49.
7. Sesti G, Federici M, Hribal ML, Lauro D, Sbraccia P, Lauro R. Defects of the insulin receptor substrate (IRS) system in human metabolic disorders. FASEB J 2001;15:2099-2111.
8. Rother KI, Imai Y, Caruso M, Beguinot F, Formisano P, Accili D. Evidence that IRS-2 phosphorylation is required for insulin action in hepatocytes. J Biol Chem 1998;273:17491-17497.
9. Foretz M, Guichard C, Ferré P, Foufelle F. Sterol regulatory element binding protein-1c is a major mediator of insulin action on the hepatic expression of glucokinase and lipogenesis-related genes. Proc Natl Acad Sci USA 1999;96:12737-12742.
10. Bécard D, Hainault I, Azzout-Marniche D, Bertry-Coussot L, Ferré P, Foufelle F. Adenovirus-mediated overexpression of sterol regulatory element binding protein-1c mimics insulin effects on hepatic gene expression and glucose homeostasis in diabetic mice. Diabetes 2001;50:2425-2430.
11. Sul HS, Latasa MJ, Moon Y, Kim KH. Regulation of the fatty acid synthase promoter by insulin. J Nutr 2000;130(Suppl 2S): 315S-320S.
12. Dallinga-Thie GM, Groenendijk M, Blom RN, De Bruin TW, De Kant E. Genetic heterogeneity in the apolipoprotein C-III promoter and effects of insulin. J Lipid Res 2001;42:1450-1456.
13. Lee PD, Conover CA, Powell DR. Regulation and function of insulin-like growth factor-binding protein-1. Proc Soc Exp Biol Med 1993;204:4-29.
14. Desbois-Mouthon C, Blivet-Van Eggelpoel MJ, Beurel E, Boissan M, Delelo R, Cadoret A, Capeau J. Dysregulation of glycogen synthase kinase-3β signaling in hepatocellular carcinoma cells. Hepatology 2002;36:1528-1536.
15. Biguzas M, Jablonski P, Howden BO, Thomas AC, Walls K, Scott DF, Marshall VC. Evaluation of UW solution in rat kidney preservation. II. The effect of pharmacological additives. Transplantation 1990;49:1051-1055.
16. Kamada N, Calne RY. Orthotopic liver transplantation in the rat. Technique using cuff for portal vein anastomosis and biliary drainage. Transplantation 1979;28:47-50.
17. Wynants J, Van Belle H. Single-run high-performance liquid chromatography of nucleotides, nucleosides, and major purine bases and its application to different tissue extracts. Anal Biochem 1985;144:258-266.
18. Postic C, Shiota M, Magnuson MA. Cell-specific roles of glucokinase in glucose homeostasis. Recent Prog Horm Res 2001; 56:195-217.
19. Jamieson NV, Sundberg R, Lindell S, Claesson K, Moen J, Vreugdenhil PK, et al. Preservation of the canine liver for 24-48 hours using simple cold storage with UW solution. Transplantation 1988;46:517-522.
20. Morimoto T, Ukikusa M, Taki Y, Koizumi K, Yokoo N, Tanaka A, et al. Changes in energy metabolism of allografts after liver transplantation. Eur Surg Res 1988;20:120-127.
21. Zhang J, Ou J, Bashmakov Y, Horton JD, Brown MS, Goldstein JL. Insulin inhibits transcription of IRS-2 gene in rat liver through an insulin response element (IRE) that resembles IREs of other insulin-repressed genes. Proc Natl Acad Sci USA 2001; 98:3756-3761.
22. Peak M, Rochford JJ, Borthwick AC, Yeaman SJ, Agius L. Signalling pathways involved in the stimulation of glycogen synthesis by insulin in rat hepatocytes. Diabetologia 1998;41:16-25.
23. Adam R, Bismuth H, Diamond T, Ducot B, Morino M, Astarcioglu I, et al. Effect of extended cold ischemia with UW solution on graft function after liver transplantation. Lancet 1992;340:1373-1376.
24. Coffee CJ. Regulation of metabolism. In: Metabolism. Madison, CT: Fence Creek, 1998:111-125.
25. Peralta C, Bartrons R, Riera L, Manzano A, Xaus C, Gelpí E, Roselló-Catafau J. Hepatic preconditioning preserves energy metabolism during sustained ischemia. Am J Physiol Gastrointest Liver Physiol 2000;279:G163-G171.
26. Oreña SJ, Torchia AJ, Garofalo RS. Inhibition of glycogen-synthase kinase 3 stimulates glycogen synthase and glucose transport by distinct mechanisms in 3T3-L1 adipocytes. J Biol Chem 2000;275:15765-15772.
27. Ragano-Caracciolo M, Berlin WK, Miller MW, Hanover JA. Nuclear glycogen and glycogen synthase kinase 3. Biochem Biophys Res Commun 1998;249:422-427.
28. Radziuk J, Pye S. Hepatic glucose uptake, gluconeogenesis and the regulation of glycogen synthesis. Diabetes Metab Res Rev 2001;17:250-272.
29. Schwabe RF, Brenner DA. Role of glycogen synthase kinase-3 in TNF-α-induced NF-κB activation and apoptosis in hepatocytes. Am J Physiol Gastrointest Liver Physiol 2002;283:G204-G211.
30. Hoeflich KP, Luo J, Rubie EA, Tsao MS, Jin O, Woodgett JR. Requirement for glycogen synthase kinase-3β in cell survival and NF-κB activation. Nature 2000;406:86-90.
31. Coffee CJ. Fatty acid metabolism. In: Metabolism. Madison, CT: Fence Creek, 1998:273-287.
32. Wan C, Shafizadeh SF, Polito CC, Schmidt M, Chavin KD. Fatty acid synthase inhibition is protective in a lethal fatty liver transplantation model. Am J Transplant 2003;3(Suppl 5): 185.
33. Chen M, Breslow JL, Li W, Leff T. Transcriptional regulation of the apo C-III gene by insulin in diabetic mice: correlation with changes in plasma triglyceride levels. J Lipid Res 1994;35:1918-1924.
34. Lavoie JM, Fillion Y, Couturier K, Corriveau P. Evidence that the decrease in liver glycogen is associated with the exercise-induced increase in IGFBP-1. J Appl Physiol 2002;93:798-804.
35. + / taurocholate cotransport polypeptides is mediated via the phosphoinositide 3-kinase signaling pathway. J Biol Chem 2000;275:29754-29760.
36. Carini R, Autelli R, Bellomo G, Albano E. Alteration of cell volume regulation in the development of hepatocyte necrosis. Exp Cell Res 1999;248:280-293.
37. Vajdová K, Graf R, Clavien PA. ATP-supplies in the cold-preserved liver: a long-neglected factor of organ viability. Hepatology 2002;36:1543-1552.
38. Coffee CJ. Connections between metabolism pathways. In: Metabolism. Madison, CT: Fence Creek, 1998:233-242.
39. Debroy M, Dykstra DM, Roberts JP, Rudich SM, Punch JD, Maraschio MA, et al. The impact of cold ischemic time and donor age on liver transplant outcome. Am J Transplant 2003; 3(Suppl 5):451.
40. De Carlis L, Sansalone CV, Rondinara GF, Colella G, Slim AO, Rossetti O, et al. Is the use of marginal donors justified in liver transplantation? Analysis of results and proposal of modern criteria. Transpl Int 1996;9(Suppl 1):S414-S417.