Differential effects of 5-HT1 and 5-HT2 receptor agonists on hindlimb movements in paraplegic mice

Progress in Neuro-Psychopharmacology and Biological Psychiatry

Volumn 28, Issue 6, 2004, Pages 1053-1060

  Landry, Eric S ^a   Guertin, Pierre A ^a  

^a UNIVERSITÉ LAVAL   (Canada)

Author keywords

5 HT; 5 HTP; 5 hydroxytryptophan; central pattern generator; CPG; DOI; L DOPA; Locomotion; m CPP; n methyl D aspartate; NMDA; Quipazine; R( ) 1 (2,5 dimethoxy 4 iodophenyl) 2 aminopropane hydrochloride; serotonin; Spinal cord injury; TFMPP

Indexed keywords

(3 CHLOROPHENYL)PIPERAZINE; 1 (3 TRIFLUOROMETHYLPHENYL)PIPERAZINE; LEVODOPA; QUIPAZINE; SEROTONIN 1 AGONIST; SEROTONIN 1B AGONIST; SEROTONIN 2 AGONIST; SEROTONIN 2A AGONIST; SEROTONIN 2C AGONIST; SEROTONIN RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; EXAMINATION; HINDLIMB; LIMB MOVEMENT; LOCOMOTION; MALE; MOUSE; NONHUMAN; PARAPLEGIA; SPINAL CORD TRANSSECTION; THORACIC SPINE; TREADMILL;

ANALYSIS OF VARIANCE; ANIMALS; ANTIPARKINSON AGENTS; DISEASE MODELS, ANIMAL; DRUG INTERACTIONS; EXERCISE TEST; HINDLIMB; LEVODOPA; LOCOMOTION; MALE; MICE; MOVEMENT; PARAPLEGIA; PIPERAZINES; PYRIDINES; QUIPAZINE; RECEPTORS, SEROTONIN, 5-HT1; RECEPTORS, SEROTONIN, 5-HT2; SEROTONIN AGONISTS; SPINAL CORD INJURIES;

EID: 4544305676     PISSN: 02785846     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pnpbp.2004.05.001     Document Type: Article

References (46)

1. Alhaider A.A., Wilcox G.L. Differential roles of 5-hydroxytryptamine1A and 5-hydroxytryptamine1B receptor subtypes in modulating spinal nociceptive transmission in mice. J. Pharmacol. Exp. Ther. 265:1993;378-385
2. Antri M., Orsal D., Barthe J.Y. Locomotor recovery in the chronic spinal rat: effects of long-term treatment with a 5-HT2 agonist. Eur. J. Neurosci. 16:2002;467-476
3. Antri M., Mouffle C., Orsal D., Barthe J.Y. 5-HT1A receptors are involved in short- and long-term processes responsible for 5-HT-induced locomotor function recovery in chronic spinal rat. Eur. J. Neurosci. 18:2003;1963-1972
4. Asarch K.B., Ransom R.W., Shih J.C. 5-HT-1a and 5-HT-1b selectivity of two phenylpiperazine derivatives: evidence for 5-HT-1b heterogeneity. Life Sci. 36:1985;1265-1273
5. Aulakh C.S., Hill J.L., Murphy D.L. Effects of various serotonin receptor subtype-selective antagonists alone and on m-chlorophenylpiperazine-induced neuroendocrine changes in rats. J. Pharmacol. Exp. Ther. 263:1992;588-595
6. Barbeau H., Rossignol S. The effects of serotonergic drugs on the locomotor pattern and on cutaneous reflexes of the adult chronic spinal cat. Brain Res. 514:1990;55-67
7. Barbeau H., Rossignol S. Initiation and modulation of the locomotor pattern in the adult chronic spinal cat by noradrenergic, serotonergic and dopaminergic drugs. Brain Res. 546:1991;250-260
8. Barnes N.M., Sharp T. A review of central 5-HT receptors and their function. Neuropharmacology. 38:1999;1083-1152
9. Beato M., Nistri A. Serotonin-induced inhibition of locomotor rhythm of the rat isolated spinal cord is mediated by the 5-HT1 receptor class. Proc. R. Soc. Lond., B. Biol. Sci. 265:1998;2073-2080
10. Bouhelal R., Smounya L., Bockaert J. 5-HT1B receptors are negatively coupled with adenylate cyclase in rat substantia nigra. Eur. J. Pharmacol. 151:1988;189-196
11. Branchereau P., Morin D., Bonnot A., Ballion B., Chapron J., Viala D. Development of lumbar rhythmic networks: from embryonic to neonate locomotor-like patterns in the mouse. Brain Res. Bull. 53:2000;711-718
12. Britt S.G., Gonias S.L., Sanders J.M., Vandenberg S.R. Agonist and antagonist activities of arylpiperazines at human platelet serotonin2 receptors. J. Pharmacol. Exp. Ther. 247:1988;965-970
13. Carver J.G., Grahame-Smith D.G., Johnson E.S., Madgwick Z. The effects of 5-HT and m-chlorophenylpiperazine (m-CPP) on the efflux of [3H]-5-HT from human perfused platelets. Br. J. Clin. Pharmacol. 35:1993;473-478
14. Cazalets J.R., Gardette M., Hilaire G. Locomotor network maturation is transiently delayed in the MAOA-deficient mouse. J. Neurophysiol. 83:2000;2468-2470
15. Cazalets J.R., Sqalli-Houssaini Y., Clarac F. Activation of the central pattern generators for locomotion by serotonin and excitatory amino acids in neonatal rat. J. Physiol. 455:1992;187-204
16. Cina C., Hochman S. Diffuse distribution of sulforhodamine-labeled neurons during serotonin-evoked locomotion in the neonatal rat thoracolumbar spinal cord. J. Comp. Neurol. 423:2000;590-602
17. Cohen M.L., Fuller R.W. Antagonism of vascular serotonin receptors by m-chlorophenylpiperazine and m-trifluoromethylphenylpiperazine. Life Sci. 32:1983;711-718
18. Conn P.J., Sanders-Bush E. Central serotonin receptors: effector systems, physiological roles and regulation. Psychopharmacology (Berl.). 92:1987;267-277
19. Conn P.J., Sanders-Bush E. Relative efficacies of piperazines at the phosphoinositide hydrolysis-linked serotonergic (5-HT-2 and 5-HT-1c) receptors. J. Pharmacol. Exp. Ther. 242:1987;552-557
20. Cowley K.C., Schmidt B.J. A comparison of motor patterns induced by N-methyl-D-aspartate, acetylcholine and serotonin in the in vitro neonatal rat spinal cord. Neurosci. Lett. 171:1994;147-150
21. Crick H., Manuel N.A., Wallis D.I. A novel 5-HT receptor or a combination of 5-HT receptor subtypes may mediate depression of a spinal monosynaptic reflex in vitro. Neuropharmacology. 33:1994;897-904
22. Daval G., Verge D., Basbaum A.I., Bourgoin S., Hamon M. Autoradiographic evidence of serotonin1 binding sites on primary afferent fibres in the dorsal horn of the rat spinal cord. Neurosci. Lett. 83:1987;71-76
23. Eide P.K., Joly N.M., Hole K. The role of spinal cord 5-HT1A and 5-HT1B receptors in the modulation of a spinal nociceptive reflex. Brain Res. 536:1990;195-200
24. el Yassir N., Fleetwood-Walker S.M. A 5-HT1-type receptor mediates the antinociceptive effect of nucleus raphe magnus stimulation in the rat. Brain Res. 523:1990;92-99
25. Feraboli-Lohnherr D., Barthe J.Y., Orsal D. Serotonin-induced activation of the network for locomotion in adult spinal rats. J. Neurosci. Res. 55:1999;87-98
26. Grillner S., Shik M.L. On the descending control of the lumbosacral spinal cord from the "mesencephalic locomotor region" Acta Physiol. Scand. 87:1973;320-333
27. Grotewiel M.S., Chu H., Sanders-Bush E. m-chlorophenylpiperazine and m-trifluoromethylphenylpiperazine are partial agonists at cloned 5-HT2A receptors expressed in fibroblasts. J. Pharmacol. Exp. Ther. 271:1994;1122-1126
28. Guertin P.A. Role of NMDA receptor activation in serotonin agonist-induced air-stepping in paraplegic mice. Spinal Cord. 42(3):2004;185-190
29. Guertin P.A. Synergistic activation of the central pattern generator for locomotion by l-beta-3,4-dihydroxyphenylalanine and quipazine in adult paraplegic mice. Neurosci. Lett. 358(2):2004;71-74
30. Ike J., Canton H., Sanders-Bush E. Developmental switch in the hippocampal serotonin receptor linked to phosphoinositide hydrolysis. Brain Res. 678:1995;49-54
31. Julius D. Molecular biology of serotonin receptors. Annu. Rev. Neurosci. 14:1991;335-360
32. Kennett G.A., Curzon G. Potencies of antagonists indicate that 5-HT1C receptors mediate 1-3(chlorophenyl)piperazine-induced hypophagia. Br. J. Pharmacol. 103:1991;2016-2020
33. Kim D., Adipudi V., Shibayama M., Giszter S., Tessler A., Murray M., Simansky K.J. Direct agonists for serotonin receptors enhance locomotor function in rats that received neural transplants after neonatal spinal transection. J. Neurosci. 19:1999;6213-6224
34. Kim D., Murray M., Simansky K.J. The serotonergic 5-HT(2C) agonist m-chlorophenylpiperazine increases weight-supported locomotion without development of tolerance in rats with spinal transections. Exp. Neurol. 169:2001;496-500
35. Kjaerulff O., Barajon I., Kiehn O. Sulphorhodamine-labelled cells in the neonatal rat spinal cord following chemically induced locomotor activity in vitro. J. Physiol. 478(Pt 2):1994;265-273
36. Leblond H., L'Esperance M., Orsal D., Rossignol S. Treadmill locomotion in the intact and spinal mouse. J. Neurosci. 23:2003;11411-11419
37. McEwen M.L., Van Hartesveldt C., Stehouwer D.J. L-DOPA and quipazine elicit air-stepping in neonatal rats with spinal cord transections. Behav. Neurosci. 111:1997;825-833
38. Nishimaru H., Takizawa H., Kudo N. 5-Hydroxytryptamine-induced locomotor rhythm in the neonatal mouse spinal cord in vitro. Neurosci. Lett. 280:2000;187-190
39. Norreel J.C., Pflieger J.F., Pearlstein E., Simeoni-Alias J., Clarac F., Vinay L. Reversible disorganization of the locomotor pattern after neonatal spinal cord transection in the rat. J. Neurosci. 23:2003;1924-1932
40. Pompeiano M., Palacios J.M., Mengod G. Distribution and cellular localization of mRNA coding for 5-HT1A receptor in the rat brain: correlation with receptor binding. J. Neurosci. 12:1992;440-453
41. Rotzinger S., Fang J., Baker G.B. Trazodone is metabolized to m-chlorophenylpiperazine by CYP3A4 from human sources. Drug Metab. Dispos. 26:1998;572-575
42. Steardo L., Monteleone P., Trabace L., Cannizzaro C., Maj M., Cuomo V. Serotonergic modulation of rat pineal gland activity: in vivo evidence for a 5-Hydroxytryptamine(2C) receptor involvement. J. Pharmacol. Exp. Ther. 295:2000;266-273
43. Tozawa Y., Ueki A., Shimosawa T., Fujita T. 5-HT(2A/2C) receptor agonist-induced increase in urinary isatin excretion in rats: reversal by both diazepam and dexamethasone. Biochem. Pharmacol. 58:1999;1329-1334
44. Viala D., Buser P. Methods of obtaining locomotor rhythms in the spinal rabbit by pharmacological treatments (DOPA, 5-HTP, D-amphetamine). Brain Res. 35:1971;151-165
45. Whelan P., Bonnot A., O'Donovan M.J. Properties of rhythmic activity generated by the isolated spinal cord of the neonatal mouse. J. Neurophysiol. 84:2000;2821-2833
46. Zhang W., Grillner S. The spinal 5-HT system contributes to the generation of fictive locomotion in lamprey. Brain Res. 879:2000;188-192